Home

Search

Browse

RAGs

User guide

FAQs

Links

Questions

Contribute

Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Hormone treatment;;Human Chorionic Gonadotropin
Top 10            Top 100            All genes            References
Up-regulated Genes Score GO annotation TSC22D3 2 BP    MF    CC biological_process anti-apoptosis body fluid secretion negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter more... regulation of transcription, DNA-dependent response to osmotic stress transcription, DNA-dependent less... cellular_component cytoplasm nucleus molecular_function MyoD binding sequence-specific DNA binding transcription factor activity C5orf13 2 BP    MF    CC biological_process axon regeneration regulation of neuron differentiation regulation of transforming growth factor beta receptor signaling pathway cellular_component cytoplasm nucleus molecular_function PLOD1 2 BP    MF    CC biological_process epidermis development hydroxylysine biosynthetic process oxidation-reduction process protein modification process more... response to hypoxia less... cellular_component collagen endoplasmic reticulum membrane rough endoplasmic reticulum membrane more... molecular_function L-ascorbic acid binding iron ion binding metal ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors more... oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen procollagen-lysine 5-dioxygenase activity protein homodimerization activity less... ENAH 2 BP    MF    CC biological_process T cell receptor signaling pathway actin cytoskeleton organization actin polymerization or depolymerization axon guidance more... intracellular transport neural tube closure less... cellular_component cell junction cytoplasm cytoskeleton cytosol more... filopodium focal adhesion lamellipodium stress fiber synapse less... molecular_function SH3 domain binding WW domain binding actin binding EPB41L2 2 BP    MF    CC biological_process cortical actin cytoskeleton organization cellular_component cytoplasm cytoskeleton extrinsic to membrane plasma membrane more... signalosome spectrin less... molecular_function PH domain binding actin binding binding cytoskeletal protein binding more... spectrin binding structural molecule activity less... BARD1 2 BP    MF    CC biological_process DNA repair cell cycle arrest negative regulation of apoptosis negative regulation of mRNA 3'-end processing more... negative regulation of protein export from nucleus positive regulation of apoptosis positive regulation of protein catabolic process protein K6-linked ubiquitination protein ubiquitination regulation of phosphorylation response to DNA damage stimulus spermatogenesis tissue homeostasis less... cellular_component BRCA1-A complex BRCA1-BARD1 complex cytoplasm intracellular more... nucleus ubiquitin ligase complex less... molecular_function RNA binding kinase binding ligase activity metal ion binding more... protein binding protein heterodimerization activity protein homodimerization activity ubiquitin-protein ligase activity zinc ion binding less... PAPOLA 2 BP    MF    CC biological_process RNA polyadenylation RNA splicing gene expression mRNA 3'-end processing more... mRNA polyadenylation mRNA processing nuclear mRNA splicing, via spliceosome termination of RNA polymerase II transcription transcription from RNA polymerase II promoter transcription, DNA-dependent less... cellular_component cytoplasm nucleolus nucleoplasm nucleus more... molecular_function ATP binding RNA binding magnesium ion binding manganese ion binding more... nucleotide binding nucleotidyltransferase activity polynucleotide adenylyltransferase activity transferase activity less... ACPP 2 BP    MF    CC biological_process cellular_component extracellular region intracellular lysosomal membrane plasma membrane more... molecular_function 5'-nucleotidase activity acid phosphatase activity hydrolase activity PCDH7 2 BP    MF    CC biological_process cell adhesion homophilic cell adhesion cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function calcium ion binding HEY2 2 BP    MF    CC biological_process Notch signaling pathway cardiac ventricle morphogenesis cochlea development negative regulation of Notch signaling pathway more... negative regulation of gene expression negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent pattern specification process positive regulation of cardiac muscle cell proliferation regulation of transcription, DNA-dependent smooth muscle cell differentiation transcription, DNA-dependent vascular smooth muscle cell development vasculogenesis ventricular cardiac muscle cell development less... cellular_component Sin3 complex cytoplasm nucleus transcriptional repressor complex more... molecular_function DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity histone deacetylase binding more... microsatellite binding protein binding protein binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding less...	Down-regulated Genes Score GO annotation DKK1 6 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... STAR 4 BP    MF    CC biological_process C21-steroid hormone biosynthetic process cellular lipid metabolic process glucocorticoid metabolic process lipid transport more... regulation of steroid biosynthetic process steroid biosynthetic process steroid metabolic process transport less... cellular_component mitochondrial intermembrane space mitochondrion molecular_function cholesterol binding cholesterol transporter activity lipid binding CXCL13 4 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... TIMP3 4 BP    MF    CC biological_process aging central nervous system development negative regulation of membrane protein ectodomain proteolysis negative regulation of proteolysis more... response to amino acid stimulus response to estrogen stimulus response to folic acid response to hormone stimulus response to mechanical stimulus response to organic cyclic compound response to stimulus tissue regeneration visual perception less... cellular_component basement membrane cytoplasm extracellular matrix extracellular region more... molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... COX7A1 2 BP    MF    CC biological_process generation of precursor metabolites and energy cellular_component integral to membrane membrane mitochondrial respiratory chain mitochondrion more... molecular_function cytochrome-c oxidase activity electron carrier activity NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding ID4 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cellular protein localization central nervous system myelination more... cerebral cortex neuron differentiation hippocampus development negative regulation of astrocyte differentiation negative regulation of fat cell differentiation negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent neuroblast proliferation positive regulation of cell proliferation positive regulation of osteoblast differentiation regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm nucleus molecular_function RNA polymerase II transcription factor binding protein binding transcription corepressor activity EMP1 2 BP    MF    CC biological_process cell growth cell proliferation epidermis development multicellular organismal development more... cellular_component integral to membrane membrane membrane fraction plasma membrane more... molecular_function F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... ALDH1A3 2 BP    MF    CC biological_process embryonic camera-type eye development embryonic eye morphogenesis face development kidney development more... nucleus accumbens development olfactory pit development optic cup morphogenesis involved in camera-type eye development pituitary gland development positive regulation of apoptosis response to drug retinal metabolic process retinoic acid biosynthetic process retinoic acid metabolic process less... cellular_component cytoplasm molecular_function NAD+ binding aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity more... oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor protein homodimerization activity thyroid hormone binding less...
