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Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Early (Pre-receptive) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
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Up-regulated Genes Score GO annotation CCNB2 8 BP    MF    CC biological_process G2/M transition of mitotic cell cycle T cell homeostasis cell cycle checkpoint cell division more... growth in utero embryonic development mitosis mitotic cell cycle regulation of G2/M transition of mitotic cell cycle regulation of cyclin-dependent protein kinase activity thymus development less... cellular_component centrosome cytosol membrane fraction microtubule cytoskeleton more... nucleus less... molecular_function protein kinase binding BUB1B 8 BP    MF    CC biological_process M phase of mitotic cell cycle anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process apoptosis cell cycle more... cell cycle checkpoint cell division cell proliferation mitosis mitotic cell cycle mitotic cell cycle checkpoint mitotic cell cycle spindle assembly checkpoint mitotic metaphase/anaphase transition mitotic prometaphase negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle phosphatidylinositol-mediated signaling protein localization to kinetochore protein phosphorylation regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle spindle organization less... cellular_component anaphase-promoting complex chromosome condensed chromosome kinetochore condensed chromosome outer kinetochore more... cytoplasm cytoskeleton cytosol kinetochore microtubule organizing center nucleus perinuclear region of cytoplasm spindle midzone less... molecular_function ATP binding nucleotide binding protein binding protein kinase activity more... protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups less... MSX1 6 BP    MF    CC biological_process apoptotic nuclear change cell morphogenesis embryonic nail plate morphogenesis face morphogenesis more... multicellular organismal development negative regulation of cell growth negative regulation of transcription from RNA polymerase II promoter odontogenesis of dentine-containing tooth positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of apoptosis protein localization to nucleus protein stabilization less... cellular_component nucleus molecular_function p53 binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity MMP26 4 BP    MF    CC biological_process collagen catabolic process proteolysis cellular_component extracellular region proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... PTTG1 4 BP    MF    CC biological_process DNA metabolic process DNA repair anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell division more... chromosome organization chromosome segregation mitosis mitotic cell cycle regulation of transcription, DNA-dependent spermatogenesis transcription from RNA polymerase II promoter less... cellular_component cytoplasm cytosol nucleus molecular_function SH3 domain binding cysteine-type endopeptidase inhibitor activity protein binding sequence-specific DNA binding transcription factor activity more... MPPED2 4 BP    MF    CC biological_process nervous system development cellular_component molecular_function hydrolase activity metal ion binding SCGB1D2 4 BP    MF    CC biological_process cellular_component extracellular region extracellular space molecular_function binding EDN3 4 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding ALPL 4 BP    MF    CC biological_process biomineral tissue development cellular response to organic cyclic compound cementum mineralization response to antibiotic more... response to glucocorticoid stimulus response to lipopolysaccharide response to vitamin D skeletal system development less... cellular_component anchored to membrane cytoplasm extracellular space integral to membrane more... plasma membrane less... molecular_function alkaline phosphatase activity catalytic activity hydrolase activity metal ion binding more... SQLE 4 BP    MF    CC biological_process cellular aromatic compound metabolic process cholesterol biosynthetic process cholesterol metabolic process oxidation-reduction process more... response to organic substance sterol biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity squalene monooxygenase activity	Down-regulated Genes Score GO annotation SPP1 18 BP    MF    CC biological_process biomineral tissue development cell adhesion decidualization embryo implantation more... inflammatory response negative regulation of collateral sprouting of intact axon in response to injury ossification osteoblast differentiation positive regulation of bone resorption positive regulation of cell-substrate adhesion response to organic substance response to steroid hormone stimulus response to vitamin D less... cellular_component apical part of cell cell projection cytoplasm extracellular region more... extracellular space membrane-bounded vesicle perinuclear region of cytoplasm less... molecular_function cytokine activity extracellular matrix binding GPX3 14 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... PAEP 12 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity IGFBP7 12 BP    MF    CC biological_process cell adhesion negative regulation of cell proliferation regulation of cell growth cellular_component extracellular matrix extracellular region extracellular space molecular_function insulin-like growth factor binding protein binding IL15 12 BP    MF    CC biological_process NK T cell proliferation aging cell-cell signaling cellular response to vitamin D more... extrathymic T cell selection hyaluronan metabolic process immune response lymph node development negative regulation of smooth muscle cell proliferation positive regulation of T cell proliferation positive regulation of cell proliferation positive regulation of immune response positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of natural killer cell proliferation positive regulation of tissue remodeling positive regulation of tyrosine phosphorylation of Stat3 protein regulation of T cell differentiation regulation of defense response to virus by host response to nutrient levels signal transduction skeletal muscle atrophy less... cellular_component Golgi apparatus cytoplasm endosome extracellular region more... extracellular space integral to plasma membrane membrane fraction nucleus less... molecular_function cytokine activity cytokine receptor binding protein binding signal transducer activity more... CD55 10 BP    MF    CC biological_process complement activation, classical pathway elevation of cytosolic calcium ion concentration innate immune response respiratory burst more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane raft more... plasma membrane soluble fraction less... molecular_function receptor activity DPP4 8 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... CLDN4 6 BP    MF    CC biological_process calcium-independent cell-cell adhesion female pregnancy response to progesterone stimulus cellular_component apical plasma membrane apicolateral plasma membrane basal plasma membrane cell junction more... integral to membrane integral to plasma membrane lateral plasma membrane membrane plasma membrane tight junction less... molecular_function identical protein binding structural molecule activity transmembrane signaling receptor activity LAMB3 6 BP    MF    CC biological_process cell adhesion cell junction assembly epidermis development hemidesmosome assembly more... cellular_component basement membrane extracellular region molecular_function protein binding protein complex binding structural molecule activity COMP 6 BP    MF    CC biological_process anti-apoptosis apoptosis cell adhesion limb development more... organ morphogenesis skeletal system development less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding collagen binding extracellular matrix structural constituent heparan sulfate proteoglycan binding more... heparin binding protein binding less...
Up-regulated Genes Score GO annotation CCNB2 8 BP    MF    CC biological_process G2/M transition of mitotic cell cycle T cell homeostasis cell cycle checkpoint cell division more... growth in utero embryonic development mitosis mitotic cell cycle regulation of G2/M transition of mitotic cell cycle regulation of cyclin-dependent protein kinase activity thymus development less... cellular_component centrosome cytosol membrane fraction microtubule cytoskeleton more... nucleus less... molecular_function protein kinase binding BUB1B 8 BP    MF    CC biological_process M phase of mitotic cell cycle anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process apoptosis cell cycle more... cell cycle checkpoint cell division cell proliferation mitosis mitotic cell cycle mitotic cell cycle checkpoint mitotic cell cycle spindle assembly checkpoint mitotic metaphase/anaphase transition mitotic prometaphase negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle phosphatidylinositol-mediated signaling protein localization to kinetochore protein phosphorylation regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle spindle organization less... cellular_component anaphase-promoting complex chromosome condensed chromosome kinetochore condensed chromosome outer kinetochore more... cytoplasm cytoskeleton cytosol kinetochore microtubule organizing center nucleus perinuclear region of cytoplasm spindle midzone less... molecular_function ATP binding nucleotide binding protein binding protein kinase activity more... protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups less... MSX1 6 BP    MF    CC biological_process apoptotic nuclear change cell morphogenesis embryonic nail plate morphogenesis face morphogenesis more... multicellular organismal development negative regulation of cell growth negative regulation of transcription from RNA polymerase II promoter odontogenesis of dentine-containing tooth positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of apoptosis protein localization to nucleus protein stabilization less... cellular_component nucleus molecular_function p53 binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity MMP26 4 BP    MF    CC biological_process collagen catabolic process proteolysis cellular_component extracellular region proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... PTTG1 4 BP    MF    CC biological_process DNA metabolic process DNA repair anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell division more... chromosome organization chromosome segregation mitosis mitotic cell cycle regulation of transcription, DNA-dependent spermatogenesis transcription from RNA polymerase II promoter less... cellular_component cytoplasm cytosol nucleus molecular_function SH3 domain binding cysteine-type endopeptidase inhibitor activity protein binding sequence-specific DNA binding transcription factor activity more... MPPED2 4 BP    MF    CC biological_process nervous system development cellular_component molecular_function hydrolase activity metal ion binding SCGB1D2 4 BP    MF    CC biological_process cellular_component extracellular region extracellular space molecular_function binding EDN3 4 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding ALPL 4 BP    MF    CC biological_process biomineral tissue development cellular response to organic cyclic compound cementum mineralization response to antibiotic more... response to glucocorticoid stimulus response to lipopolysaccharide response to vitamin D skeletal system development less... cellular_component anchored to membrane cytoplasm extracellular space integral to membrane more... plasma membrane less... molecular_function alkaline phosphatase activity catalytic activity hydrolase activity metal ion binding more... SQLE 4 BP    MF    CC biological_process cellular aromatic compound metabolic process cholesterol biosynthetic process cholesterol metabolic process oxidation-reduction process more... response to organic substance sterol biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity squalene monooxygenase activity LRRC17 4 BP    MF    CC biological_process bone marrow development negative regulation of osteoclast differentiation osteoblast differentiation osteoblast proliferation more... cellular_component extracellular region extracellular space molecular_function OLFM1 4 BP    MF    CC biological_process multicellular organismal development nervous system development protein oligomerization cellular_component endoplasmic reticulum endoplasmic reticulum lumen extracellular space molecular_function protein binding E2F2 4 BP    MF    CC biological_process G1 phase of mitotic cell cycle apoptosis mitotic cell cycle regulation of cell cycle more... regulation of transcription, DNA-dependent transcription initiation from RNA polymerase II promoter transcription, DNA-dependent less... cellular_component nucleoplasm nucleus transcription factor complex molecular_function DNA binding protein binding sequence-specific DNA binding transcription factor activity transcription factor binding more... CSRP2 4 BP    MF    CC biological_process cell differentiation multicellular organismal development myoblast differentiation cellular_component nucleus molecular_function metal ion binding molecular_function zinc ion binding RASSF2 4 BP    MF    CC biological_process cell cycle signal transduction cellular_component nucleus molecular_function protein binding CDC2 4 BP    MF    CC biological_process cellular_component molecular_function CTNNA2 4 BP    MF    CC biological_process axonogenesis brain morphogenesis cell adhesion cell-cell adhesion more... dendrite morphogenesis multicellular organismal development muscle cell differentiation positive regulation of muscle cell differentiation prepulse inhibition radial glia guided migration of Purkinje cell regulation of synapse structural plasticity less... cellular_component actin cytoskeleton adherens junction axon basolateral plasma