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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SOCS3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001666 response to hypoxia IEA GO:0001932 regulation of protein phosphorylation IEA GO:0006916 anti-apoptosis TAS GO:0007259 JAK-STAT cascade IEA GO:0007568 aging IEA GO:0009408 response to heat IEA GO:0009617 response to bacterium IEA GO:0010332 response to gamma radiation IEA GO:0014070 response to organic cyclic compound IEA GO:0019221 cytokine-mediated signaling pathway TAS GO:0031100 organ regeneration IEA GO:0032094 response to food IEA GO:0032355 response to estradiol stimulus IEA GO:0032496 response to lipopolysaccharide IEA GO:0032570 response to progesterone stimulus IEA GO:0032868 response to insulin stimulus IEA GO:0034097 response to cytokine stimulus IEA GO:0040008 regulation of growth IEA GO:0042493 response to drug IEA GO:0045597 positive regulation of cell differentiation IEA GO:0046627 negative regulation of insulin receptor signaling pathway IEA GO:0051384 response to glucocorticoid stimulus IEA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060338 regulation of type I interferon-mediated signaling pathway TAS GO:0060670 branching involved in embryonic placenta morphogenesis IEA GO:0060674 placenta blood vessel development IEA GO:0060707 trophoblast giant cell differentiation IEA GO:0060708 spongiotrophoblast differentiation IEA cellular_component GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS molecular_function GO:0004860 protein kinase inhibitor activity TAS

Protein-protein interaction details for SOCS3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PIN1 Two-hybrid physical 16169070 PRLR Affinity Capture-Western physical 11713228 INSR Affinity Capture-Western physical 12560330 CXCR4 Affinity Capture-Western physical 12163560 LEPR Reconstituted Complex physical 11018044 IL6ST Affinity Capture-Western physical 12403768 IL6ST Reconstituted Complex physical 12403768 PTPN11 Affinity Capture-Western physical 12403768 PTPN11 Reconstituted Complex physical 12403768 JAK2 Affinity Capture-Western physical 10882725 JAK2 Affinity Capture-Western physical 10882725 EPOR Affinity Capture-Western physical 10882725 EPOR Affinity Capture-Western physical 10882725 EPOR Reconstituted Complex physical 10882725 GHR Reconstituted Complex physical 10585430 JAK2 Two-hybrid physical 10421843 JAK2 Affinity Capture-Western physical 10421843 JAK2 Reconstituted Complex physical 10421843 CSF1R Affinity Capture-Western physical 12133942 RASA1 Reconstituted Complex physical 11331873 RASA1 Affinity Capture-Western physical 11331873 EGFR Affinity Capture-Western physical 12070153 EPOR Reconstituted Complex physical 12027890 JAK2 Two-hybrid physical 9344848 PTK2B Two-hybrid physical 9344848 JAK2 Reconstituted Complex physical 9344848 IGF1R Reconstituted Complex physical 11071852 IGF1R Two-hybrid physical 11071852 IGF1R Affinity Capture-Western physical 11071852 NONO Affinity Capture-Western physical 18952062 MAP3K7 Affinity Capture-Western physical 16543409 TRAF6 Affinity Capture-Western physical 16543409 MAP3K5 Affinity Capture-Western physical 16407264 LEPR Affinity Capture-Western physical 21239736 ACADVL Two-hybrid physical 22093833 ACADVL Reconstituted Complex physical 22093833 PTK2 Affinity Capture-Western physical 18031698 PTK2 Affinity Capture-Western physical 18031698 MAPK11 Two-hybrid physical 21900206 PDPK1 Two-hybrid physical 21900206 MAPK6 Two-hybrid physical 21900206