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Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Others;;COS cycle(s)
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Up-regulated Genes Score GO annotation SLC7A4 6 BP    MF    CC biological_process basic amino acid transport cellular amino acid metabolic process transport cellular_component integral to membrane membrane molecular_function amino acid transmembrane transporter activity basic amino acid transmembrane transporter activity OLFM1 4 BP    MF    CC biological_process multicellular organismal development nervous system development protein oligomerization cellular_component endoplasmic reticulum endoplasmic reticulum lumen extracellular space molecular_function protein binding SFRP4 4 BP    MF    CC biological_process Wnt receptor signaling pathway axonogenesis brain development cell differentiation more... decidualization embryo development epithelium development gonad development mammary gland involution menstrual cycle phase multicellular organismal development negative regulation of JNK cascade negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of sodium-dependent phosphate transport phosphate ion homeostasis positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of epidermal cell differentiation positive regulation of gene expression positive regulation of receptor internalization response to estradiol stimulus response to glucocorticoid stimulus response to hormone stimulus response to peptide hormone stimulus vasculature development less... cellular_component cell surface cytoplasm extracellular region extracellular space more... neuron projection membrane nucleus less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding C5orf13 2 BP    MF    CC biological_process axon regeneration regulation of neuron differentiation regulation of transforming growth factor beta receptor signaling pathway cellular_component cytoplasm nucleus molecular_function ECM1 2 BP    MF    CC biological_process biomineral tissue development negative regulation of bone mineralization negative regulation of peptidase activity ossification more... positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of angiogenesis positive regulation of endothelial cell proliferation signal transduction less... cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function enzyme binding laminin binding protease binding protein C-terminus binding more... protein binding signal transducer activity less... RABGAP1L 2 BP    MF    CC biological_process positive regulation of Rab GTPase activity regulation of protein localization cellular_component Golgi apparatus early endosome intracellular nucleus more... molecular_function GTPase activator activity Rab GTPase activator activity Rab GTPase binding SLC26A2 2 BP    MF    CC biological_process ion transport ossification sulfate transport transmembrane transport more... cellular_component integral to plasma membrane membrane fraction plasma membrane molecular_function secondary active sulfate transmembrane transporter activity sulfate transmembrane transporter activity transporter activity CD36 2 BP    MF    CC biological_process apoptotic cell clearance blood coagulation cGMP-mediated signaling cell adhesion more... cell surface receptor linked signaling pathway cellular response to bacterial lipopeptide cellular response to hydroperoxide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cholesterol transport defense response to Gram-positive bacterium lipid metabolic process lipid storage lipoprotein transport low-density lipoprotein particle clearance low-density lipoprotein particle mediated signaling negative regulation of gene expression negative regulation of growth of symbiont in host negative regulation of transcription factor import into nucleus negative regulation of transcription from RNA polymerase II promoter nitric oxide mediated signal transduction phagocytosis, recognition plasma lipoprotein particle clearance plasma membrane long-chain fatty acid transport platelet activation platelet degranulation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAPKKK cascade positive regulation of blood coagulation positive regulation of blood microparticle formation positive regulation of cell-matrix adhesion positive regulation of cholesterol storage positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of macrophage derived foam cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species metabolic process positive regulation of tumor necrosis factor production regulation of removal of superoxide radicals response to stilbenoid transport less... cellular_component Golgi apparatus cell surface external side of plasma membrane integral to plasma membrane more... membrane membrane fraction membrane raft plasma membrane platelet alpha granule membrane less... molecular_function Gram-negative bacterial cell surface binding Gram-positive bacterial cell surface binding high-density lipoprotein particle binding lipid binding more... lipoprotein particle binding lipoteichoic acid receptor activity low-density lipoprotein particle binding low-density lipoprotein receptor activity receptor activity thrombospondin receptor activity transforming growth factor beta binding less... EDN3 2 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding ANO1 2 BP    MF    CC biological_process chloride transport ion transport multicellular organismal development trachea development more... cellular_component chloride channel complex cytoplasm integral to membrane plasma membrane more... molecular_function intracellular calcium activated chloride channel activity ion channel activity	Down-regulated Genes Score GO annotation GJB2 4 BP    MF    CC biological_process cell-cell signaling cellular membrane organization gap junction assembly male genitalia development more... sensory perception of sound transport less... cellular_component cell junction connexon complex endoplasmic reticulum-Golgi intermediate compartment integral to membrane more... lateral plasma membrane plasma membrane less... molecular_function CTNNA2 4 BP    MF    CC biological_process axonogenesis brain morphogenesis cell adhesion cell-cell adhesion more... dendrite morphogenesis multicellular organismal development muscle cell differentiation positive regulation of muscle cell differentiation prepulse inhibition radial glia guided migration of Purkinje cell regulation of synapse structural plasticity less... cellular_component actin cytoskeleton adherens junction axon basolateral plasma membrane more... cell junction cell-cell adherens junction cytoplasm cytosol lamellipodium plasma membrane less... molecular_function cadherin binding protein binding structural constituent of cytoskeleton structural molecule activity more... DKK1 4 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... GPX3 2 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... QPRT 2 BP    MF    CC biological_process NAD biosynthetic process NAD metabolic process protein oligomerization pyridine nucleotide biosynthetic process more... quinolinate catabolic process quinolinate metabolic process vitamin metabolic process water-soluble vitamin metabolic process less... cellular_component cytoplasm cytosol molecular_function catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity protein homodimerization activity RAB4A 2 BP    MF    CC biological_process GTP catabolic process protein transport small GTPase mediated signal transduction cellular_component cytoplasm cytosol insoluble fraction insulin-responsive compartment more... microsome plasma membrane recycling endosome soluble fraction less... molecular_function ATPase activator activity ATPase binding GDP binding GTP binding more... GTPase activity ionotropic glutamate receptor binding nucleotide binding protein binding syntaxin binding less... AOX1 2 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less... KHDRBS3 2 BP    MF    CC biological_process mRNA processing positive regulation of RNA splicing regulation of transcription, DNA-dependent spermatogenesis more... cellular_component nucleolus nucleus molecular_function RNA binding SH3 domain binding protein binding single-stranded RNA binding more...
Up-regulated Genes Score GO annotation SLC7A4 6 BP    MF    CC biological_process basic amino acid transport cellular amino acid metabolic process transport cellular_component integral to membrane membrane molecular_function amino acid transmembrane transporter activity basic amino acid transmembrane transporter activity OLFM1 4 BP    MF    CC biological_process multicellular organismal development nervous system development protein oligomerization cellular_component endoplasmic reticulum endoplasmic reticulum lumen extracellular space molecular_function protein binding SFRP4 4 BP    MF    CC biological_process Wnt receptor signaling pathway axonogenesis brain development cell differentiation more... decidualization embryo development epithelium development gonad development mammary gland involution menstrual cycle phase multicellular organismal development negative regulation of JNK cascade negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of sodium-dependent phosphate transport phosphate ion homeostasis positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of epidermal cell differentiation positive regulation of gene expression positive regulation of receptor internalization response to estradiol stimulus response to glucocorticoid stimulus response to hormone stimulus response to peptide hormone stimulus vasculature development less... cellular_component cell surface cytoplasm extracellular region extracellular space more... neuron projection membrane nucleus less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding C5orf13 2 BP    MF    CC biological_process axon regeneration regulation of neuron differentiation regulation of transforming growth factor beta receptor signaling pathway cellular_component cytoplasm nucleus molecular_function ECM1 2 BP    MF    CC biological_process biomineral tissue development negative regulation of bone mineralization negative regulation of peptidase activity ossification more... positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of angiogenesis positive regulation of endothelial cell proliferation signal transduction less... cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function enzyme binding laminin binding protease binding protein C-terminus binding more... protein binding signal transducer activity less... RABGAP1L 2 BP    MF    CC biological_process positive regulation of Rab GTPase activity regulation of protein localization cellular_component Golgi apparatus early endosome intracellular nucleus more... molecular_function GTPase activator activity Rab GTPase activator