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Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Hormone treatment;;Follicle stimulating hormone
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Up-regulated Genes Score GO annotation GPX3 4 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... DPP4 4 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... PAEP 4 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity TCN1 4 BP    MF    CC biological_process cobalamin metabolic process cobalamin transport cobalt ion transport ion transport more... cellular_component extracellular region molecular_function cobalamin binding LCN2 2 BP    MF    CC biological_process cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to lipopolysaccharide cellular response to nutrient levels more... cellular response to tumor necrosis factor innate immune response ion transport iron ion homeostasis positive regulation of cell projection organization positive regulation of gene expression protein homotrimerization regulation of apoptosis response to bacterium response to drug response to herbicide response to oxidative stress response to virus siderophore transport less... cellular_component cytosol extracellular region extracellular space molecular_function binding iron ion binding protease binding protein homodimerization activity more... transporter activity less... LMOD1 2 BP    MF    CC biological_process muscle contraction cellular_component cytoplasm cytoskeleton cytosol membrane fraction more... molecular_function tropomyosin binding F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... MMP7 2 BP    MF    CC biological_process antibacterial peptide secretion collagen catabolic process defense response to Gram-negative bacterium defense response to Gram-positive bacterium more... metabolic process proteolysis regulation of cell proliferation response to drug less... cellular_component extracellular region extracellular space proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... IL6ST 2 BP    MF    CC biological_process JAK-STAT cascade ciliary neurotrophic factor-mediated signaling pathway cytokine-mediated signaling pathway interleukin-27-mediated signaling pathway more... interleukin-6-mediated signaling pathway leukemia inhibitory factor signaling pathway negative regulation of interleukin-6-mediated signaling pathway positive regulation of T cell proliferation positive regulation of acute inflammatory response positive regulation of adaptive immune response positive regulation of anti-apoptosis positive regulation of cardiac muscle hypertrophy positive regulation of cell proliferation positive regulation of osteoblast differentiation positive regulation of smooth muscle cell migration positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation vascular endothelial growth factor production reduction of cytosolic calcium ion concentration response to cytokine stimulus response to nutrient triglyceride mobilization less... cellular_component ciliary neurotrophic factor receptor complex extracellular region extracellular space integral to membrane more... interleukin-6 receptor complex oncostatin-M receptor complex plasma membrane less... molecular_function ciliary neurotrophic factor receptor activity ciliary neurotrophic factor receptor binding growth factor binding interleukin-27 receptor activity more... interleukin-6 binding interleukin-6 receptor activity interleukin-6 receptor binding leukemia inhibitory factor receptor activity oncostatin-M receptor activity protein binding protein homodimerization activity receptor activity less... AOX1 2 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less...	Down-regulated Genes Score GO annotation SQLE 4 BP    MF    CC biological_process cellular aromatic compound metabolic process cholesterol biosynthetic process cholesterol metabolic process oxidation-reduction process more... response to organic substance sterol biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity squalene monooxygenase activity SCGB1D2 4 BP    MF    CC biological_process cellular_component extracellular region extracellular space molecular_function binding TRPM6 2 BP    MF    CC biological_process ion transport metal ion transport protein phosphorylation response to toxin more... transmembrane transport less... cellular_component apical plasma membrane brush border membrane integral to membrane membrane more... molecular_function ATP binding calcium channel activity ion channel activity kinase activity more... metal ion binding nucleotide binding protein binding protein serine/threonine kinase activity receptor activity transferase activity, transferring phosphorus-containing groups less... NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding SEPT4 2 BP    MF    CC biological_process GTP catabolic process apoptosis brain development cell cycle more... cytokinesis positive regulation of apoptosis positive regulation of protein ubiquitination regulation of apoptosis sperm capacitation sperm mitochondrion organization less... cellular_component cell projection cytoplasm cytoskeleton microtubule-based flagellum more... mitochondrion nucleus less... molecular_function GTP binding GTPase activity nucleotide binding protein binding more... structural molecule activity less... BARD1 2 BP    MF    CC biological_process DNA repair cell cycle arrest negative regulation of apoptosis negative regulation of mRNA 3'-end processing more... negative regulation of protein export from nucleus positive regulation of apoptosis positive regulation of protein catabolic process protein K6-linked ubiquitination protein ubiquitination regulation of phosphorylation response to DNA damage stimulus spermatogenesis tissue homeostasis less... cellular_component BRCA1-A complex BRCA1-BARD1 complex cytoplasm intracellular more... nucleus ubiquitin ligase complex less... molecular_function RNA binding kinase binding ligase activity metal ion binding more... protein binding protein heterodimerization activity protein homodimerization activity ubiquitin-protein ligase activity zinc ion binding less... SERHL2 2 BP    MF    CC biological_process cellular_component cytoplasm cytoplasmic membrane-bounded vesicle mitochondrion perinuclear region of cytoplasm more... peroxisome less... molecular_function hydrolase activity HSD11B2 2 BP    MF    CC biological_process female pregnancy glucocorticoid biosynthetic process regulation of blood volume by renal aldosterone response to drug more... response to food response to glucocorticoid stimulus response to hypoxia response to insulin stimulus response to steroid hormone stimulus less... cellular_component cytoplasm endoplasmic reticulum microsome molecular_function 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity NAD binding binding oxidoreductase activity more... steroid binding less... MPPED2 2 BP    MF    CC biological_process nervous system development cellular_component molecular_function hydrolase activity metal ion binding IFNGR1 2 BP    MF    CC biological_process cytokine-mediated signaling pathway interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway response to virus more... signal transduction less... cellular_component integral to plasma membrane membrane plasma membrane molecular_function cytokine binding interferon-gamma receptor activity receptor activity
Up-regulated Genes Score GO annotation GPX3 4 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... DPP4 4 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... PAEP 4 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity TCN1 4 BP    MF    CC biological_process cobalamin metabolic process cobalamin transport cobalt ion transport ion transport more... cellular_component extracellular region molecular_function cobalamin binding LCN2 2 BP    MF    CC biological_process cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to lipopolysaccharide cellular response to nutrient levels more... cellular response to tumor necrosis factor innate immune response ion transport iron ion homeostasis positive regulation of cell projection organization positive regulation of gene expression protein homotrimerization regulation of apoptosis response to bacterium response to drug response to herbicide response to oxidative stress response to virus siderophore transport less... cellular_component cytosol extracellular region extracellular space molecular_function binding iron ion binding protease binding protein homodimerization activity more... transporter activity less... LMOD1 2 BP    MF    CC biological_process muscle contraction cellular_component cytoplasm cytoskeleton cytosol membrane fraction more... molecular_function tropomyosin binding F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... MMP7 2 BP    MF    CC biological_process antibacterial peptide secretion collagen catabolic process defense response to Gram-negative bacterium defense response to Gram-positive bacterium more... metabolic process proteolysis regulation of cell proliferation response to drug less... cellular_component extracellular region extracellular space proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... IL6ST 2 BP    MF    CC biological_process JAK-STAT cascade ciliary neurotrophic factor-mediated signaling pathway cytokine-mediated signaling pathway interleukin-27-mediated signaling pathway more... interleukin-6-mediated signaling pathway leukemia inhibitory factor signaling pathway negative regulation of interleukin-6-mediated signaling pathway positive regulation of T cell proliferation positive regulation of acute inflammatory response positive regulation of adaptive immune response positive regulation of anti-apoptosis positive regulation of cardiac muscle hypertrophy positive regulation of cell proliferation positive regulation of osteoblast differentiation positive regulation of smooth muscle cell migration positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation vascular endothelial growth factor production reduction of cytosolic calcium ion concentration response to cytokine stimulus response to nutrient triglyceride mobilization less... cellular_component ciliary neurotrophic factor receptor complex extracellular region extracellular space integral to membrane more... interleukin-6 receptor complex oncostatin-M receptor complex plasma membrane less... molecular_function ciliary neurotrophic factor receptor activity ciliary neurotrophic factor receptor binding growth factor binding interleukin-27 receptor activity more... interleukin-6 binding interleukin-6 receptor activity interleukin-6 receptor binding leukemia inhibitory factor receptor activity oncostatin-M receptor activity protein binding protein homodimerization activity receptor activity less... AOX1 2 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less... PSD 2 BP    MF    CC biological_process neuron differentiation regulation of ARF protein signal transduction signal transduction cellular_component cytoplasm integral to membrane intracellular plasma membrane more... ruffle less... molecular_function ARF guanyl-nucleotide exchange factor activity signal transducer activity CTTN 2 BP    MF    CC biological_process cellular_component cell cortex cytoplasm cytoskeleton lamellipodium more... ruffle soluble fraction less... molecular_function protein binding C4BPA 2 BP    MF    CC biological_process binding of sperm to zona pellucida complement activation, classical pathway innate immune response cellular_component acrosomal matrix extracellular region molecular_function protein binding TAGLN 2 BP    MF    CC biological_process muscle organ development cellular_component cytoplasm molecular_function actin binding LIF 2 BP    MF    CC biological_process blood vessel