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Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Others;;Contraception
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Up-regulated Genes Score GO annotation PAEP 8 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity GPX3 4 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... LIF 4 BP    MF    CC biological_process blood vessel remodeling decidualization embryo implantation immune response more... leukemia inhibitory factor signaling pathway lung alveolus development lung lobe morphogenesis lung vasculature development maternal process involved in female pregnancy multicellular organismal development muscle organ morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis negative regulation of cell proliferation negative regulation of hormone secretion negative regulation of meiosis neuron development organ regeneration positive regulation of MAPKKK cascade positive regulation of astrocyte differentiation positive regulation of cell proliferation positive regulation of corticotropin secretion positive regulation of macrophage differentiation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of neuron projection development positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation retina development in camera-type eye spongiotrophoblast differentiation stem cell maintenance transdifferentiation trophoblast giant cell differentiation less... cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity leukemia inhibitory factor receptor binding receptor binding more... DDX46 4 BP    MF    CC biological_process RNA splicing mRNA processing cellular_component Cajal body nuclear speck nucleus molecular_function ATP binding ATP-dependent helicase activity RNA binding helicase activity more... hydrolase activity nucleic acid binding nucleotide binding less... CCL14 4 BP    MF    CC biological_process cellular calcium ion homeostasis immune response positive regulation of cell proliferation signal transduction more... cellular_component extracellular region extracellular space molecular_function chemokine activity signal transducer activity TBXAS1 4 BP    MF    CC biological_process cellular chloride ion homeostasis fatty acid biosynthetic process oxidation-reduction process positive regulation of vasoconstriction more... prostaglandin biosynthetic process prostanoid metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane integral to membrane more... membrane microsome less... molecular_function electron carrier activity heme binding isomerase activity metal ion binding more... monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen thromboxane-A synthase activity less... ITM2A 4 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function protein binding HABP2 4 BP    MF    CC biological_process cell adhesion proteolysis cellular_component extracellular region extracellular space molecular_function glycosaminoglycan binding peptidase activity serine-type endopeptidase activity ACY3 4 BP    MF    CC biological_process interspecies interaction between organisms metabolic process cellular_component apical plasma membrane cytoplasm membrane fraction plasma membrane more... molecular_function aminoacylase activity hydrolase activity, acting on ester bonds identical protein binding metal ion binding more... FXYD2 4 BP    MF    CC biological_process ion transmembrane transport ion transport potassium ion transport sodium ion transport more... transmembrane transport transport less... cellular_component integral to membrane membrane plasma membrane sodium:potassium-exchanging ATPase complex more... molecular_function ion channel activity sodium:potassium-exchanging ATPase activity transporter activity	Down-regulated Genes Score GO annotation GPR132 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle response to stress cellular_component integral to membrane plasma membrane molecular_function G-protein coupled receptor activity receptor activity signal transducer activity NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding SEPT4 2 BP    MF    CC biological_process GTP catabolic process apoptosis brain development cell cycle more... cytokinesis positive regulation of apoptosis positive regulation of protein ubiquitination regulation of apoptosis sperm capacitation sperm mitochondrion organization less... cellular_component cell projection cytoplasm cytoskeleton microtubule-based flagellum more... mitochondrion nucleus less... molecular_function GTP binding GTPase activity nucleotide binding protein binding more... structural molecule activity less... FAM13A 2 BP    MF    CC biological_process regulation of small GTPase mediated signal transduction signal transduction small GTPase mediated signal transduction cellular_component cytosol intracellular molecular_function GTPase activator activity DLG5 2 BP    MF    CC biological_process cell-cell adhesion intracellular signal transduction negative regulation of cell proliferation regulation of apoptosis more... signal transduction less... cellular_component cell junction cell-cell adherens junction cytoplasm intracellular more... plasma membrane less... molecular_function beta-catenin binding cytoskeletal protein binding receptor signaling complex scaffold activity PIR 2 BP    MF    CC biological_process transcription from RNA polymerase II promoter cellular_component cytoplasm nucleus molecular_function metal ion binding oxidoreductase activity protein binding quercetin 2,3-dioxygenase activity more... transcription cofactor activity less... PAPSS1 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process skeletal system development sulfate assimilation more... xenobiotic metabolic process less... cellular_component cytosol molecular_function ATP binding adenylylsulfate kinase activity nucleotide binding nucleotidyltransferase activity more... sulfate adenylyltransferase (ATP) activity less... TFPI2 2 BP    MF    CC biological_process blood coagulation cellular_component extracellular region proteinaceous extracellular matrix molecular_function extracellular matrix structural constituent peptidase inhibitor activity serine-type endopeptidase inhibitor activity PPARG 2 BP    MF    CC biological_process activation of caspase activity cell fate commitment cell maturation cellular response to insulin stimulus more... epithelial cell differentiation gene expression glucose homeostasis heart development induction of apoptosis innate immune response intracellular receptor mediated signaling pathway lipid homeostasis lipid metabolic process lipoprotein transport long-chain fatty acid transport low-density lipoprotein particle receptor biosynthetic process monocyte differentiation negative regulation of acute inflammatory response negative regulation of cell growth negative regulation of cell proliferation negative regulation of cholesterol storage negative regulation of interferon-gamma-mediated signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of sequestering of triglyceride negative regulation of telomerase activity negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent organ regeneration placenta development positive regulation of fat cell differentiation positive regulation of fatty acid oxidation positive regulation of oligodendrocyte differentiation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent regulation of blood pressure regulation of cholesterol transporter activity regulation of fat cell differentiation regulation of lipid metabolic process regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor response to caffeine response to cold response to drug response to estrogen stimulus response to lipid response to low-density lipoprotein particle stimulus response to nutrient response to organic cyclic compound response to vitamin A signal transduction transcription, DNA-dependent white fat cell differentiation less... cellular_component cytosol nucleoplasm nucleus molecular_function DNA binding activating transcription factor binding arachidonic acid binding drug binding more... enzyme binding ligand-dependent nuclear receptor activity metal ion binding prostaglandin receptor activity protein binding receptor activity retinoid X receptor binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity transcription regulatory region DNA binding zinc ion binding less... PHF8 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cell cycle chromatin modification more... histone H3-K27 demethylation histone H3-K36 demethylation histone H3-K9 demethylation histone H4-K20 demethylation negative regulation of chromatin silencing at rDNA positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription, DNA-dependent less... cellular_component nucleolus nucleus molecular_function chromatin binding histone demethylase activity histone demethylase activity (H3-K27 specific) histone demethylase activity (H3-K36 specific) more... histone demethylase activity (H3-K9 specific) histone demethylase activity (H4-K20 specific) iron ion binding metal ion binding methylated histone residue binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen protein binding zinc ion binding less...