activity Rab GTPase binding SLC26A2 2 BP    MF    CC biological_process ion transport ossification sulfate transport transmembrane transport more... cellular_component integral to plasma membrane membrane fraction plasma membrane molecular_function secondary active sulfate transmembrane transporter activity sulfate transmembrane transporter activity transporter activity CD36 2 BP    MF    CC biological_process apoptotic cell clearance blood coagulation cGMP-mediated signaling cell adhesion more... cell surface receptor linked signaling pathway cellular response to bacterial lipopeptide cellular response to hydroperoxide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cholesterol transport defense response to Gram-positive bacterium lipid metabolic process lipid storage lipoprotein transport low-density lipoprotein particle clearance low-density lipoprotein particle mediated signaling negative regulation of gene expression negative regulation of growth of symbiont in host negative regulation of transcription factor import into nucleus negative regulation of transcription from RNA polymerase II promoter nitric oxide mediated signal transduction phagocytosis, recognition plasma lipoprotein particle clearance plasma membrane long-chain fatty acid transport platelet activation platelet degranulation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAPKKK cascade positive regulation of blood coagulation positive regulation of blood microparticle formation positive regulation of cell-matrix adhesion positive regulation of cholesterol storage positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of macrophage derived foam cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species metabolic process positive regulation of tumor necrosis factor production regulation of removal of superoxide radicals response to stilbenoid transport less... cellular_component Golgi apparatus cell surface external side of plasma membrane integral to plasma membrane more... membrane membrane fraction membrane raft plasma membrane platelet alpha granule membrane less... molecular_function Gram-negative bacterial cell surface binding Gram-positive bacterial cell surface binding high-density lipoprotein particle binding lipid binding more... lipoprotein particle binding lipoteichoic acid receptor activity low-density lipoprotein particle binding low-density lipoprotein receptor activity receptor activity thrombospondin receptor activity transforming growth factor beta binding less... EDN3 2 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding ANO1 2 BP    MF    CC biological_process chloride transport ion transport multicellular organismal development trachea development more... cellular_component chloride channel complex cytoplasm integral to membrane plasma membrane more... molecular_function intracellular calcium activated chloride channel activity ion channel activity CACNA1D 2 BP    MF    CC biological_process axon guidance calcium ion transport energy reserve metabolic process ion transport more... regulation of calcium ion transport via voltage-gated calcium channel activity regulation of insulin secretion transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated calcium channel complex more... molecular_function voltage-gated calcium channel activity voltage-gated ion channel activity MOXD1 2 BP    MF    CC biological_process catecholamine metabolic process cellular process oxidation-reduction process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function copper ion binding dopamine beta-monooxygenase activity metal ion binding monooxygenase activity more... PAGE4 2 BP    MF    CC biological_process biological_process cellular_component cellular_component molecular_function molecular_function DKK2 2 BP    MF    CC biological_process multicellular organismal development negative regulation of Wnt receptor signaling pathway negative regulation of canonical Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway more... cellular_component extracellular region extracellular space molecular_function OPRK1 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway behavior immune response inhibition of adenylate cyclase activity by G-protein signaling pathway more... sensory perception synaptic transmission viral genome replication less... cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity kappa-opioid receptor activity protein binding receptor activity more... signal transducer activity less... MATN2 2 BP    MF    CC biological_process biological_process cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function calcium ion binding molecular_function SQLE 2 BP    MF    CC biological_process cellular aromatic compound metabolic process cholesterol biosynthetic process cholesterol metabolic process oxidation-reduction process more... response to organic substance sterol biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity squalene monooxygenase activity ZNF652 2 BP    MF    CC biological_process regulation of transcription, DNA-dependent cellular_component intracellular nucleus molecular_function DNA binding metal ion binding nucleic acid binding protein binding more... zinc ion binding less... ESR1 2 BP    MF    CC biological_process Sertoli cell proliferation androgen metabolic process antral ovarian follicle growth cellular response to estrogen stimulus more... epithelial cell development epithelial cell