membrane more... cell junction cell-cell adherens junction cytoplasm cytosol lamellipodium plasma membrane less... molecular_function cadherin binding protein binding structural constituent of cytoskeleton structural molecule activity more... CDC20 4 BP    MF    CC biological_process M phase of mitotic cell cycle activation of anaphase-promoting complex activity anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell cycle more... cell cycle checkpoint cell differentiation cell division mitotic cell cycle mitotic cell cycle spindle assembly checkpoint mitotic prometaphase negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle nervous system development positive regulation of cell proliferation positive regulation of synapse maturation positive regulation of synaptic plasticity positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of dendrite development regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle less... cellular_component anaphase-promoting complex centrosome cytoplasm cytoskeleton more... cytosol nucleoplasm perinuclear region of cytoplasm protein complex spindle spindle pole less... molecular_function enzyme binding protein C-terminus binding protein binding CCNB1 4 BP    MF    CC biological_process G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell cycle checkpoint more... cell division cellular response to fatty acid cellular response to hypoxia cellular response to iron(III) ion cellular response to organic cyclic compound digestive tract development in utero embryonic development mitotic cell cycle mitotic cell cycle spindle checkpoint mitotic metaphase plate congression mitotic prometaphase mitotic spindle stabilization negative regulation of gene expression negative regulation of protein phosphorylation oocyte maturation positive regulation of attachment of spindle microtubules to kinetochore positive regulation of cardiac muscle cell proliferation positive regulation of histone phosphorylation positive regulation of mRNA 3'-end processing positive regulation of mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle protein complex assembly regulation of chromosome condensation regulation of cyclin-dependent protein kinase activity regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle response to DDT response to drug response to mechanical stimulus response to toxin spermatogenesis tissue regeneration ventricular cardiac muscle cell development less... cellular_component condensed nuclear chromosome outer kinetochore cytoplasm cytoskeleton cytosol more... membrane fraction microtubule organizing center nucleoplasm nucleus soluble fraction spindle pole less... molecular_function histone kinase activity kinase activity protein binding protein kinase binding more... EPHB3 4 BP    MF    CC biological_process angiogenesis axon guidance axonal fasciculation cell migration more... central nervous system projection neuron axonogenesis corpus callosum development dendritic spine development dendritic spine morphogenesis digestive tract morphogenesis ephrin receptor signaling pathway palate development positive regulation of synapse assembly protein autophosphorylation regulation of Cdc42 GTPase activity regulation of Rac GTPase activity regulation of axonogenesis regulation of cell-cell adhesion retinal ganglion cell axon guidance substrate adhesion-dependent cell spreading thymus development urogenital system development less... cellular_component integral to plasma membrane membrane molecular_function ATP binding axon guidance receptor activity ephrin receptor activity nucleotide binding more... receptor activity less... PRKCQ 4 BP    MF    CC biological_process T cell receptor signaling pathway aging apoptosis axon guidance more... blood coagulation cellular component disassembly involved in apoptosis intracellular signal transduction membrane protein ectodomain proteolysis neuron differentiation platelet activation positive regulation of NF-kappaB import into nucleus positive regulation of T cell proliferation positive regulation of filopodium assembly positive regulation of interleukin-2 biosynthetic process positive regulation of protein secretion positive regulation of stress fiber assembly protein phosphorylation regulation of G2/M transition of mitotic cell cycle regulation of cell growth regulation of vasoconstriction respiratory burst response to glucose stimulus response to heat response to hypoxia response to insulin stimulus response to organic cyclic compound tissue regeneration less... cellular_component cytoplasm cytosol immunological synapse intracellular more... membrane fraction neuromuscular junction nucleus plasma membrane sarcolemma soluble fraction less... molecular_function ATP binding metal ion binding nucleotide binding protein binding more... protein kinase C activity protein serine/threonine kinase activity less... SLC7A1 2 BP    MF    CC biological_process amino acid transport cellular nitrogen compound metabolic process ion transport regulation of TOR signaling cascade more... transmembrane transport transport less... cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function amino acid transmembrane transporter activity arginine transmembrane transporter activity receptor activity KIAA0802 2 BP    MF    CC biological_process cellular_component molecular_function TRH 2 BP    MF    CC biological_process adult walking behavior cell-cell signaling eating behavior hormone-mediated signaling pathway more... negative regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion positive regulation of insulin secretion response to cold response to corticosterone stimulus response to ethanol response to glucose stimulus response to hypoxia response to organic cyclic compound signal transduction less... cellular_component cytoplasm extracellular region nucleus plasma membrane more... soluble fraction stored secretory granule less... molecular_function neuropeptide hormone activity thyrotropin-releasing hormone activity S100A5 2 BP    MF    CC biological_process cellular_component nucleus molecular_function calcium ion binding copper ion binding protein homodimerization activity zinc ion binding more... ANK3 2 BP    MF    CC biological_process establishment of protein localization signal transduction cellular_component basolateral plasma membrane cytoplasm cytoskeleton molecular_function protein binding ATP6V0E2 2 BP    MF    CC biological_process ATP hydrolysis coupled proton transport cell growth cellular iron ion homeostasis insulin receptor signaling pathway more... ion transport transferrin transport transmembrane transport vacuolar acidification less... cellular_component endosome membrane integral to membrane membrane proton-transporting V-type ATPase, V0 domain more... vacuole less... molecular_function ATPase activity, coupled to transmembrane movement of ions hydrogen ion transmembrane transporter activity hydrolase activity S100Z 2 BP    MF    CC biological_process cellular_component molecular_function calcium ion binding E2F3 2 BP    MF    CC biological_process G1 phase of mitotic cell cycle G2 phase of mitotic cell cycle mitotic cell cycle positive regulation of cell proliferation more... positive regulation of transcription, DNA-dependent regulation of transcription, DNA-dependent transcription initiation from RNA polymerase II promoter less... cellular_component nucleoplasm nucleus transcription factor complex molecular_function DNA binding cyclin-dependent protein kinase activity protein binding sequence-specific DNA binding transcription factor activity more... CDC45L 2 BP    MF    CC biological_process cellular_component molecular_function SLC26A4 2 BP    MF    CC biological_process chloride transport inorganic anion transport iodide transport ion transport more... regulation of pH regulation of protein localization sensory perception of sound sulfate transport transmembrane transport less... cellular_component apical plasma membrane integral to membrane membrane plasma membrane more... molecular_function chloride transmembrane transporter activity iodide transmembrane transporter activity secondary active sulfate transmembrane transporter activity sulfate transmembrane transporter activity more... transporter activity less... ITGB8 2 BP    MF    CC biological_process cell adhesion cell-matrix adhesion ganglioside metabolic process integrin-mediated signaling pathway more... multicellular organismal development placenta blood vessel development less... cellular_component integral to membrane integrin complex membrane plasma membrane more... molecular_function binding receptor activity PIP5K1B 2 BP    MF    CC biological_process phosphorylation cellular_component endomembrane system membrane uropod molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity ATP binding kinase activity nucleotide binding more... protein binding transferase activity less... NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding FANCI 2 BP    MF    CC biological_process DNA repair cell cycle cellular_component nucleoplasm nucleus molecular_function protein binding MCM4 2 BP    MF    CC biological_process DNA replication DNA strand elongation involved in DNA replication DNA unwinding involved in replication DNA-dependent DNA replication initiation more... G1/S transition of mitotic cell cycle M/G1 transition of mitotic cell cycle S phase of mitotic cell cycle cell cycle checkpoint mitotic cell cycle less... cellular_component MCM complex nucleolus nucleoplasm nucleus more... molecular_function ATP binding ATP-dependent DNA helicase activity DNA binding DNA helicase activity more... helicase activity hydrolase activity nucleoside-triphosphatase activity nucleotide binding protein binding single-stranded DNA binding less... BTG3 2 BP    MF    CC biological_process negative regulation of cell proliferation negative regulation of mitotic cell cycle response to oxidative stress cellular_component cytoplasm molecular_function ECM1 2 BP    MF    CC biological_process biomineral tissue development negative regulation of bone mineralization negative regulation of peptidase activity ossification more... positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of angiogenesis positive regulation of endothelial cell proliferation signal transduction less... cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function enzyme binding laminin binding protease binding protein C-terminus binding more... protein binding signal transducer activity less... TACC3 2 BP    MF    CC biological_process astral microtubule organization cell proliferation cerebral cortex development cytoplasmic sequestering of transcription factor more... hemopoiesis interkinetic nuclear migration microtubule cytoskeleton organization neurogenesis regulation of cell cycle regulation of microtubule-based process response to stress less... cellular_component centrosome cytoplasm molecular_function protein domain specific binding CDC6 2 BP    MF    CC biological_process DNA replication DNA replication checkpoint G1/S transition of mitotic cell cycle M/G1 transition of mitotic cell cycle more... S phase of mitotic cell cycle cell cycle checkpoint cell division mitosis mitotic cell cycle negative regulation of DNA replication negative regulation of cell proliferation positive regulation of cell cycle cytokinesis positive regulation of chromosome segregation regulation of cyclin-dependent protein kinase activity regulation of mitotic anaphase regulation of transcription involved in G1/S phase of mitotic cell cycle traversing start control point of mitotic cell cycle less... cellular_component cytoplasm cytosol nucleoplasm nucleus more... spindle midzone spindle pole less... molecular_function ATP binding chromatin binding kinase binding nucleoside-triphosphatase activity more... nucleotide binding protein binding less... HPRT1 2 BP    MF    CC biological_process GMP catabolic process GMP salvage IMP metabolic process IMP salvage more... adenine metabolic process adenine salvage behavior central nervous system neuron development cerebral cortex neuron differentiation cytolysis dendrite morphogenesis glucose 1-phosphate metabolic process grooming behavior guanine salvage hypoxanthine metabolic process hypoxanthine salvage lymphocyte proliferation nucleobase-containing small molecule metabolic process nucleoside metabolic process positive regulation of dopamine metabolic process protein homotetramerization purine base metabolic process purine nucleotide biosynthetic process purine ribonucleoside salvage purine-containing compound salvage response to amphetamine spermatogenesis striatum development less... cellular_component cytoplasm cytosol soluble fraction molecular_function guanine phosphoribosyltransferase activity hypoxanthine phosphoribosyltransferase activity magnesium ion binding nucleotide binding more... phosphoglucomutase activity protein binding protein homodimerization activity transferase activity, transferring glycosyl groups less... ANO1 2 BP    MF    CC biological_process chloride transport ion transport multicellular organismal development trachea development more... cellular_component chloride channel complex cytoplasm integral to membrane plasma membrane more... molecular_function intracellular calcium activated chloride channel activity ion channel activity ATR 2 BP    MF    CC biological_process DNA damage checkpoint DNA repair DNA replication cell cycle more... cell cycle checkpoint cellular response to UV cellular response to gamma radiation multicellular organismal development negative regulation of DNA replication peptidyl-serine phosphorylation positive regulation of DNA damage response, signal transduction by p53 class mediator protein autophosphorylation protein phosphorylation regulation of protein binding replicative senescence response to DNA damage stimulus less... cellular_component PML body XY body nucleoplasm nucleus more... molecular_function ATP binding DNA binding MutLalpha complex binding