Up-regulated Genes Score GO annotation PAEP 8 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity GPX3 4 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... LIF 4 BP    MF    CC biological_process blood vessel remodeling decidualization embryo implantation immune response more... leukemia inhibitory factor signaling pathway lung alveolus development lung lobe morphogenesis lung vasculature development maternal process involved in female pregnancy multicellular organismal development muscle organ morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis negative regulation of cell proliferation negative regulation of hormone secretion negative regulation of meiosis neuron development organ regeneration positive regulation of MAPKKK cascade positive regulation of astrocyte differentiation positive regulation of cell proliferation positive regulation of corticotropin secretion positive regulation of macrophage differentiation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of neuron projection development positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation retina development in camera-type eye spongiotrophoblast differentiation stem cell maintenance transdifferentiation trophoblast giant cell differentiation less... cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity leukemia inhibitory factor receptor binding receptor binding more... DDX46 4 BP    MF    CC biological_process RNA splicing mRNA processing cellular_component Cajal body nuclear speck nucleus molecular_function ATP binding ATP-dependent helicase activity RNA binding helicase activity more... hydrolase activity nucleic acid binding nucleotide binding less... CCL14 4 BP    MF    CC biological_process cellular calcium ion homeostasis immune response positive regulation of cell proliferation signal transduction more... cellular_component extracellular region extracellular space molecular_function chemokine activity signal transducer activity TBXAS1 4 BP    MF    CC biological_process cellular chloride ion homeostasis fatty acid biosynthetic process oxidation-reduction process positive regulation of vasoconstriction more... prostaglandin biosynthetic process prostanoid metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane integral to membrane more... membrane microsome less... molecular_function electron carrier activity heme binding isomerase activity metal ion binding more... monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen thromboxane-A synthase activity less... ITM2A 4 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function protein binding HABP2 4 BP    MF    CC biological_process cell adhesion proteolysis cellular_component extracellular region extracellular space molecular_function glycosaminoglycan binding peptidase activity serine-type endopeptidase activity ACY3 4 BP    MF    CC biological_process interspecies interaction between organisms metabolic process cellular_component apical plasma membrane cytoplasm membrane fraction plasma membrane more... molecular_function aminoacylase activity hydrolase activity, acting on ester bonds identical protein binding metal ion binding more... FXYD2 4 BP    MF    CC biological_process ion transmembrane transport ion transport potassium ion transport sodium ion transport more... transmembrane transport transport less... cellular_component integral to membrane membrane plasma membrane sodium:potassium-exchanging ATPase complex more... molecular_function ion channel activity sodium:potassium-exchanging ATPase activity transporter activity CYP2C9 4 BP    MF    CC biological_process cellular amide metabolic process drug catabolic process drug metabolic process exogenous drug catabolic process more... monocarboxylic acid metabolic process monoterpenoid metabolic process oxidation-reduction process oxidative demethylation steroid metabolic process urea metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function (R)-limonene 6-monooxygenase activity (S)-limonene 6-monooxygenase activity (S)-limonene 7-monooxygenase activity caffeine oxidase activity more... drug binding electron carrier activity heme binding metal ion binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen steroid hydroxylase activity less... TAGLN3 4 BP    MF    CC biological_process central nervous system development muscle organ development cellular_component molecular_function IGFBP3 4 BP    MF    CC biological_process negative regulation of cell proliferation negative regulation of protein phosphorylation negative regulation of signal transduction negative regulation of smooth muscle cell migration more... negative regulation of smooth muscle cell proliferation positive regulation of apoptosis positive regulation of myoblast differentiation protein phosphorylation regulation of cell growth less... cellular_component extracellular region extracellular space insulin-like growth factor binding protein complex nucleus more... molecular_function insulin-like growth factor I binding insulin-like growth factor binding metal ion binding protein binding more... protein tyrosine phosphatase activator activity less... G0S2 4 BP    MF    CC biological_process cell cycle cellular_component cellular_component molecular_function molecular_function PRG2 4 BP    MF    CC biological_process defense response to bacterium immune response cellular_component cytoplasmic vesicle extracellular region transport vesicle molecular_function binding heparin binding sugar binding TSPAN8 4 BP    MF    CC biological_process negative regulation of blood coagulation protein glycosylation signal transduction cellular_component integral to membrane lysosome membrane molecular_function signal transducer activity PRLR 4 BP    MF    CC biological_process T cell activation activation of JAK2 kinase activity activation of transmembrane receptor protein tyrosine kinase activity anti-apoptosis more... cell surface receptor linked signaling pathway embryo implantation lactation steroid biosynthetic process less... cellular_component cell surface extracellular region integral to membrane membrane more... molecular_function cytokine receptor activity metal ion binding ornithine decarboxylase activator activity peptide hormone binding more... prolactin receptor activity protein homodimerization activity receptor activity less... HTR2B 4 BP    MF    CC biological_process ERK1 and ERK2 cascade G-protein coupled receptor internalization G-protein coupled receptor protein signaling pathway activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway more... cGMP biosynthetic process calcium ion transmembrane transport calcium-mediated signaling cardiac muscle hypertrophy cellular response to calcium ion cellular response to temperature stimulus embryonic morphogenesis heart morphogenesis intestine smooth muscle contraction negative regulation of apoptosis negative regulation of autophagy negative regulation of cell death neural crest cell differentiation neural crest cell migration phosphatidylinositol 3-kinase cascade phosphatidylinositol biosynthetic process phosphorylation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAP kinase activity positive regulation of Ras GTPase activity positive regulation of cell division positive regulation of cell proliferation positive regulation of cytokine production positive regulation of cytokine secretion positive regulation of endothelial cell proliferation positive regulation of nitric-oxide synthase activity protein kinase C signaling cascade regulation of behavior release of sequestered calcium ion into cytosol response to drug serotonin receptor signaling pathway vasoconstriction less... cellular_component cytoplasm integral to membrane plasma membrane molecular_function G-protein alpha-subunit binding G-protein coupled receptor activity