proliferation involved in mammary gland duct elongation estrogen receptor signaling pathway gene expression mammary gland alveolus development mammary gland branching involved in pregnancy neuroprotection osteoblast development positive regulation of ERK1 and ERK2 cascade positive regulation of epidermal growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of retinoic acid receptor signaling pathway positive regulation of survival gene product expression positive regulation of transcription from RNA polymerase II promoter prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate epithelial cord elongation regulation of apoptosis regulation of branching involved in prostate gland morphogenesis regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor regulation of transcription, DNA-dependent response to estradiol stimulus response to estrogen stimulus signal transduction steroid hormone mediated signaling pathway transcription, DNA-dependent uterus development vagina development less... cellular_component T-tubule chromatin remodeling complex cytoplasm membrane more... mitochondrial part neuron projection nucleoplasm nucleus perikaryon perinuclear region of cytoplasm plasma membrane protein complex terminal button less... molecular_function DNA binding beta-catenin binding chromatin binding enzyme binding more... estrogen receptor activity estrogen response element binding hormone binding metal ion binding nitric-oxide synthase regulator activity protein binding protein complex binding receptor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid binding steroid hormone receptor activity transcription factor binding type 1 metabotropic glutamate receptor binding zinc ion binding less... ACSM3 2 BP    MF    CC biological_process fatty acid biosynthetic process lipid metabolic process regulation of blood pressure cellular_component cellular_component mitochondrial matrix mitochondrion molecular_function ATP binding butyrate-CoA ligase activity catalytic activity fatty acid ligase activity more... ligase activity metal ion binding molecular_function nucleotide binding less... RGS4 2 BP    MF    CC biological_process inactivation of MAPK activity negative regulation of signal transduction positive regulation of GTPase activity regulation of G-protein coupled receptor protein signaling pathway more... cellular_component cytoplasm cytosol membrane fraction plasma membrane more... molecular_function GTPase activator activity calmodulin binding signal transducer activity SOD2 2 BP    MF    CC biological_process age-dependent response to oxidative stress age-dependent response to reactive oxygen species aging anti-apoptosis more... cellular response to ethanol detection of oxygen erythrophore differentiation glutathione metabolic process heart development hemopoiesis hydrogen peroxide biosynthetic process iron ion homeostasis liver development locomotory behavior mitochondrion organization negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of fibroblast proliferation negative regulation of neuron apoptosis neuron development oxidation-reduction process oxygen homeostasis positive regulation of nitric oxide biosynthetic process post-embryonic development protein homooligomerization protein homotetramerization regulation of blood pressure regulation of catalytic activity regulation of mitochondrial membrane potential regulation of transcription from RNA polymerase II promoter release of cytochrome c from mitochondria removal of superoxide radicals respiratory electron transport chain response to L-ascorbic acid response to activity response to axon injury response to cadmium ion response to drug response to electrical stimulus response to hydrogen peroxide response to hyperoxia response to hypoxia response to lipopolysaccharide response to manganese ion response to nutrient levels response to selenium ion response to silicon dioxide response to superoxide response to zinc ion superoxide anion generation superoxide metabolic process vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure less... cellular_component cytoplasm mitochondrial inner membrane mitochondrial matrix mitochondrial nucleoid more... mitochondrion soluble fraction less... molecular_function DNA binding identical protein binding manganese ion binding metal ion binding more... oxidoreductase activity oxygen binding superoxide dismutase activity less... IGFBP7 2 BP    MF    CC biological_process cell adhesion negative regulation of cell proliferation regulation of cell growth cellular_component extracellular matrix extracellular region extracellular space molecular_function insulin-like growth factor binding protein binding KMO 2 BP    MF    CC biological_process NAD metabolic process cellular nitrogen compound metabolic process kynurenine metabolic process pyridine nucleotide biosynthetic process more... response to salt stress tryptophan catabolic process tryptophan catabolic process to kynurenine less... cellular_component cytosol integral to membrane membrane mitochondrial inner membrane more... mitochondrial outer membrane mitochondrion less... molecular_function NAD(P)H oxidase activity electron carrier activity flavin adenine dinucleotide binding kynurenine 3-monooxygenase activity more... monooxygenase activity less... S100P 2 BP    MF    CC biological_process endothelial cell migration cellular_component cytoplasm nucleus molecular_function