MutSalpha complex binding more... nucleotide binding protein binding protein kinase activity protein serine/threonine kinase activity less... PAQR4 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function receptor activity OLFM4 2 BP    MF    CC biological_process cell adhesion cellular_component extracellular region extracellular space molecular_function GREM2 2 BP    MF    CC biological_process BMP signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity SOX17 2 BP    MF    CC biological_process angiogenesis cardiac cell fate determination cardiogenic plate morphogenesis embryonic foregut morphogenesis more... embryonic heart tube development embryonic heart tube morphogenesis endocardial cell differentiation endocardium formation endoderm formation endodermal digestive tract morphogenesis heart formation heart looping negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell growth negative regulation of mesodermal cell fate specification negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis positive regulation of cell differentiation positive regulation of protein catabolic process positive regulation of skeletal muscle tissue development positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent protein destabilization protein stabilization regulation of embryonic development regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification regulation of transcription, DNA-dependent renal system development signal transduction involved in regulation of gene expression spermatogenesis vasculogenesis less... cellular_component nucleus transcription factor complex molecular_function beta-catenin binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity sequence-specific distal enhancer binding RNA polymerase II transcription factor activity more... transcription coactivator activity transcription factor binding transcription regulatory region DNA binding less... S100A10 2 BP    MF    CC biological_process cellular response to acid positive regulation of binding signal transduction cellular_component extrinsic to plasma membrane molecular_function calcium ion binding receptor binding PENK 2 BP    MF    CC biological_process behavior behavioral fear response neuropeptide signaling pathway sensory perception of pain more... signal transduction less... cellular_component extracellular region molecular_function neuropeptide hormone activity opioid peptide activity S100A2 2 BP    MF    CC biological_process endothelial cell migration cellular_component cellular_component molecular_function calcium ion binding SPAG5 2 BP    MF    CC biological_process cell cycle cell division mitosis phosphatidylinositol-mediated signaling more... spindle organization less... cellular_component chromosome condensed chromosome kinetochore cytoplasm cytoskeleton more... spindle microtubule spindle pole less... molecular_function protein binding MFAP2 2 BP    MF    CC biological_process platelet formation cellular_component extracellular region microfibril proteinaceous extracellular matrix molecular_function fibrinogen binding fibronectin binding GPR64 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway neuropeptide signaling pathway spermatogenesis cellular_component apical plasma membrane cytoplasm integral to membrane integral to plasma membrane more... plasma membrane less... molecular_function G-protein coupled receptor activity receptor activity signal transducer activity KIF4A 2 BP    MF    CC biological_process anterograde axon cargo transport axon guidance blood coagulation microtubule-based movement more... organelle organization less... cellular_component chromosome cytoplasm cytoskeleton cytosol more... midbody nuclear matrix nucleus spindle microtubule less... molecular_function ATP binding DNA binding microtubule motor activity nucleotide binding more... DLGAP5 2 BP    MF    CC biological_process M phase of mitotic cell cycle cell cycle cell proliferation cell-cell signaling more... mitotic chromosome movement towards spindle pole positive regulation of mitotic metaphase/anaphase transition less... cellular_component cytoplasm cytoskeleton nucleus spindle more... spindle pole centrosome less... molecular_function phosphoprotein phosphatase activity protein binding CCNA2 2 BP    MF    CC biological_process G2/M transition of mitotic cell cycle Ras protein signal transduction cell division mitosis more... mitotic cell cycle mitotic cell cycle G2/M transition DNA damage checkpoint positive regulation of transcription, DNA-dependent regulation of cyclin-dependent protein kinase activity less... cellular_component cytoplasm female pronucleus male pronucleus nucleoplasm more... nucleus less... molecular_function protein binding protein kinase binding PKMYT1 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle mitosis mitotic cell cycle more... phosphorylation protein phosphorylation regulation of cell cycle regulation of cyclin-dependent protein kinase activity regulation of mitosis less... cellular_component Golgi apparatus Golgi membrane cytoplasm endoplasmic reticulum more... endoplasmic reticulum membrane membrane membrane fraction nucleoplasm nucleus less... molecular_function ATP binding kinase activity metal ion binding nucleotide binding more... protein binding protein kinase activity protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups less... ATP1B1 2 BP    MF    CC biological_process ATP biosynthetic process blood coagulation ion transmembrane transport leukocyte migration more... potassium ion transport response to hypoxia sodium ion transport transmembrane transport transport less... cellular_component apical plasma membrane basolateral plasma membrane caveola integral to membrane more... membrane plasma membrane sodium:potassium-exchanging ATPase complex less... molecular_function protein binding sodium:potassium-exchanging ATPase activity MSX2 2 BP    MF    CC biological_process BMP signaling pathway involved in heart development anagen anterior/posterior pattern specification bone morphogenesis more... bone trabecula formation branching involved in mammary gland duct morphogenesis cartilage development cellular response to estradiol stimulus cellular response to growth factor stimulus chondrocyte development cranial suture morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis enamel mineralization endochondral bone growth epithelial to mesenchymal transition involved in endocardial cushion formation frontal suture morphogenesis heart morphogenesis mammary gland epithelium development multicellular organismal development negative regulation of CREB transcription factor activity negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent odontogenesis osteoblast development osteoblast differentiation positive regulation of BMP signaling pathway positive regulation of apoptosis positive regulation of catagen positive regulation of osteoblast differentiation signal transduction involved in regulation of gene expression stem cell differentiation wound healing wound healing, spreading of epidermal cells less... cellular_component cytoplasm nucleus transcription factor complex molecular_function protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding more... transcription regulatory region DNA binding less... HPGD 2 BP    MF    CC biological_process ductus arteriosus closure fatty acid metabolic process female pregnancy lipid metabolic process more... lipoxygenase pathway negative regulation of cell cycle ovulation parturition prostaglandin metabolic process thrombin receptor signaling pathway transforming growth factor beta receptor signaling pathway less... cellular_component cytoplasm cytosol nucleolus nucleus more... molecular_function 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAD binding NAD+ binding binding more... catalytic activity oxidoreductase activity prostaglandin E receptor activity protein homodimerization activity less... KIF11 2 BP    MF    CC biological_process blood coagulation cell cycle cell division microtubule-based movement more... mitosis mitotic centrosome separation mitotic spindle organization spindle assembly involved in mitosis spindle organization less... cellular_component chromatin remodeling complex cytoplasm cytoskeleton cytosol more... kinesin complex spindle spindle microtubule spindle pole less... molecular_function ATP binding microtubule motor activity nucleotide binding protein kinase binding more... EFNA2 2 BP    MF    CC biological_process axon guidance bone remodeling cell-cell signaling ephrin receptor signaling pathway more... olfactory bulb development osteoclast differentiation less... cellular_component anchored to membrane neuromuscular junction perikaryon plasma membrane more... molecular_function ephrin receptor binding CENPA 2 BP    MF    CC biological_process CenH3-containing nucleosome assembly at centromere M phase of mitotic cell cycle establishment of mitotic spindle orientation interspecies interaction between organisms more... kinetochore assembly mitotic cell cycle mitotic prometaphase nucleosome assembly protein localization to chromosome, centromeric region less... cellular_component chromosome chromosome, centromeric region condensed chromosome inner kinetochore condensed nuclear chromosome kinetochore more... condensed nuclear chromosome, centromeric region cytosol nucleoplasm nucleosome nucleus less... molecular_function DNA binding chromatin binding protein binding HERPUD1 2 BP    MF    CC biological_process cellular calcium ion homeostasis endoplasmic reticulum unfolded protein response negative regulation of caspase activity response to stress more... response to unfolded protein less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function molecular_function S100A7 2 BP    MF    CC biological_process angiogenesis defense response to Gram-negative bacterium epidermis development innate immune response more... keratinocyte differentiation positive regulation of ERK1 and ERK2 cascade positive regulation of T cell chemotaxis positive regulation of granulocyte chemotaxis positive regulation of monocyte chemotaxis response to lipopolysaccharide response to reactive oxygen species sequestering of metal ion less... cellular_component cytoplasm cytosol endoplasmic reticulum extracellular region more... focal adhesion nucleus less... molecular_function RAGE receptor binding calcium ion binding protein binding zinc ion binding more... POSTN 2 BP    MF    CC biological_process cell adhesion extracellular matrix organization regulation of Notch signaling pathway skeletal system development more... tissue development less... cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function heparin binding COL16A1 2 BP    MF    CC biological_process cell adhesion cellular response to amino acid stimulus female pregnancy integrin-mediated signaling pathway more... cellular_component collagen collagen type XVI extracellular region molecular_function integrin binding protein binding structural molecule activity CCNE2 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle cell cycle checkpoint cell division mitotic cell cycle more... regulation of cyclin-dependent protein kinase activity less... cellular_component cytosol nucleoplasm nucleus molecular_function protein binding protein kinase binding ATAD4 2 BP    MF    CC biological_process cellular_component molecular_function SORD 2 BP    MF    CC biological_process L-xylitol catabolic process L-xylitol metabolic process fructose biosynthetic process glucose metabolic process more... sorbitol catabolic process sperm motility less... cellular_component cilium extracellular space flagellum membrane more... membrane fraction mitochondrial membrane mitochondrion soluble fraction less... molecular_function L-iditol 2-dehydrogenase activity NAD binding binding metal ion binding more... oxidoreductase activity sugar binding zinc ion binding less... TOP2A 2 BP    MF    CC biological_process DNA ligation DNA repair DNA replication DNA topological change more... DNA-dependent DNA replication aging apoptotic chromosome condensation chromosome segregation mitotic cell cycle G2/M transition decatenation checkpoint mitotic recombination phosphatidylinositol-mediated signaling positive regulation of apoptosis positive regulation of retroviral genome replication positive regulation of viral genome replication regulation of transcription, DNA-dependent resolution of meiotic recombination intermediates response to DNA damage stimulus response to drug response to parathyroid hormone stimulus sister chromatid segregation less... cellular_component DNA topoisomerase complex (ATP-hydrolyzing) centriole chromosome cytoplasm more... nuclear chromosome nucleolus nucleoplasm nucleus protein complex synaptonemal complex viral integration complex less... molecular_function ATP binding DNA binding DNA topoisomerase (ATP-hydrolyzing) activity DNA-dependent ATPase activity more... chromatin binding drug binding enzyme binding histone deacetylase binding nucleotide binding protein C-terminus binding protein binding protein heterodimerization activity protein homodimerization activity protein kinase C binding sequence-specific DNA binding structure-specific DNA binding ubiquitin binding less... BMP7 2 BP    MF    CC biological_process BMP signaling pathway SMAD protein signal transduction anatomical structure formation involved in morphogenesis axon guidance more... branching involved in salivary gland morphogenesis branching morphogenesis of a tube cartilage development cell development cellular response to hypoxia embryonic camera-type eye morphogenesis embryonic limb morphogenesis embryonic pattern specification embryonic skeletal joint morphogenesis epithelial cell differentiation epithelial to mesenchymal transition eye development growth mesenchymal cell differentiation mesenchyme development mesoderm formation mesonephros development metanephric mesenchymal cell proliferation involved in metanephros development metanephric