Ras GTPase activator activity calcium channel activity more... drug binding phosphatidylinositol phospholipase C activity receptor activity serotonin binding serotonin receptor activity signal transducer activity less... LMOD1 2 BP    MF    CC biological_process muscle contraction cellular_component cytoplasm cytoskeleton cytosol membrane fraction more... molecular_function tropomyosin binding VTN 2 BP    MF    CC biological_process cell adhesion cell adhesion mediated by integrin cell-matrix adhesion extracellular matrix organization more... immune response negative regulation of blood coagulation negative regulation of endopeptidase activity positive regulation of cell-substrate adhesion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein binding positive regulation of receptor-mediated endocytosis positive regulation of smooth muscle cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of wound healing smooth muscle cell-matrix adhesion less... cellular_component alphav-beta3 integrin-vitronectin complex extracellular matrix extracellular region extracellular space more... nucleus proteinaceous extracellular matrix less... molecular_function extracellular matrix binding heparin binding integrin binding polysaccharide binding more... scavenger receptor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity less... TGM2 2 BP    MF    CC biological_process apoptotic cell clearance blood vessel remodeling branching involved in salivary gland morphogenesis elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger more... induction of apoptosis isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine peptide cross-linking positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of cell adhesion positive regulation of inflammatory response positive regulation of smooth muscle cell proliferation protein homooligomerization salivary gland cavitation less... cellular_component cytoplasm mitochondrion plasma membrane molecular_function GTP binding metal ion binding protein binding protein domain specific binding more... protein-glutamine gamma-glutamyltransferase activity transferase activity transferase activity, transferring acyl groups less... TAGLN 2 BP    MF    CC biological_process muscle organ development cellular_component cytoplasm molecular_function actin binding LAMA4 2 BP    MF    CC biological_process blood vessel development brown fat cell differentiation regulation of cell adhesion regulation of cell migration more... regulation of embryonic development less... cellular_component basal lamina basement membrane extracellular region laminin-1 complex more... molecular_function extracellular matrix structural constituent receptor binding C3 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway complement activation complement activation, alternative pathway complement activation, classical pathway more... immune response inflammatory response innate immune response positive regulation of activation of membrane attack complex positive regulation of angiogenesis positive regulation of phagocytosis positive regulation of type IIa hypersensitivity positive regulation vascular endothelial growth factor production regulation of immune response signal transduction less... cellular_component extracellular region extracellular space molecular_function endopeptidase inhibitor activity protein binding receptor binding LUM 2 BP    MF    CC biological_process cartilage development collagen fibril organization response to growth factor stimulus response to organic cyclic compound more... visual perception less... cellular_component extracellular matrix extracellular region extracellular space fibrillar collagen more... proteinaceous extracellular matrix less... molecular_function collagen binding extracellular matrix structural constituent COLEC11 2 BP    MF    CC biological_process developmental process cellular_component collagen extracellular region molecular_function binding mannose binding sugar binding LCP1 2 BP    MF    CC biological_process T cell activation involved in immune response actin filament bundle assembly organ regeneration regulation of intracellular protein transport more... cellular_component actin cytoskeleton actin filament cell junction cytoplasm more... cytosol phagocytic cup plasma membrane ruffle ruffle membrane less... molecular_function actin binding actin filament binding calcium ion binding identical protein binding more... DPP4 2 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... FGF7 2 BP    MF    CC biological_process actin cytoskeleton reorganization branching involved in salivary gland morphogenesis epidermis development fibroblast growth factor receptor signaling pathway more... hair follicle morphogenesis insulin receptor signaling pathway lung development mesenchymal cell proliferation ovarian follicle development phosphatidylcholine biosynthetic process phospholipid biosynthetic process positive chemotaxis positive regulation of cell division positive regulation of cell proliferation positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in lung morphogenesis positive regulation of keratinocyte migration positive regulation of keratinocyte proliferation positive regulation of peptidyl-tyrosine phosphorylation protein localization at cell surface regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling response to wounding secretion by lung epithelial cell involved in lung growth signal transduction surfactant homeostasis wound healing less... cellular_component Golgi apparatus extracellular region extracellular space molecular_function chemoattractant activity growth factor activity heparin binding type 2 fibroblast growth factor receptor binding more... CLU 2 BP    MF    CC biological_process anti-apoptosis blood coagulation cell death cellular response to growth factor stimulus more... chaperone-mediated protein folding complement activation complement activation, classical pathway endocrine pancreas development induction of apoptosis by intracellular signals innate immune response lipid metabolic process negative regulation of apoptosis negative regulation of protein homooligomerization neuron projection morphogenesis platelet activation platelet degranulation positive regulation of NF-kappaB transcription factor activity positive regulation of apoptosis positive regulation of cell differentiation positive regulation of cell proliferation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein stabilization release of cytochrome c from mitochondria response to misfolded protein response to oxidative stress response to virus response to wounding reverse cholesterol transport less... cellular_component aggresome chromaffin granule cytoplasm cytoplasmic vesicle more... cytosol endoplasmic reticulum extracellular matrix extracellular region extracellular space growth cone membrane microsome mitochondrial membrane mitochondrion nucleus perinuclear region of cytoplasm platelet alpha granule lumen spherical high-density lipoprotein particle less... molecular_function ATPase activity misfolded protein binding protein binding ubiquitin protein ligase binding more... TAF1 2 BP    MF    CC biological_process G1 phase of mitotic cell cycle RNA polymerase II transcriptional preinitiation complex assembly cell cycle gene expression more... histone acetylation interspecies interaction between organisms peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription initiation from RNA polymerase II promoter protein autophosphorylation regulation of transcription involved in G2/M-phase of mitotic cell cycle regulation of transcription, DNA-dependent response to DNA damage stimulus transcription elongation from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription initiation, DNA-dependent viral reproduction less... cellular_component MLL1 complex nucleolus nucleoplasm nucleus more... transcription factor TFIID complex less... molecular_function ATP binding TBP-class protein binding histone acetyl-lysine binding histone acetyltransferase activity more... kinase activity nucleotide binding p53 binding protein binding protein serine/threonine kinase activity sequence-specific DNA binding transcription coactivator activity transcription factor binding transcription regulatory region DNA binding transferase activity less... SLA 2 BP    MF    CC biological_process cellular_component cytoplasm endosome molecular_function SH3/SH2 adaptor activity DHRS3 2 BP    MF    CC biological_process retinol