Up-regulated Genes Score GO annotation TSC22D3 2 BP    MF    CC biological_process anti-apoptosis body fluid secretion negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter more... regulation of transcription, DNA-dependent response to osmotic stress transcription, DNA-dependent less... cellular_component cytoplasm nucleus molecular_function MyoD binding sequence-specific DNA binding transcription factor activity C5orf13 2 BP    MF    CC biological_process axon regeneration regulation of neuron differentiation regulation of transforming growth factor beta receptor signaling pathway cellular_component cytoplasm nucleus molecular_function PLOD1 2 BP    MF    CC biological_process epidermis development hydroxylysine biosynthetic process oxidation-reduction process protein modification process more... response to hypoxia less... cellular_component collagen endoplasmic reticulum membrane rough endoplasmic reticulum membrane more... molecular_function L-ascorbic acid binding iron ion binding metal ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors more... oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen procollagen-lysine 5-dioxygenase activity protein homodimerization activity less... ENAH 2 BP    MF    CC biological_process T cell receptor signaling pathway actin cytoskeleton organization actin polymerization or depolymerization axon guidance more... intracellular transport neural tube closure less... cellular_component cell junction cytoplasm cytoskeleton cytosol more... filopodium focal adhesion lamellipodium stress fiber synapse less... molecular_function SH3 domain binding WW domain binding actin binding EPB41L2 2 BP    MF    CC biological_process cortical actin cytoskeleton organization cellular_component cytoplasm cytoskeleton extrinsic to membrane plasma membrane more... signalosome spectrin less... molecular_function PH domain binding actin binding binding cytoskeletal protein binding more... spectrin binding structural molecule activity less... BARD1 2 BP    MF    CC biological_process DNA repair cell cycle arrest negative regulation of apoptosis negative regulation of mRNA 3'-end processing more... negative regulation of protein export from nucleus positive regulation of apoptosis positive regulation of protein catabolic process protein K6-linked ubiquitination protein ubiquitination regulation of phosphorylation response to DNA damage stimulus spermatogenesis tissue homeostasis less... cellular_component BRCA1-A complex BRCA1-BARD1 complex cytoplasm intracellular more... nucleus ubiquitin ligase complex less... molecular_function RNA binding kinase binding ligase activity metal ion binding more... protein binding protein heterodimerization activity protein homodimerization activity ubiquitin-protein ligase activity zinc ion binding less... PAPOLA 2 BP    MF    CC biological_process RNA polyadenylation RNA splicing gene expression mRNA 3'-end processing more... mRNA polyadenylation mRNA processing nuclear mRNA splicing, via spliceosome termination of RNA polymerase II transcription transcription from RNA polymerase II promoter transcription, DNA-dependent less... cellular_component cytoplasm nucleolus nucleoplasm nucleus more... molecular_function ATP binding RNA binding magnesium ion binding manganese ion binding more... nucleotide binding nucleotidyltransferase activity polynucleotide adenylyltransferase activity transferase activity less... ACPP 2 BP    MF    CC biological_process cellular_component extracellular region intracellular lysosomal membrane plasma membrane more... molecular_function 5'-nucleotidase activity acid phosphatase activity hydrolase activity PCDH7 2 BP    MF    CC biological_process cell adhesion homophilic cell adhesion cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function calcium ion binding HEY2 2 BP    MF    CC biological_process Notch signaling pathway cardiac ventricle morphogenesis cochlea development negative regulation of Notch signaling pathway more... negative regulation of gene expression negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent pattern specification process positive regulation of cardiac muscle cell proliferation regulation of transcription, DNA-dependent smooth muscle cell differentiation transcription, DNA-dependent vascular smooth muscle cell development vasculogenesis ventricular cardiac muscle cell development less... cellular_component Sin3 complex cytoplasm nucleus transcriptional repressor complex more... molecular_function DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity histone deacetylase binding more... microsatellite binding protein binding protein binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding less... BTG3 2 BP    MF    CC biological_process negative regulation of cell proliferation negative regulation of mitotic cell cycle response to oxidative stress cellular_component cytoplasm molecular_function ECM1 2 BP    MF    CC biological_process biomineral tissue development negative regulation of bone mineralization negative regulation of peptidase activity ossification more... positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of angiogenesis positive regulation of endothelial cell proliferation signal transduction less... cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function enzyme binding laminin binding protease binding protein C-terminus binding more... protein binding signal transducer activity less... CST1 2 BP    MF    CC biological_process cellular_component extracellular region molecular_function cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity RABGAP1L 2 BP    MF    CC biological_process positive regulation of Rab GTPase activity regulation of protein localization cellular_component Golgi apparatus early endosome intracellular nucleus more... molecular_function GTPase activator activity Rab GTPase activator activity Rab GTPase binding IGF1 2 BP    MF    CC biological_process DNA replication Ras protein signal transduction Type I pneumocyte differentiation Type II pneumocyte differentiation more... anti-apoptosis blood coagulation blood vessel remodeling bone mineralization involved in bone maturation branching morphogenesis of a tube cellular component movement chondroitin sulfate proteoglycan biosynthetic process exocrine pancreas development glial cell differentiation glycolate metabolic process lung alveolus development lung lobe morphogenesis lung vasculature development mammary gland development muscle hypertrophy muscle organ development myoblast differentiation myoblast proliferation myotube cell development negative regulation of ERK1 and ERK2 cascade negative regulation of androgen receptor signaling pathway negative regulation of cell proliferation negative regulation of release of cytochrome c from mitochondria negative regulation of smooth muscle cell apoptosis nervous system development phosphatidylinositol-mediated signaling platelet activation platelet degranulation positive regulation of DNA binding positive regulation of DNA replication positive regulation of MAPKKK cascade positive regulation of Ras protein signal transduction positive regulation of activated T cell proliferation positive regulation of calcineurin-NFAT signaling pathway positive regulation of cardiac muscle hypertrophy positive regulation of cell proliferation positive regulation of cerebellar granule cell precursor proliferation positive regulation of epithelial cell proliferation positive regulation of fibroblast proliferation positive regulation of glucose import positive regulation of glycogen biosynthetic process positive regulation of glycolysis positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of mitosis positive regulation of osteoblast differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase cascade positive regulation of protein import into nucleus, translocation positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent positive regulation of tyrosine phosphorylation of Stat5 protein prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate gland epithelium morphogenesis prostate gland growth prostate gland stromal morphogenesis proteoglycan biosynthetic process regulation of establishment or maintenance of cell polarity regulation of multicellular organism growth regulation of protein metabolic process regulation of protein phosphorylation satellite cell maintenance involved in skeletal muscle regeneration signal transduction skeletal system development water homeostasis less... cellular_component extracellular region extracellular space insulin-like growth factor binding protein complex platelet alpha granule lumen more... molecular_function growth factor activity hormone activity insulin receptor binding insulin-like growth factor receptor binding more... integrin binding protein binding less... GSTM3 2 BP    MF    CC biological_process establishment of blood-nerve barrier glutathione metabolic process metabolic process response to estrogen stimulus more... cellular_component cytoplasm molecular_function glutathione transferase activity identical protein binding transferase activity NUP153 2 BP    MF    CC biological_process carbohydrate metabolic process glucose transport hexose transport interspecies interaction between organisms more... mRNA transport protein transport regulation of glucose transport transmembrane transport viral reproduction less... cellular_component cytoplasm intracellular nuclear membrane nuclear pore more... nucleolus nucleoplasm nucleus protein complex less... molecular_function DNA binding Ran GTPase binding metal ion binding protein binding more... transporter activity zinc ion binding less... STEAP4 2 BP    MF    CC biological_process fat cell differentiation ion transport iron ion homeostasis cellular_component Golgi apparatus Golgi membrane integral to membrane plasma membrane more... molecular_function binding electron carrier activity flavin adenine dinucleotide binding iron ion binding more... metal ion binding oxidoreductase activity less... PELI1 2 BP    MF    CC biological_process MyD88-dependent toll-like receptor signaling pathway Toll signaling pathway innate immune response positive regulation of B cell proliferation more... positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of cytokine production positive regulation of protein ubiquitination positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway response to dsRNA response to lipopolysaccharide toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytosol molecular_function ligase activity ubiquitin-protein ligase activity ST7 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function binding CD36 2 BP    MF    CC biological_process apoptotic cell clearance blood coagulation cGMP-mediated signaling cell adhesion more... cell surface receptor linked signaling pathway cellular response to bacterial lipopeptide cellular response to hydroperoxide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cholesterol transport defense response to Gram-positive bacterium lipid