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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CXCR4 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity TAS GO:0001666 response to hypoxia IEP GO:0002407 dendritic cell chemotaxis TAS GO:0006915 apoptosis TAS GO:0006954 inflammatory response TAS GO:0007186 G-protein coupled receptor protein signaling pathway IDA GO:0007186 G-protein coupled receptor protein signaling pathway IEA GO:0007186 G-protein coupled receptor protein signaling pathway TAS GO:0007204 elevation of cytosolic calcium ion concentration TAS GO:0009615 response to virus TAS GO:0016032 viral reproduction TAS GO:0019059 initiation of viral infection TAS GO:0030260 entry into host cell TAS GO:0043217 myelin maintenance ISS GO:0044419 interspecies interaction between organisms IEA GO:0048714 positive regulation of oligodendrocyte differentiation ISS GO:0050920 regulation of chemotaxis IMP cellular_component GO:0005737 cytoplasm TAS GO:0005886 plasma membrane TAS GO:0009986 cell surface IDA GO:0016021 integral to membrane IEA GO:0016023 cytoplasmic membrane-bounded vesicle IDA GO:0031252 cell leading edge IDA GO:0031410 cytoplasmic vesicle IDA molecular_function GO:0003779 actin binding IDA GO:0004871 signal transducer activity IEA GO:0004872 receptor activity IEA GO:0004930 G-protein coupled receptor activity IEA GO:0005515 protein binding IPI GO:0015026 coreceptor activity TAS GO:0016494 C-X-C chemokine receptor activity IEA GO:0016494 C-X-C chemokine receptor activity NAS GO:0031625 ubiquitin protein ligase binding IPI GO:0032027 myosin light chain binding IDA GO:0043130 ubiquitin binding IDA

Protein-protein interaction details for CXCR4 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CCR5 Reconstituted Complex physical 12429730 JAK3 Affinity Capture-Western physical 10506573 JAK2 Affinity Capture-Western physical 10506573 PTPN6 Affinity Capture-Western physical 10506573 ADRBK2 Affinity Capture-Western physical 11668182 PTK2 Affinity Capture-Western physical 11668182 SOCS3 Affinity Capture-Western physical 12163560 CD4 Affinity Capture-Western physical 10816381 ITCH Reconstituted Complex physical 19116316 ITCH Affinity Capture-Western physical 19116316 ITCH FRET physical 19116316 ITCH Reconstituted Complex physical 19116316 USP14 Affinity Capture-Western physical 19106094 USP14 Reconstituted Complex physical 19106094 UBC Affinity Capture-Western physical 17947233 UBC Affinity Capture-Western physical 14602072 UBC Affinity Capture-Western physical 11641392 HLA-C Affinity Capture-Western physical 18083706 HLA-C Reconstituted Complex physical 18083706 STAM Co-localization physical 20505072 UBC Affinity Capture-Western physical 20505072 UBC Affinity Capture-MS physical 21987572