metabolic process visual perception cellular_component integral to membrane membrane molecular_function NADP-retinol dehydrogenase activity binding electron carrier activity nucleotide binding more... oxidoreductase activity less... C6orf48 2 BP    MF    CC biological_process cellular_component molecular_function NFATC3 2 BP    MF    CC biological_process cellular respiration cellular response to lithium ion heart development inflammatory response more... muscle cell development patterning of blood vessels positive regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation transcription from RNA polymerase II promoter less... cellular_component cytoplasm cytosol nucleolus nucleus more... plasma membrane less... molecular_function DNA binding chromatin binding sequence-specific DNA binding transcription factor activity SERPING1 2 BP    MF    CC biological_process blood circulation blood coagulation blood coagulation, intrinsic pathway complement activation, classical pathway more... innate immune response negative regulation of complement activation, lectin pathway negative regulation of endopeptidase activity platelet activation platelet degranulation less... cellular_component extracellular region extracellular space platelet alpha granule lumen molecular_function peptidase activity peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity more... KIAA0664 2 BP    MF    CC biological_process cellular_component molecular_function binding EDNRB 2 BP    MF    CC biological_process activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger cell surface receptor linked signaling pathway developmental pigmentation enteric nervous system development more... enteric smooth muscle cell differentiation macrophage chemotaxis melanocyte differentiation negative regulation of adenylate cyclase activity negative regulation of cellular protein metabolic process negative regulation of neuron maturation negative regulation of transcription from RNA polymerase II promoter nervous system development neural crest cell migration peripheral nervous system development posterior midgut development regulation of blood pressure regulation of pH vasoconstriction vein smooth muscle contraction less... cellular_component integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity endothelin-B receptor activity peptide hormone binding receptor activity more... signal transducer activity less... NCAM1 2 BP    MF    CC biological_process axon guidance cell adhesion cytokine-mediated signaling pathway interferon-gamma-mediated signaling pathway more... cellular_component Golgi membrane anchored to membrane cell surface extracellular region more... integral to membrane membrane plasma membrane less... molecular_function CD52 2 BP    MF    CC biological_process elevation of cytosolic calcium ion concentration respiratory burst cellular_component anchored to membrane integral to plasma membrane membrane fraction plasma membrane more... molecular_function PRODH 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process glutamate biosynthetic process induction of apoptosis by oxidative stress oxidation-reduction process more... proline catabolic process proline metabolic process less... cellular_component mitochondrial inner membrane mitochondrial matrix mitochondrion molecular_function oxidoreductase activity proline dehydrogenase activity CST7 2 BP    MF    CC biological_process immune response negative regulation of endopeptidase activity cellular_component cytoplasm extracellular region molecular_function cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity EPHA1 2 BP    MF    CC biological_process activation of Rho GTPase activity cell surface receptor linked signaling pathway negative regulation of cell migration negative regulation of protein kinase activity more... positive regulation of angiogenesis positive regulation of cell migration positive regulation of cell proliferation positive regulation of cell-matrix adhesion protein autophosphorylation regulation of Rac GTPase activity substrate adhesion-dependent cell spreading less... cellular_component integral to plasma membrane membrane molecular_function ATP binding nucleotide binding protein kinase binding receptor activity more... transmembrane-ephrin receptor activity less... APOC2 2 BP    MF    CC biological_process cholesterol efflux cholesterol homeostasis chylomicron remnant clearance chylomicron remodeling more... high-density lipoprotein particle clearance lipid catabolic process lipid metabolic process lipid transport lipoprotein metabolic process lipoprotein transport negative regulation of cholesterol transport negative regulation of lipid metabolic process negative regulation of receptor-mediated endocytosis negative regulation of very-low-density lipoprotein particle clearance phospholipid efflux positive regulation of fatty acid biosynthetic process positive regulation of lipoprotein lipase activity positive regulation of phospholipase activity positive regulation of phospholipid catabolic process positive regulation of triglyceride catabolic process positive regulation of very-low-density lipoprotein particle remodeling response to drug reverse cholesterol transport transport triglyceride homeostasis triglyceride-rich lipoprotein particle remodeling very-low-density lipoprotein particle remodeling less... cellular_component chylomicron extracellular region extracellular space intermediate-density lipoprotein particle more... low-density lipoprotein particle spherical high-density lipoprotein particle very-low-density lipoprotein particle less... molecular_function enzyme activator activity lipase inhibitor activity lipid binding lipoprotein lipase activator activity more... phospholipase activator activity phospholipase binding protein homodimerization activity less... CNN1 2 BP    MF    CC biological_process actomyosin structure organization regulation of smooth muscle contraction cellular_component cytoskeleton molecular_function actin binding calmodulin binding TNFSF13 2 BP    MF    CC biological_process RNA metabolic process immune response immunoglobulin mediated immune response immunoglobulin production in mucosal tissue more... mRNA metabolic process positive regulation of cell proliferation positive regulation of germinal center formation positive regulation of isotype switching to IgA isotypes regulation of immune response signal transduction less... cellular_component cytosol external side of plasma membrane extracellular region extracellular space more... membrane nucleoplasm less... molecular_function cytokine activity receptor binding tumor necrosis factor receptor binding LEFTY1 2 BP    MF    CC biological_process cell growth multicellular organismal development transforming growth factor beta receptor signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity transforming growth factor beta receptor binding PAPSS2 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process skeletal system development sulfate assimilation more... xenobiotic metabolic process less... cellular_component cytosol molecular_function ATP binding adenylylsulfate kinase activity kinase activity nucleotide binding more... nucleotidyltransferase activity sulfate adenylyltransferase (ATP) activity less... C4A 2 BP    MF    CC biological_process complement activation complement activation, classical pathway inflammatory response innate immune response more... cellular_component extracellular region extracellular space molecular_function endopeptidase inhibitor activity CDH3 2 BP    MF    CC biological_process adherens junction organization cell adhesion cell junction assembly cell-cell junction organization more... homophilic cell adhesion response to stimulus visual perception less... cellular_component cell-cell adherens junction integral to membrane plasma membrane molecular_function calcium ion binding LEFTY2 2 BP    MF    CC biological_process blood coagulation cell growth multicellular organismal development platelet activation more... platelet degranulation transforming growth factor beta receptor signaling pathway less... cellular_component extracellular region extracellular space platelet alpha granule lumen molecular_function cytokine activity growth factor activity transforming growth factor beta receptor binding FZD4 2 BP    MF    CC biological_process Wnt receptor signaling pathway Wnt receptor signaling pathway, calcium modulating pathway blood vessel development brain development