metabolic process lipid storage lipoprotein transport low-density lipoprotein particle clearance low-density lipoprotein particle mediated signaling negative regulation of gene expression negative regulation of growth of symbiont in host negative regulation of transcription factor import into nucleus negative regulation of transcription from RNA polymerase II promoter nitric oxide mediated signal transduction phagocytosis, recognition plasma lipoprotein particle clearance plasma membrane long-chain fatty acid transport platelet activation platelet degranulation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAPKKK cascade positive regulation of blood coagulation positive regulation of blood microparticle formation positive regulation of cell-matrix adhesion positive regulation of cholesterol storage positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of macrophage derived foam cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species metabolic process positive regulation of tumor necrosis factor production regulation of removal of superoxide radicals response to stilbenoid transport less... cellular_component Golgi apparatus cell surface external side of plasma membrane integral to plasma membrane more... membrane membrane fraction membrane raft plasma membrane platelet alpha granule membrane less... molecular_function Gram-negative bacterial cell surface binding Gram-positive bacterial cell surface binding high-density lipoprotein particle binding lipid binding more... lipoprotein particle binding lipoteichoic acid receptor activity low-density lipoprotein particle binding low-density lipoprotein receptor activity receptor activity thrombospondin receptor activity transforming growth factor beta binding less... KYNU 2 BP    MF    CC biological_process NAD biosynthetic process anthranilate metabolic process cellular nitrogen compound metabolic process pyridine nucleotide biosynthetic process more... quinolinate biosynthetic process response to interferon-gamma response to vitamin B6 tryptophan catabolic process tryptophan catabolic process to acetyl-CoA tryptophan catabolic process to kynurenine less... cellular_component cytoplasm cytosol mitochondrion soluble fraction more... molecular_function catalytic activity hydrolase activity kynureninase activity protein homodimerization activity more... pyridoxal phosphate binding less... SEMA3C 2 BP    MF    CC biological_process blood vessel remodeling cardiac right ventricle morphogenesis dichotomous subdivision of terminal units involved in salivary gland branching heart development more... immune response limb bud formation multicellular organismal development neural crest cell migration neural tube development outflow tract morphogenesis post-embryonic development pulmonary myocardium development response to drug somitogenesis less... cellular_component extracellular region extracellular space membrane molecular_function receptor activity semaphorin receptor binding GALNT10 2 BP    MF    CC biological_process protein O-linked glycosylation cellular_component Golgi apparatus Golgi membrane integral to membrane membrane more... molecular_function metal ion binding polypeptide N-acetylgalactosaminyltransferase activity sugar binding transferase activity more... transferase activity, transferring glycosyl groups less... EDN3 2 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding NEDD9 2 BP    MF    CC biological_process actin filament bundle assembly cell adhesion cell cycle cell division more... cytoskeleton organization integrin-mediated signaling pathway mitosis regulation of growth signal transduction less... cellular_component Golgi apparatus cell cortex cell junction cytoplasm more... cytoskeleton focal adhesion lamellipodium nucleus spindle spindle pole less... molecular_function protein binding STXBP6 2 BP    MF    CC biological_process vesicle-mediated transport cellular_component cytoplasm integral to membrane membrane molecular_function PYY 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway cell proliferation cell-cell signaling cellular component movement more... cytoskeleton organization digestion eating behavior feeding behavior negative regulation of response to food less... cellular_component extracellular region extracellular space soluble fraction molecular_function hormone activity neuropeptide hormone activity SCD 2 BP    MF    CC biological_process fatty acid biosynthetic process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water stearoyl-CoA 9-desaturase activity more... ANO1 2 BP    MF    CC biological_process chloride transport ion transport multicellular organismal development trachea development more... cellular_component chloride channel complex cytoplasm integral to membrane plasma membrane more... molecular_function intracellular calcium activated chloride channel activity ion channel activity DDIT4 2 BP    MF    CC biological_process apoptosis negative regulation of TOR signaling cascade negative regulation of glycolysis protein complex disassembly more... reactive oxygen species metabolic process response to hypoxia less... cellular_component cytoplasm intracellular mitochondrion molecular_function 14-3-3 protein binding SLC16A6 2 BP    MF    CC biological_process monocarboxylic acid transport transmembrane transport cellular_component integral to membrane integral to plasma membrane membrane fraction plasma membrane more... molecular_function monocarboxylic acid transmembrane transporter activity symporter activity CACNA1D 2 BP    MF    CC biological_process axon guidance calcium ion transport energy reserve metabolic process ion transport more... regulation of calcium ion transport via voltage-gated calcium channel activity regulation of insulin secretion transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated calcium channel complex more... molecular_function voltage-gated calcium channel activity voltage-gated ion channel activity PIKFYVE 2 BP    MF    CC biological_process cellular protein metabolic process intracellular signal transduction protein localization to nucleus receptor-mediated endocytosis more... retrograde transport, endosome to Golgi less... cellular_component cytoplasmic vesicle cytosol early endosome membrane endosome more... endosome membrane membrane membrane raft perinuclear region of cytoplasm vesicle membrane less... molecular_function 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity ATP binding kinase activity more... metal ion binding nucleotide binding protein binding transferase activity zinc ion binding less... MOXD1 2 BP    MF    CC biological_process catecholamine metabolic process cellular process oxidation-reduction process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function copper ion binding dopamine beta-monooxygenase activity metal ion binding monooxygenase activity more... PPPDE1 2 BP    MF    CC biological_process cellular_component molecular_function EPHB3 2 BP    MF    CC biological_process angiogenesis axon guidance axonal fasciculation cell migration more... central nervous system projection neuron axonogenesis corpus callosum development dendritic spine development dendritic spine morphogenesis digestive tract morphogenesis ephrin receptor signaling pathway palate development positive regulation of synapse assembly protein autophosphorylation regulation of Cdc42 GTPase activity regulation of Rac GTPase activity regulation of axonogenesis regulation of cell-cell adhesion retinal ganglion cell axon guidance substrate adhesion-dependent cell spreading thymus development urogenital system development less... cellular_component integral to plasma membrane membrane molecular_function ATP binding axon guidance receptor activity ephrin receptor activity nucleotide binding more... receptor activity less... DHRS7 2 BP    MF    CC biological_process cellular_component molecular_function binding oxidoreductase activity CDC25A 2 BP    MF    CC biological_process DNA replication G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle M phase of mitotic cell cycle more... S phase of mitotic cell cycle cell cycle checkpoint cell division cell proliferation cellular response to UV mitosis mitotic cell cycle regulation of cyclin-dependent protein kinase activity less... cellular_component cytoplasm cytosol intracellular nucleoplasm more... nucleus less... molecular_function hydrolase activity protein binding protein tyrosine phosphatase activity ACSL3 2 BP    MF    CC biological_process brain development cellular lipid metabolic process fatty acid biosynthetic process long-chain fatty-acyl-CoA biosynthetic process more... response to nutrient response to organic cyclic compound triglyceride biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome mitochondrial outer membrane mitochondrion peroxisomal membrane peroxisome less... molecular_function ATP binding catalytic activity fatty-acyl-CoA synthase activity ligase activity more... long-chain fatty acid-CoA ligase activity nucleotide binding less... VLDLR 2 BP    MF    CC biological_process cellular response to glucose starvation cellular response to hypoxia cellular response to insulin stimulus cellular response to interleukin-1 more... cellular response to lipopolysaccharide cerebral cortex development cholesterol metabolic process endocytosis heart development lipid transport memory nervous system development response to drug response to hormone stimulus response to nutrient signal transduction steroid metabolic process transport ventral spinal cord development very-low-density lipoprotein particle clearance less... cellular_component apical part of cell cell surface coated pit extracellular space more... integral to membrane membrane membrane fraction nucleus perinuclear region of cytoplasm plasma membrane very-low-density lipoprotein particle less... molecular_function apolipoprotein binding calcium ion binding low-density lipoprotein receptor activity protein binding more... receptor activity very-low-density lipoprotein particle receptor activity less... PAGE4 2 BP    MF    CC biological_process biological_process cellular_component cellular_component molecular_function molecular_function PLCB1 2 BP    MF    CC biological_process CD24 biosynthetic process G1 phase G2/M transition of mitotic cell cycle activation of meiosis involved in egg activation more... cerebral cortex development fat cell differentiation glutamate signaling pathway insulin-like growth factor receptor signaling pathway interleukin-1-mediated signaling pathway interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway intracellular signal transduction learning lipid catabolic process memory muscarinic acetylcholine receptor signaling pathway negative regulation of monocyte extravasation negative regulation of transcription, DNA-dependent phosphatidylinositol metabolic process positive regulation of GTPase activity positive regulation of JNK cascade positive regulation of acrosome reaction positive regulation of developmental growth positive regulation