calcium ion binding calcium-dependent protein binding magnesium ion binding protein binding more... ATAD4 2 BP    MF    CC biological_process cellular_component molecular_function ATP6V0E2 2 BP    MF    CC biological_process ATP hydrolysis coupled proton transport cell growth cellular iron ion homeostasis insulin receptor signaling pathway more... ion transport transferrin transport transmembrane transport vacuolar acidification less... cellular_component endosome membrane integral to membrane membrane proton-transporting V-type ATPase, V0 domain more... vacuole less... molecular_function ATPase activity, coupled to transmembrane movement of ions hydrogen ion transmembrane transporter activity hydrolase activity IGFBP3 2 BP    MF    CC biological_process negative regulation of cell proliferation negative regulation of protein phosphorylation negative regulation of signal transduction negative regulation of smooth muscle cell migration more... negative regulation of smooth muscle cell proliferation positive regulation of apoptosis positive regulation of myoblast differentiation protein phosphorylation regulation of cell growth less... cellular_component extracellular region extracellular space insulin-like growth factor binding protein complex nucleus more... molecular_function insulin-like growth factor I binding insulin-like growth factor binding metal ion binding protein binding more... protein tyrosine phosphatase activator activity less... TIMP2 2 BP    MF    CC biological_process negative regulation of cell proliferation regulation of MAPKKK cascade regulation of cAMP metabolic process regulation of neuron differentiation more... cellular_component basement membrane cell surface extracellular region molecular_function enzyme activator activity enzyme inhibitor activity integrin binding metal ion binding more... metalloendopeptidase inhibitor activity less... GJA1 2 BP    MF    CC biological_process ATP transport adult heart development apoptosis blood vessel morphogenesis more... cell-cell signaling cellular membrane organization embryonic heart tube development epithelial cell maturation gap junction assembly heart development heart looping in utero embryonic development ion transmembrane transport limb bud formation muscle contraction negative regulation of cell proliferation negative regulation of gene expression neuron migration neuron projection morphogenesis positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of gene expression positive regulation of protein catabolic process positive regulation of striated muscle tissue development protein oligomerization regulation of calcium ion transport regulation of heart contraction response to pH response to peptide hormone stimulus signal transduction skeletal muscle tissue regeneration transport vascular transport less... cellular_component Golgi apparatus Golgi membrane Golgi-associated vesicle membrane cell junction more... connexon complex cytoplasm cytosol early endosome endoplasmic reticulum endoplasmic reticulum membrane fascia adherens gap junction integral to membrane integral to plasma membrane lysosome membrane fraction membrane raft mitochondrial outer membrane multivesicular body plasma membrane less... molecular_function PDZ domain binding SH3 domain binding gap junction channel activity ion transmembrane transporter activity more... receptor binding signal transducer activity transmembrane transporter activity less... GPM6B 2 BP    MF    CC biological_process cell differentiation multicellular organismal development nervous system development cellular_component integral to membrane membrane molecular_function molecular_function ATP1B1 2 BP    MF    CC biological_process ATP biosynthetic process blood coagulation ion transmembrane transport leukocyte migration more... potassium ion transport response to hypoxia sodium ion transport transmembrane transport transport less... cellular_component apical plasma membrane basolateral plasma membrane caveola integral to membrane more... membrane plasma membrane sodium:potassium-exchanging ATPase complex less... molecular_function protein binding sodium:potassium-exchanging ATPase activity PTGS2 2 BP    MF    CC biological_process anagen bone mineralization cellular component movement cyclooxygenase pathway more... decidualization embryo implantation fatty acid biosynthetic process memory negative regulation of calcium ion transport negative regulation of cell proliferation negative regulation of synaptic transmission, dopaminergic ovulation positive regulation of apoptosis positive regulation of brown fat cell differentiation positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fever generation positive regulation of fibroblast growth factor production positive regulation of nitric oxide biosynthetic process positive regulation of platelet-derived growth factor production positive regulation of prostaglandin biosynthetic process positive regulation of smooth muscle cell proliferation positive regulation of smooth muscle contraction positive regulation of synaptic plasticity positive regulation of synaptic transmission, glutamatergic positive regulation of transforming growth factor beta production positive regulation of vasoconstriction positive regulation vascular endothelial growth factor production prostaglandin biosynthetic process prostaglandin metabolic process prostanoid metabolic