more... canonical Wnt receptor signaling pathway cellular response to retinoic acid cerebellum vasculature morphogenesis embryo development extracellular matrix-cell signaling locomotion involved in locomotory behavior negative regulation of cell-substrate adhesion neuron differentiation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription, DNA-dependent progesterone secretion regulation of vascular endothelial growth factor receptor signaling pathway retina vasculature morphogenesis in camera-type eye retinal blood vessel morphogenesis sensory perception of sound substrate adhesion-dependent cell spreading vasculogenesis less... cellular_component cell projection cell surface cytoplasm integral to plasma membrane more... plasma membrane less... molecular_function G-protein coupled receptor activity PDZ domain binding Wnt-activated receptor activity Wnt-protein binding more... cytokine binding protein binding protein heterodimerization activity protein homodimerization activity receptor activity signal transducer activity less... APOC1 2 BP    MF    CC biological_process cholesterol efflux cholesterol metabolic process chylomicron remnant clearance high-density lipoprotein particle remodeling more... lipid metabolic process lipoprotein metabolic process negative regulation of cholesterol transport negative regulation of fatty acid biosynthetic process negative regulation of lipid catabolic process negative regulation of lipid metabolic process negative regulation of lipoprotein lipase activity negative regulation of phosphatidylcholine catabolic process negative regulation of receptor-mediated endocytosis negative regulation of very-low-density lipoprotein particle clearance phospholipid efflux plasma lipoprotein particle remodeling positive regulation of cholesterol esterification regulation of cholesterol transport regulation of lipid transport transport triglyceride metabolic process very-low-density lipoprotein particle assembly very-low-density lipoprotein particle clearance less... cellular_component chylomicron endoplasmic reticulum extracellular region high-density lipoprotein particle more... very-low-density lipoprotein particle less... molecular_function fatty acid binding lipase inhibitor activity phosphatidylcholine binding phosphatidylcholine-sterol O-acyltransferase activator activity more... phospholipase inhibitor activity less... WARS 2 BP    MF    CC biological_process gene expression negative regulation of cell proliferation regulation of angiogenesis tRNA aminoacylation for protein translation more... translation tryptophanyl-tRNA aminoacylation less... cellular_component cytoplasm cytosol soluble fraction molecular_function ATP binding ligase activity nucleotide binding protein binding more... tryptophan-tRNA ligase activity less... PSTPIP1 2 BP    MF    CC biological_process activation of innate immune response cell adhesion innate immune response signal transduction more... cellular_component actomyosin contractile ring cleavage furrow cytoplasm cytoskeleton more... cytosol lamellipodium perinuclear region of cytoplasm stress fiber less... molecular_function actin binding oxidoreductase activity protein phosphatase binding IGFBP6 2 BP    MF    CC biological_process negative regulation of cell proliferation regulation of cell growth signal transduction cellular_component Golgi apparatus cytoplasm extracellular region extracellular space more... molecular_function insulin-like growth factor I binding insulin-like growth factor binding MLPH 2 BP    MF    CC biological_process intracellular protein transport melanocyte differentiation melanosome localization pigmentation more... protein targeting less... cellular_component actin cytoskeleton cytoplasm molecular_function Rab GTPase binding actin binding metal ion binding microtubule plus-end binding more... myosin V binding less... UGT1A6 2 BP    MF    CC biological_process metabolic process xenobiotic metabolic process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function enzyme binding glucuronosyltransferase activity protein heterodimerization activity protein homodimerization activity more... retinoic acid binding less... FBLN5 2 BP    MF    CC biological_process cell adhesion cell-matrix adhesion elastic fiber assembly extracellular matrix organization more... protein localization at cell surface regulation of removal of superoxide radicals less... cellular_component elastic fiber extracellular matrix extracellular region extracellular space more... proteinaceous extracellular matrix soluble fraction less... molecular_function calcium ion binding integrin binding protein C-terminus binding IL2RB 2 BP    MF    CC biological_process cytokine-mediated signaling pathway interspecies interaction between organisms positive regulation of survival gene product expression protein complex assembly more... signal transduction less... cellular_component external side of plasma membrane integral to plasma membrane plasma membrane molecular_function interleukin-2 binding interleukin-2 receptor activity receptor activity	Down-regulated Genes Score GO annotation GPR132 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle response to stress cellular_component integral to membrane plasma membrane molecular_function G-protein coupled receptor activity receptor activity signal transducer activity NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding SEPT4 2 BP    MF    CC biological_process GTP catabolic process apoptosis brain development cell cycle more... cytokinesis positive regulation of apoptosis positive regulation of protein ubiquitination regulation of apoptosis sperm capacitation sperm mitochondrion organization less... cellular_component cell projection cytoplasm cytoskeleton microtubule-based flagellum more... mitochondrion nucleus less... molecular_function GTP binding GTPase activity nucleotide binding protein binding more... structural molecule activity less... FAM13A 2 BP    MF    CC biological_process regulation of small GTPase mediated signal transduction signal transduction small GTPase mediated signal transduction cellular_component cytosol intracellular molecular_function GTPase activator activity DLG5 2 BP    MF    CC biological_process cell-cell adhesion intracellular signal transduction negative regulation of cell proliferation regulation of apoptosis more... signal transduction less... cellular_component cell junction cell-cell adherens junction cytoplasm intracellular more... plasma membrane less... molecular_function beta-catenin binding cytoskeletal protein binding receptor signaling complex scaffold activity PIR 2 BP    MF    CC biological_process transcription from RNA polymerase II promoter cellular_component cytoplasm nucleus molecular_function metal ion binding oxidoreductase activity protein binding quercetin 2,3-dioxygenase activity more... transcription cofactor activity less... PAPSS1 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process skeletal system development sulfate assimilation more... xenobiotic metabolic process less... cellular_component cytosol molecular_function ATP binding adenylylsulfate kinase activity nucleotide binding nucleotidyltransferase activity more... sulfate adenylyltransferase (ATP) activity less... TFPI2 2 BP    MF    CC biological_process blood coagulation cellular_component extracellular region proteinaceous extracellular matrix molecular_function extracellular matrix structural constituent peptidase inhibitor activity serine-type endopeptidase inhibitor activity PPARG 2 BP    MF    CC biological_process activation of caspase activity cell fate commitment cell maturation cellular response to insulin stimulus more... epithelial cell differentiation gene expression glucose homeostasis heart development induction of apoptosis innate immune response intracellular receptor mediated signaling pathway lipid homeostasis lipid metabolic process lipoprotein transport long-chain fatty acid transport low-density lipoprotein particle receptor biosynthetic process monocyte differentiation negative regulation of acute inflammatory response negative regulation of cell growth negative regulation of cell proliferation negative regulation of cholesterol storage negative regulation of interferon-gamma-mediated signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of sequestering of triglyceride negative regulation of telomerase activity negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent organ regeneration placenta development positive regulation of fat cell differentiation positive regulation of fatty acid oxidation positive regulation of oligodendrocyte differentiation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent regulation of blood pressure regulation of cholesterol transporter activity regulation of fat cell differentiation regulation of lipid metabolic process regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor response to caffeine response to cold response to drug response to estrogen stimulus response to lipid response to low-density lipoprotein particle stimulus response to nutrient response to organic cyclic compound response to vitamin A signal transduction transcription, DNA-dependent white fat cell differentiation less... cellular_component cytosol nucleoplasm nucleus molecular_function DNA binding activating transcription factor binding arachidonic acid binding drug binding more... enzyme binding ligand-dependent nuclear receptor activity metal ion binding prostaglandin receptor activity protein binding receptor activity retinoid X receptor binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity transcription regulatory region DNA binding zinc ion binding less... PHF8 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cell cycle chromatin modification more... histone H3-K27 demethylation histone H3-K36 demethylation histone H3-K9 demethylation histone H4-K20 demethylation negative regulation of chromatin silencing at rDNA positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription, DNA-dependent less... cellular_component nucleolus nucleus molecular_function chromatin binding histone demethylase activity histone demethylase activity (H3-K27 specific) histone demethylase activity (H3-K36 specific) more... histone demethylase activity (H3-K9 specific) histone demethylase activity (H4-K20 specific) iron ion binding metal ion binding methylated histone residue binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen protein binding zinc ion binding less... CSTB 2 BP    MF    CC biological_process adult locomotory behavior negative regulation of endopeptidase activity negative regulation of peptidase activity regulation of apoptosis more... cellular_component cytoplasm intracellular nucleolus nucleus more... molecular_function cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity protease binding SERPINA5 2 BP    MF    CC biological_process fusion of sperm to egg plasma membrane negative regulation of endopeptidase activity negative regulation of proteolysis regulation of proteolysis more... spermatogenesis less... cellular_component extracellular region membrane protein complex molecular_function acrosin binding glycosaminoglycan binding heparin binding peptidase inhibitor activity more... protease binding serine-type endopeptidase inhibitor activity less... CRK 2 BP    MF    CC biological_process activation of MAPKK activity blood coagulation ephrin receptor signaling pathway insulin receptor signaling pathway more... nerve growth factor receptor signaling pathway regulation of Rac protein signal transduction regulation of Rho GTPase activity regulation of actin cytoskeleton organization regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm cytosol endosome nucleus more... plasma membrane less... molecular_function SH2 domain binding SH3/SH2 adaptor activity ephrin receptor binding protein binding more... protein phosphorylated amino acid binding less... C6orf142 2 BP    MF    CC biological_process cellular_component molecular_function ALDH6A1 2 BP    MF    CC biological_process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process thymine metabolic process valine metabolic process more... cellular_component mitochondrial matrix mitochondrion nucleolus nucleus more... molecular_function fatty-acyl-CoA binding malonate-semialdehyde dehydrogenase (acetylating) activity methylmalonate-semialdehyde dehydrogenase (acylating) activity oxidoreductase activity more... SCD 2 BP    MF    CC biological_process fatty acid biosynthetic process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water stearoyl-CoA 9-desaturase activity more... MT1X 2 BP    MF    CC biological_process response to metal ion cellular_component molecular_function metal ion binding CA2 2 BP    MF    CC biological_process carbon dioxide transport kidney development morphogenesis of an epithelium odontogenesis of dentine-containing tooth more... one-carbon metabolic process positive regulation of bone resorption positive regulation of cellular pH reduction positive regulation of osteoclast differentiation response to estrogen stimulus response to organic substance response to pH response to stress response to zinc ion secretion less... cellular_component apical part of cell axon basolateral plasma membrane cytoplasm more... cytosol extracellular space microvillus less... molecular_function carbonate dehydratase activity lyase activity metal ion binding zinc ion binding more... CKB 2 BP    MF    CC biological_process brain development cellular chloride ion homeostasis cellular nitrogen compound metabolic process creatine metabolic process more... cellular_component cytoplasm cytosol mitochondrion molecular_function ATP binding creatine kinase activity kinase activity nucleotide binding more... SERHL 2 BP    MF    CC biological_process cellular_component molecular_function hydrolase activity MMP12 2 BP    MF    CC biological_process metabolic process positive regulation of epithelial cell proliferation involved in wound healing proteolysis wound healing, spreading of epidermal cells more... cellular_component extracellular region proteinaceous extracellular matrix molecular_function calcium ion binding endopeptidase activity metalloendopeptidase activity peptidase activity more... zinc ion binding less... MMP10 2 BP    MF    CC biological_process collagen catabolic process metabolic process proteolysis cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding metal ion binding metalloendopeptidase activity peptidase activity more... zinc ion binding less... AMD1 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process polyamine metabolic process spermidine biosynthetic process spermine biosynthetic process more... cellular_component cytosol molecular_function adenosylmethionine decarboxylase activity lyase activity TM4SF4 2 BP    MF    CC biological_process tissue regeneration cellular_component integral to membrane membrane molecular_function CPT1A 2 BP    MF    CC biological_process carnitine shuttle cellular lipid metabolic process eating behavior fatty acid beta-oxidation more... glucose metabolic process long-chain fatty acid metabolic process positive regulation of fatty acid beta-oxidation protein homooligomerization regulation of fatty acid oxidation regulation of insulin secretion response to drug response to organic cyclic compound transport triglyceride metabolic process less... cellular_component integral to membrane membrane microsome mitochondrial inner membrane more... mitochondrial outer membrane mitochondrion less... molecular_function carnitine O-palmitoyltransferase activity identical protein binding transferase activity, transferring acyl groups NFIB 2 BP    MF    CC biological_process Clara cell differentiation DNA replication Type I pneumocyte differentiation Type II pneumocyte differentiation more... anterior commissure morphogenesis chondrocyte differentiation commissural neuron axon guidance epithelial cell proliferation involved in lung morphogenesis forebrain development glial cell differentiation hindbrain development lung ciliated cell differentiation mesenchymal cell proliferation involved in lung development negative regulation of DNA binding negative regulation of cell proliferation negative regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter principal sensory nucleus of trigeminal nerve development transcription from RNA polymerase II promoter less... cellular_component cerebellar mossy fiber intracellular nucleolus nucleus more... molecular_function DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription RNA polymerase II transcription corepressor activity double-stranded DNA binding more... sequence-specific DNA binding RNA polymerase II transcription factor activity sequence-specific DNA binding transcription factor activity less... PITPNA 2 BP    MF    CC biological_process axon guidance lipid metabolic process phospholipid transport transport more... visual