of embryonic development positive regulation of interleukin-12 production positive regulation of myoblast differentiation positive regulation of transcription, DNA-dependent regulation of G-protein coupled receptor protein signaling pathway regulation of fertilization response to monosaccharide stimulus response to organic nitrogen response to peptide hormone stimulus signal transduction synaptic transmission less... cellular_component cytoplasm cytosol membrane fraction nuclear chromatin more... nuclear speck nucleus less... molecular_function GTPase activator activity calcium ion binding calmodulin binding enzyme binding more... hydrolase activity lamin binding phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phospholipase C activity protein homodimerization activity signal transducer activity less... PCTP 2 BP    MF    CC biological_process cholesterol metabolic process lipid transport phospholipid transport transport more... cellular_component cytoplasm cytosol molecular_function lipid binding phosphatidylcholine binding phosphatidylcholine transmembrane transporter activity BEX4 2 BP    MF    CC biological_process cellular_component cytoplasm nucleus molecular_function DKK2 2 BP    MF    CC biological_process multicellular organismal development negative regulation of Wnt receptor signaling pathway negative regulation of canonical Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway more... cellular_component extracellular region extracellular space molecular_function OPRK1 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway behavior immune response inhibition of adenylate cyclase activity by G-protein signaling pathway more... sensory perception synaptic transmission viral genome replication less... cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity kappa-opioid receptor activity protein binding receptor activity more... signal transducer activity less... CBARA1 2 BP    MF    CC biological_process cellular_component molecular_function MATN2 2 BP    MF    CC biological_process biological_process cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function calcium ion binding molecular_function HK2 2 BP    MF    CC biological_process apoptotic mitochondrial changes carbohydrate metabolic process carbohydrate phosphorylation glucose metabolic process more... glucose transport glycolysis hexose transport lactation regulation of glucose import transmembrane transport less... cellular_component cytosol membrane mitochondrial outer membrane mitochondrion more... molecular_function ATP binding glucose binding hexokinase activity kinase activity more... nucleotide binding transferase activity less... SQLE 2 BP    MF    CC biological_process cellular aromatic compound metabolic process cholesterol biosynthetic process cholesterol metabolic process oxidation-reduction process more... response to organic substance sterol biosynthetic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... microsome less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity squalene monooxygenase activity NR4A2 2 BP    MF    CC biological_process adult locomotory behavior cellular response to extracellular stimulus cellular response to stress central nervous system neuron differentiation more... central nervous system projection neuron axonogenesis death dopamine biosynthetic process dopaminergic neuron differentiation gene expression habenula development intracellular receptor mediated signaling pathway negative regulation of neuron apoptosis nervous system development neuron maturation neuron migration positive regulation of catalytic activity positive regulation of transcription from RNA polymerase II promoter post-embryonic development regulation of dopamine metabolic process regulation of respiratory gaseous exchange regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor response to amphetamine response to hypoxia response to inorganic substance response to insecticide signal transduction transcription, DNA-dependent less... cellular_component cytoplasm nucleoplasm nucleus molecular_function ligand-dependent nuclear receptor activity metal ion binding protein binding protein heterodimerization activity more... receptor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity zinc ion binding less... KRT18 2 BP    MF    CC biological_process Golgi to plasma membrane CFTR protein transport anatomical structure morphogenesis cell cycle interspecies interaction between organisms more... negative regulation of apoptosis tumor necrosis factor-mediated signaling pathway less... cellular_component centriolar satellite cytoplasm intermediate filament keratin filament more... microtubule organizing center perinuclear region of cytoplasm less... molecular_function protein binding structural molecule activity ESR1 2 BP    MF    CC biological_process Sertoli cell proliferation androgen metabolic process antral ovarian follicle growth cellular response to estrogen stimulus more... epithelial cell development epithelial cell proliferation involved in mammary gland duct elongation estrogen receptor signaling pathway gene expression mammary gland alveolus development mammary gland branching involved in pregnancy neuroprotection osteoblast development positive regulation of ERK1 and ERK2 cascade positive regulation of epidermal growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of retinoic acid receptor signaling pathway positive regulation of survival gene product expression positive regulation of transcription from RNA polymerase II promoter prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate epithelial cord elongation regulation of apoptosis regulation of branching involved in prostate gland morphogenesis regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor regulation of transcription, DNA-dependent response to estradiol stimulus response to estrogen stimulus signal transduction steroid hormone mediated signaling pathway transcription, DNA-dependent uterus development vagina development less... cellular_component T-tubule chromatin remodeling complex cytoplasm membrane more... mitochondrial part neuron projection nucleoplasm nucleus perikaryon perinuclear region of cytoplasm plasma membrane protein complex terminal button less... molecular_function DNA binding beta-catenin binding chromatin binding enzyme binding more... estrogen receptor activity estrogen response element binding hormone binding metal ion binding nitric-oxide synthase regulator activity protein binding protein complex binding receptor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid binding steroid hormone receptor activity transcription factor binding type 1 metabotropic glutamate receptor binding zinc ion binding less... ACSM3 2 BP    MF    CC biological_process fatty acid biosynthetic process lipid metabolic process regulation of blood pressure cellular_component cellular_component mitochondrial matrix mitochondrion molecular_function ATP binding butyrate-CoA ligase activity catalytic activity fatty acid ligase activity more... ligase activity metal ion binding molecular_function nucleotide binding less... RGS4 2 BP    MF    CC biological_process inactivation of MAPK activity negative regulation of signal transduction positive regulation of GTPase activity regulation of G-protein coupled receptor protein signaling pathway more... cellular_component cytoplasm cytosol membrane fraction plasma membrane more... molecular_function GTPase activator activity calmodulin binding signal transducer activity MAGED1 2 BP    MF    CC biological_process apoptosis induction of apoptosis by extracellular signals negative regulation of epithelial cell proliferation nerve growth factor receptor signaling pathway more... regulation of apoptosis regulation of transcription, DNA-dependent less... cellular_component cytoplasm plasma membrane protein complex molecular_function protein binding MORC4 2 BP    MF    CC biological_process cellular_component molecular_function ATP binding metal ion binding zinc ion binding CKMT2 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process creatine metabolic process muscle contraction cellular_component membrane mitochondrial inner membrane mitochondrion molecular_function ATP binding creatine kinase activity kinase activity nucleotide binding more... ST3GAL6 2 BP    MF    CC biological_process amino sugar metabolic process glycolipid metabolic process protein glycosylation protein lipoylation more... cellular_component Golgi apparatus Golgi membrane integral to Golgi membrane integral to membrane more... membrane less... molecular_function sialyltransferase activity KMO 2 BP    MF    CC biological_process NAD metabolic process cellular nitrogen compound metabolic process kynurenine metabolic process pyridine nucleotide biosynthetic process more... response to salt stress tryptophan catabolic process tryptophan catabolic process to kynurenine less... cellular_component cytosol integral to membrane membrane mitochondrial inner membrane more... mitochondrial outer membrane mitochondrion less... molecular_function NAD(P)H oxidase activity electron carrier activity flavin adenine dinucleotide binding kynurenine 3-monooxygenase activity more... monooxygenase activity less... TMEFF1 2 BP    MF    CC biological_process multicellular organismal development cellular_component integral to membrane plasma membrane molecular_function ATAD4 2 BP    MF    CC biological_process cellular_component molecular_function HIBCH 2 BP    MF    CC biological_process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process cellular_component mitochondrial matrix mitochondrion molecular_function 3-hydroxyisobutyryl-CoA hydrolase activity catalytic activity hydrolase activity LOXL1 2 BP    MF    CC biological_process oxidation-reduction process protein deamination cellular_component extracellular matrix extracellular region extracellular space molecular_function copper ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor more... ATP6V0E2 2 BP    MF    CC biological_process ATP hydrolysis coupled proton transport cell growth cellular iron ion homeostasis insulin receptor signaling pathway more... ion transport transferrin transport transmembrane transport vacuolar acidification less... cellular_component endosome membrane integral to membrane membrane proton-transporting V-type ATPase, V0 domain more... vacuole less... molecular_function ATPase activity, coupled to transmembrane movement of ions hydrogen ion transmembrane transporter activity hydrolase activity BAG5 2 BP    MF    CC biological_process apoptosis negative regulation of protein refolding negative regulation of protein ubiquitination negative regulation of ubiquitin-protein ligase activity more... neuron death protein folding regulation of inclusion body assembly less... cellular_component inclusion body perinuclear region of cytoplasm molecular_function chaperone binding ubiquitin protein ligase binding TM4SF1 2 BP    MF    CC biological_process biological_process cellular_component integral to