process regulation of blood pressure regulation of cell cycle regulation of inflammatory response response to cytokine stimulus response to drug response to estradiol stimulus response to fructose stimulus response to glucocorticoid stimulus response to lipopolysaccharide response to manganese ion response to organic cyclic compound response to organic nitrogen response to oxidative stress response to vitamin D xenobiotic metabolic process less... cellular_component caveola cytoplasm endoplasmic reticulum endoplasmic reticulum lumen more... endoplasmic reticulum membrane membrane microsome neuron projection nucleus protein complex less... molecular_function enzyme binding heme binding lipid binding metal ion binding more... oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen peroxidase activity prostaglandin-endoperoxide synthase activity less... KCNG1 2 BP    MF    CC biological_process ion transport potassium ion transmembrane transport potassium ion transport synaptic transmission more... transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated potassium channel complex more... molecular_function potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity LRRC17 2 BP    MF    CC biological_process bone marrow development negative regulation of osteoclast differentiation osteoblast differentiation osteoblast proliferation more... cellular_component extracellular region extracellular space molecular_function SULT1E1 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid metabolic process sulfation xenobiotic metabolic process more... cellular_component cytoplasm cytosol nuclear membrane nucleus more... molecular_function estrone sulfotransferase activity flavonol 3-sulfotransferase activity steroid binding steroid sulfotransferase activity more... transferase activity less... LRP4 2 BP    MF    CC biological_process anatomical structure development dorsal/ventral pattern formation embryonic digit morphogenesis endocytosis more... hair follicle development kidney development negative regulation of canonical Wnt receptor signaling pathway odontogenesis of dentine-containing tooth protein localization proximal/distal pattern formation receptor clustering synaptic growth at neuromuscular junction less... cellular_component cellular_component integral to membrane membrane plasma membrane more... molecular_function calcium ion binding receptor activity DAAM2 2 BP    MF    CC biological_process actin cytoskeleton organization cellular component organization cellular_component molecular_function Rho GTPase binding actin binding binding GDF15 2 BP    MF    CC biological_process cell-cell signaling signal transduction transforming growth factor beta receptor signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity PTGS1 2 BP    MF    CC biological_process aging cyclooxygenase pathway fatty acid biosynthetic process lipid metabolic process more... negative regulation of epinephrine secretion negative regulation of norepinephrine secretion oxidation-reduction process positive regulation of smooth muscle contraction positive regulation of vasoconstriction prostaglandin biosynthetic process prostanoid metabolic process regulation of blood pressure regulation of cell proliferation response to corticosterone stimulus response to organic nitrogen response to oxidative stress xenobiotic metabolic process less... cellular_component Golgi apparatus cytoplasm cytoplasmic part endoplasmic reticulum more... endoplasmic reticulum membrane intracellular membrane-bounded organelle microsome nuclear envelope nucleus photoreceptor outer segment plasma membrane less... molecular_function heme binding lipid binding metal ion binding oxidoreductase activity more... oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen peroxidase activity prostaglandin-endoperoxide synthase activity less... GREM2 2 BP    MF    CC biological_process BMP signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity PCSK6 2 BP    MF    CC biological_process determination of left/right symmetry glycoprotein metabolic process nerve growth factor processing nerve growth factor production more... nerve growth factor receptor signaling pathway peptide hormone processing protein processing proteolysis regulation of BMP signaling pathway secretion by cell zygotic determination of anterior/posterior axis, embryo less... cellular_component Golgi lumen cell surface endomembrane system endoplasmic reticulum more... extracellular matrix extracellular region extracellular space membrane soluble fraction less... molecular_function endopeptidase activity eukaryotic cell surface binding heparin binding nerve growth factor binding more... peptidase activity serine-type endopeptidase activity less... PDGFC 2 BP    MF    CC biological_process activation of transmembrane receptor protein tyrosine kinase activity cellular response to amino acid stimulus central nervous system development organ morphogenesis more... platelet-derived growth factor receptor signaling pathway positive regulation of DNA replication positive regulation of cell division positive regulation of cell proliferation positive regulation of fibroblast proliferation regulation of peptidyl-tyrosine phosphorylation vascular endothelial growth factor receptor signaling pathway less... cellular_component Golgi membrane cytoplasm endoplasmic reticulum lumen extracellular region more... extracellular space