perception less... cellular_component cytoplasm cytosol intracellular molecular_function phosphatidylcholine transmembrane transporter activity phosphatidylinositol transporter activity phospholipid binding CNDP2 2 BP    MF    CC biological_process glutathione biosynthetic process metabolic process proteolysis xenobiotic metabolic process more... cellular_component cytoplasm cytosol molecular_function carboxypeptidase activity dipeptidase activity metal ion binding metallopeptidase activity more... peptidase activity tripeptidase activity less... MRPL3 2 BP    MF    CC biological_process translation cellular_component intracellular mitochondrial large ribosomal subunit mitochondrion ribosome more... molecular_function RNA binding structural constituent of ribosome PDE9A 2 BP    MF    CC biological_process blood coagulation platelet activation signal transduction cellular_component Golgi apparatus cell projection cytoplasm cytosol more... endoplasmic reticulum perinuclear region of cytoplasm plasma membrane ruffle membrane less... molecular_function 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding more... phosphoric diester hydrolase activity protein binding less... ANK3 2 BP    MF    CC biological_process establishment of protein localization signal transduction cellular_component basolateral plasma membrane cytoplasm cytoskeleton molecular_function protein binding SAA1 2 BP    MF    CC biological_process acute-phase response elevation of cytosolic calcium ion concentration innate immune response lymphocyte chemotaxis more... macrophage chemotaxis negative regulation of inflammatory response neutrophil chemotaxis platelet activation positive regulation of cell adhesion positive regulation of cytokine secretion positive regulation of interleukin-1 secretion regulation of protein secretion less... cellular_component extracellular region high-density lipoprotein particle molecular_function G-protein-coupled receptor binding SCGB2A1 2 BP    MF    CC biological_process biological_process cellular_component cellular_component extracellular region molecular_function androgen binding binding CYP26A1 2 BP    MF    CC biological_process anterior/posterior pattern specification central nervous system development metabolic process negative regulation of retinoic acid receptor signaling pathway more... neural crest cell development retinoic acid catabolic process retinoic acid metabolic process retinoic acid receptor signaling pathway xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function electron carrier activity heme binding metal ion binding monooxygenase activity more... oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxygen binding retinoic acid 4-hydroxylase activity retinoic acid binding less... S100P 2 BP    MF    CC biological_process endothelial cell migration cellular_component cytoplasm nucleus molecular_function calcium ion binding calcium-dependent protein binding magnesium ion binding protein binding more... ATAD4 2 BP    MF    CC biological_process cellular_component molecular_function SERPINB3 2 BP    MF    CC biological_process negative regulation of endopeptidase activity regulation of proteolysis cellular_component cytoplasm extracellular region molecular_function peptidase inhibitor activity serine-type endopeptidase inhibitor activity BIRC3 2 BP    MF    CC biological_process anti-apoptosis cell surface receptor linked signaling pathway protein ubiquitination regulation of apoptosis more... cellular_component cytoplasm intracellular nucleus molecular_function metal ion binding protein binding ubiquitin-protein ligase activity zinc ion binding more... CAPN6 2 BP    MF    CC biological_process microtubule bundle formation proteolysis regulation of cytoskeleton organization cellular_component cytoplasm cytoskeleton intracellular microtubule more... perinuclear region of cytoplasm spindle microtubule less... molecular_function calcium-dependent cysteine-type endopeptidase activity microtubule binding CYB5R2 2 BP    MF    CC biological_process oxidation-reduction process sterol biosynthetic process cellular_component membrane mitochondrion soluble fraction molecular_function cytochrome-b5 reductase activity oxidoreductase activity SAT1 2 BP    MF    CC biological_process angiogenesis cellular nitrogen compound metabolic process metabolic process polyamine biosynthetic process more... polyamine metabolic process regulation of cell proliferation less... cellular_component cytoplasm cytosol intracellular soluble fraction more... molecular_function N-acetyltransferase activity diamine N-acetyltransferase activity protein binding spermidine binding more... transferase activity, transferring acyl groups less... FOLR1 2 BP    MF    CC biological_process cell death folic acid metabolic process folic acid transport receptor-mediated endocytosis more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane fraction more... plasma membrane less... molecular_function folic acid binding receptor activity GRHPR 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process excretion glyoxylate metabolic process metabolic process more... oxidation-reduction process less... cellular_component cytoplasm peroxisomal matrix molecular_function NAD binding cofactor binding glycerate dehydrogenase activity glyoxylate reductase (NADP) activity more... hydroxypyruvate reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor less... AZGP1 2 BP    MF    CC biological_process antigen processing and presentation cell adhesion immune response lipid catabolic process more... negative regulation of cell proliferation less... cellular_component MHC class I protein complex extracellular region membrane molecular_function fatty acid binding protein transmembrane transporter activity ribonuclease activity DCXR 2 BP    MF    CC biological_process D-xylose metabolic process NADP metabolic process carbohydrate metabolic process glucose metabolic process more... protein homotetramerization xylulose metabolic process less... cellular_component brush border membrane microvillus molecular_function L-xylulose reductase (NADP+) activity binding oxidoreductase activity, acting on CH-OH group of donors CXCL1 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway actin cytoskeleton organization cell proliferation chemotaxis more... immune response inflammatory response intracellular signal transduction negative regulation of cell proliferation nervous system development positive regulation of catalytic activity signal transduction less... cellular_component extracellular region extracellular space intracellular molecular_function chemokine activity enzyme activator activity growth factor activity receptor binding more... COBL 2 BP    MF    CC biological_process neural tube closure cellular_component molecular_function ANXA3 2 BP    MF    CC biological_process defense response to bacterium hippocampus development neutrophil degranulation organ regeneration more... phagocytosis positive regulation of DNA metabolic process positive regulation of angiogenesis positive regulation of endothelial cell migration positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid stimulus response to growth factor stimulus less... cellular_component axon cytoplasm dendrite membrane more... neuronal cell body phagocytic vesicle membrane plasma membrane specific granule less... molecular_function calcium ion binding calcium-dependent phospholipid binding phospholipase A2 inhibitor activity phospholipase inhibitor activity more... SULT1C2 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process amine metabolic process sulfation xenobiotic metabolic process more... cellular_component cytoplasm cytosol microtubule cytoskeleton molecular_function sulfotransferase activity transferase activity SORD 2 BP    MF    CC biological_process L-xylitol catabolic process L-xylitol metabolic process fructose biosynthetic process glucose metabolic process more... sorbitol catabolic process sperm motility less... cellular_component cilium extracellular space flagellum membrane more... membrane fraction mitochondrial membrane mitochondrion soluble fraction less... molecular_function L-iditol 2-dehydrogenase activity NAD binding binding metal ion binding more... oxidoreductase activity sugar binding zinc ion binding less... TPD52L1 2 BP    MF    CC biological_process DNA fragmentation involved in apoptotic nuclear change G2/M transition of mitotic cell cycle activation of caspase activity induction