membrane integral to plasma membrane membrane molecular_function molecular_function PRAME 2 BP    MF    CC biological_process negative regulation of apoptosis negative regulation of cell differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription, DNA-dependent more... positive regulation of cell proliferation regulation of growth less... cellular_component nucleus plasma membrane molecular_function protein binding retinoic acid receptor binding GPM6B 2 BP    MF    CC biological_process cell differentiation multicellular organismal development nervous system development cellular_component integral to membrane membrane molecular_function molecular_function CEL 2 BP    MF    CC biological_process ceramide catabolic process cholesterol catabolic process fatty acid catabolic process intestinal cholesterol absorption more... intestinal lipid catabolic process lipid catabolic process lipid digestion lipid metabolic process pancreatic juice secretion protein esterification triglyceride metabolic process less... cellular_component cytoplasm cytosol extracellular region extracellular space more... molecular_function acylglycerol lipase activity carboxylesterase activity catalytic activity heparin binding more... hydrolase activity sterol esterase activity triglyceride lipase activity less... TMEM144 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function WDR77 2 BP    MF    CC biological_process RNA metabolic process ncRNA metabolic process negative regulation of cell proliferation negative regulation of epithelial cell proliferation involved in prostate gland development more... positive regulation of cell proliferation regulation of transcription from RNA polymerase II promoter secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development spliceosomal snRNP assembly less... cellular_component cytoplasm cytosol nucleus molecular_function ligand-dependent nuclear receptor transcription coactivator activity protein binding TPD52 2 BP    MF    CC biological_process B cell differentiation anatomical structure morphogenesis secretion cellular_component cytoplasm endoplasmic reticulum perinuclear region of cytoplasm molecular_function calcium ion binding protein binding protein heterodimerization activity protein homodimerization activity more... DUSP4 2 BP    MF    CC biological_process MAPKKK cascade MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway more... endoderm formation inactivation of MAPK activity innate immune response nerve growth factor receptor signaling pathway protein dephosphorylation response to organic substance stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component nucleoplasm nucleus soluble fraction molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity protein tyrosine phosphatase activity protein tyrosine/threonine phosphatase activity more... MSX2 2 BP    MF    CC biological_process BMP signaling pathway involved in heart development anagen anterior/posterior pattern specification bone morphogenesis more... bone trabecula formation branching involved in mammary gland duct morphogenesis cartilage development cellular response to estradiol stimulus cellular response to growth factor stimulus chondrocyte development cranial suture morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis enamel mineralization endochondral bone growth epithelial to mesenchymal transition involved in endocardial cushion formation frontal suture morphogenesis heart morphogenesis mammary gland epithelium development multicellular organismal development negative regulation of CREB transcription factor activity negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent odontogenesis osteoblast development osteoblast differentiation positive regulation of BMP signaling pathway positive regulation of apoptosis positive regulation of catagen positive regulation of osteoblast differentiation signal transduction involved in regulation of gene expression stem cell differentiation wound healing wound healing, spreading of epidermal cells less... cellular_component cytoplasm nucleus transcription factor complex molecular_function protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding more... transcription regulatory region DNA binding less... PTGS2 2 BP    MF    CC biological_process anagen bone mineralization cellular component movement cyclooxygenase pathway more... decidualization embryo implantation fatty acid biosynthetic process memory negative regulation of calcium ion transport negative regulation of cell proliferation negative regulation of synaptic transmission, dopaminergic ovulation positive regulation of apoptosis positive regulation of brown fat cell differentiation positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fever generation positive regulation of fibroblast growth factor production positive regulation of nitric oxide biosynthetic process positive regulation of platelet-derived growth factor production positive regulation of prostaglandin biosynthetic process positive regulation of smooth muscle cell proliferation positive regulation of smooth muscle contraction positive regulation of synaptic plasticity positive regulation of synaptic transmission, glutamatergic positive regulation of transforming growth factor beta production positive regulation of vasoconstriction positive regulation vascular endothelial growth factor production prostaglandin biosynthetic process prostaglandin metabolic process prostanoid metabolic process regulation of blood pressure regulation of cell cycle regulation of inflammatory response response to cytokine stimulus response to drug response to estradiol stimulus response to fructose stimulus response to glucocorticoid stimulus response to lipopolysaccharide response to manganese ion response to organic cyclic compound response to organic nitrogen response to oxidative stress response to vitamin D xenobiotic metabolic process less... cellular_component caveola cytoplasm endoplasmic reticulum endoplasmic reticulum lumen more... endoplasmic reticulum membrane membrane microsome neuron projection nucleus protein complex less... molecular_function enzyme binding heme binding lipid binding metal ion binding more... oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen peroxidase activity prostaglandin-endoperoxide synthase activity less... LRRC17 2 BP    MF    CC biological_process bone marrow development negative regulation of osteoclast differentiation osteoblast differentiation osteoblast proliferation more... cellular_component extracellular region extracellular space molecular_function KCNK13 2 BP    MF    CC biological_process ion transport potassium ion transmembrane transport potassium ion transport synaptic transmission more... cellular_component integral to membrane plasma membrane molecular_function potassium channel activity voltage-gated ion channel activity ZNF589 2 BP    MF    CC biological_process regulation of transcription, DNA-dependent cellular_component intracellular nucleus molecular_function DNA binding metal ion binding nucleic acid binding zinc ion binding more... SULT1E1 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid metabolic process sulfation xenobiotic metabolic process more... cellular_component cytoplasm cytosol nuclear membrane nucleus more... molecular_function estrone sulfotransferase activity flavonol 3-sulfotransferase activity steroid binding steroid sulfotransferase activity more... transferase activity less... DAAM2 2 BP    MF    CC biological_process actin cytoskeleton organization cellular component organization cellular_component molecular_function Rho GTPase binding actin binding binding LRP4 2 BP    MF    CC biological_process anatomical structure development dorsal/ventral pattern formation embryonic digit morphogenesis endocytosis more... hair follicle development kidney development negative regulation of canonical Wnt receptor signaling pathway odontogenesis of dentine-containing tooth protein localization proximal/distal pattern formation receptor clustering synaptic growth at neuromuscular junction less... cellular_component cellular_component integral to membrane membrane plasma membrane more... molecular_function calcium ion binding receptor activity DIO2 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process hormone biosynthetic process selenocysteine incorporation thyroid hormone generation more... thyroid hormone metabolic process less... cellular_component integral to membrane membrane plasma membrane molecular_function selenium binding thyroxine 5'-deiodinase activity ubiquitin protein ligase binding TRAK1 2 BP    MF    CC biological_process endosome to lysosome transport protein O-linked glycosylation protein targeting regulation of transcription from RNA polymerase II promoter more... cellular_component cytoplasm early endosome mitochondrion nucleus more... molecular_function protein binding ENDOG 2 BP    MF    CC biological_process DNA fragmentation involved in apoptotic nuclear change in utero embryonic development positive regulation of apoptosis response to antibiotic more... response to tumor necrosis factor less... cellular_component mitochondrion molecular_function endonuclease activity hydrolase activity metal ion binding nucleic acid binding more... FAM174B 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function SLMO2 2 BP    MF    CC biological_process cellular_component mitochondrion molecular_function RMI1 2 BP    MF    CC biological_process DNA replication cellular_component nucleus molecular_function protein binding TPPP3 2 BP    MF    CC biological_process microtubule bundle formation cellular_component cytoplasm cytoskeleton microtubule molecular_function calcium ion binding tubulin binding PION 2 BP    MF    CC biological_process beta-amyloid formation regulation of proteolysis cellular_component Golgi apparatus trans-Golgi network molecular_function beta-amyloid binding NEBL 2 BP    MF    CC biological_process regulation of actin filament length cellular_component molecular_function actin binding protein binding structural constituent of muscle ACP6 2 BP    MF    CC biological_process lipid metabolic process cellular_component extracellular region mitochondrion molecular_function acid phosphatase activity hydrolase activity PECI 2 BP    MF    CC biological_process cellular_component molecular_function PTGS1 2 BP    MF    CC biological_process aging cyclooxygenase pathway fatty acid biosynthetic process lipid metabolic process more... negative regulation of epinephrine secretion negative regulation of norepinephrine secretion oxidation-reduction process positive regulation of smooth muscle contraction positive regulation of vasoconstriction prostaglandin biosynthetic process prostanoid metabolic process regulation of blood pressure regulation of cell proliferation response to corticosterone stimulus response to organic nitrogen response to oxidative stress xenobiotic metabolic process less... cellular_component Golgi apparatus cytoplasm cytoplasmic part endoplasmic