membrane nucleus less... molecular_function cell surface binding growth factor activity platelet-derived growth factor receptor binding protein homodimerization activity more... RASSF2 2 BP    MF    CC biological_process cell cycle signal transduction cellular_component nucleus molecular_function protein binding AKR1C3 2 BP    MF    CC biological_process oxidation-reduction process prostaglandin metabolic process cellular_component cytoplasm intracellular molecular_function aldo-keto reductase (NADP) activity androsterone dehydrogenase (A-specific) activity indanol dehydrogenase activity oxidoreductase activity more... prostaglandin-F synthase activity testosterone 17-beta-dehydrogenase (NAD+) activity testosterone 17-beta-dehydrogenase (NADP+) activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity less... FZD5 2 BP    MF    CC biological_process Spemann organizer formation T cell differentiation in thymus Wnt receptor signaling pathway involved in dorsal/ventral axis specification angiogenesis more... anterior/posterior axis specification, embryo apoptosis axonogenesis brain development canonical Wnt receptor signaling pathway cellular response to molecule of bacterial origin embryonic axis specification embryonic camera-type eye development gonad development labyrinthine layer blood vessel development multicellular organismal development neuron differentiation positive regulation of interferon-gamma production positive regulation of transcription from RNA polymerase II promoter post-embryonic camera-type eye development less... cellular_component Golgi apparatus Golgi membrane cell projection cell surface more... cytoplasm integral to membrane plasma membrane less... molecular_function G-protein coupled receptor activity PDZ domain binding Wnt-activated receptor activity Wnt-protein binding more... protein binding protein kinase binding receptor activity signal transducer activity less...	Down-regulated Genes Score GO annotation GJB2 4 BP    MF    CC biological_process cell-cell signaling cellular membrane organization gap junction assembly male genitalia development more... sensory perception of sound transport less... cellular_component cell junction connexon complex endoplasmic reticulum-Golgi intermediate compartment integral to membrane more... lateral plasma membrane plasma membrane less... molecular_function CTNNA2 4 BP    MF    CC biological_process axonogenesis brain morphogenesis cell adhesion cell-cell adhesion more... dendrite morphogenesis multicellular organismal development muscle cell differentiation positive regulation of muscle cell differentiation prepulse inhibition radial glia guided migration of Purkinje cell regulation of synapse structural plasticity less... cellular_component actin cytoskeleton adherens junction axon basolateral plasma membrane more... cell junction cell-cell adherens junction cytoplasm cytosol lamellipodium plasma membrane less... molecular_function cadherin binding protein binding structural constituent of cytoskeleton structural molecule activity more... DKK1 4 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... GPX3 2 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... QPRT 2 BP    MF    CC biological_process NAD biosynthetic process NAD metabolic process protein oligomerization pyridine nucleotide biosynthetic process more... quinolinate catabolic process quinolinate metabolic process vitamin metabolic process water-soluble vitamin metabolic process less... cellular_component cytoplasm cytosol molecular_function catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity protein homodimerization activity RAB4A 2 BP    MF    CC biological_process GTP catabolic process protein transport small GTPase mediated signal transduction cellular_component cytoplasm cytosol insoluble fraction insulin-responsive compartment more... microsome plasma membrane recycling endosome soluble fraction less... molecular_function ATPase activator activity ATPase binding GDP binding GTP binding more... GTPase activity ionotropic glutamate receptor binding nucleotide binding protein binding syntaxin binding less... AOX1 2 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less... KHDRBS3 2 BP    MF    CC biological_process mRNA processing positive regulation of RNA splicing regulation of transcription, DNA-dependent spermatogenesis more... cellular_component nucleolus nucleus molecular_function RNA binding SH3 domain binding protein binding single-stranded RNA binding more... GGCT 2 BP    MF    CC biological_process glutathione biosynthetic process release of cytochrome c from mitochondria xenobiotic metabolic process cellular_component cytosol molecular_function gamma-glutamylcyclotransferase activity protein homodimerization activity transferase activity, transferring acyl groups AHNAK2 2 BP    MF    CC biological_process cellular_component nucleus molecular_function ABCC3 2 BP    MF    CC biological_process bile acid and bile salt transport bile acid metabolic process organic anion transport transmembrane transport more... transport less... cellular_component integral to plasma membrane membrane fraction plasma membrane molecular_function ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding more... organic anion transmembrane transporter activity transporter activity less... NUDT9 2 BP    MF    CC biological_process ADP catabolic process IDP catabolic process