mesenchyme morphogenesis metanephros development negative regulation of MAP kinase activity negative regulation of NF-kappaB import into nucleus negative regulation of NF-kappaB transcription factor activity negative regulation of Notch signaling pathway negative regulation of cell cycle negative regulation of cell death negative regulation of glomerular mesangial cell proliferation negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis negative regulation of mitosis negative regulation of neurogenesis negative regulation of neuron differentiation negative regulation of phosphorylation negative regulation of prostatic bud formation negative regulation of striated muscle cell apoptosis negative regulation of transcription, DNA-dependent nephrogenic mesenchyme morphogenesis neuron projection morphogenesis odontogenesis of dentine-containing tooth organ morphogenesis ossification pathway-restricted SMAD protein phosphorylation positive regulation of apoptosis positive regulation of bone mineralization positive regulation of cell death positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of transcription, DNA-dependent protein localization to nucleus regulation of branching involved in prostate gland morphogenesis regulation of removal of superoxide radicals skeletal system development steroid hormone mediated signaling pathway ureteric bud development less... cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity protein binding IL9R 2 BP    MF    CC biological_process cell proliferation signal transduction cellular_component extracellular region extracellular space integral to plasma membrane membrane more... plasma membrane less... molecular_function cytokine receptor activity interleukin-9 receptor activity receptor activity IL15RA 2 BP    MF    CC biological_process cell proliferation cytokine-mediated signaling pathway positive regulation of natural killer cell differentiation signal transduction more... cellular_component Golgi apparatus Golgi membrane cytoplasmic vesicle cytoplasmic vesicle membrane more... endoplasmic reticulum endoplasmic reticulum membrane extracellular region extracellular space integral to membrane membrane nuclear membrane nucleus less... molecular_function cytokine receptor activity protein binding receptor activity signal transducer activity more... NRG2 2 BP    MF    CC biological_process embryo development signal transduction cellular_component extracellular region integral to membrane plasma membrane molecular_function ErbB-3 class receptor binding epidermal growth factor receptor binding epidermal growth factor-activated receptor activity growth factor activity more... receptor binding less... BARD1 2 BP    MF    CC biological_process DNA repair cell cycle arrest negative regulation of apoptosis negative regulation of mRNA 3'-end processing more... negative regulation of protein export from nucleus positive regulation of apoptosis positive regulation of protein catabolic process protein K6-linked ubiquitination protein ubiquitination regulation of phosphorylation response to DNA damage stimulus spermatogenesis tissue homeostasis less... cellular_component BRCA1-A complex BRCA1-BARD1 complex cytoplasm intracellular more... nucleus ubiquitin ligase complex less... molecular_function RNA binding kinase binding ligase activity metal ion binding more... protein binding protein heterodimerization activity protein homodimerization activity ubiquitin-protein ligase activity zinc ion binding less... HEY2 2 BP    MF    CC biological_process Notch signaling pathway cardiac ventricle morphogenesis cochlea development negative regulation of Notch signaling pathway more... negative regulation of gene expression negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent pattern specification process positive regulation of cardiac muscle cell proliferation regulation of transcription, DNA-dependent smooth muscle cell differentiation transcription, DNA-dependent vascular smooth muscle cell development vasculogenesis ventricular cardiac muscle cell development less... cellular_component Sin3 complex cytoplasm nucleus transcriptional repressor complex more... molecular_function DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity histone deacetylase binding more... microsatellite binding protein binding protein binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding less... RABGAP1L 2 BP    MF    CC biological_process positive regulation of Rab GTPase activity regulation of protein localization cellular_component Golgi apparatus early endosome intracellular nucleus more... molecular_function GTPase activator activity Rab GTPase activator activity Rab GTPase binding GJB2 2 BP    MF    CC biological_process cell-cell signaling cellular membrane organization gap junction assembly male genitalia development more... sensory perception of sound transport less... cellular_component cell junction connexon complex endoplasmic reticulum-Golgi intermediate compartment integral to membrane more... lateral plasma membrane plasma membrane less... molecular_function SERPINA5 2 BP    MF    CC biological_process fusion of sperm to egg plasma membrane negative regulation of endopeptidase activity negative regulation of proteolysis regulation of proteolysis more... spermatogenesis less... cellular_component extracellular region membrane protein complex molecular_function acrosin binding glycosaminoglycan binding heparin binding peptidase inhibitor activity more... protease binding serine-type endopeptidase inhibitor activity less... FAM169A 2 BP    MF    CC biological_process cellular_component molecular_function GJB6 2 BP    MF    CC biological_process cell communication ear morphogenesis sensory perception of sound cellular_component cell junction connexon complex integral to membrane intracellular membrane-bounded organelle more... plasma membrane less... molecular_function KIF20A 2 BP    MF    CC biological_process M phase of mitotic cell cycle cytokinesis microtubule-based movement mitotic cell cycle more... protein transport vesicle-mediated transport less... cellular_component Golgi apparatus cytoplasm cytoskeleton microtubule more... nucleoplasm less... molecular_function ATP binding microtubule motor activity nucleotide binding transporter activity more... PLA1A 2 BP    MF    CC biological_process lipid catabolic process lipid metabolic process phosphatidylserine metabolic process cellular_component extracellular region molecular_function catalytic activity hydrolase activity phosphatidylcholine 1-acylhydrolase activity OFD1 2 BP    MF    CC biological_process G2/M transition of mitotic cell cycle cell projection organization centriole replication cilium axoneme assembly more... cilium morphogenesis epithelial cilium movement involved in determination of left/right asymmetry mitosis mitotic cell cycle spindle assembly involved in mitosis less... cellular_component centriole centrosome cilium cytoplasm more... cytoskeleton cytosol intracellular membrane-bounded organelle microtubule basal body nuclear membrane nucleus less... molecular_function alpha-tubulin binding gamma-tubulin binding protein binding TMSB15A 2 BP    MF    CC biological_process actin cytoskeleton organization sequestering of actin monomers cellular_component cytoplasm cytoskeleton molecular_function actin binding GALNT12 2 BP    MF    CC biological_process cellular_component Golgi apparatus Golgi membrane integral to membrane membrane more... molecular_function polypeptide N-acetylgalactosaminyltransferase activity sugar binding transferase activity, transferring glycosyl groups PKP2 2 BP    MF    CC biological_process cell-cell adhesion heart development cellular_component adherens junction cell-cell junction desmosome integral to membrane more... nucleus plasma membrane less... molecular_function binding molecular_function CCND1 2 BP    MF    CC biological_process G1 phase of mitotic cell cycle G1/S transition of mitotic cell cycle Leydig cell differentiation S phase of mitotic cell cycle more... canonical Wnt receptor signaling pathway cell division cellular response to organic substance endoplasmic reticulum unfolded protein response fat cell differentiation lactation liver development mammary gland alveolus development mitotic cell cycle mitotic cell cycle G1/S transition DNA damage checkpoint negative regulation of Wnt receptor signaling pathway negative regulation of epithelial cell differentiation organ regeneration positive regulation of cell proliferation positive regulation of cyclin-dependent protein kinase activity positive regulation of mammary gland epithelial cell proliferation positive regulation of protein phosphorylation re-entry into mitotic cell cycle regulation of cyclin-dependent protein kinase activity response to DNA damage stimulus response to UV-A response to X-ray response to calcium ion response to corticosterone stimulus response to drug response to estrogen stimulus response to ethanol response to iron ion response to magnesium ion response to organic cyclic compound response to organic nitrogen response to vitamin E less... cellular_component cyclin-dependent protein kinase holoenzyme complex cytoplasm cytosol intracellular more... membrane nucleoplasm nucleus less... molecular_function cyclin-dependent protein kinase regulator activity enzyme binding protein binding protein kinase activity more... protein kinase binding less... KMO 2 BP    MF    CC biological_process NAD metabolic process cellular nitrogen compound metabolic process kynurenine metabolic process pyridine nucleotide biosynthetic process more... response to salt stress tryptophan catabolic process tryptophan catabolic process to kynurenine less... cellular_component cytosol integral to membrane membrane mitochondrial inner membrane more... mitochondrial outer membrane mitochondrion less... molecular_function NAD(P)H oxidase activity electron carrier activity flavin adenine dinucleotide binding kynurenine 3-monooxygenase activity more... monooxygenase activity less... FAM155B 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function MCM3 2 BP    MF    CC biological_process DNA replication DNA strand elongation involved in DNA replication DNA-dependent DNA replication initiation G1/S transition of mitotic cell cycle more... M/G1 transition of mitotic cell cycle S phase of mitotic cell cycle cell cycle checkpoint mitotic cell cycle less... cellular_component MCM complex alpha DNA polymerase:primase complex centrosome cytoplasm more... intracellular membrane-bounded organelle nucleolus nucleoplasm nucleus perinuclear region of cytoplasm less... molecular_function ATP binding DNA binding helicase activity hydrolase activity more... nucleotide binding protein binding less... PECI 2 BP    MF    CC biological_process cellular_component molecular_function SFRP4 2 BP    MF    CC biological_process Wnt receptor signaling pathway axonogenesis brain development cell differentiation more... decidualization embryo development epithelium development gonad development mammary gland involution menstrual cycle phase multicellular organismal development negative regulation of JNK cascade negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of sodium-dependent phosphate transport phosphate ion homeostasis positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of epidermal cell differentiation positive regulation of gene expression positive regulation of receptor internalization response to estradiol stimulus response to glucocorticoid stimulus response to hormone stimulus response to peptide hormone stimulus vasculature development less... cellular_component cell surface cytoplasm extracellular region extracellular space more... neuron projection membrane nucleus less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding CENPE 2 BP    MF    CC biological_process M phase of mitotic cell cycle blood coagulation cell division kinetochore assembly more... microtubule-based movement mitotic cell cycle mitotic chromosome movement towards spindle pole mitotic metaphase mitotic metaphase plate congression mitotic prometaphase multicellular organismal development positive regulation of protein kinase activity less... cellular_component chromosome chromosome, centromeric region condensed chromosome outer kinetochore condensed chromosome, centromeric region more... cytoplasm cytoskeleton cytosol kinetochore microtubule nucleus spindle less... molecular_function ATP binding kinetochore binding microtubule motor activity nucleotide binding more... protein binding less... HLA-DOB 2 BP    MF    CC biological_process T cell costimulation T cell receptor signaling pathway antigen processing and presentation of peptide or polysaccharide antigen via MHC class II cytokine-mediated signaling pathway more... immune response interferon-gamma-mediated signaling pathway less... cellular_component MHC class II protein complex endosome endosome membrane integral to membrane more... intracellular lysosomal membrane lysosome membrane plasma membrane less... molecular_function MHC class II receptor activity NDC80 2 BP    MF    CC biological_process M phase of mitotic cell cycle attachment of spindle microtubules to kinetochore cell cycle cell division more... chromosome segregation establishment of mitotic spindle orientation mitosis mitotic cell cycle mitotic prometaphase mitotic sister chromatid segregation mitotic spindle organization phosphatidylinositol-mediated signaling spindle organization less... cellular_component Ndc80 complex chromosome chromosome, centromeric region condensed chromosome kinetochore more... condensed nuclear chromosome outer kinetochore cytosol kinetochore nucleus less... molecular_function protein binding PCNA 2 BP    MF    CC biological_process DNA repair DNA replication DNA strand elongation involved in DNA replication G1/S transition of mitotic cell cycle more... S phase of mitotic cell cycle base-excision repair base-excision repair, gap-filling cell