reticulum more... endoplasmic reticulum membrane intracellular membrane-bounded organelle microsome nuclear envelope nucleus photoreceptor outer segment plasma membrane less... molecular_function heme binding lipid binding metal ion binding oxidoreductase activity more... oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen peroxidase activity prostaglandin-endoperoxide synthase activity less... GREM2 2 BP    MF    CC biological_process BMP signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity SLC7A4 2 BP    MF    CC biological_process basic amino acid transport cellular amino acid metabolic process transport cellular_component integral to membrane membrane molecular_function amino acid transmembrane transporter activity basic amino acid transmembrane transporter activity SOX17 2 BP    MF    CC biological_process angiogenesis cardiac cell fate determination cardiogenic plate morphogenesis embryonic foregut morphogenesis more... embryonic heart tube development embryonic heart tube morphogenesis endocardial cell differentiation endocardium formation endoderm formation endodermal digestive tract morphogenesis heart formation heart looping negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell growth negative regulation of mesodermal cell fate specification negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis positive regulation of cell differentiation positive regulation of protein catabolic process positive regulation of skeletal muscle tissue development positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent protein destabilization protein stabilization regulation of embryonic development regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification regulation of transcription, DNA-dependent renal system development signal transduction involved in regulation of gene expression spermatogenesis vasculogenesis less... cellular_component nucleus transcription factor complex molecular_function beta-catenin binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity sequence-specific distal enhancer binding RNA polymerase II transcription factor activity more... transcription coactivator activity transcription factor binding transcription regulatory region DNA binding less... SPAG4 2 BP    MF    CC biological_process spermatogenesis cellular_component cilium cytoplasm cytoskeleton flagellar axoneme more... flagellum integral to membrane membrane microtubule less... molecular_function identical protein binding structural molecule activity SLC25A1 2 BP    MF    CC biological_process carbohydrate metabolic process cellular lipid metabolic process gluconeogenesis glucose metabolic process more... long-chain fatty-acyl-CoA biosynthetic process mitochondrial citrate transport transmembrane transport transport triglyceride biosynthetic process less... cellular_component integral to membrane membrane mitochondrial inner membrane mitochondrion more... molecular_function binding citrate transmembrane transporter activity	Down-regulated Genes Score GO annotation DKK1 6 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... STAR 4 BP    MF    CC biological_process C21-steroid hormone biosynthetic process cellular lipid metabolic process glucocorticoid metabolic process lipid transport more... regulation of steroid biosynthetic process steroid biosynthetic process steroid metabolic process transport less... cellular_component mitochondrial intermembrane space mitochondrion molecular_function cholesterol binding cholesterol transporter activity lipid binding CXCL13 4 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... TIMP3 4 BP    MF    CC biological_process aging central nervous system development negative regulation of membrane protein ectodomain proteolysis negative regulation of proteolysis more... response to amino acid stimulus response to estrogen stimulus response to folic acid response to hormone stimulus response to mechanical stimulus response to organic cyclic compound response to stimulus tissue regeneration visual perception less... cellular_component basement membrane cytoplasm extracellular matrix extracellular region more... molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... COX7A1 2 BP    MF    CC biological_process generation of precursor metabolites and energy cellular_component integral to membrane membrane mitochondrial respiratory chain mitochondrion more... molecular_function cytochrome-c oxidase activity electron carrier activity NDRG2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development negative regulation of ERK1 and ERK2 cascade negative regulation of cytokine production more... negative regulation of smooth muscle cell proliferation nervous system development regulation of platelet-derived growth factor production regulation of vascular endothelial growth factor production signal transduction less... cellular_component Golgi apparatus centrosome cytoplasm cytosol more... nucleolus nucleus perinuclear region of cytoplasm less... molecular_function molecular_function protein binding ID4 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cellular protein localization central nervous system myelination more... cerebral cortex neuron differentiation hippocampus development negative regulation of astrocyte differentiation negative regulation of fat cell differentiation negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent neuroblast proliferation positive regulation of cell proliferation positive regulation of osteoblast differentiation regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm nucleus molecular_function RNA polymerase II transcription factor binding protein binding transcription corepressor activity EMP1 2 BP    MF    CC biological_process cell growth cell proliferation epidermis development multicellular organismal development more... cellular_component integral to membrane membrane membrane fraction plasma membrane more... molecular_function F3 2 BP    MF    CC biological_process activation of blood coagulation via clotting cascade activation of caspase activity activation of plasma proteins involved in acute inflammatory response aging more... anti-apoptosis blood coagulation blood coagulation, extrinsic pathway cellular response to hydrogen peroxide positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration response to estradiol stimulus response to fluid shear stress response to lipopolysaccharide response to low-density lipoprotein particle stimulus response to mechanical stimulus response to temperature stimulus response to wounding less... cellular_component cell surface cytoplasm extracellular matrix extracellular space more... integral to membrane intrinsic to external side of plasma membrane plasma membrane less... molecular_function cell surface binding phospholipid binding protease binding protein binding more... ALDH1A3 2 BP    MF    CC biological_process embryonic camera-type eye development embryonic eye morphogenesis face development kidney development more... nucleus accumbens development olfactory pit development optic cup morphogenesis involved in camera-type eye development pituitary gland development positive regulation of apoptosis response to drug retinal metabolic process retinoic acid biosynthetic process retinoic acid metabolic process less... cellular_component cytoplasm molecular_function NAD+ binding aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity more... oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor protein homodimerization activity thyroid hormone binding less... SLC16A7 2 BP    MF    CC biological_process organic anion transport pyruvate transport transmembrane transport cellular_component integral to membrane integral to plasma membrane membrane fraction plasma membrane more... molecular_function pyruvate secondary active transmembrane transporter activity secondary active monocarboxylate transmembrane transporter activity symporter activity KHDRBS3 2 BP    MF    CC biological_process mRNA processing positive regulation of RNA splicing regulation of transcription, DNA-dependent spermatogenesis more... cellular_component nucleolus nucleus molecular_function RNA binding SH3 domain binding protein binding single-stranded RNA binding more... GGCT 2 BP    MF    CC biological_process glutathione biosynthetic process release of cytochrome c from mitochondria xenobiotic metabolic process cellular_component cytosol molecular_function gamma-glutamylcyclotransferase activity protein homodimerization activity transferase activity, transferring acyl groups COL15A1 2 BP    MF    CC biological_process angiogenesis cell adhesion cell differentiation multicellular organismal development more... signal transduction less... cellular_component basement membrane collagen type XV extracellular matrix extracellular region more... extracellular space integral to membrane less... molecular_function binding extracellular matrix structural constituent structural molecule activity NUDT9 2 BP    MF    CC biological_process ADP catabolic process IDP catabolic process cellular_component intracellular mitochondrion molecular_function ADP-ribose diphosphatase activity ADP-sugar diphosphatase activity adenosine-diphosphatase activity hydrolase activity more... IGFBP4 2 BP    MF    CC biological_process DNA metabolic process cell proliferation inflammatory response regulation of cell growth more... signal transduction skeletal system development less... cellular_component extracellular region extracellular space molecular_function insulin-like growth factor binding TGFBR2 2 BP    MF    CC biological_process activation of protein kinase activity apoptosis blood vessel development brain development more... embryonic cranial skeleton morphogenesis embryonic hemopoiesis heart development myeloid dendritic cell differentiation palate development pathway-restricted SMAD protein phosphorylation patterning of blood vessels peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of B cell tolerance induction positive regulation of NK T cell differentiation positive regulation of T cell tolerance induction positive regulation of cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of reactive oxygen species metabolic process positive regulation of tolerance induction to self antigen protein phosphorylation regulation of cell proliferation regulation of growth response to cholesterol response to drug transforming growth factor beta receptor signaling pathway vasculogenesis less... cellular_component caveola external side of plasma membrane integral to membrane membrane more... plasma membrane receptor complex transforming growth factor beta receptor complex less... molecular_function ATP binding SMAD binding glycosaminoglycan binding metal ion binding more... nucleotide binding protein binding protein serine/threonine kinase activity receptor activity receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups transforming growth factor beta binding transforming growth factor beta receptor activity, type II transforming growth factor beta-activated