remodeling decidualization embryo implantation immune response more... leukemia inhibitory factor signaling pathway lung alveolus development lung lobe morphogenesis lung vasculature development maternal process involved in female pregnancy multicellular organismal development muscle organ morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis negative regulation of cell proliferation negative regulation of hormone secretion negative regulation of meiosis neuron development organ regeneration positive regulation of MAPKKK cascade positive regulation of astrocyte differentiation positive regulation of cell proliferation positive regulation of corticotropin secretion positive regulation of macrophage differentiation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of neuron projection development positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation retina development in camera-type eye spongiotrophoblast differentiation stem cell maintenance transdifferentiation trophoblast giant cell differentiation less... cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity leukemia inhibitory factor receptor binding receptor binding more... IGFBP1 2 BP    MF    CC biological_process insulin receptor signaling pathway positive regulation of cell growth regulation of cell growth signal transduction more... tissue regeneration less... cellular_component extracellular region extracellular space molecular_function insulin-like growth factor binding DNAJC6 2 BP    MF    CC biological_process cellular membrane organization post-Golgi vesicle-mediated transport cellular_component cytosol molecular_function SH3 domain binding heat shock protein binding hydrolase activity protein tyrosine phosphatase activity more... CDA 2 BP    MF    CC biological_process cell surface receptor linked signaling pathway cellular response to external biotic stimulus cytidine deamination cytosine metabolic process more... negative regulation of cell growth negative regulation of nucleotide metabolic process nucleobase-containing small molecule metabolic process protein homotetramerization pyrimidine base metabolic process pyrimidine nucleoside salvage pyrimidine-containing compound salvage response to cycloheximide less... cellular_component cytosol extracellular region molecular_function cytidine deaminase activity hydrolase activity metal ion binding nucleoside binding more... protein homodimerization activity zinc ion binding less... CD36 2 BP    MF    CC biological_process apoptotic cell clearance blood coagulation cGMP-mediated signaling cell adhesion more... cell surface receptor linked signaling pathway cellular response to bacterial lipopeptide cellular response to hydroperoxide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cholesterol transport defense response to Gram-positive bacterium lipid metabolic process lipid storage lipoprotein transport low-density lipoprotein particle clearance low-density lipoprotein particle mediated signaling negative regulation of gene expression negative regulation of growth of symbiont in host negative regulation of transcription factor import into nucleus negative regulation of transcription from RNA polymerase II promoter nitric oxide mediated signal transduction phagocytosis, recognition plasma lipoprotein particle clearance plasma membrane long-chain fatty acid transport platelet activation platelet degranulation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAPKKK cascade positive regulation of blood coagulation positive regulation of blood microparticle formation positive regulation of cell-matrix adhesion positive regulation of cholesterol storage positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of macrophage derived foam cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species metabolic process positive regulation of tumor necrosis factor production regulation of removal of superoxide radicals response to stilbenoid transport less... cellular_component Golgi apparatus cell surface external side of plasma membrane integral to plasma membrane more... membrane membrane fraction membrane raft plasma membrane platelet alpha granule membrane less... molecular_function Gram-negative bacterial cell surface binding Gram-positive bacterial cell surface binding high-density lipoprotein particle binding lipid binding more... lipoprotein particle binding lipoteichoic acid receptor activity low-density lipoprotein particle binding low-density lipoprotein receptor activity receptor activity thrombospondin receptor activity transforming growth factor beta binding less... MYH11 2 BP    MF    CC biological_process axon guidance cardiac muscle fiber development elastic fiber assembly muscle contraction more... skeletal muscle myosin thick filament assembly smooth muscle contraction less... cellular_component cytosol melanosome muscle myosin complex myosin complex more... myosin filament less... molecular_function ATP binding actin binding calmodulin binding motor activity more... nucleotide binding structural constituent of muscle less... CYP3A5 2 BP    MF    CC biological_process alkaloid catabolic process drug catabolic process oxidation-reduction process oxidative demethylation more... steroid metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function aromatase activity electron carrier activity heme binding metal ion binding more... monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding less... VPS13D 2 BP    MF    CC biological_process protein localization cellular_component molecular_function ABCC3 2 BP    MF    CC biological_process bile acid and bile salt transport bile acid metabolic process organic anion transport transmembrane transport more... transport less... cellular_component integral to plasma membrane membrane fraction plasma membrane molecular_function ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding more... organic anion transmembrane transporter activity transporter activity less... CLU 2 BP    MF    CC biological_process anti-apoptosis blood coagulation cell death cellular response to growth factor stimulus more... chaperone-mediated protein folding complement activation complement activation, classical pathway endocrine pancreas development induction of apoptosis by intracellular signals innate immune response lipid metabolic process negative regulation of apoptosis negative regulation of protein homooligomerization neuron projection morphogenesis platelet activation platelet degranulation positive regulation of NF-kappaB transcription factor activity positive regulation of apoptosis positive regulation of cell differentiation positive regulation of cell proliferation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein stabilization release of cytochrome c from mitochondria response to misfolded protein response to oxidative stress response to virus response to wounding reverse cholesterol transport less... cellular_component aggresome chromaffin granule cytoplasm cytoplasmic vesicle more... cytosol endoplasmic reticulum extracellular matrix extracellular region extracellular space growth cone membrane microsome mitochondrial membrane mitochondrion nucleus perinuclear region of cytoplasm platelet alpha granule lumen spherical high-density lipoprotein particle less... molecular_function ATPase activity misfolded protein binding protein binding ubiquitin protein ligase binding more... PPARGC1A 2 BP    MF    CC biological_process RNA splicing androgen receptor signaling pathway brown fat cell differentiation cellular glucose homeostasis more... cellular respiration cellular response to oxidative stress digestion fatty acid oxidation gluconeogenesis mRNA processing mitochondrion organization negative regulation of neuron apoptosis neuron death positive regulation of fatty acid oxidation positive regulation of gluconeogenesis positive regulation of histone acetylation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent protein complex assembly protein stabilization regulation of cell death respiratory electron transport chain response to muscle activity response to starvation temperature homeostasis transcription initiation from RNA polymerase II promoter less... cellular_component DNA-directed RNA polymerase II, core complex cytosol nucleus molecular_function DNA binding RNA binding RNA polymerase II transcription cofactor activity androgen receptor binding more... ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity nucleotide binding protein binding receptor activity transcription coactivator activity transcription factor binding less... ANKRD55 2 BP    MF    CC biological_process cellular_component molecular_function SLC15A1 2 BP    MF    CC biological_process digestion ion transport oligopeptide transport protein transport more... transmembrane transport transport less... cellular_component integral to membrane integral to plasma membrane membrane membrane fraction more... plasma membrane less... molecular_function oligopeptide transporter activity peptide:hydrogen symporter activity symporter activity transporter activity more... ST6GAL1 2 BP    MF    CC biological_process cellular protein metabolic process humoral immune response post-translational protein modification protein N-linked glycosylation via asparagine more... protein glycosylation protein modification process less... cellular_component Golgi apparatus Golgi cisterna membrane Golgi membrane extracellular region more... integral to Golgi membrane integral to membrane membrane less... molecular_function beta-galactoside alpha-2,6-sialyltransferase activity sialyltransferase activity DHRS3 2 BP    MF    CC biological_process retinol metabolic process visual perception cellular_component integral to membrane membrane molecular_function NADP-retinol dehydrogenase activity binding electron carrier activity nucleotide binding more... oxidoreductase activity less... SLC1A1 2 BP    MF    CC biological_process D-aspartate import L-glutamate import L-glutamate transport dicarboxylic acid transport more... ion transport protein homooligomerization synaptic transmission transmembrane transport less... cellular_component integral to plasma membrane membrane membrane fraction plasma membrane more... molecular_function L-glutamate transmembrane transporter activity glutamate binding glutamate:sodium symporter activity sodium:dicarboxylate symporter activity more... symporter activity less... THBS1 2 BP    MF    CC biological_process activation of MAPK activity anti-apoptosis blood coagulation cell adhesion more... cell cycle arrest cell migration cellular response to heat chronic inflammatory response engulfment of apoptotic cell immune response induction of apoptosis negative regulation of angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of apoptosis negative regulation of blood vessel endothelial cell migration negative regulation of cGMP-mediated signaling negative regulation of caspase activity negative regulation of cell-matrix adhesion negative regulation of dendritic cell antigen processing and presentation negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of fibrinolysis negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of focal adhesion assembly negative regulation of interleukin-12 production negative regulation of nitric oxide mediated signal transduction negative regulation of plasma membrane long-chain fatty acid transport negative regulation of plasminogen activation peptide cross-linking platelet activation platelet degranulation positive regulation of angiogenesis positive regulation of blood coagulation positive regulation of blood vessel endothelial cell migration positive regulation of cell migration positive regulation of chemotaxis positive regulation of endothelial cell migration positive