of apoptosis more... positive regulation of JNK cascade positive regulation of MAP kinase activity less... cellular_component cytoplasm perinuclear region of cytoplasm molecular_function caspase activator activity identical protein binding protein binding protein heterodimerization activity more... protein homodimerization activity less... ALDH3B2 2 BP    MF    CC biological_process alcohol metabolic process cellular aldehyde metabolic process lipid metabolic process cellular_component molecular_function 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity FUT2 2 BP    MF    CC biological_process L-fucose catabolic process carbohydrate metabolic process protein glycosylation cellular_component Golgi apparatus Golgi cisterna membrane integral to Golgi membrane integral to membrane more... membrane less... molecular_function fucosyltransferase activity galactoside 2-alpha-L-fucosyltransferase activity transferase activity, transferring glycosyl groups CPB2 2 BP    MF    CC biological_process blood coagulation negative regulation of fibrinolysis proteolysis response to drug more... response to heat less... cellular_component extracellular region extracellular space molecular_function metal ion binding metallocarboxypeptidase activity metallopeptidase activity peptidase activity more... zinc ion binding less... CD9 2 BP    MF    CC biological_process blood coagulation brain development cell adhesion cellular component movement more... fusion of sperm to egg plasma membrane negative regulation of cell proliferation oligodendrocyte development paranodal junction assembly platelet activation platelet degranulation response to water deprivation less... cellular_component apical plasma membrane cell surface integral to membrane integral to plasma membrane more... membrane plasma membrane platelet alpha granule membrane less... molecular_function integrin binding protein binding NIACR2 2 BP    MF    CC biological_process cellular_component molecular_function VGLL1 2 BP    MF    CC biological_process regulation of transcription, DNA-dependent cellular_component nucleus molecular_function transcription coactivator activity PSAT1 2 BP    MF    CC biological_process L-serine biosynthetic process cellular amino acid biosynthetic process pyridoxine biosynthetic process cellular_component molecular_function O-phospho-L-serine:2-oxoglutarate aminotransferase activity pyridoxal phosphate binding transferase activity GDPD3 2 BP    MF    CC biological_process glycerol metabolic process lipid metabolic process cellular_component integral to membrane membrane molecular_function glycerophosphodiester phosphodiesterase activity hydrolase activity metal ion binding ATP2B2 2 BP    MF    CC biological_process ATP biosynthetic process auditory receptor cell stereocilium organization blood coagulation brain development more... cGMP metabolic process calcium ion transmembrane transport calcium ion transport cation transport cell morphogenesis cerebellar Purkinje cell differentiation cerebellar Purkinje cell layer morphogenesis cerebellar granule cell differentiation cerebellum development cochlea development cytosolic calcium ion homeostasis detection of mechanical stimulus involved in sensory perception of sound inner ear morphogenesis inner ear receptor cell differentiation ion transmembrane transport lactation locomotion locomotory behavior neural retina development neuromuscular process controlling balance neuron differentiation organelle organization otolith mineralization platelet activation positive regulation of calcium ion transport regulation of cell size regulation of synaptic plasticity sensory perception of sound serotonin metabolic process synapse organization transmembrane transport transport less... cellular_component apical plasma membrane cilium cytoplasm cytosol more... dendrite endoplasmic reticulum integral to membrane membrane membrane raft microsome neuronal cell body plasma membrane less... molecular_function ATP binding PDZ domain binding calcium ion binding calcium-dependent ATPase activity more... calcium-transporting ATPase activity calmodulin binding glutamate receptor binding hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding nucleotide binding protein C-terminus binding protein binding less... KRT6A 2 BP    MF    CC biological_process cell differentiation ectoderm development positive regulation of cell proliferation cellular_component intermediate filament keratin filament molecular_function protein binding structural constituent of cytoskeleton structural molecule activity MAP2K6 2 BP    MF    CC biological_process DNA damage induced protein phosphorylation MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway more... activation of MAPK activity activation of innate immune response cardiac muscle contraction cell cycle arrest innate immune response muscle cell differentiation nucleotide-binding oligomerization domain containing signaling pathway positive regulation of apoptosis positive regulation of muscle cell differentiation response to drug signal transduction stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytosol nucleoplasm molecular_function ATP binding MAP kinase kinase activity nucleotide binding protein kinase binding more... protein serine/threonine kinase activity protein tyrosine kinase activity less... ZG16B 2 BP    MF    CC biological_process cellular_component extracellular region molecular_function sugar binding SLC43A1 2 BP    MF    CC biological_process amino acid transport cellular nitrogen compound metabolic process ion transport neutral amino acid transport more... transmembrane transport less... cellular_component integral to plasma membrane plasma membrane molecular_function L-amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity ABCG1 2 BP    MF    CC biological_process amyloid precursor protein catabolic process cholesterol efflux cholesterol homeostasis cholesterol metabolic process more... detection of hormone stimulus glycoprotein transport high-density lipoprotein particle remodeling intracellular cholesterol transport lipid metabolic process lipoprotein metabolic process low-density lipoprotein particle remodeling negative regulation of cholesterol storage negative regulation of macrophage derived foam cell differentiation phospholipid efflux phospholipid homeostasis phospholipid transport positive regulation of cholesterol biosynthetic process positive regulation of cholesterol efflux regulation of cholesterol esterification regulation of transcription, DNA-dependent response to high density lipoprotein particle stimulus response to lipid response to organic substance reverse cholesterol transport transport less... cellular_component Golgi apparatus Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane more... endosome external side of plasma membrane integral to membrane integral to plasma membrane intracellular membrane plasma membrane recycling endosome less... molecular_function ADP binding ATP binding ATPase activity cholesterol binding more... cholesterol transporter activity glycoprotein transporter activity nucleotide binding phospholipid binding phospholipid transporter activity protein dimerization activity protein heterodimerization activity protein homodimerization activity sterol-transporting ATPase activity toxin transporter activity less...
Up-regulated Genes Score PAEP 8 GPX3 4 LIF 4 DDX46 4 CCL14 4 TBXAS1 4 ITM2A 4 HABP2 4 ACY3 4 FXYD2 4 CYP2C9 4 TAGLN3 4 IGFBP3 4 G0S2 4 PRG2 4 TSPAN8 4 PRLR 4 HTR2B 4 LMOD1 2 VTN 2 TGM2 2 TAGLN 2 LAMA4 2 C3 2 LUM 2 COLEC11 2 LCP1 2 DPP4 2 FGF7 2 CLU 2 TAF1 2 SLA 2 DHRS3 2 C6orf48 2 NFATC3 2 SERPING1 2 KIAA0664 2 EDNRB 2 NCAM1 2 CD52 2 PRODH 2 CST7 2 EPHA1 2 APOC2 2 CNN1 2 TNFSF13 2 LEFTY1 2 PAPSS2 2 C4A 2 CDH3 2 LEFTY2 2 FZD4 2 APOC1 2 WARS 2 PSTPIP1 2 IGFBP6 2 MLPH 2 UGT1A6 2 FBLN5 2 IL2RB 2	Down-regulated Genes Score GPR132 2 NDRG2 2 SEPT4 2 FAM13A 2 DLG5 2 PIR 2 PAPSS1 2 TFPI2 2 PPARG 2 PHF8 2 CSTB 2 SERPINA5 2 CRK 2 C6orf142 2 ALDH6A1 2 SCD 2 MT1X 2 CA2 2 CKB 2 SERHL 2 MMP12 2 MMP10 2 AMD1 2 TM4SF4 2 CPT1A 2 NFIB 2 PITPNA 2 CNDP2 2 MRPL3 2 PDE9A 2 ANK3 2 SAA1 2 SCGB2A1 2 CYP26A1 2 S100P 2 ATAD4 2 SERPINB3 2 BIRC3 2 CAPN6 2 CYB5R2 2 SAT1 2 FOLR1 2 GRHPR 2 AZGP1 2 DCXR 2 CXCL1 2 COBL 2 ANXA3 2 SULT1C2 2 SORD 2 TPD52L1 2 ALDH3B2 2 FUT2 2 CPB2 2 CD9 2 NIACR2 2 VGLL1 2 PSAT1 2 GDPD3 2 ATP2B2 2 KRT6A 2 MAP2K6 2 ZG16B 2 SLC43A1 2 ABCG1 2
Identifiers Repository Data-sets 16735486 PubMed 12
Up-regulated(60) Down-regulated(65)