receptor activity transmembrane receptor protein serine/threonine kinase activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding less... DYNC1I1 2 BP    MF    CC biological_process transport vesicle transport along microtubule cellular_component chromosome condensed chromosome kinetochore cytoplasm cytoplasmic dynein complex more... cytoskeleton kinetochore microtubule perinuclear region of cytoplasm spindle pole vesicle less... molecular_function microtubule binding microtubule motor activity motor activity protein binding more... HOXC6 2 BP    MF    CC biological_process multicellular organismal development regulation of transcription from RNA polymerase II promoter cellular_component nucleus molecular_function DNA binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription corepressor activity more... IFITM1 2 BP    MF    CC biological_process cell surface receptor linked signaling pathway cytokine-mediated signaling pathway innate immune response negative regulation of cell proliferation more... regulation of immune response response to biotic stimulus response to virus type I interferon-mediated signaling pathway less... cellular_component integral to membrane plasma membrane molecular_function receptor signaling protein activity TIMP1 2 BP    MF    CC biological_process aging blood coagulation cell activation erythrocyte maturation more... negative regulation of apoptosis negative regulation of membrane protein ectodomain proteolysis platelet activation platelet degranulation positive regulation of cell proliferation response to cytokine stimulus response to peptide hormone stimulus wound healing less... cellular_component basement membrane extracellular region platelet alpha granule lumen molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... CCL8 2 BP    MF    CC biological_process calcium ion transport cell-cell signaling chemotaxis exocytosis more... immune response inflammatory response response to virus signal transduction less... cellular_component extracellular region extracellular space molecular_function chemokine activity heparin binding signal transducer activity APOE 2 BP    MF    CC biological_process Cdc42 protein signal transduction G-protein coupled receptor protein signaling pathway aging anti-apoptosis more... artery morphogenesis cGMP-mediated signaling cardiovascular system development cell death cellular calcium ion homeostasis cellular response to growth factor stimulus cholesterol catabolic process cholesterol efflux cholesterol homeostasis cholesterol metabolic process chylomicron remnant clearance cytoskeleton organization high-density lipoprotein particle assembly high-density lipoprotein particle clearance high-density lipoprotein particle remodeling induction of apoptosis intracellular transport lipid homeostasis lipid metabolic process lipoprotein biosynthetic process lipoprotein catabolic process lipoprotein metabolic process low-density lipoprotein particle remodeling maintenance of location in cell negative regulation of MAP kinase activity negative regulation of blood coagulation negative regulation of blood vessel endothelial cell migration negative regulation of cholesterol biosynthetic process negative regulation of endothelial cell proliferation negative regulation of inflammatory response negative regulation of platelet activation nitric oxide mediated signal transduction peripheral nervous system axon regeneration phospholipid efflux positive regulation of cGMP biosynthetic process positive regulation of cholesterol efflux positive regulation of cholesterol esterification positive regulation of low-density lipoprotein particle receptor catabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of nitric-oxide synthase activity receptor-mediated endocytosis regulation of axon extension regulation of gene expression regulation of neuronal synaptic plasticity response to dietary excess response to ethanol response to oxidative stress response to reactive oxygen species reverse cholesterol transport synaptic transmission, cholinergic triglyceride metabolic process vasodilation very-low-density lipoprotein particle clearance very-low-density lipoprotein particle remodeling less... cellular_component Golgi apparatus chylomicron cytoplasm dendrite more... early endosome extracellular region extracellular space extrinsic to external side of plasma membrane high-density lipoprotein particle intermediate-density lipoprotein particle late endosome low-density lipoprotein particle microtubule neuronal cell body plasma membrane very-low-density lipoprotein particle less... molecular_function antioxidant activity beta-amyloid binding cholesterol transporter activity heparin binding more... identical protein binding lipid binding lipid transporter activity lipoprotein particle binding low-density lipoprotein particle receptor binding metal chelating activity phosphatidylcholine-sterol O-acyltransferase activator activity phospholipid binding protein binding protein heterodimerization activity protein homodimerization activity tau protein binding very-low-density lipoprotein particle receptor binding less... CTSW 2 BP    MF    CC biological_process immune response proteolysis cellular_component molecular_function cysteine-type endopeptidase activity cysteine-type peptidase activity peptidase activity CREG1 2 BP    MF    CC biological_process cell proliferation multicellular organismal development regulation of growth regulation of transcription from RNA polymerase II promoter more... cellular_component extracellular region transcription factor complex molecular_function FMN binding oxidoreductase activity transcription corepressor activity transcription factor binding more... ANXA4 2 BP    MF    CC biological_process anti-apoptosis negative regulation of coagulation signal transduction cellular_component cytoplasm molecular_function calcium ion binding calcium-dependent phospholipid binding phospholipase inhibitor activity ANGPTL1 2 BP    MF    CC biological_process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cellular_component extracellular region extracellular space molecular_function receptor binding ISG15 2 BP    MF    CC biological_process ISG15-protein conjugation cell-cell signaling cytokine-mediated signaling pathway innate immune response more... interspecies interaction between organisms modification-dependent protein catabolic process negative regulation of type I interferon production response to virus type I interferon-mediated signaling pathway less... cellular_component cytoplasm cytosol extracellular region extracellular space more... molecular_function protein tag VCAN 2 BP    MF    CC biological_process axon regeneration cell adhesion cell recognition glial cell migration more... heart development multicellular organismal development response to wounding less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function binding calcium ion binding glycosaminoglycan binding hyaluronic acid binding more... sugar binding less... IGFBP5 2 BP    MF    CC biological_process cellular response to cAMP cellular response to organic cyclic compound glucose homeostasis glucose metabolic process more... hair follicle morphogenesis intracellular signal transduction mammary gland involution negative regulation of cell migration negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of smooth muscle cell migration negative regulation of smooth muscle cell proliferation negative regulation of translation osteoblast differentiation positive regulation of protein kinase B signaling cascade regulation of cell growth signal transduction skeletal muscle tissue growth striated muscle cell differentiation less... cellular_component extracellular region insulin-like growth factor binding protein complex molecular_function fibronectin binding insulin-like growth factor I binding insulin-like growth factor binding protein binding more... CEBPG 2 BP    MF    CC biological_process B cell differentiation enucleate erythrocyte differentiation immune response liver development more... mRNA metabolic process natural killer cell mediated cytotoxicity negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of DNA binding positive regulation of DNA repair positive regulation of interferon-gamma biosynthetic process positive regulation of sequence-specific DNA binding transcription factor activity regulation of transcription from RNA polymerase II promoter less... cellular_component nucleolus nucleus molecular_function DNA binding double-stranded DNA binding protein binding protein heterodimerization activity more... sequence-specific DNA binding transcription factor binding less... IFITM2 2 BP    MF    CC biological_process cytokine-mediated signaling pathway immune response innate immune response response to biotic stimulus more... response to virus type I interferon-mediated signaling pathway less... cellular_component integral to membrane membrane plasma membrane molecular_function PAPSS2 2 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process skeletal system development sulfate assimilation more... xenobiotic metabolic process less... cellular_component cytosol molecular_function ATP binding adenylylsulfate kinase activity kinase activity nucleotide binding more... nucleotidyltransferase activity sulfate adenylyltransferase (ATP) activity less... IL15 2 BP    MF    CC biological_process NK T cell proliferation aging cell-cell signaling cellular response to vitamin D more... extrathymic T cell selection hyaluronan metabolic process immune response lymph node development negative regulation of smooth muscle cell proliferation positive regulation of T cell proliferation positive regulation of cell proliferation positive regulation of immune response positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of natural killer cell proliferation positive regulation of tissue remodeling positive regulation of tyrosine phosphorylation of Stat3 protein regulation of T cell differentiation regulation of defense response to virus by host response to nutrient levels signal transduction skeletal muscle atrophy less... cellular_component Golgi apparatus cytoplasm endosome extracellular region more... extracellular space integral to plasma membrane membrane fraction nucleus less... molecular_function cytokine activity cytokine receptor binding protein binding signal transducer activity more... ANK3 2 BP    MF    CC biological_process establishment of protein localization signal transduction cellular_component basolateral plasma membrane cytoplasm cytoskeleton molecular_function protein binding PKP2 2 BP    MF    CC biological_process cell-cell adhesion heart development cellular_component adherens junction cell-cell junction desmosome integral to membrane more... nucleus plasma membrane less... molecular_function binding molecular_function IER3 2 BP    MF    CC biological_process anatomical structure morphogenesis anti-apoptosis apoptosis cellular_component integral to membrane membrane molecular_function protein