regulation of fibroblast migration positive regulation of macrophage activation positive regulation of macrophage chemotaxis positive regulation of phosphorylation positive regulation of protein kinase B signaling cascade positive regulation of reactive oxygen species metabolic process positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta1 production positive regulation of translation positive regulation of tumor necrosis factor biosynthetic process response to calcium ion response to drug response to glucose stimulus response to hypoxia response to magnesium ion response to progesterone stimulus sprouting angiogenesis less... cellular_component external side of plasma membrane extracellular matrix extracellular region extracellular space more... fibrinogen complex platelet alpha granule platelet alpha granule lumen stored secretory granule less... molecular_function calcium ion binding collagen V binding eukaryotic cell surface binding fibrinogen binding more... fibroblast growth factor 2 binding fibronectin binding glycoprotein binding heparin binding identical protein binding integrin binding laminin binding low-density lipoprotein particle binding phosphatidylserine binding protein binding proteoglycan binding structural molecule activity transforming growth factor beta binding less... ELF3 2 BP    MF    CC biological_process anatomical structure morphogenesis blastocyst development embryo development epidermis development more... epithelial cell differentiation extracellular matrix organization inflammatory response mammary gland involution multicellular organismal development negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent regulation of transcription, DNA-dependent transcription from RNA polymerase II promoter transcription, DNA-dependent less... cellular_component Golgi apparatus cytoplasm nucleolus nucleus more... molecular_function protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription coactivator activity more... EFEMP1 2 BP    MF    CC biological_process epidermal growth factor receptor signaling pathway negative regulation of chondrocyte differentiation peptidyl-tyrosine phosphorylation regulation of transcription, DNA-dependent more... visual perception less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding epidermal growth factor receptor binding epidermal growth factor-activated receptor activity growth factor activity more... protein binding less... RARRES1 2 BP    MF    CC biological_process negative regulation of cell proliferation cellular_component integral to membrane membrane molecular_function C1orf106 2 BP    MF    CC biological_process cellular_component molecular_function EDNRB 2 BP    MF    CC biological_process activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger cell surface receptor linked signaling pathway developmental pigmentation enteric nervous system development more... enteric smooth muscle cell differentiation macrophage chemotaxis melanocyte differentiation negative regulation of adenylate cyclase activity negative regulation of cellular protein metabolic process negative regulation of neuron maturation negative regulation of transcription from RNA polymerase II promoter nervous system development neural crest cell migration peripheral nervous system development posterior midgut development regulation of blood pressure regulation of pH vasoconstriction vein smooth muscle contraction less... cellular_component integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity endothelin-B receptor activity peptide hormone binding receptor activity more... signal transducer activity less... ABLIM3 2 BP    MF    CC biological_process axon guidance cytoskeleton organization positive regulation of transcription from RNA polymerase II promoter cellular_component cytoplasm molecular_function actin binding metal ion binding zinc ion binding VNN1 2 BP    MF    CC biological_process acute inflammatory response anti-apoptosis cell-cell adhesion cellular component movement more... chronic inflammatory response inflammatory response innate immune response nitrogen compound metabolic process pantothenate metabolic process positive regulation of T cell differentiation in thymus response to oxidative stress less... cellular_component anchored to membrane integral to membrane plasma membrane molecular_function GPI anchor binding pantetheine hydrolase activity NUDT4 2 BP    MF    CC biological_process calcium-mediated signaling cyclic nucleotide metabolic process cyclic-nucleotide-mediated signaling intracellular signal transduction more... intracellular transport regulation of RNA export from nucleus less... cellular_component cytoplasm intracellular molecular_function diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity metal ion binding PLS1 2 BP    MF    CC biological_process cellular_component cytoplasm molecular_function actin binding actin filament binding calcium ion binding structural constituent of cytoskeleton more... HABP2 2 BP    MF    CC biological_process cell adhesion proteolysis cellular_component extracellular region extracellular space molecular_function glycosaminoglycan binding peptidase activity serine-type endopeptidase activity CNN1 2 BP    MF    CC biological_process actomyosin structure organization regulation of smooth muscle contraction cellular_component cytoskeleton molecular_function actin binding calmodulin binding FXYD2 2 BP    MF    CC biological_process ion transmembrane transport ion transport potassium ion transport sodium ion transport more... transmembrane transport transport less... cellular_component integral to membrane membrane plasma membrane sodium:potassium-exchanging ATPase complex more... molecular_function ion channel activity sodium:potassium-exchanging ATPase activity transporter activity PDZK1IP1 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function AIMP1 2 BP    MF    CC biological_process angiogenesis apoptosis carbohydrate metabolic process cell adhesion more... cell-cell signaling chemotaxis gene expression glucose metabolic process inflammatory response leukocyte migration negative regulation of endothelial cell proliferation response to wounding signal transduction tRNA aminoacylation for protein translation less... cellular_component Golgi apparatus aminoacyl-tRNA synthetase multienzyme complex cytoplasm cytoplasmic vesicle more... cytosol endoplasmic reticulum extracellular region extracellular space nucleus transport vesicle less... molecular_function cell surface binding cytokine activity protein homodimerization activity tRNA binding more... SFN 2 BP    MF    CC biological_process DNA damage response, signal transduction resulting in induction of apoptosis apoptosis cell proliferation negative regulation of caspase activity more... negative regulation of protein kinase activity positive regulation of cell growth positive regulation of protein export from nucleus release of cytochrome c from mitochondria signal transduction less... cellular_component cytoplasm extracellular region extracellular space nucleus more... molecular_function phosphoprotein binding protein binding protein domain specific binding protein kinase C inhibitor activity more... DUSP6 2 BP    MF    CC biological_process MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway cell differentiation more... dorsal/ventral pattern formation inactivation of MAPK activity innate immune response negative regulation of ERK1 and ERK2 cascade negative regulation of protein phosphorylation nerve growth factor receptor signaling pathway peptidyl-tyrosine dephosphorylation positive regulation of apoptosis protein dephosphorylation regulation of endodermal cell fate specification regulation of fibroblast growth factor receptor signaling pathway regulation of heart growth response to drug response to growth factor stimulus response to nitrosative stress response to organic cyclic compound stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytoplasm cytosol nucleoplasm molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity phosphatase activity protein tyrosine phosphatase activity more... CYP2C9 2 BP    MF    CC biological_process cellular amide metabolic process drug catabolic process drug metabolic process exogenous drug catabolic process more... monocarboxylic acid metabolic process monoterpenoid metabolic process oxidation-reduction process oxidative demethylation steroid metabolic process urea metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function (R)-limonene 6-monooxygenase activity (S)-limonene 6-monooxygenase activity (S)-limonene 7-monooxygenase activity caffeine oxidase activity more... drug binding electron carrier activity heme binding metal ion binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen steroid hydroxylase activity less... PAPSS2 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process skeletal system development sulfate assimilation more... xenobiotic metabolic process less... cellular_component cytosol molecular_function ATP binding adenylylsulfate kinase activity kinase activity nucleotide binding more... nucleotidyltransferase activity sulfate adenylyltransferase (ATP) activity less... KIAA1199 2 BP    MF    CC biological_process cellular_component cytoplasm molecular_function ABP1 2 BP    MF    CC biological_process amine metabolic process oxidation-reduction process cellular_component extracellular region extracellular space peroxisome molecular_function copper ion binding diamine oxidase activity heparin binding histamine oxidase activity more... metal ion binding methylputrescine oxidase activity oxidoreductase activity primary amine oxidase activity propane-1,3-diamine oxidase activity quinone binding less... ATP2C2 2 BP    MF    CC biological_process ATP biosynthetic process calcium ion transport cation transport ion transmembrane transport more... transmembrane transport less... cellular_component Golgi membrane integral to membrane membrane molecular_function ATP binding calcium-transporting ATPase activity catalytic activity hydrolase activity more... hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding nucleotide binding protein binding less... PTGER2 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway regulation of cell proliferation cellular_component integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity prostaglandin E receptor activity receptor activity signal transducer activity more... DARC 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway defense response inflammatory response cellular_component integral to membrane plasma membrane molecular_function C-C chemokine binding G-protein coupled receptor activity chemokine receptor activity receptor activity more... signal transducer activity transmembrane signaling receptor activity less... MUC16 2 BP    MF    CC biological_process cell adhesion cellular_component extracellular region extracellular space extrinsic to membrane integral to membrane more... plasma membrane less... molecular_function protein binding CDH13 2 BP    MF    CC biological_process Rac protein signal transduction Rho protein signal transduction adherens junction organization calcium-dependent cell-cell adhesion more... cell adhesion cell junction assembly cell-cell junction organization endothelial cell migration homophilic cell adhesion keratinocyte proliferation lamellipodium assembly localization within membrane low-density lipoprotein particle mediated signaling mitotic cell cycle negative regulation of cell adhesion negative regulation of cell proliferation positive regulation of calcium-mediated signaling positive regulation of cell migration positive regulation of cell-matrix adhesion positive regulation of endothelial cell proliferation positive regulation of