proliferation heart development intracellular protein transport mismatch repair mitotic cell cycle nucleotide-excision repair nucleotide-excision repair, DNA gap filling phosphatidylinositol-mediated signaling positive regulation of deoxyribonuclease activity regulation of DNA replication regulation of transcription involved in G1/S phase of mitotic cell cycle response to cadmium ion response to lipid telomere maintenance telomere maintenance via recombination telomere maintenance via semi-conservative replication transcription-coupled nucleotide-excision repair translesion synthesis less... cellular_component DNA replication factor C complex PCNA complex PCNA-p21 complex cyclin-dependent protein kinase holoenzyme complex more... cytoplasm microtubule cytoskeleton nuclear lamina nuclear replication fork nucleolus nucleoplasm nucleus less... molecular_function DNA binding DNA polymerase processivity factor activity MutLalpha complex binding dinucleotide insertion or deletion binding more... identical protein binding protein binding purine-specific mismatch base pair DNA N-glycosylase activity less... IDH1 2 BP    MF    CC biological_process 2-oxoglutarate metabolic process NADPH regeneration carbohydrate metabolic process cellular lipid metabolic process more... glutathione metabolic process glyoxylate cycle isocitrate metabolic process oxidation-reduction process response to oxidative stress tricarboxylic acid cycle less... cellular_component cytoplasm cytosol mitochondrion peroxisomal matrix more... peroxisome less... molecular_function NAD binding isocitrate dehydrogenase (NADP+) activity magnesium ion binding oxidoreductase activity more... oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein homodimerization activity less... PLCH1 2 BP    MF    CC biological_process intracellular signal transduction lipid catabolic process lipid metabolic process phosphatidylinositol-mediated signaling more... cellular_component cytoplasm cytosol membrane membrane fraction more... molecular_function calcium ion binding calcium-dependent phospholipase C activity hydrolase activity phosphatidylinositol phospholipase C activity more... signal transducer activity less...	Down-regulated Genes Score GO annotation SPP1 18 BP    MF    CC biological_process biomineral tissue development cell adhesion decidualization embryo implantation more... inflammatory response negative regulation of collateral sprouting of intact axon in response to injury ossification osteoblast differentiation positive regulation of bone resorption positive regulation of cell-substrate adhesion response to organic substance response to steroid hormone stimulus response to vitamin D less... cellular_component apical part of cell cell projection cytoplasm extracellular region more... extracellular space membrane-bounded vesicle perinuclear region of cytoplasm less... molecular_function cytokine activity extracellular matrix binding GPX3 14 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... PAEP 12 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity IGFBP7 12 BP    MF    CC biological_process cell adhesion negative regulation of cell proliferation regulation of cell growth cellular_component extracellular matrix extracellular region extracellular space molecular_function insulin-like growth factor binding protein binding IL15 12 BP    MF    CC biological_process NK T cell proliferation aging cell-cell signaling cellular response to vitamin D more... extrathymic T cell selection hyaluronan metabolic process immune response lymph node development negative regulation of smooth muscle cell proliferation positive regulation of T cell proliferation positive regulation of cell proliferation positive regulation of immune response positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of natural killer cell proliferation positive regulation of tissue remodeling positive regulation of tyrosine phosphorylation of Stat3 protein regulation of T cell differentiation regulation of defense response to virus by host response to nutrient levels signal transduction skeletal muscle atrophy less... cellular_component Golgi apparatus cytoplasm endosome extracellular region more... extracellular space integral to plasma membrane membrane fraction nucleus less... molecular_function cytokine activity cytokine receptor binding protein binding signal transducer activity more... CD55 10 BP    MF    CC biological_process complement activation, classical pathway elevation of cytosolic calcium ion concentration innate immune response respiratory burst more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane raft more... plasma membrane soluble fraction less... molecular_function receptor activity DPP4 8 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... CLDN4 6 BP    MF    CC biological_process calcium-independent cell-cell adhesion female pregnancy response to progesterone stimulus cellular_component apical plasma membrane apicolateral plasma membrane basal plasma membrane cell junction more... integral to membrane integral to plasma membrane lateral plasma membrane membrane plasma membrane tight junction less... molecular_function identical protein binding structural molecule activity transmembrane signaling receptor activity LAMB3 6 BP    MF    CC biological_process cell adhesion cell junction assembly epidermis development hemidesmosome assembly more... cellular_component basement membrane extracellular region molecular_function protein binding protein complex binding structural molecule activity COMP 6 BP    MF    CC biological_process anti-apoptosis apoptosis cell adhesion limb development more... organ morphogenesis skeletal system development less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding collagen binding extracellular matrix structural constituent heparan sulfate proteoglycan binding more... heparin binding protein binding less... MMP7 4 BP    MF    CC biological_process antibacterial peptide secretion collagen catabolic process defense response to Gram-negative bacterium defense response to Gram-positive bacterium more... metabolic process proteolysis regulation of cell proliferation response to drug less... cellular_component extracellular region extracellular space proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... C4BPA 4 BP    MF    CC biological_process binding of sperm to zona pellucida complement activation, classical pathway innate immune response cellular_component acrosomal matrix extracellular region molecular_function protein binding FXYD2 4 BP    MF    CC biological_process ion transmembrane transport ion transport potassium ion transport sodium ion transport more... transmembrane transport transport less... cellular_component integral to membrane membrane plasma membrane sodium:potassium-exchanging ATPase complex more... molecular_function ion channel activity sodium:potassium-exchanging ATPase activity transporter activity S100P 4 BP    MF    CC biological_process endothelial cell migration cellular_component cytoplasm nucleus molecular_function calcium ion binding calcium-dependent protein binding magnesium ion binding protein binding more... IL6ST 4 BP    MF    CC biological_process JAK-STAT cascade ciliary neurotrophic factor-mediated signaling pathway cytokine-mediated signaling pathway interleukin-27-mediated signaling pathway more... interleukin-6-mediated signaling pathway leukemia inhibitory factor signaling pathway negative regulation of interleukin-6-mediated signaling pathway positive regulation of T cell proliferation positive regulation of acute inflammatory response positive regulation of adaptive immune response positive regulation of anti-apoptosis positive regulation of cardiac muscle hypertrophy positive regulation of cell proliferation positive regulation of osteoblast differentiation positive regulation of smooth muscle cell migration positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation vascular endothelial growth factor production reduction of cytosolic calcium ion concentration response to cytokine stimulus response to nutrient triglyceride mobilization less... cellular_component ciliary neurotrophic factor receptor complex extracellular region extracellular space integral to membrane more... interleukin-6 receptor complex oncostatin-M receptor complex plasma membrane less... molecular_function ciliary neurotrophic factor receptor activity ciliary neurotrophic factor receptor binding growth factor binding interleukin-27 receptor activity more... interleukin-6 binding interleukin-6 receptor activity interleukin-6 receptor binding leukemia inhibitory factor receptor activity oncostatin-M receptor activity protein binding protein homodimerization activity receptor activity less... FAM148B 4 BP    MF    CC biological_process cellular_component molecular_function TIMP1 4 BP    MF    CC biological_process aging blood coagulation cell activation erythrocyte maturation more... negative regulation of apoptosis negative regulation of membrane protein ectodomain proteolysis platelet activation platelet degranulation positive regulation of cell proliferation response to cytokine stimulus response to peptide hormone stimulus wound healing less... cellular_component basement membrane extracellular region platelet alpha granule lumen molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... ANGPTL1 4 BP    MF    CC biological_process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cellular_component extracellular region extracellular space molecular_function receptor binding IGFBP3 4 BP    MF    CC biological_process negative regulation of cell proliferation negative regulation of protein phosphorylation negative regulation of signal transduction negative regulation of smooth muscle cell migration more... negative regulation of smooth muscle cell proliferation positive regulation of apoptosis positive regulation of myoblast differentiation protein phosphorylation regulation of cell growth less... cellular_component extracellular region extracellular space insulin-like growth factor binding protein complex nucleus more... molecular_function insulin-like growth factor I binding insulin-like growth factor binding metal ion binding protein binding more... protein tyrosine phosphatase activator activity less... MAOA 4 BP    MF    CC biological_process behavior catecholamine metabolic process cellular biogenic amine metabolic process dopamine catabolic process more... neurotransmitter biosynthetic process neurotransmitter catabolic process neurotransmitter secretion phenylethylamine metabolic process serotonin metabolic process synaptic transmission xenobiotic metabolic process less... cellular_component integral to membrane membrane mitochondrial outer membrane mitochondrion more... soluble fraction less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity primary amine oxidase activity serotonin binding more... DCN 4 BP    MF    CC biological_process aging kidney development organ morphogenesis peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan more... placenta development response to lipopolysaccharide response to mechanical stimulus skeletal muscle tissue development wound healing less... cellular_component collagen type VI extracellular matrix extracellular region extracellular space more... proteinaceous extracellular matrix less... molecular_function collagen binding extracellular matrix binding glycosaminoglycan binding protein N-terminus binding more... MFAP5 4 BP    MF    CC biological_process cellular_component extracellular region microfibril proteinaceous extracellular matrix molecular_function extracellular matrix structural constituent TCN1 4 BP    MF    CC biological_process cobalamin metabolic process cobalamin transport cobalt ion transport ion transport more... cellular_component extracellular region molecular_function cobalamin binding DARC 4 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway defense response inflammatory response cellular_component integral to membrane plasma membrane molecular_function C-C chemokine binding G-protein coupled receptor activity chemokine receptor activity receptor activity more... signal transducer activity transmembrane signaling receptor activity less... GADD45A 4 BP    MF    CC biological_process DNA repair G2/M transition of mitotic cell cycle apoptosis cell cycle arrest more... cellular response to ionizing radiation cellular response to mechanical stimulus centrosome cycle negative regulation of protein kinase activity positive regulation of reactive oxygen species metabolic process regulation of cyclin-dependent protein kinase activity signal transduction in response to DNA damage less... cellular_component nucleus molecular_function protein binding IGFBP1 4 BP    MF    CC biological_process insulin receptor signaling pathway positive regulation of cell growth regulation of cell growth signal transduction more... tissue regeneration less... cellular_component extracellular region extracellular space molecular_function insulin-like growth factor binding TIMP2 4 BP    MF    CC biological_process negative regulation of cell proliferation regulation of MAPKKK cascade regulation of cAMP metabolic process regulation of neuron differentiation more... cellular_component basement membrane cell surface extracellular region molecular_function enzyme activator activity enzyme inhibitor activity integrin binding metal ion binding more... metalloendopeptidase inhibitor activity less... TSPAN8 4 BP    MF    CC biological_process negative regulation of blood coagulation protein glycosylation signal transduction cellular_component integral to membrane lysosome membrane molecular_function signal transducer activity ABCC3 4 BP    MF    CC biological_process bile acid and bile salt transport bile acid metabolic process organic anion transport transmembrane transport more... transport less... cellular_component integral to plasma membrane membrane fraction plasma membrane molecular_function ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding more... organic anion transmembrane transporter activity transporter activity less... LMOD1 2 BP    MF    CC biological_process muscle contraction cellular_component cytoplasm cytoskeleton cytosol membrane fraction more... molecular_function tropomyosin binding CDA 2 BP    MF    CC biological_process cell surface receptor linked signaling pathway cellular response to external biotic stimulus cytidine deamination cytosine metabolic process more... negative regulation of cell growth negative regulation of nucleotide metabolic process nucleobase-containing small molecule metabolic process protein homotetramerization pyrimidine base metabolic process pyrimidine nucleoside salvage pyrimidine-containing compound salvage response to cycloheximide less... cellular_component cytosol extracellular region molecular_function cytidine deaminase activity hydrolase activity metal ion binding nucleoside binding more... protein homodimerization activity zinc ion binding less... LCP1 2 BP    MF    CC biological_process T cell activation involved in immune response actin filament bundle assembly organ regeneration regulation of intracellular protein transport more... cellular_component actin cytoskeleton actin filament cell junction cytoplasm more... cytosol phagocytic cup plasma membrane ruffle ruffle membrane less... molecular_function actin binding actin filament binding calcium ion binding identical protein binding more... AHNAK 2 BP    MF    CC biological_process nervous system development cellular_component nucleus molecular_function nucleic acid binding protein binding ANKRD55 2 BP    MF    CC biological_process cellular_component molecular_function TSPO 2 BP    MF    CC biological_process adrenal gland development aging anion transport apoptosis more... behavioral response to pain cell proliferation cellular hypotonic response cellular response to lipopolysaccharide cellular response to zinc ion contact inhibition glial cell migration heme biosynthetic process negative regulation of glial cell proliferation negative regulation of nitric oxide biosynthetic process negative regulation of tumor necrosis factor production peripheral nervous system axon regeneration positive regulation of apoptosis positive regulation of calcium ion transport positive regulation of glial cell proliferation positive regulation of mitochondrial depolarization positive regulation of necrotic cell death positive regulation of reactive oxygen species metabolic process protein targeting to mitochondrion regulation of cholesterol transport regulation of steroid biosynthetic process response to axon injury response to drug response to manganese ion response to progesterone stimulus response to stress response to testosterone stimulus response to vitamin B1 steroid metabolic process less... cellular_component integral to membrane membrane mitochondrial outer membrane mitochondrion more... molecular_function androgen binding benzodiazepine receptor activity cholesterol binding receptor activity more... TNFAIP2 2 BP    MF    CC biological_process angiogenesis cell differentiation multicellular organismal development cellular_component extracellular space molecular_function RARRES1 2 BP    MF    CC biological_process negative regulation of cell proliferation cellular_component integral to membrane membrane molecular_function ARID5B 2 BP    MF    CC biological_process adipose tissue development adrenal gland development cell development face morphogenesis more... fat cell differentiation fat pad development female gonad development fibroblast migration kidney development liver development male gonad development multicellular organism growth muscle organ morphogenesis negative regulation of transcription, DNA-dependent nitrogen compound metabolic process palate development platelet-derived growth factor receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity post-embryonic development skeletal system morphogenesis less... cellular_component intracellular nucleus molecular_function DNA binding protein binding transcription coactivator activity transcription regulatory region DNA binding more... IL1R1 2 BP    MF    CC biological_process cell surface receptor linked signaling pathway immune response innate immune response interleukin-1-mediated signaling pathway more... ovulation response to interleukin-1 response to nitric oxide signal transduction less... cellular_component cell surface integral to membrane integral to plasma membrane intrinsic to membrane more... membrane plasma membrane less... molecular_function interleukin-1 receptor activity interleukin-1, Type I, activating receptor activity platelet-derived growth factor receptor binding protease binding more... protein binding receptor activity signal transducer activity transmembrane signaling receptor activity less... MUC16 2 BP    MF    CC biological_process cell adhesion cellular_component extracellular region extracellular space extrinsic to membrane integral to membrane more... plasma membrane less... molecular_function protein binding SNX10 2 BP    MF    CC biological_process cell communication endosome organization protein transport cellular_component cytoplasm endosome extrinsic to endosome membrane membrane more... molecular_function 1-phosphatidylinositol binding lipid binding phosphatidylinositol binding G0S2 2 BP    MF    CC biological_process cell cycle cellular_component cellular_component molecular_function molecular_function TRPC6 2 BP    MF    CC biological_process axon guidance blood coagulation cation transport elevation of cytosolic calcium ion concentration more... ion transport platelet activation positive regulation of calcium ion transport via store-operated calcium channel activity positive regulation of ion transmembrane transporter activity transmembrane transport less... cellular_component integral to membrane membrane plasma membrane molecular_function calcium channel activity cation channel activity ion channel activity protein binding more... THBD 2 BP    MF    CC biological_process blood coagulation embryo development female pregnancy leukocyte migration more... negative regulation of blood coagulation negative regulation of fibrinolysis negative regulation of platelet activation response to X-ray response to cAMP response to lipopolysaccharide less... cellular_component cell surface extracellular space integral to membrane integral to plasma membrane more... membrane plasma membrane less... molecular_function binding calcium ion binding protein binding receptor activity more... transmembrane signaling receptor activity less... SLC44A4 2 BP    MF    CC biological_process transmembrane transport cellular_component integral to membrane membrane plasma membrane molecular_function NID1 2 BP    MF    CC biological_process cell adhesion cell-matrix adhesion glomerular basement membrane development positive regulation of cell-substrate adhesion more... cellular_component basal lamina cytoplasm extracellular matrix extracellular region more... molecular_function calcium ion binding collagen binding extracellular matrix binding laminin-1 binding more... PROM1 2 BP    MF    CC biological_process camera-type eye photoreceptor cell differentiation photoreceptor cell maintenance retina layer formation retina morphogenesis in camera-type eye more... cellular_component apical plasma membrane cell surface cilium integral to membrane more... integral to plasma membrane microvillus membrane photoreceptor outer segment photoreceptor outer segment membrane plasma membrane less... molecular_function beta-actinin binding cadherin binding protein binding MT1E 2 BP    MF    CC biological_process biological_process cellular_component cytoplasm molecular_function cadmium ion binding copper ion binding metal ion binding zinc ion binding more... TGM2 2 BP    MF    CC biological_process apoptotic cell clearance blood vessel remodeling branching involved in salivary gland morphogenesis elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger more... induction of apoptosis isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine peptide cross-linking positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of cell adhesion positive regulation of inflammatory response positive regulation of smooth muscle cell proliferation protein homooligomerization salivary gland cavitation less... cellular_component cytoplasm mitochondrion plasma membrane molecular_function GTP binding metal ion binding protein binding protein domain specific binding more... protein-glutamine gamma-glutamyltransferase activity transferase activity transferase activity, transferring acyl groups less... FOXO1 2 BP    MF    CC biological_process anti-apoptosis blood vessel development embryo development endocrine pancreas development more... fibroblast growth factor receptor signaling pathway insulin receptor signaling pathway negative regulation of stress-activated MAPK cascade nerve growth factor receptor signaling pathway organ development pattern specification process phosphatidylinositol-mediated signaling positive regulation of gluconeogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent regulation of cell proliferation regulation of sequence-specific DNA binding transcription factor activity response to DNA damage stimulus tissue development less... cellular_component cytoplasm cytosol nucleoplasm nucleus more... transcription factor complex less... molecular_function DNA bending activity double-stranded DNA binding protein binding protein kinase binding more... sequence-specific DNA binding sequence-specific distal enhancer binding RNA polymerase II transcription factor activity transcription factor binding less... FBLN1 2 BP    MF    CC biological_process embryo implantation extracellular matrix organization interspecies interaction between organisms cellular_component basement membrane extracellular matrix extracellular region extracellular space more... proteinaceous extracellular matrix soluble fraction less... molecular_function calcium ion binding extracellular matrix structural constituent peptidase activator activity UBE2L6 2 BP    MF    CC biological_process ISG15-protein conjugation innate immune response modification-dependent protein catabolic process negative regulation of type I interferon production more... protein modification process protein ubiquitination less... cellular_component cytosol molecular_function ATP binding ISG15 ligase activity acid-amino acid ligase activity ligase activity more... nucleotide binding protein binding ubiquitin-protein ligase activity less... ABLIM3 2 BP    MF    CC biological_process axon guidance cytoskeleton organization positive regulation of transcription from RNA polymerase II promoter cellular_component cytoplasm molecular_function actin binding metal ion binding zinc ion binding PDZK1IP1 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function AIMP1 2 BP    MF    CC biological_process angiogenesis apoptosis carbohydrate metabolic process cell adhesion more... cell-cell signaling chemotaxis gene expression glucose metabolic process inflammatory response leukocyte migration negative regulation of endothelial cell proliferation response to wounding signal transduction tRNA aminoacylation for protein translation less... cellular_component Golgi apparatus aminoacyl-tRNA synthetase multienzyme complex cytoplasm cytoplasmic vesicle more... cytosol endoplasmic reticulum extracellular region extracellular space nucleus transport vesicle less... molecular_function cell surface binding cytokine activity protein homodimerization activity tRNA binding more... CYP2C9 2 BP    MF    CC biological_process cellular amide metabolic process drug catabolic process drug metabolic process exogenous drug catabolic process more... monocarboxylic acid metabolic process monoterpenoid metabolic process oxidation-reduction process oxidative demethylation steroid metabolic process urea metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function (R)-limonene 6-monooxygenase activity (S)-limonene 6-monooxygenase activity (S)-limonene 7-monooxygenase activity caffeine oxidase activity more... drug binding electron carrier activity heme binding metal ion binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen steroid hydroxylase activity less... ABP1 2 BP    MF    CC biological_process amine metabolic process oxidation-reduction process cellular_component extracellular region extracellular space peroxisome molecular_function copper ion binding diamine oxidase activity heparin binding histamine oxidase activity more... metal ion binding methylputrescine oxidase activity oxidoreductase activity primary amine oxidase activity propane-1,3-diamine oxidase activity quinone binding less... CDH3 2 BP    MF    CC biological_process adherens junction organization cell adhesion cell junction assembly cell-cell junction organization more... homophilic cell adhesion response to stimulus visual perception less... cellular_component cell-cell adherens junction integral to membrane plasma membrane molecular_function calcium ion binding KIAA0040 2 BP    MF    CC biological_process cellular_component molecular_function AQP3 2 BP    MF    CC biological_process excretion glycerol transport odontogenesis positive regulation of immune system process more... regulation of keratinocyte differentiation renal water absorption response to calcium ion response to retinoic acid response to vitamin D transmembrane transport transport urea transport water transport less... cellular_component basolateral plasma membrane cell-cell junction cytoplasm integral to membrane more... membrane plasma membrane less... molecular_function glycerol channel activity transporter activity water channel activity HAL 2 BP    MF    CC biological_process biosynthetic process cellular nitrogen compound metabolic process histidine catabolic process cellular_component cytoplasm cytosol soluble