cellular_component intracellular mitochondrion molecular_function ADP-ribose diphosphatase activity ADP-sugar diphosphatase activity adenosine-diphosphatase activity hydrolase activity more... MMP26 2 BP    MF    CC biological_process collagen catabolic process proteolysis cellular_component extracellular region proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... DYNC1I1 2 BP    MF    CC biological_process transport vesicle transport along microtubule cellular_component chromosome condensed chromosome kinetochore cytoplasm cytoplasmic dynein complex more... cytoskeleton kinetochore microtubule perinuclear region of cytoplasm spindle pole vesicle less... molecular_function microtubule binding microtubule motor activity motor activity protein binding more... ALPL 2 BP    MF    CC biological_process biomineral tissue development cellular response to organic cyclic compound cementum mineralization response to antibiotic more... response to glucocorticoid stimulus response to lipopolysaccharide response to vitamin D skeletal system development less... cellular_component anchored to membrane cytoplasm extracellular space integral to membrane more... plasma membrane less... molecular_function alkaline phosphatase activity catalytic activity hydrolase activity metal ion binding more... CKB 2 BP    MF    CC biological_process brain development cellular chloride ion homeostasis cellular nitrogen compound metabolic process creatine metabolic process more... cellular_component cytoplasm cytosol mitochondrion molecular_function ATP binding creatine kinase activity kinase activity nucleotide binding more... CREG1 2 BP    MF    CC biological_process cell proliferation multicellular organismal development regulation of growth regulation of transcription from RNA polymerase II promoter more... cellular_component extracellular region transcription factor complex molecular_function FMN binding oxidoreductase activity transcription corepressor activity transcription factor binding more... CYB5A 2 BP    MF    CC biological_process electron transport chain transport vitamin metabolic process water-soluble vitamin metabolic process more... cellular_component cytoplasm endoplasmic reticulum endoplasmic reticulum membrane integral to membrane more... membrane microsome mitochondrial outer membrane mitochondrion less... molecular_function aldo-keto reductase (NADP) activity cytochrome-c oxidase activity enzyme binding heme binding more... metal ion binding less... OFD1 2 BP    MF    CC biological_process G2/M transition of mitotic cell cycle cell projection organization centriole replication cilium axoneme assembly more... cilium morphogenesis epithelial cilium movement involved in determination of left/right asymmetry mitosis mitotic cell cycle spindle assembly involved in mitosis less... cellular_component centriole centrosome cilium cytoplasm more... cytoskeleton cytosol intracellular membrane-bounded organelle microtubule basal body nuclear membrane nucleus less... molecular_function alpha-tubulin binding gamma-tubulin binding protein binding ANK3 2 BP    MF    CC biological_process establishment of protein localization signal transduction cellular_component basolateral plasma membrane cytoplasm cytoskeleton molecular_function protein binding PKP2 2 BP    MF    CC biological_process cell-cell adhesion heart development cellular_component adherens junction cell-cell junction desmosome integral to membrane more... nucleus plasma membrane less... molecular_function binding molecular_function MUC16 2 BP    MF    CC biological_process cell adhesion cellular_component extracellular region extracellular space extrinsic to membrane integral to membrane more... plasma membrane less... molecular_function protein binding PART1 2 BP    MF    CC biological_process cellular_component molecular_function GREB1 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function FIG4 2 BP    MF    CC biological_process cell death locomotory behavior neuron development phosphatidylinositol metabolic process more... pigmentation positive regulation of neuron projection development vacuole organization less... cellular_component Golgi apparatus endoplasmic reticulum endosome membrane membrane more... recycling endosome less... molecular_function hydrolase activity phosphoric ester hydrolase activity polyphosphatidylinositol phosphatase activity protein binding more... PDE4DIP 2 BP    MF    CC biological_process cellular protein complex assembly cellular_component Golgi apparatus centrosome cytoplasm cytoskeleton more... myofibril nucleus less... molecular_function enzyme binding protein binding
Up-regulated Genes Score SLC7A4 6 OLFM1 4 SFRP4 4 C5orf13 2 ECM1 2 RABGAP1L 2 SLC26A2 2 CD36 2 EDN3 2 ANO1 2 CACNA1D 2 MOXD1 2 PAGE4 2 DKK2 2 OPRK1 2 MATN2 2 SQLE 2 ZNF652 2 ESR1 2 ACSM3 2 RGS4 2 SOD2 2 IGFBP7 2 KMO 2 S100P 2 ATAD4 2 ATP6V0E2 2 IGFBP3 2 TIMP2 2 GJA1 2 GPM6B 2 ATP1B1 2 PTGS2 2 KCNG1 2 LRRC17 2 SULT1E1 2 LRP4 2 DAAM2 2 GDF15 2 PTGS1 2 GREM2 2 PCSK6 2 PDGFC 2 RASSF2 2 AKR1C3 2 FZD5 2	Down-regulated Genes Score GJB2 4 CTNNA2 4 DKK1 4 GPX3 2 NDRG2 2 F3 2 QPRT 2 RAB4A 2 AOX1 2 KHDRBS3 2 GGCT 2 AHNAK2 2 ABCC3 2 NUDT9 2 MMP26 2 DYNC1I1 2 ALPL 2 CKB 2 CREG1 2 CYB5A 2 OFD1 2 ANK3 2 PKP2 2 MUC16 2 PART1 2 GREB1 2 FIG4 2 PDE4DIP 2
Identifiers Repository Data-sets 19955106 PubMed 6 19796763 PubMed 4 18191855 PubMed 5 18697870 PubMed 2
Up-regulated(46) Down-regulated(28)