positive chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of survival gene product expression regulation of cell growth regulation of endocytosis regulation of epidermal growth factor receptor signaling pathway response to organic substance sprouting angiogenesis less... cellular_component anchored to membrane caveola cytoplasm external side of plasma membrane more... extracellular space integral to membrane membrane neuron projection perinuclear region of cytoplasm plasma membrane less... molecular_function adiponectin binding cadherin binding calcium ion binding lipoprotein particle binding more... low-density lipoprotein particle binding protein homodimerization activity less... CATSPERB 2 BP    MF    CC biological_process cell differentiation multicellular organismal development spermatogenesis cellular_component flagellum integral to membrane membrane molecular_function TSPAN1 2 BP    MF    CC biological_process cellular_component integral to membrane lysosomal membrane membrane molecular_function SNX10 2 BP    MF    CC biological_process cell communication endosome organization protein transport cellular_component cytoplasm endosome extrinsic to endosome membrane membrane more... molecular_function 1-phosphatidylinositol binding lipid binding phosphatidylinositol binding COMP 2 BP    MF    CC biological_process anti-apoptosis apoptosis cell adhesion limb development more... organ morphogenesis skeletal system development less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding collagen binding extracellular matrix structural constituent heparan sulfate proteoglycan binding more... heparin binding protein binding less... SLC22A5 2 BP    MF    CC biological_process carnitine transport drug transmembrane transport drug transport positive regulation of intestinal epithelial structure maintenance more... quaternary ammonium group transport quorum sensing involved in interaction with host sodium ion transport sodium-dependent organic cation transport transmembrane transport less... cellular_component apical plasma membrane basolateral plasma membrane brush border membrane integral to membrane more... plasma membrane less... molecular_function ATP binding PDZ domain binding antibiotic transporter activity carnitine transporter activity more... drug transmembrane transporter activity ion transmembrane transporter activity nucleotide binding protein binding quaternary ammonium group transmembrane transporter activity symporter activity less... IGFBP3 2 BP    MF    CC biological_process negative regulation of cell proliferation negative regulation of protein phosphorylation negative regulation of signal transduction negative regulation of smooth muscle cell migration more... negative regulation of smooth muscle cell proliferation positive regulation of apoptosis positive regulation of myoblast differentiation protein phosphorylation regulation of cell growth less... cellular_component extracellular region extracellular space insulin-like growth factor binding protein complex nucleus more... molecular_function insulin-like growth factor I binding insulin-like growth factor binding metal ion binding protein binding more... protein tyrosine phosphatase activator activity less... FAP 2 BP    MF    CC biological_process endothelial cell migration negative regulation of extracellular matrix disassembly proteolysis cellular_component cell junction integral to membrane invadopodium membrane lamellipodium more... lamellipodium membrane membrane plasma membrane less... molecular_function dipeptidyl-peptidase activity metalloendopeptidase activity peptidase activity protein binding more... protein dimerization activity protein homodimerization activity serine-type endopeptidase activity serine-type peptidase activity less... MALL 2 BP    MF    CC biological_process cholesterol homeostasis cellular_component Golgi membrane clathrin-coated vesicle cytoplasmic membrane-bounded vesicle integral to membrane more... membrane raft plasma membrane less... molecular_function protein binding KIAA0040 2 BP    MF    CC biological_process cellular_component molecular_function AQP3 2 BP    MF    CC biological_process excretion glycerol transport odontogenesis positive regulation of immune system process more... regulation of keratinocyte differentiation renal water absorption response to calcium ion response to retinoic acid response to vitamin D transmembrane transport transport urea transport water transport less... cellular_component basolateral plasma membrane cell-cell junction cytoplasm integral to membrane more... membrane plasma membrane less... molecular_function glycerol channel activity transporter activity water channel activity G0S2 2 BP    MF    CC biological_process cell cycle cellular_component cellular_component molecular_function molecular_function TRPC6 2 BP    MF    CC biological_process axon guidance blood coagulation cation transport elevation of cytosolic calcium ion concentration more... ion transport platelet activation positive regulation of calcium ion transport via store-operated calcium channel activity positive regulation of ion transmembrane transporter activity transmembrane transport less... cellular_component integral to membrane membrane plasma membrane molecular_function calcium channel activity cation channel activity ion channel activity protein binding more... CXCL14 2 BP    MF    CC biological_process cell-cell signaling chemotaxis immune response signal transduction more... cellular_component Golgi apparatus extracellular region extracellular space molecular_function chemokine activity MAOA 2 BP    MF    CC biological_process behavior catecholamine metabolic process cellular biogenic amine metabolic process dopamine catabolic process more... neurotransmitter biosynthetic process neurotransmitter catabolic process neurotransmitter secretion phenylethylamine metabolic process serotonin metabolic process synaptic transmission xenobiotic metabolic process less... cellular_component integral to membrane membrane mitochondrial outer membrane mitochondrion more... soluble fraction less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity primary amine oxidase activity serotonin binding more... TTC39A 2 BP    MF    CC biological_process biological_process cellular_component cellular_component molecular_function binding molecular_function THBD 2 BP    MF    CC biological_process blood coagulation embryo development female pregnancy leukocyte migration more... negative regulation of blood coagulation negative regulation of fibrinolysis negative regulation of platelet activation response to X-ray response to cAMP response to lipopolysaccharide less... cellular_component cell surface extracellular space integral to membrane integral to plasma membrane more... membrane plasma membrane less... molecular_function binding calcium ion binding protein binding receptor activity more... transmembrane signaling receptor activity less... SLC44A4 2 BP    MF    CC biological_process transmembrane transport cellular_component integral to membrane membrane plasma membrane molecular_function HAL 2 BP    MF    CC biological_process biosynthetic process cellular nitrogen compound metabolic process histidine catabolic process cellular_component cytoplasm cytosol soluble fraction molecular_function ammonia-lyase activity catalytic activity histidine ammonia-lyase activity lyase activity more... GAST 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway signal transduction cellular_component extracellular region molecular_function hormone activity AGR2 2 BP    MF    CC biological_process mucus secretion cellular_component endoplasmic reticulum extracellular region mitochondrion molecular_function alpha-dystroglycan binding protein binding LAMB3 2 BP    MF    CC biological_process cell adhesion cell junction assembly epidermis development hemidesmosome assembly more... cellular_component basement membrane extracellular region molecular_function protein binding protein complex binding structural molecule activity TSPAN8 2 BP    MF    CC biological_process negative regulation of blood coagulation protein glycosylation signal transduction cellular_component integral to membrane lysosome membrane molecular_function signal transducer activity ANG 2 BP    MF    CC biological_process actin filament polymerization activation of phospholipase A2 activity activation of phospholipase C activity activation of protein kinase B activity more... angiogenesis cell communication cell death cell differentiation cell migration diacylglycerol biosynthetic process homeostatic process multicellular organismal development negative regulation of smooth muscle cell proliferation negative regulation of translation oocyte maturation ovarian follicle development placenta development positive regulation of endothelial cell proliferation positive regulation of phosphorylation positive regulation of protein secretion rRNA transcription response to hormone stimulus response to hypoxia less... cellular_component angiogenin-PRI complex basal lamina extracellular region extracellular space more... growth cone neuronal cell body nucleolus nucleus less... molecular_function DNA binding actin binding copper ion binding endonuclease activity more... heparin binding hydrolase activity pancreatic ribonuclease activity peptide binding protein binding rRNA binding receptor binding ribonuclease activity less... CXCL12 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway T cell proliferation adult locomotory behavior ameboidal cell migration more... blood circulation brain development cell adhesion cellular calcium ion homeostasis chemokine-mediated signaling pathway chemotaxis germ cell development germ cell migration immune response induction of positive chemotaxis motor axon guidance negative regulation of apoptosis negative regulation of leukocyte apoptosis neuron migration organ regeneration patterning of blood vessels positive regulation of axon extension involved in axon guidance positive regulation of calcium ion transport via voltage-gated calcium channel activity positive regulation of cell migration positive regulation of cell proliferation positive regulation of dopamine secretion positive regulation of endothelial cell proliferation positive regulation of monocyte chemotaxis positive regulation of neuron differentiation regulation of actin polymerization or depolymerization response to heat response to hypoxia response to mechanical stimulus response to peptide hormone stimulus response to radiation response to virus signal transduction telencephalon cell migration less... cellular_component external side of plasma membrane extracellular region extracellular space plasma membrane more... molecular_function CXCR chemokine receptor binding chemokine activity growth factor activity receptor binding more... signal transducer activity less... IMPA2 2 BP    MF    CC biological_process inositol phosphate dephosphorylation phosphate-containing compound metabolic process signal transduction cellular_component cytoplasm molecular_function hydrolase activity inositol monophosphate phosphatase activity inositol or phosphatidylinositol phosphatase activity metal ion binding more... protein homodimerization activity less... ADRA2A 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway Ras protein signal transduction Rho protein signal transduction actin cytoskeleton organization more... activation of MAPK activity by adrenergic receptor signaling pathway activation of phospholipase C activity by adrenergic receptor signaling pathway activation of protein kinase B activity activation of protein kinase activity blood coagulation cellular component movement cellular response to hormone stimulus energy reserve