fraction molecular_function ammonia-lyase activity catalytic activity histidine ammonia-lyase activity lyase activity more... AGR2 2 BP    MF    CC biological_process mucus secretion cellular_component endoplasmic reticulum extracellular region mitochondrion molecular_function alpha-dystroglycan binding protein binding GDF15 2 BP    MF    CC biological_process cell-cell signaling signal transduction transforming growth factor beta receptor signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity C9orf71 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function DKK1 2 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... TMOD1 2 BP    MF    CC biological_process muscle filament sliding myofibril assembly cellular_component cortical cytoskeleton cytoplasm cytoskeleton cytosol more... membrane myofibril nucleus signalosome less... molecular_function actin binding tropomyosin binding CXCR4 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway activation of MAPK activity apoptosis dendritic cell chemotaxis more... elevation of cytosolic calcium ion concentration entry into host cell inflammatory response initiation of viral infection interspecies interaction between organisms myelin maintenance positive regulation of oligodendrocyte differentiation regulation of chemotaxis response to hypoxia response to virus viral reproduction less... cellular_component cell leading edge cell surface cytoplasm cytoplasmic membrane-bounded vesicle more... cytoplasmic vesicle integral to membrane plasma membrane less... molecular_function C-X-C chemokine receptor activity G-protein coupled receptor activity actin binding coreceptor activity more... myosin light chain binding protein binding receptor activity signal transducer activity ubiquitin binding ubiquitin protein ligase binding less... IGF2 2 BP    MF    CC biological_process carbohydrate metabolic process exocrine pancreas development glucose metabolic process insulin receptor signaling pathway more... multicellular organismal development organ morphogenesis ossification osteoblast differentiation positive regulation of MAPKKK cascade positive regulation of activated T cell proliferation positive regulation of catalytic activity positive regulation of cell division positive regulation of cell proliferation positive regulation of glycogen (starch) synthase activity positive regulation of glycogen biosynthetic process positive regulation of insulin receptor signaling pathway positive regulation of mitosis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase B signaling cascade positive regulation of protein phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of receptor activity positive regulation of steroid hormone biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of gene expression by genetic imprinting regulation of transcription, DNA-dependent response to drug response to estradiol stimulus response to nicotine response to nutrient levels response to radiation skeletal system development striated muscle cell differentiation less... cellular_component extracellular region extracellular space molecular_function growth factor activity hormone activity insulin receptor binding insulin-like growth factor receptor binding more... protein binding protein serine/threonine kinase activator activity receptor activator activity less... SLPI 2 BP    MF    CC biological_process negative regulation of endopeptidase activity negative regulation of protein binding negative regulation of viral genome replication cellular_component extracellular matrix extracellular region molecular_function endopeptidase inhibitor activity enzyme binding protein binding serine-type endopeptidase inhibitor activity more... LIF 2 BP    MF    CC biological_process blood vessel remodeling decidualization embryo implantation immune response more... leukemia inhibitory factor signaling pathway lung alveolus development lung lobe morphogenesis lung vasculature development maternal process involved in female pregnancy multicellular organismal development muscle organ morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis negative regulation of cell proliferation negative regulation of hormone secretion negative regulation of meiosis neuron development organ regeneration positive regulation of MAPKKK cascade positive regulation of astrocyte differentiation positive regulation of cell proliferation positive regulation of corticotropin secretion positive regulation of macrophage differentiation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of neuron projection development positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation retina development in camera-type eye spongiotrophoblast differentiation stem cell maintenance transdifferentiation trophoblast giant cell differentiation less... cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity leukemia inhibitory factor receptor binding receptor binding more... APOD 2 BP    MF    CC biological_process lipid metabolic process lipid transport cellular_component extracellular region extracellular space intracellular molecular_function lipid binding lipid transporter activity protein binding transporter activity more... CYP3A5 2 BP    MF    CC biological_process alkaloid catabolic process drug catabolic process oxidation-reduction process oxidative demethylation more... steroid metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function aromatase activity electron carrier activity heme binding metal ion binding more... monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding less... RARRES3 2 BP    MF    CC biological_process lipid catabolic process negative regulation of cell proliferation cellular_component molecular_function hydrolase activity ST6GAL1 2 BP    MF    CC biological_process cellular protein metabolic process humoral immune response post-translational protein modification protein N-linked glycosylation via asparagine more... protein glycosylation protein modification process less... cellular_component Golgi apparatus Golgi cisterna membrane Golgi membrane extracellular region more... integral to Golgi membrane integral to membrane membrane less... molecular_function beta-galactoside alpha-2,6-sialyltransferase activity sialyltransferase activity THBS1 2 BP    MF    CC biological_process activation of MAPK activity anti-apoptosis blood coagulation cell adhesion more... cell cycle arrest cell migration cellular response to heat chronic inflammatory response engulfment of apoptotic cell immune response induction of apoptosis negative regulation of angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of apoptosis negative regulation of blood vessel endothelial cell migration negative regulation of cGMP-mediated signaling negative regulation of caspase activity negative regulation of cell-matrix adhesion negative regulation of dendritic cell antigen processing and presentation negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of fibrinolysis negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of focal adhesion assembly negative regulation of interleukin-12 production negative regulation of nitric oxide mediated signal transduction negative regulation of plasma membrane long-chain fatty acid transport negative regulation of plasminogen activation peptide cross-linking platelet activation platelet degranulation positive regulation of angiogenesis positive regulation of blood coagulation positive regulation of blood vessel endothelial cell migration positive regulation of cell migration positive regulation of chemotaxis positive regulation of endothelial cell migration positive regulation of fibroblast migration positive regulation of macrophage activation positive regulation of macrophage chemotaxis positive regulation of phosphorylation positive regulation of protein kinase B signaling cascade positive regulation of reactive oxygen species metabolic process positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta1 production positive regulation of translation positive regulation of tumor necrosis factor biosynthetic process response to calcium ion response to drug response to glucose stimulus response to hypoxia response to magnesium ion response to progesterone stimulus sprouting angiogenesis less... cellular_component external side of plasma membrane extracellular matrix extracellular region extracellular space more... fibrinogen complex platelet alpha granule platelet alpha granule lumen stored secretory granule less... molecular_function calcium ion binding collagen V binding eukaryotic cell surface binding fibrinogen binding more... fibroblast growth factor 2 binding fibronectin binding glycoprotein binding heparin binding identical protein binding integrin binding laminin binding low-density lipoprotein particle binding phosphatidylserine binding protein binding proteoglycan binding structural molecule activity transforming growth factor beta binding less... APOL1 2 BP    MF    CC biological_process chloride transport cholesterol metabolic process cytolysis innate immune response more... killing of cells of other organism lipid transport lipoprotein metabolic process steroid metabolic process transport less... cellular_component extracellular region extracellular space high-density lipoprotein particle intrinsic to membrane more... very-low-density lipoprotein particle less... molecular_function chloride channel activity lipid binding protein binding CXCL13 2 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... ANXA4 2 BP    MF    CC biological_process anti-apoptosis negative regulation of coagulation signal transduction cellular_component cytoplasm molecular_function calcium ion binding calcium-dependent phospholipid binding phospholipase inhibitor activity VCAN 2 BP    MF    CC biological_process axon regeneration cell adhesion cell recognition glial cell migration more... heart development multicellular organismal development response to wounding less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function binding calcium ion binding glycosaminoglycan binding hyaluronic acid binding more... sugar binding less... DUSP6 2 BP    MF    CC biological_process MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway cell differentiation more... dorsal/ventral pattern formation inactivation of MAPK activity innate immune response negative regulation of ERK1 and ERK2 cascade negative regulation of protein phosphorylation nerve growth factor receptor signaling pathway peptidyl-tyrosine dephosphorylation positive regulation of apoptosis protein dephosphorylation regulation of endodermal cell fate specification regulation of fibroblast growth factor receptor signaling pathway regulation of heart growth response to drug response to growth factor stimulus response to nitrosative stress response to organic cyclic compound stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytoplasm cytosol nucleoplasm molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity phosphatase activity protein tyrosine phosphatase activity more... ATP2C2 2 BP    MF    CC biological_process ATP biosynthetic process calcium ion transport cation transport ion transmembrane transport more... transmembrane transport less... cellular_component Golgi membrane integral to membrane membrane molecular_function ATP binding calcium-transporting ATPase activity catalytic activity hydrolase activity more... hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding nucleotide binding protein binding less... HLA-A 2 BP    MF    CC biological_process antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class I cytokine-mediated signaling pathway immune response more... interferon-gamma-mediated signaling pathway interspecies interaction between organisms regulation of defense response to virus by virus regulation of immune response type I interferon-mediated signaling pathway viral reproduction less... cellular_component ER to Golgi transport vesicle membrane Golgi membrane MHC class I protein complex early endosome membrane more... integral to lumenal side of endoplasmic reticulum membrane integral to membrane integral to plasma membrane membrane plasma membrane less... molecular_function MHC class I receptor activity protein binding TIMP3 2 BP    MF    CC biological_process aging central nervous system development negative regulation of membrane protein ectodomain proteolysis negative regulation of proteolysis more... response to amino acid stimulus response to estrogen stimulus response to folic acid response to hormone stimulus response to mechanical stimulus response to organic cyclic compound response to stimulus tissue regeneration visual perception less... cellular_component basement membrane cytoplasm extracellular matrix extracellular region more... molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... ACADSB 2 BP    MF    CC biological_process acyl-CoA metabolic process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process fatty acid metabolic process more... lipid metabolic process less... cellular_component mitochondrial matrix mitochondrion molecular_function acyl-CoA dehydrogenase activity electron carrier activity flavin adenine dinucleotide binding short-branched-chain-acyl-CoA dehydrogenase activity more... FGFR2 2 BP    MF    CC biological_process angiogenesis axonogenesis bone development bone mineralization more... bone morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in embryonic placenta morphogenesis branching involved in prostate gland morphogenesis branching involved in salivary gland morphogenesis branching morphogenesis of a nerve bud elongation involved in lung branching cell fate commitment cell-cell signaling digestive tract development embryonic digestive tract morphogenesis embryonic organ development embryonic organ morphogenesis embryonic pattern specification epidermis morphogenesis epithelial cell differentiation epithelial cell proliferation involved in salivary gland morphogenesis fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in mammary gland specification fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow gland morphogenesis hair follicle morphogenesis in utero embryonic development inner ear morphogenesis insulin receptor signaling pathway lacrimal gland development lateral sprouting from an epithelium limb bud formation lung alveolus development lung development lung lobe morphogenesis lung-associated mesenchyme development mammary gland bud formation membranous septum morphogenesis mesenchymal cell differentiation mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development midbrain development morphogenesis of embryonic epithelium multicellular organism growth negative regulation of transcription from RNA polymerase II promoter odontogenesis orbitofrontal cortex development organ growth organ morphogenesis otic vesicle formation outflow tract septum morphogenesis peptidyl-tyrosine phosphorylation positive regulation of ERK1 and ERK2 cascade positive regulation of MAPKKK cascade positive regulation of Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway positive regulation of cardiac muscle cell proliferation positive regulation of cell cycle positive regulation of cell division positive regulation of cell proliferation positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in lung morphogenesis positive regulation of mesenchymal cell proliferation positive regulation of phospholipase activity positive regulation of transcription from RNA polymerase II promoter post-embryonic development prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate epithelial cord elongation prostate gland morphogenesis protein autophosphorylation pyramidal neuron development regulation of ERK1 and ERK2 cascade regulation of branching involved in prostate gland morphogenesis regulation of cell fate commitment regulation of fibroblast growth factor receptor signaling pathway regulation of morphogenesis of a branching structure regulation of multicellular organism growth regulation of osteoblast differentiation regulation of osteoblast proliferation regulation of smooth muscle cell differentiation regulation of smoothened signaling pathway reproductive structure development skeletal system morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ureteric bud development ventricular cardiac muscle tissue morphogenesis ventricular zone neuroblast division less... cellular_component cell cortex cell surface cytoplasm excitatory synapse more... extracellular matrix extracellular region integral to membrane integral to plasma membrane membrane nucleus plasma membrane less... molecular_function ATP binding fibroblast growth factor binding fibroblast growth factor-activated receptor activity heparin binding more... nucleotide binding protein binding protein homodimerization activity protein tyrosine kinase activity receptor activity less... F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... CTTN 2 BP    MF    CC biological_process cellular_component cell cortex cytoplasm cytoskeleton lamellipodium more... ruffle soluble fraction less... molecular_function protein binding MMP13 2 BP    MF    CC biological_process bone mineralization cartilage development collagen catabolic process embryonic hindlimb morphogenesis more... metabolic process peptide catabolic process proteolysis receptor internalization response to estrogen stimulus response to hypoxia response to mechanical stimulus less... cellular_component Golgi apparatus collagen extracellular matrix extracellular region more... extracellular space fibrillar collagen intercellular canaliculus lysosome proteinaceous extracellular matrix less... molecular_function calcium ion binding calcium-dependent protein binding fibronectin binding low-density lipoprotein particle receptor binding more... metalloendopeptidase activity peptidase activity zinc ion binding less... BTBD3 2 BP    MF    CC biological_process cellular_component molecular_function TAGLN 2 BP    MF    CC biological_process muscle organ development cellular_component cytoplasm molecular_function actin binding CLU 2 BP    MF    CC biological_process anti-apoptosis blood coagulation cell death cellular response to growth factor stimulus more... chaperone-mediated protein folding complement activation complement activation, classical pathway endocrine pancreas development induction of apoptosis by intracellular signals innate immune response lipid metabolic process negative regulation of apoptosis negative regulation of protein homooligomerization neuron projection morphogenesis platelet activation platelet degranulation positive regulation of NF-kappaB transcription factor activity positive regulation of apoptosis positive regulation of cell differentiation positive regulation of cell proliferation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein stabilization release of cytochrome c from mitochondria response to misfolded protein response to oxidative stress response to virus response to wounding reverse cholesterol transport less... cellular_component aggresome chromaffin granule cytoplasm cytoplasmic vesicle more... cytosol endoplasmic reticulum extracellular matrix extracellular region extracellular space growth cone membrane microsome mitochondrial membrane mitochondrion nucleus perinuclear region of cytoplasm platelet alpha granule lumen spherical high-density lipoprotein particle less... molecular_function ATPase activity misfolded protein binding protein binding ubiquitin protein ligase binding more... PPARGC1A 2 BP    MF    CC biological_process RNA splicing androgen receptor signaling pathway brown fat cell differentiation cellular glucose homeostasis more... cellular respiration cellular response to oxidative stress digestion fatty acid oxidation gluconeogenesis mRNA processing mitochondrion organization negative regulation of neuron apoptosis neuron death positive regulation of fatty acid oxidation positive regulation of gluconeogenesis positive regulation of histone acetylation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent protein complex assembly protein stabilization regulation of cell death respiratory electron transport chain response to muscle activity response to starvation temperature homeostasis transcription initiation from RNA polymerase II promoter less... cellular_component DNA-directed RNA polymerase II, core complex cytosol nucleus molecular_function DNA binding RNA binding RNA polymerase II transcription cofactor activity androgen receptor binding more... ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity nucleotide binding protein binding receptor activity transcription coactivator activity transcription factor binding less... C1orf106 2 BP    MF    CC biological_process cellular_component molecular_function SCGB2A2 2 BP    MF    CC biological_process biological_process cellular_component cellular_component extracellular region molecular_function binding molecular_function steroid binding NUDT4 2 BP    MF    CC biological_process calcium-mediated signaling cyclic nucleotide metabolic process cyclic-nucleotide-mediated signaling intracellular signal transduction more... intracellular transport regulation of RNA export from nucleus less... cellular_component cytoplasm intracellular molecular_function diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity metal ion binding NFIL3 2 BP    MF    CC biological_process circadian rhythm immune response regulation of transcription, DNA-dependent transcription from RNA polymerase II promoter more... cellular_component nucleus molecular_function DNA binding protein dimerization activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity more... transcription corepressor activity less... KIAA1199 2 BP    MF    CC biological_process cellular_component cytoplasm molecular_function SOD2 2 BP    MF    CC biological_process age-dependent response to oxidative stress age-dependent response to reactive oxygen species aging anti-apoptosis more... cellular response to ethanol detection of oxygen erythrophore differentiation glutathione metabolic process heart development hemopoiesis hydrogen peroxide biosynthetic process iron ion homeostasis liver development locomotory behavior mitochondrion organization negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of fibroblast proliferation negative regulation of neuron apoptosis neuron development oxidation-reduction process oxygen homeostasis positive regulation of nitric oxide biosynthetic process post-embryonic development protein homooligomerization protein homotetramerization regulation of blood pressure regulation of catalytic activity regulation of mitochondrial membrane potential regulation of transcription from RNA polymerase II promoter release of cytochrome c from mitochondria removal of superoxide radicals respiratory electron transport chain response to L-ascorbic acid response to activity response to axon injury response to cadmium ion response to drug response to electrical stimulus response to hydrogen peroxide response to hyperoxia response to hypoxia response to lipopolysaccharide response to manganese ion response to nutrient levels response to selenium ion response to silicon dioxide response to superoxide response to zinc ion superoxide anion generation superoxide metabolic process vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure less... cellular_component cytoplasm mitochondrial inner membrane mitochondrial matrix mitochondrial nucleoid more... mitochondrion soluble fraction less... molecular_function DNA binding identical protein binding manganese ion binding metal ion binding more... oxidoreductase activity oxygen binding superoxide dismutase activity less... GJA1 2 BP    MF    CC biological_process ATP transport adult heart development apoptosis blood vessel morphogenesis more... cell-cell signaling cellular membrane organization embryonic heart tube development epithelial cell maturation gap junction assembly heart development heart looping in utero embryonic development ion transmembrane transport limb bud formation muscle contraction negative regulation of cell proliferation negative regulation of gene expression neuron migration neuron projection morphogenesis positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of gene expression positive regulation of protein catabolic process positive regulation of striated muscle tissue development protein oligomerization regulation of calcium ion transport regulation of heart contraction response to pH response to peptide hormone stimulus signal transduction skeletal muscle tissue regeneration transport vascular transport less... cellular_component Golgi apparatus Golgi membrane Golgi-associated vesicle membrane cell junction more... connexon complex cytoplasm cytosol early endosome endoplasmic reticulum endoplasmic reticulum membrane fascia adherens gap junction integral to membrane integral to plasma membrane lysosome membrane fraction membrane raft mitochondrial outer membrane multivesicular body plasma membrane less... molecular_function PDZ domain binding SH3 domain binding gap junction channel activity ion transmembrane transporter activity more... receptor binding signal transducer activity transmembrane transporter activity less...
Up-regulated Genes Score CCNB2 8 BUB1B 8 MSX1 6 MMP26 4 PTTG1 4 MPPED2 4 SCGB1D2 4 EDN3 4 ALPL 4 SQLE 4 LRRC17 4 OLFM1 4 E2F2 4 CSRP2 4 RASSF2 4 CDC2 4 CTNNA2 4 CDC20 4 CCNB1 4 EPHB3 4 PRKCQ 4 SLC7A1 2 KIAA0802 2 TRH 2 S100A5 2 ANK3 2 ATP6V0E2 2 S100Z 2 E2F3 2 CDC45L 2 SLC26A4 2 ITGB8 2 PIP5K1B 2 NDRG2 2 FANCI 2 MCM4 2 BTG3 2 ECM1 2 TACC3 2 CDC6 2 HPRT1 2 ANO1 2 ATR 2 PAQR4 2 OLFM4 2 GREM2 2 SOX17 2 S100A10 2 PENK 2 S100A2 2 SPAG5 2 MFAP2 2 GPR64 2 KIF4A 2 DLGAP5 2 CCNA2 2 PKMYT1 2 ATP1B1 2 MSX2 2 HPGD 2 KIF11 2 EFNA2 2 CENPA 2 HERPUD1 2 S100A7 2 POSTN 2 COL16A1 2 CCNE2 2 ATAD4 2 SORD 2 TOP2A 2 BMP7 2 IL9R 2 IL15RA 2 NRG2 2 BARD1 2 HEY2 2 RABGAP1L 2 GJB2 2 SERPINA5 2 FAM169A 2 GJB6 2 KIF20A 2 PLA1A 2 OFD1 2 TMSB15A 2 GALNT12 2 PKP2 2 CCND1 2 KMO 2 FAM155B 2 MCM3 2 PECI 2 SFRP4 2 CENPE 2 HLA-DOB 2 NDC80 2 PCNA 2 IDH1 2 PLCH1 2 MCM6 2 S100B 2 SORBS2 2 OPRK1 2 FOXM1 2 CEP55 2 KCNG1 2 CRABP2 2 BUB1 2 UBE2C 2 PBK 2 S100A7A 2 S100G 2 CALB2 2 NEDD4L 2 DYNC1I1 2 SPDEF 2 PMEPA1 2 PRC1 2 HSD11B2 2 GALNT4 2 LRP4 2 ASPM 2 SLC15A2 2 MAP2K6 2	Down-regulated Genes Score SPP1 18 GPX3 14 PAEP 12 IGFBP7 12 IL15 12 CD55 10 DPP4 8 CLDN4 6 LAMB3 6 COMP 6 MMP7 4 C4BPA 4 FXYD2 4 S100P 4 IL6ST 4 FAM148B 4 TIMP1 4 ANGPTL1 4 IGFBP3 4 MAOA 4 DCN 4 MFAP5 4 TCN1 4 DARC 4 GADD45A 4 IGFBP1 4 TIMP2 4 TSPAN8 4 ABCC3 4 LMOD1 2 CDA 2 LCP1 2 AHNAK 2 ANKRD55 2 TSPO 2 TNFAIP2 2 RARRES1 2 ARID5B 2 IL1R1 2 MUC16 2 SNX10 2 G0S2 2 TRPC6 2 THBD 2 SLC44A4 2 NID1 2 PROM1 2 MT1E 2 TGM2 2 FOXO1 2 FBLN1 2 UBE2L6 2 ABLIM3 2 PDZK1IP1 2 AIMP1 2 CYP2C9 2 ABP1 2 CDH3 2 KIAA0040 2 AQP3 2 HAL 2 AGR2 2 GDF15 2 C9orf71 2 DKK1 2 TMOD1 2 CXCR4 2 IGF2 2 SLPI 2 LIF 2 APOD 2 CYP3A5 2 RARRES3 2 ST6GAL1 2 THBS1 2 APOL1 2 CXCL13 2 ANXA4 2 VCAN 2 DUSP6 2 ATP2C2 2 HLA-A 2 TIMP3 2 ACADSB 2 FGFR2 2 F3 2 CTTN 2 MMP13 2 BTBD3 2 TAGLN 2 CLU 2 PPARGC1A 2 C1orf106 2 SCGB2A2 2 NUDT4 2 NFIL3 2 KIAA1199 2 SOD2 2 GJA1 2 TRPM8 2 CXCL14 2 PTN 2 ANG 2 ACTA2 2 MT1G 2 BCL2A1 2 GRAMD1C 2 PSD 2 CD36 2 MYH11 2 RBP4 2 SLC15A1 2 SLC1A1 2 ELF3 2 MT1H 2 NP 2 PLS1 2 C1R 2 HABP2 2 C1S 2 PAPSS2 2 CDH13 2 CATSPERB 2 SLC22A5 2 FAP 2 MALL 2 B2M 2 IMPA2 2 FGB 2 MFGE8 2 WNT7A 2 DHRS3 2 EFEMP1 2 EDNRB 2 SFN 2 TTC39A 2 ADRA2A 2 MMP11 2 PAX8 2 AOX1 2 DNAJC6 2 NUPR1 2 COL15A1 2 VPS13D 2 ITGA3 2 CNN1 2 IGFBP5 2 MAP3K5 2 ANXA2 2 THBS2 2 LCN2 2 GPR110 2 FAM148A 2 PPAP2B 2 PTGER2 2 WFDC2 2 GAST 2 CXCL12 2 OTUB2 2
Identifiers Repository Data-sets 20042535 PubMed 1 15373944 PubMed 2 12200466 PubMed 4 12728018 PubMed 7 12679483 PubMed 7 19246470 PubMed 3 22480820 PubMed 7 15704471 PubMed 2 20619403 PubMed 6 20979995 PubMed 4 12062828 PubMed 2 19556289 PubMed 8 18524812 PubMed 4 15878921 PubMed 4 18835874 PubMed 2 19796763 PubMed 4 15695772 PubMed 4
Up-regulated(125) Down-regulated(159)