metabolic process epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway fear response glucose homeostasis inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway intestinal absorption negative regulation of adenylate cyclase activity negative regulation of adrenergic receptor signaling pathway negative regulation of cAMP biosynthetic process negative regulation of calcium ion transport via voltage-gated calcium channel activity negative regulation of calcium ion-dependent exocytosis negative regulation of epinephrine secretion negative regulation of insulin secretion negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of lipid catabolic process negative regulation of norepinephrine secretion positive regulation of MAP kinase activity positive regulation of cell migration positive regulation of cell proliferation positive regulation of cytokine production positive regulation of epidermal growth factor-activated receptor activity positive regulation of membrane protein ectodomain proteolysis positive regulation of potassium ion transport positive regulation of wound healing regulation of insulin secretion signal transduction less... cellular_component basolateral plasma membrane cytoplasm integral to plasma membrane plasma membrane more... receptor complex less... molecular_function G-protein coupled receptor activity adrenergic receptor activity alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding more... alpha2-adrenergic receptor activity epinephrine binding heterotrimeric G-protein binding norepinephrine binding protein binding protein heterodimerization activity protein homodimerization activity protein kinase binding receptor activity signal transducer activity thioesterase binding less... MMP11 2 BP    MF    CC biological_process collagen catabolic process multicellular organismal development proteolysis cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function calcium ion binding metal ion binding metalloendopeptidase activity peptidase activity more... zinc ion binding less... THBS2 2 BP    MF    CC biological_process cell adhesion negative regulation of angiogenesis positive regulation of synapse assembly cellular_component basement membrane extracellular matrix extracellular region molecular_function calcium ion binding heparin binding protein binding structural molecule activity more... TMOD1 2 BP    MF    CC biological_process muscle filament sliding myofibril assembly cellular_component cortical cytoskeleton cytoplasm cytoskeleton cytosol more... membrane myofibril nucleus signalosome less... molecular_function actin binding tropomyosin binding PROM1 2 BP    MF    CC biological_process camera-type eye photoreceptor cell differentiation photoreceptor cell maintenance retina layer formation retina morphogenesis in camera-type eye more... cellular_component apical plasma membrane cell surface cilium integral to membrane more... integral to plasma membrane microvillus membrane photoreceptor outer segment photoreceptor outer segment membrane plasma membrane less... molecular_function beta-actinin binding cadherin binding protein binding CXCR4 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway activation of MAPK activity apoptosis dendritic cell chemotaxis more... elevation of cytosolic calcium ion concentration entry into host cell inflammatory response initiation of viral infection interspecies interaction between organisms myelin maintenance positive regulation of oligodendrocyte differentiation regulation of chemotaxis response to hypoxia response to virus viral reproduction less... cellular_component cell leading edge cell surface cytoplasm cytoplasmic membrane-bounded vesicle more... cytoplasmic vesicle integral to membrane plasma membrane less... molecular_function C-X-C chemokine receptor activity G-protein coupled receptor activity actin binding coreceptor activity more... myosin light chain binding protein binding receptor activity signal transducer activity ubiquitin binding ubiquitin protein ligase binding less... ACADSB 2 BP    MF    CC biological_process acyl-CoA metabolic process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process fatty acid metabolic process more... lipid metabolic process less... cellular_component mitochondrial matrix mitochondrion molecular_function acyl-CoA dehydrogenase activity electron carrier activity flavin adenine dinucleotide binding short-branched-chain-acyl-CoA dehydrogenase activity more... GADD45A 2 BP    MF    CC biological_process DNA repair G2/M transition of mitotic cell cycle apoptosis cell cycle arrest more... cellular response to ionizing radiation cellular response to mechanical stimulus centrosome cycle negative regulation of protein kinase activity positive regulation of reactive oxygen species metabolic process regulation of cyclin-dependent protein kinase activity signal transduction in response to DNA damage less... cellular_component nucleus molecular_function protein binding PAX8 2 BP    MF    CC biological_process anatomical structure morphogenesis branching involved in ureteric bud morphogenesis cell differentiation cellular response to gonadotropin stimulus more... central nervous system development inner ear morphogenesis kidney development mesenchymal to epithelial transition involved in metanephros morphogenesis mesonephric tubule development mesonephros development metanephric S-shaped body morphogenesis metanephric collecting duct development metanephric comma-shaped body morphogenesis metanephric distal convoluted tubule development metanephric epithelium development metanephric nephron tubule formation multicellular organismal development negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis otic vesicle development positive regulation of branching involved in ureteric bud morphogenesis positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of metanephric DCT cell differentiation positive regulation of thyroid hormone generation positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent pronephric field specification pronephros development regulation of apoptosis regulation of metanephric nephron tubule epithelial cell differentiation regulation of thyroid-stimulating hormone secretion regulation of transcription, DNA-dependent thyroid gland development transcription, DNA-dependent urogenital system development less... cellular_component nucleolus nucleoplasm nucleus molecular_function DNA binding RNA polymerase II core promoter sequence-specific DNA binding protein binding sequence-specific DNA binding more... sequence-specific DNA binding transcription factor activity thyroid-stimulating hormone receptor activity transcription regulatory region DNA binding less... BCL2A1 2 BP    MF    CC biological_process anti-apoptosis regulation of apoptosis cellular_component cytoplasm molecular_function protein binding OTUB2 2 BP    MF    CC biological_process cellular amino acid metabolic process protein K48-linked deubiquitination protein K63-linked deubiquitination protein deubiquitination more... protein metabolic process less... cellular_component cellular_component molecular_function cysteine-type peptidase activity omega peptidase activity peptidase activity ubiquitin-specific protease activity more... GRAMD1C 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function	Down-regulated Genes Score GO annotation SQLE 4 BP    MF    CC biological_process cellular aromatic compound metabolic process cholesterol biosynthetic process cholesterol metabolic process oxidation-reduction process more... response to organic substance sterol biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity squalene monooxygenase activity SCGB1D2 4 BP    MF    CC biological_process cellular_component extracellular region extracellular space molecular_function binding TRPM6 2 BP    MF    CC biological_process ion transport metal ion transport protein phosphorylation response to toxin more... transmembrane transport less... cellular_component apical plasma membrane brush border membrane integral to membrane membrane more... molecular_function ATP binding calcium channel activity ion channel activity kinase activity more... metal ion binding nucleotide binding protein binding protein serine/threonine kinase activity receptor activity transferase activity, transferring phosphorus-containing groups less... NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding SEPT4 2 BP    MF    CC biological_process GTP catabolic process apoptosis brain development cell cycle more... cytokinesis positive regulation of apoptosis positive regulation of protein ubiquitination regulation of apoptosis sperm capacitation sperm mitochondrion organization less... cellular_component cell projection cytoplasm cytoskeleton microtubule-based flagellum more... mitochondrion nucleus less... molecular_function GTP binding GTPase activity nucleotide binding protein binding more... structural molecule activity less... BARD1 2 BP    MF    CC biological_process DNA repair cell cycle arrest negative regulation of apoptosis negative regulation of mRNA 3'-end processing more... negative regulation of protein export from nucleus positive regulation of apoptosis positive regulation of protein catabolic process protein K6-linked ubiquitination protein ubiquitination regulation of phosphorylation response to DNA damage stimulus spermatogenesis tissue homeostasis less... cellular_component BRCA1-A complex BRCA1-BARD1 complex cytoplasm intracellular more... nucleus ubiquitin ligase complex less... molecular_function RNA binding kinase binding ligase activity metal ion binding more... protein binding protein heterodimerization activity protein homodimerization activity ubiquitin-protein ligase activity zinc ion binding less... SERHL2 2 BP    MF    CC biological_process cellular_component cytoplasm cytoplasmic membrane-bounded vesicle mitochondrion perinuclear region of cytoplasm more... peroxisome less... molecular_function hydrolase activity HSD11B2 2 BP    MF    CC biological_process female pregnancy glucocorticoid biosynthetic process regulation of blood volume by renal aldosterone response to drug more... response to food response to glucocorticoid stimulus response to hypoxia response to insulin stimulus response to steroid hormone stimulus less... cellular_component cytoplasm endoplasmic reticulum microsome molecular_function 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity NAD binding binding oxidoreductase activity more... steroid binding less... MPPED2 2 BP    MF    CC biological_process nervous system development cellular_component molecular_function hydrolase activity metal ion binding IFNGR1 2 BP    MF    CC biological_process cytokine-mediated signaling pathway interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway response to virus more... signal transduction less... cellular_component integral to plasma membrane membrane plasma membrane molecular_function cytokine binding interferon-gamma receptor activity receptor activity TFPI2 2 BP    MF    CC biological_process blood coagulation cellular_component extracellular region proteinaceous extracellular matrix molecular_function extracellular matrix structural constituent peptidase inhibitor activity serine-type endopeptidase inhibitor activity HLA-DMB 2 BP    MF    CC biological_process T cell costimulation T cell receptor signaling pathway antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II more... cytokine-mediated signaling pathway immune response interferon-gamma-mediated signaling pathway less... cellular_component MHC class II protein complex endosome integral to membrane late endosome membrane more... lysosomal membrane membrane plasma membrane less... molecular_function SERPINA5 2 BP    MF    CC biological_process fusion of sperm to egg plasma membrane negative regulation of endopeptidase activity negative regulation of proteolysis regulation of proteolysis more... spermatogenesis less... cellular_component extracellular region membrane protein complex molecular_function acrosin binding glycosaminoglycan binding heparin binding peptidase inhibitor activity more... protease binding serine-type endopeptidase inhibitor activity less... GSN 2 BP    MF    CC biological_process actin filament polymerization actin filament severing actin polymerization or depolymerization aging more... apoptosis barbed-end actin filament capping cell projection organization cellular component disassembly involved in apoptosis cellular response to cadmium ion cilium morphogenesis oligodendrocyte development phosphatidylinositol-mediated signaling regulation of cell adhesion response to ethanol response to folic acid tissue regeneration vesicle-mediated transport less... cellular_component actin cytoskeleton cytoplasm cytosol extracellular region more... extracellular space lamellipodium perinuclear region of cytoplasm protein complex ruffle less... molecular_function actin binding calcium ion binding protein binding KHDRBS3 2 BP    MF    CC biological_process mRNA processing positive regulation of RNA splicing regulation of transcription, DNA-dependent spermatogenesis more... cellular_component nucleolus nucleus molecular_function RNA binding SH3 domain binding protein binding single-stranded RNA binding more... TNNC1 2 BP    MF    CC biological_process cardiac muscle contraction muscle filament sliding regulation of ATPase activity regulation of muscle contraction more... regulation of muscle filament sliding speed ventricular cardiac muscle tissue morphogenesis less... cellular_component cytosol troponin complex molecular_function actin filament binding calcium ion binding calcium-dependent protein binding protein binding more... protein homodimerization activity troponin I binding troponin T binding less... MMP26 2 BP    MF    CC biological_process collagen catabolic process proteolysis cellular_component extracellular region proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... CWH43 2 BP    MF    CC biological_process GPI anchor biosynthetic process cellular_component integral to membrane membrane molecular_function STXBP6 2 BP    MF    CC biological_process vesicle-mediated transport cellular_component cytoplasm integral to membrane membrane molecular_function CYP2J2 2 BP    MF    CC biological_process epoxygenase P450 pathway icosanoid metabolic process linoleic acid metabolic process regulation of heart contraction more... xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function arachidonic acid 11,12-epoxygenase activity arachidonic acid 14,15-epoxygenase activity arachidonic acid epoxygenase activity aromatase activity more... electron carrier activity heme binding linoleic acid epoxygenase activity metal ion binding less... NEDD9 2 BP    MF    CC biological_process actin filament bundle assembly cell adhesion cell cycle cell division more... cytoskeleton organization integrin-mediated signaling pathway mitosis regulation of growth signal transduction less... cellular_component Golgi apparatus cell cortex cell junction cytoplasm more... cytoskeleton focal adhesion lamellipodium nucleus spindle spindle pole less... molecular_function protein binding MTL5 2 BP    MF    CC biological_process cell differentiation cellular metal ion homeostasis multicellular organismal development response to metal ion more... spermatogenesis less... cellular_component cytoplasm nucleus soluble fraction molecular_function metal ion binding DYNC1I1 2 BP    MF    CC biological_process transport vesicle transport along microtubule cellular_component chromosome condensed chromosome kinetochore cytoplasm cytoplasmic dynein complex more... cytoskeleton kinetochore microtubule perinuclear region of cytoplasm spindle pole vesicle less... molecular_function microtubule binding microtubule motor activity motor activity protein binding more... PROL1 2 BP    MF    CC biological_process negative regulation of endopeptidase activity negative regulation of peptidase activity regulation of sensory perception of pain cellular_component extracellular region molecular_function endopeptidase inhibitor activity peptidase inhibitor activity ALPL 2 BP    MF    CC biological_process biomineral tissue development cellular response to organic cyclic compound cementum mineralization response to antibiotic more... response to glucocorticoid stimulus response to lipopolysaccharide response to vitamin D skeletal system development less... cellular_component anchored to membrane cytoplasm extracellular space integral to membrane more... plasma membrane less... molecular_function alkaline phosphatase activity catalytic activity hydrolase activity metal ion binding more... CXCL13 2 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... BCKDHB 2 BP    MF    CC biological_process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process response to cAMP response to glucocorticoid stimulus more... response to nutrient less... cellular_component mitochondrial alpha-ketoglutarate dehydrogenase complex mitochondrial matrix mitochondrion molecular_function 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity alpha-ketoacid dehydrogenase activity carboxy-lyase activity catalytic activity more... protein binding protein complex binding less... HOMER2 2 BP    MF    CC biological_process metabotropic glutamate receptor signaling pathway cellular_component cell junction cytoplasm dendrite neuronal cell body more... plasma membrane postsynaptic density postsynaptic membrane synapse less... molecular_function GKAP/Homer scaffold activity actin binding metabotropic glutamate receptor binding protein domain specific binding more... protein heterodimerization activity protein homodimerization activity less... ELP3 2 BP    MF    CC biological_process regulation of transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter cellular_component DNA-directed RNA polymerase II, holoenzyme cytoplasm nucleolus nucleus more... transcription elongation factor complex less... molecular_function DNA binding N-acetyltransferase activity catalytic activity histone acetyltransferase activity more... iron-sulfur cluster binding metal ion binding phosphorylase kinase regulator activity protein binding transferase activity, transferring acyl groups less... SORBS2 2 BP    MF    CC biological_process biological_process cellular_component Z disc actin cytoskeleton cytoplasm intracellular more... nucleus perinuclear region of cytoplasm less... molecular_function cytoskeletal adaptor activity structural constituent of cytoskeleton structural constituent of muscle zinc ion binding more... NFIB 2 BP    MF    CC biological_process Clara cell differentiation DNA replication Type I pneumocyte differentiation Type II pneumocyte differentiation more... anterior commissure morphogenesis chondrocyte differentiation commissural neuron axon guidance epithelial cell proliferation involved in lung morphogenesis forebrain development glial cell differentiation hindbrain development lung ciliated cell differentiation mesenchymal cell proliferation involved in lung development negative regulation of DNA binding negative regulation of cell proliferation negative regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter principal sensory nucleus of trigeminal nerve development transcription from RNA polymerase II promoter less... cellular_component cerebellar mossy fiber intracellular nucleolus nucleus more... molecular_function DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription RNA polymerase II transcription corepressor activity double-stranded DNA binding more... sequence-specific DNA binding RNA polymerase II transcription factor activity sequence-specific DNA binding transcription factor activity less... PRKAG2 2 BP    MF    CC biological_process ATP biosynthetic process carnitine shuttle cell cycle arrest cellular lipid metabolic process more... energy reserve metabolic process glycogen metabolic process insulin receptor signaling pathway intracellular protein kinase cascade negative regulation of protein kinase activity positive regulation of peptidyl-threonine phosphorylation positive regulation of protein kinase activity regulation of catalytic activity regulation of fatty acid biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid oxidation regulation of glucose import regulation of glycolysis sterol biosynthetic process less... cellular_component AMP-activated protein kinase complex cytosol nucleoplasm molecular_function ADP binding AMP binding AMP-activated protein kinase activity ATP binding more... cAMP-dependent protein kinase activity cAMP-dependent protein kinase inhibitor activity cAMP-dependent protein kinase regulator activity catalytic activity phosphorylase kinase regulator activity protein kinase activator activity protein kinase binding less... SCGB1D1 2 BP    MF    CC biological_process cellular_component extracellular region extracellular space molecular_function binding HGD 2 BP    MF    CC biological_process L-phenylalanine catabolic process cellular amino acid metabolic process cellular nitrogen compound metabolic process oxidation-reduction process more... tyrosine catabolic process tyrosine metabolic process less... cellular_component cytosol molecular_function homogentisate 1,2-dioxygenase activity metal ion binding oxidoreductase activity ADAMTS8 2 BP    MF    CC biological_process negative regulation of cell proliferation proteolysis cellular_component extracellular region proteinaceous extracellular matrix molecular_function heparin binding integrin binding low affinity phosphate transmembrane transporter activity metal ion binding more... metalloendopeptidase activity metallopeptidase activity peptidase activity zinc ion binding less... NR4A2 2 BP    MF    CC biological_process adult locomotory behavior cellular response to extracellular stimulus cellular response to stress central nervous system neuron differentiation more... central nervous system projection neuron axonogenesis death dopamine biosynthetic process dopaminergic neuron differentiation gene expression habenula development intracellular receptor mediated signaling pathway negative regulation of neuron apoptosis nervous system development neuron maturation neuron migration positive regulation of catalytic activity positive regulation of transcription from RNA polymerase II promoter post-embryonic development regulation of dopamine metabolic process regulation of respiratory gaseous exchange regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor response to amphetamine response to hypoxia response to inorganic substance response to insecticide signal transduction transcription, DNA-dependent less... cellular_component cytoplasm nucleoplasm nucleus molecular_function ligand-dependent nuclear receptor activity metal ion binding protein binding protein heterodimerization activity more... receptor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity zinc ion binding less... PDE9A 2 BP    MF    CC biological_process blood coagulation platelet activation signal transduction cellular_component Golgi apparatus cell projection cytoplasm cytosol more... endoplasmic reticulum perinuclear region of cytoplasm plasma membrane ruffle membrane less... molecular_function 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding more... phosphoric diester hydrolase activity protein binding less... CSRP2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development myoblast differentiation cellular_component nucleus molecular_function metal ion binding molecular_function zinc ion binding CRIP1 2 BP    MF    CC biological_process cell proliferation cellular_component cytoplasm molecular_function AT DNA binding DNA bending activity metal ion binding zinc ion binding more... TFCP2L1 2 BP    MF    CC biological_process cell morphogenesis cytoplasm organization determination of adult lifespan epithelial cell maturation more... female pregnancy negative regulation of transcription from RNA polymerase II promoter positive regulation of growth regulation of transcription from RNA polymerase II promoter salivary gland development steroid biosynthetic process transcription, DNA-dependent less... cellular_component cytoplasm membrane mitochondrion nucleolus more... nucleus less... molecular_function DNA binding sequence-specific DNA binding transcription factor activity transcription corepressor activity PLA2G4A 2 BP    MF    CC biological_process aging arachidonic acid metabolic process arachidonic acid secretion blood coagulation more... cellular response to antibiotic decidualization icosanoid biosynthetic process icosanoid metabolic process lipid catabolic process luteolysis metabolic process ovulation from ovarian follicle phospholipid catabolic process platelet activating factor biosynthetic process platelet activation positive regulation of apoptosis positive regulation of bone mineralization positive regulation of cell proliferation positive regulation of fever generation positive regulation of inflammatory response positive regulation of prostaglandin biosynthetic process positive regulation of vesicle fusion response to calcium ion response to glucocorticoid stimulus response to heat response to hormone stimulus response to hydrogen peroxide response to lipopolysaccharide response to methylmercury response to organic nitrogen response to vitamin D surfactant homeostasis less... cellular_component Golgi apparatus cytoplasm cytoplasmic membrane-bounded vesicle cytosol more... endoplasmic reticulum endoplasmic reticulum membrane membrane fraction nucleus perinuclear region of cytoplasm zymogen granule less... molecular_function calcium ion binding calcium-dependent phospholipase A2 activity calcium-dependent phospholipid binding hydrolase activity more... lysophospholipase activity phospholipase A2 activity phospholipase activity less... GAL 2 BP    MF    CC biological_process feeding behavior growth hormone secretion inflammatory response insulin secretion more... negative regulation of cell proliferation negative regulation of lymphocyte proliferation nervous system development neuropeptide signaling pathway positive regulation of apoptosis regulation of glucocorticoid metabolic process response to drug response to estrogen stimulus response to insulin stimulus response to stress smooth muscle contraction less... cellular_component Golgi apparatus cellular_component cytoplasm extracellular region more... stored secretory granule less... molecular_function neuropeptide hormone activity NQO1 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process negative regulation of catalytic activity nitric oxide biosynthetic process positive regulation of neuron apoptosis more... regulation of cellular amino acid metabolic process response to oxidative stress response to toxin synaptic transmission, cholinergic xenobiotic metabolic process less... cellular_component cytoplasm cytosol molecular_function NAD(P)H dehydrogenase (quinone) activity coenzyme binding cytochrome-b5 reductase activity electron carrier activity more... oxidoreductase activity protein binding less... PDK4 2 BP    MF    CC biological_process carbohydrate metabolic process glucose metabolic process peptidyl-histidine phosphorylation protein phosphorylation more... pyruvate metabolic process regulation of acetyl-CoA biosynthetic process from pyruvate less... cellular_component mitochondrial inner membrane mitochondrial matrix mitochondrion molecular_function ATP binding kinase activity nucleotide binding protein kinase activity more... pyruvate dehydrogenase (acetyl-transferring) kinase activity transferase activity two-component sensor activity less... ANK3 2 BP    MF    CC biological_process establishment of protein localization signal transduction cellular_component basolateral plasma membrane cytoplasm cytoskeleton molecular_function protein binding UCK2 2 BP    MF    CC biological_process cellular response to oxygen levels feeding behavior metabolic process nucleobase-containing small molecule metabolic process more... nucleotide biosynthetic process pyrimidine base metabolic process pyrimidine nucleoside salvage response to axon injury less... cellular_component cellular_component cytosol microsome molecular_function ATP binding kinase activity nucleoside kinase activity nucleotide binding more... phosphotransferase activity, alcohol group as acceptor transferase activity uridine kinase activity less... GMPR 2 BP    MF    CC biological_process nucleobase-containing small molecule metabolic process nucleotide metabolic process purine base metabolic process purine-containing compound salvage more... response to cold less... cellular_component cytosol molecular_function GMP reductase activity metal ion binding oxidoreductase activity ABCB9 2 BP    MF    CC biological_process antigen processing and presentation of peptide antigen via MHC class I peptide transport positive regulation of T cell mediated cytotoxicity protein transport more... transmembrane transport less... cellular_component TAP complex early endosome endoplasmic reticulum endoplasmic reticulum membrane more... integral to endoplasmic reticulum membrane integral to membrane lysosomal membrane mitochondrial inner membrane plasma membrane less... molecular_function ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances MHC class I protein binding more... TAP1 binding TAP2 binding nucleotide binding oligopeptide-transporting ATPase activity peptide antigen binding peptide-transporting ATPase activity protein homodimerization activity substrate-specific transmembrane transporter activity tapasin binding less... CYP26A1 2 BP    MF    CC biological_process anterior/posterior pattern specification central nervous system development metabolic process negative regulation of retinoic acid receptor signaling pathway more... neural crest cell development retinoic acid catabolic process retinoic acid metabolic process retinoic acid receptor signaling pathway xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function electron carrier activity heme binding metal ion binding monooxygenase activity more... oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxygen binding retinoic acid 4-hydroxylase activity retinoic acid binding less... CTNNA2 2 BP    MF    CC biological_process axonogenesis brain morphogenesis cell adhesion cell-cell adhesion more... dendrite morphogenesis multicellular organismal development muscle cell differentiation positive regulation of muscle cell differentiation prepulse inhibition radial glia guided migration of Purkinje cell regulation of synapse structural plasticity less... cellular_component actin cytoskeleton adherens junction axon basolateral plasma membrane more... cell junction cell-cell adherens junction cytoplasm cytosol lamellipodium plasma membrane less... molecular_function cadherin binding protein binding structural constituent of cytoskeleton structural molecule activity more... WFDC2 2 BP    MF    CC biological_process negative regulation of endopeptidase activity proteolysis spermatogenesis cellular_component extracellular region extracellular space molecular_function endopeptidase inhibitor activity peptidase inhibitor activity serine-type endopeptidase inhibitor activity FAM155B 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function ATP6V0E2 2 BP    MF    CC biological_process ATP hydrolysis coupled proton transport cell growth cellular iron ion homeostasis insulin receptor signaling pathway more... ion transport transferrin transport transmembrane transport vacuolar acidification less... cellular_component endosome membrane integral to membrane membrane proton-transporting V-type ATPase, V0 domain more... vacuole less... molecular_function ATPase activity, coupled to transmembrane movement of ions hydrogen ion transmembrane transporter activity hydrolase activity KRT23 2 BP    MF    CC biological_process cellular_component intermediate filament molecular_function structural molecule activity BIRC3 2 BP    MF    CC biological_process anti-apoptosis cell surface receptor linked signaling pathway protein ubiquitination regulation of apoptosis more... cellular_component cytoplasm intracellular nucleus molecular_function metal ion binding protein binding ubiquitin-protein ligase activity zinc ion binding more... CAPN6 2 BP    MF    CC biological_process microtubule bundle formation proteolysis regulation of cytoskeleton organization cellular_component cytoplasm cytoskeleton intracellular microtubule more... perinuclear region of cytoplasm spindle microtubule less... molecular_function calcium-dependent cysteine-type endopeptidase activity microtubule binding MPZL2 2 BP    MF    CC biological_process anatomical structure morphogenesis cell adhesion homophilic cell adhesion cellular_component cytoskeleton integral to membrane membrane molecular_function PART1 2 BP    MF    CC biological_process cellular_component molecular_function CREB3L1 2 BP    MF    CC biological_process response to unfolded protein cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... nucleus less... molecular_function protein dimerization activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity RAMP2 2 BP    MF    CC biological_process intracellular protein transport protein transport receptor-mediated endocytosis regulation of G-protein coupled receptor protein signaling pathway more... cellular_component coated pit integral to membrane integral to plasma membrane lysosome more... plasma membrane less... molecular_function coreceptor activity protein transporter activity receptor activity FOLR1 2 BP    MF    CC biological_process cell death folic acid metabolic process folic acid transport receptor-mediated endocytosis more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane fraction more... plasma membrane less... molecular_function folic acid binding receptor activity ISG20 2 BP    MF    CC biological_process DNA catabolic process, exonucleolytic RNA catabolic process cell proliferation cytokine-mediated signaling pathway more... response to virus type I interferon-mediated signaling pathway less... cellular_component PML body intracellular nucleoplasm nucleus more... molecular_function 3'-5'-exoribonuclease activity RNA binding exonuclease activity exoribonuclease II activity more... hydrolase activity metal ion binding single-stranded DNA specific 3'-5' exodeoxyribonuclease activity less... SLC39A14 2 BP    MF    CC biological_process ion transport transmembrane transport zinc ion transmembrane transport cellular_component Golgi apparatus endoplasmic reticulum integral to membrane lamellipodium more... membrane plasma membrane less... molecular_function ferrous iron transmembrane transporter activity metal ion transmembrane transporter activity zinc ion transmembrane transporter activity DUOX1 2 BP    MF    CC biological_process cuticle development cytokine-mediated signaling pathway hormone biosynthetic process hydrogen peroxide biosynthetic process more... hydrogen peroxide catabolic process oxidation-reduction process response to cAMP response to oxidative stress superoxide anion generation less... cellular_component apical plasma membrane integral to membrane plasma membrane molecular_function NAD(P)H oxidase activity NADP binding calcium ion binding electron carrier activity more... flavin adenine dinucleotide binding heme binding oxidoreductase activity peroxidase activity less... OLFM4 2 BP    MF    CC biological_process cell adhesion cellular_component extracellular region extracellular space molecular_function DCXR 2 BP    MF    CC biological_process D-xylose metabolic process NADP metabolic process carbohydrate metabolic process glucose metabolic process more... protein homotetramerization xylulose metabolic process less... cellular_component brush border membrane microvillus molecular_function L-xylulose reductase (NADP+) activity binding oxidoreductase activity, acting on CH-OH group of donors FKBP5 2 BP    MF    CC biological_process peptidyl-proline modification protein folding protein peptidyl-prolyl isomerization cellular_component cytoplasm membrane nucleus molecular_function FK506 binding binding heat shock protein binding isomerase activity more... peptidyl-prolyl cis-trans isomerase activity less... COBL 2 BP    MF    CC biological_process neural tube closure cellular_component molecular_function ZNF589 2 BP    MF    CC biological_process regulation of transcription, DNA-dependent cellular_component intracellular nucleus molecular_function DNA binding metal ion binding nucleic acid binding zinc ion binding more... HEY1 2 BP    MF    CC biological_process Notch signaling pathway angiogenesis epithelial to mesenchymal transition involved in endocardial cushion formation multicellular organismal development more... negative regulation of Notch signaling pathway negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent regulation of transcription, DNA-dependent transcription, DNA-dependent less... cellular_component cytoplasm nucleus molecular_function DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity microsatellite binding protein binding more... protein binding transcription factor activity sequence-specific DNA binding transcription factor activity transcription factor binding less... DUSP2 2 BP    MF    CC biological_process endoderm formation inactivation of MAPK activity peptidyl-tyrosine dephosphorylation protein dephosphorylation more... regulation of apoptosis less... cellular_component nucleoplasm nucleus molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity mitogen-activated protein kinase binding protein tyrosine phosphatase activity more... protein tyrosine/threonine phosphatase activity less... LPAR2 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway activation of MAPK activity activation of phospholipase C activity elevation of cytosolic calcium ion concentration more... positive regulation of MAPKKK cascade positive regulation of Rho protein signal transduction less... cellular_component cell surface endocytic vesicle integral to plasma membrane plasma membrane more... molecular_function G-protein coupled receptor activity LIM domain binding PDZ domain binding lipid binding more... lysosphingolipid and lysophosphatidic acid receptor activity protein binding receptor activity signal transducer activity less... SULT1C2 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process amine metabolic process sulfation xenobiotic metabolic process more... cellular_component cytoplasm cytosol microtubule cytoskeleton molecular_function sulfotransferase activity transferase activity SORD 2 BP    MF    CC biological_process L-xylitol catabolic process L-xylitol metabolic process fructose biosynthetic process glucose metabolic process more... sorbitol catabolic process sperm motility less... cellular_component cilium extracellular space flagellum membrane more... membrane fraction mitochondrial membrane mitochondrion soluble fraction less... molecular_function L-iditol 2-dehydrogenase activity NAD binding binding metal ion binding more... oxidoreductase activity sugar binding zinc ion binding less... SERPINB9 2 BP    MF    CC biological_process anti-apoptosis cellular response to estrogen stimulus immune response mast cell mediated immunity more... negative regulation of caspase activity negative regulation of endopeptidase activity regulation of proteolysis less... cellular_component cytoplasm cytosol extracellular space nucleus more... molecular_function caspase inhibitor activity peptidase inhibitor activity protease binding protein binding more... serine-type endopeptidase inhibitor activity less... TPD52L1 2 BP    MF    CC biological_process DNA fragmentation involved in apoptotic nuclear change G2/M transition of mitotic cell cycle activation of caspase activity induction of apoptosis more... positive regulation of JNK cascade positive regulation of MAP kinase activity less... cellular_component cytoplasm perinuclear region of cytoplasm molecular_function caspase activator activity identical protein binding protein binding protein heterodimerization activity more... protein homodimerization activity less... ALDH3B2 2 BP    MF    CC biological_process alcohol metabolic process cellular aldehyde metabolic process lipid metabolic process cellular_component molecular_function 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity SLC7A4 2 BP    MF    CC biological_process basic amino acid transport cellular amino acid metabolic process transport cellular_component integral to membrane membrane molecular_function amino acid transmembrane transporter activity basic amino acid transmembrane transporter activity GOLSYN 2 BP    MF    CC biological_process cellular_component molecular_function LRRC1 2 BP    MF    CC biological_process cellular_component cytoplasm membrane molecular_function DFNB31 2 BP    MF    CC biological_process cellular_component molecular_function GP2 2 BP    MF    CC biological_process cellular_component anchored to membrane extracellular region plasma membrane molecular_function SLC15A2 2 BP    MF    CC biological_process drug transport ion transport oligopeptide transport protein transport more... transmembrane transport transport less... cellular_component integral to membrane integral to plasma membrane membrane plasma membrane more... molecular_function antibiotic transporter activity dipeptide transporter activity peptide:hydrogen symporter activity protein binding more... symporter activity transporter activity less... MOSC1 2 BP    MF    CC biological_process cellular_component mitochondrial inner membrane mitochondrion molecular_function molybdenum ion binding oxidoreductase activity pyridoxal phosphate binding BANK1 2 BP    MF    CC biological_process B cell activation cellular_component molecular_function MAP2K6 2 BP    MF    CC biological_process DNA damage induced protein phosphorylation MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway more... activation of MAPK activity activation of innate immune response cardiac muscle contraction cell cycle arrest innate immune response muscle cell differentiation nucleotide-binding oligomerization domain containing signaling pathway positive regulation of apoptosis positive regulation of muscle cell differentiation response to drug signal transduction stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytosol nucleoplasm molecular_function ATP binding MAP kinase kinase activity nucleotide binding protein kinase binding more... protein serine/threonine kinase activity protein tyrosine kinase activity less... PPM1H 2 BP    MF    CC biological_process cellular_component molecular_function hydrolase activity phosphoprotein phosphatase activity CBR3 2 BP    MF    CC biological_process phylloquinone catabolic process cellular_component cytoplasm cytosol nucleolus nucleus more... molecular_function 3-keto sterol reductase activity NADPH binding binding carbonyl reductase (NADPH) activity more... oxidoreductase activity less... HLA-DOB 2 BP    MF    CC biological_process T cell costimulation T cell receptor signaling pathway antigen processing and presentation of peptide or polysaccharide antigen via MHC class II cytokine-mediated signaling pathway more... immune response interferon-gamma-mediated signaling pathway less... cellular_component MHC class II protein complex endosome endosome membrane integral to membrane more... intracellular lysosomal membrane lysosome membrane plasma membrane less... molecular_function MHC class II receptor activity SLC43A1 2 BP    MF    CC biological_process amino acid transport cellular nitrogen compound metabolic process ion transport neutral amino acid transport more... transmembrane transport less... cellular_component integral to plasma membrane plasma membrane molecular_function L-amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity ABCG1 2 BP    MF    CC biological_process amyloid precursor protein catabolic process cholesterol efflux cholesterol homeostasis cholesterol metabolic process more... detection of hormone stimulus glycoprotein transport high-density lipoprotein particle remodeling intracellular cholesterol transport lipid metabolic process lipoprotein metabolic process low-density lipoprotein particle remodeling negative regulation of cholesterol storage negative regulation of macrophage derived foam cell differentiation phospholipid efflux phospholipid homeostasis phospholipid transport positive regulation of cholesterol biosynthetic process positive regulation of cholesterol efflux regulation of cholesterol esterification regulation of transcription, DNA-dependent response to high density lipoprotein particle stimulus response to lipid response to organic substance reverse cholesterol transport transport less... cellular_component Golgi apparatus Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane more... endosome external side of plasma membrane integral to membrane integral to plasma membrane intracellular membrane plasma membrane recycling endosome less... molecular_function ADP binding ATP binding ATPase activity cholesterol binding more... cholesterol transporter activity glycoprotein transporter activity nucleotide binding phospholipid binding phospholipid transporter activity protein dimerization activity protein heterodimerization activity protein homodimerization activity sterol-transporting ATPase activity toxin transporter activity less...
Up-regulated Genes Score GPX3 4 DPP4 4 PAEP 4 TCN1 4 LCN2 2 LMOD1 2 F3 2 MMP7 2 IL6ST 2 AOX1 2 PSD 2 CTTN 2 C4BPA 2 TAGLN 2 LIF 2 IGFBP1 2 DNAJC6 2 CDA 2 CD36 2 MYH11 2 CYP3A5 2 VPS13D 2 ABCC3 2 CLU 2 PPARGC1A 2 ANKRD55 2 SLC15A1 2 ST6GAL1 2 DHRS3 2 SLC1A1 2 THBS1 2 ELF3 2 EFEMP1 2 RARRES1 2 C1orf106 2 EDNRB 2 ABLIM3 2 VNN1 2 NUDT4 2 PLS1 2 HABP2 2 CNN1 2 FXYD2 2 PDZK1IP1 2 AIMP1 2 SFN 2 DUSP6 2 CYP2C9 2 PAPSS2 2 KIAA1199 2 ABP1 2 ATP2C2 2 PTGER2 2 DARC 2 MUC16 2 CDH13 2 CATSPERB 2 TSPAN1 2 SNX10 2 COMP 2 SLC22A5 2 IGFBP3 2 FAP 2 MALL 2 KIAA0040 2 AQP3 2 G0S2 2 TRPC6 2 CXCL14 2 MAOA 2 TTC39A 2 THBD 2 SLC44A4 2 HAL 2 GAST 2 AGR2 2 LAMB3 2 TSPAN8 2 ANG 2 CXCL12 2 IMPA2 2 ADRA2A 2 MMP11 2 THBS2 2 TMOD1 2 PROM1 2 CXCR4 2 ACADSB 2 GADD45A 2 PAX8 2 BCL2A1 2 OTUB2 2 GRAMD1C 2	Down-regulated Genes Score SQLE 4 SCGB1D2 4 TRPM6 2 NDRG2 2 SEPT4 2 BARD1 2 SERHL2 2 HSD11B2 2 MPPED2 2 IFNGR1 2 TFPI2 2 HLA-DMB 2 SERPINA5 2 GSN 2 KHDRBS3 2 TNNC1 2 MMP26 2 CWH43 2 STXBP6 2 CYP2J2 2 NEDD9 2 MTL5 2 DYNC1I1 2 PROL1 2 ALPL 2 CXCL13 2 BCKDHB 2 HOMER2 2 ELP3 2 SORBS2 2 NFIB 2 PRKAG2 2 SCGB1D1 2 HGD 2 ADAMTS8 2 NR4A2 2 PDE9A 2 CSRP2 2 CRIP1 2 TFCP2L1 2 PLA2G4A 2 GAL 2 NQO1 2 PDK4 2 ANK3 2 UCK2 2 GMPR 2 ABCB9 2 CYP26A1 2 CTNNA2 2 WFDC2 2 FAM155B 2 ATP6V0E2 2 KRT23 2 BIRC3 2 CAPN6 2 MPZL2 2 PART1 2 CREB3L1 2 RAMP2 2 FOLR1 2 ISG20 2 SLC39A14 2 DUOX1 2 OLFM4 2 DCXR 2 FKBP5 2 COBL 2 ZNF589 2 HEY1 2 DUSP2 2 LPAR2 2 SULT1C2 2 SORD 2 SERPINB9 2 TPD52L1 2 ALDH3B2 2 SLC7A4 2 GOLSYN 2 LRRC1 2 DFNB31 2 GP2 2 SLC15A2 2 MOSC1 2 BANK1 2 MAP2K6 2 PPM1H 2 CBR3 2 HLA-DOB 2 SLC43A1 2 ABCG1 2
Identifiers Repository Data-sets 15695772 PubMed 4
Up-regulated(93) Down-regulated(91)