binding BCL3 2 BP    MF    CC biological_process DNA damage response, signal transduction by p53 class mediator DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis I-kappaB kinase/NF-kappaB cascade T-helper 1 type immune response more... T-helper 2 cell differentiation antimicrobial humoral response defense response to bacterium defense response to protozoan extracellular matrix organization follicular dendritic cell differentiation germinal center formation humoral immune response mediated by circulating immunoglobulin maintenance of protein location in nucleus marginal zone B cell differentiation negative regulation of apoptosis negative regulation of interleukin-8 biosynthetic process negative regulation of transcription, DNA-dependent negative regulation of tumor necrosis factor biosynthetic process positive regulation of interferon-gamma production positive regulation of interleukin-10 biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent positive regulation of translation protein import into nucleus, translocation regulation of DNA binding regulation of NF-kappaB import into nucleus regulation of apoptosis response to DNA damage stimulus response to UV-C response to virus spleen development transcription, DNA-dependent less... cellular_component Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex cytoplasm nucleus more... perinuclear region of cytoplasm protein complex less... molecular_function protein binding protein binding, bridging sequence-specific DNA binding transcription factor activity transcription factor binding more... S100A4 2 BP    MF    CC biological_process epithelial to mesenchymal transition positive regulation of I-kappaB kinase/NF-kappaB cascade cellular_component neuron projection nucleus perinuclear region of cytoplasm molecular_function RAGE receptor binding calcium ion binding calcium-dependent protein binding identical protein binding more... protein binding less... PART1 2 BP    MF    CC biological_process cellular_component molecular_function CD14 2 BP    MF    CC biological_process Toll signaling pathway apoptosis cell surface receptor linked signaling pathway cellular response to lipopolysaccharide more... cellular response to lipoteichoic acid inflammatory response innate immune response phagocytosis positive regulation of cytokine secretion positive regulation of tumor necrosis factor production response to heat response to lipopolysaccharide less... cellular_component anchored to membrane cell surface extracellular region extracellular space more... membrane raft plasma membrane less... molecular_function lipopolysaccharide binding lipoteichoic acid binding opsonin receptor activity peptidoglycan receptor activity more... CADM1 2 BP    MF    CC biological_process T cell mediated cytotoxicity activated T cell proliferation adherens junction organization apoptosis more... brain development calcium-independent cell-cell adhesion cell adhesion cell differentiation cell junction assembly cell recognition cell-cell junction organization detection of stimulus heterophilic cell-cell adhesion homophilic cell adhesion liver development multicellular organismal development positive regulation of cytokine secretion positive regulation of natural killer cell mediated cytotoxicity spermatogenesis susceptibility to natural killer cell mediated cytotoxicity synapse assembly unidimensional cell growth less... cellular_component axon basolateral plasma membrane cell-cell junction dendrite more... integral to membrane membrane plasma membrane synapse synaptic vesicle synaptosome less... molecular_function PDZ domain binding cell adhesion molecule binding protein C-terminus binding protein homodimerization activity more... receptor binding less... SERPINA3 2 BP    MF    CC biological_process acute-phase response inflammatory response maintenance of gastrointestinal epithelium negative regulation of endopeptidase activity more... regulation of lipid metabolic process regulation of proteolysis less... cellular_component extracellular region intracellular nucleus molecular_function DNA binding peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity more... IGFBP6 2 BP    MF    CC biological_process negative regulation of cell proliferation regulation of cell growth signal transduction cellular_component Golgi apparatus cytoplasm extracellular region extracellular space more... molecular_function insulin-like growth factor I binding insulin-like growth factor binding IFI35 2 BP    MF    CC biological_process cytokine-mediated signaling pathway immune response response to virus type I interferon-mediated signaling pathway more... cellular_component cytosol nucleus molecular_function protein binding CYP4B1 2 BP    MF    CC biological_process biphenyl metabolic process cellular aromatic compound metabolic process exogenous drug catabolic process fluorene metabolic process more... oxidation-reduction process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function aromatase activity drug binding electron carrier activity fluorene oxygenase activity more... heme binding metal ion binding monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxygen binding less... GREB1 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function FIG4 2 BP    MF    CC biological_process cell death locomotory behavior neuron development phosphatidylinositol metabolic process more... pigmentation positive regulation of neuron projection development vacuole organization less... cellular_component Golgi apparatus endoplasmic reticulum endosome membrane membrane more... recycling endosome less... molecular_function hydrolase activity phosphoric ester hydrolase activity polyphosphatidylinositol phosphatase activity protein binding more... S100A6 2 BP    MF    CC biological_process axonogenesis positive regulation of fibroblast proliferation signal transduction cellular_component cytoplasm cytosol extrinsic to internal side of plasma membrane nuclear envelope more... nucleus perinuclear region of cytoplasm plasma membrane ruffle less... molecular_function S100 beta binding calcium ion binding calcium-dependent protein binding ion transmembrane transporter activity more... protein binding protein homodimerization activity tropomyosin binding less... PDE4DIP 2 BP    MF    CC biological_process cellular protein complex assembly cellular_component Golgi apparatus centrosome cytoplasm cytoskeleton more... myofibril nucleus less... molecular_function enzyme binding protein binding IFITM3 2 BP    MF    CC biological_process cytokine-mediated signaling pathway immune response innate immune response response to biotic stimulus more... response to virus type I interferon-mediated signaling pathway less... cellular_component integral to membrane membrane plasma membrane molecular_function THY1 2 BP    MF    CC biological_process T cell receptor signaling pathway angiogenesis cell-cell adhesion cytoskeleton organization more... focal adhesion assembly negative regulation of T cell receptor signaling pathway negative regulation of axonogenesis negative regulation of cell migration negative regulation of protein kinase activity positive regulation of GTPase activity positive regulation of Rho GTPase activity positive regulation of T cell activation positive regulation of release of sequestered calcium ion into cytosol retinal cone cell development less... cellular_component anchored to external side of plasma membrane cytosol dendrite endoplasmic reticulum more... external side of plasma membrane growth cone integral to plasma membrane membrane raft plasma membrane less... molecular_function GPI anchor binding Rho GTPase activator activity enzyme binding integrin binding more... protein binding protein kinase binding less... PTGDS 2 BP    MF    CC biological_process fatty acid biosynthetic process lipid metabolic process prostaglandin biosynthetic process regulation of circadian sleep/wake cycle, sleep more... response to glucocorticoid stimulus transport less... cellular_component Golgi apparatus cytoplasm extracellular region extracellular space more... membrane nuclear membrane nucleus perinuclear region of cytoplasm rough endoplasmic reticulum less... molecular_function binding fatty acid binding isomerase activity prostaglandin-D synthase activity more... retinoid binding transporter activity less... IGF2 2 BP    MF    CC biological_process carbohydrate metabolic process exocrine pancreas development glucose metabolic process insulin receptor signaling pathway more... multicellular organismal development organ morphogenesis ossification osteoblast differentiation positive regulation of MAPKKK cascade positive regulation of activated T cell proliferation positive regulation of catalytic activity positive regulation of cell division positive regulation of cell proliferation positive regulation of glycogen (starch) synthase activity positive regulation of glycogen biosynthetic process positive regulation of insulin receptor signaling pathway positive regulation of mitosis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase B signaling cascade positive regulation of protein phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of receptor activity positive regulation of steroid hormone biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of gene expression by genetic imprinting regulation of transcription, DNA-dependent response to drug response to estradiol stimulus response to nicotine response to nutrient levels response to radiation skeletal system development striated muscle cell differentiation less... cellular_component extracellular region extracellular space molecular_function growth factor activity hormone activity insulin receptor binding insulin-like growth factor receptor binding more... protein binding protein serine/threonine kinase activator activity receptor activator activity less...
Up-regulated Genes Score TSC22D3 2 C5orf13 2 PLOD1 2 ENAH 2 EPB41L2 2 BARD1 2 PAPOLA 2 ACPP 2 PCDH7 2 HEY2 2 BTG3 2 ECM1 2 CST1 2 RABGAP1L 2 IGF1 2 GSTM3 2 NUP153 2 STEAP4 2 PELI1 2 ST7 2 CD36 2 KYNU 2 SEMA3C 2 GALNT10 2 EDN3 2 NEDD9 2 STXBP6 2 PYY 2 SCD 2 ANO1 2 DDIT4 2 SLC16A6 2 CACNA1D 2 PIKFYVE 2 MOXD1 2 PPPDE1 2 EPHB3 2 DHRS7 2 CDC25A 2 ACSL3 2 VLDLR 2 PAGE4 2 PLCB1 2 PCTP 2 BEX4 2 DKK2 2 OPRK1 2 CBARA1 2 MATN2 2 HK2 2 SQLE 2 NR4A2 2 KRT18 2 ESR1 2 ACSM3 2 RGS4 2 MAGED1 2 MORC4 2 CKMT2 2 ST3GAL6 2 KMO 2 TMEFF1 2 ATAD4 2 HIBCH 2 LOXL1 2 ATP6V0E2 2 BAG5 2 TM4SF1 2 PRAME 2 GPM6B 2 CEL 2 TMEM144 2 WDR77 2 TPD52 2 DUSP4 2 MSX2 2 PTGS2 2 LRRC17 2 KCNK13 2 ZNF589 2 SULT1E1 2 DAAM2 2 LRP4 2 DIO2 2 TRAK1 2 ENDOG 2 FAM174B 2 SLMO2 2 RMI1 2 TPPP3 2 PION 2 NEBL 2 ACP6 2 PECI 2 PTGS1 2 GREM2 2 SLC7A4 2 SOX17 2 SPAG4 2 SLC25A1 2 PCSK6 2 MSX1 2 HMGN5 2 KCNJ2 2 RASSF2 2 AKR1C3 2 FBXO21 2 SFRP4 2 STX18 2 PGRMC1 2 DHFR 2 FZD5 2 HLA-DOB 2 PIP5K1B 2	Down-regulated Genes Score DKK1 6 STAR 4 CXCL13 4 TIMP3 4 COX7A1 2 NDRG2 2 ID4 2 EMP1 2 F3 2 ALDH1A3 2 SLC16A7 2 KHDRBS3 2 GGCT 2 COL15A1 2 NUDT9 2 IGFBP4 2 TGFBR2 2 DYNC1I1 2 HOXC6 2 IFITM1 2 TIMP1 2 CCL8 2 APOE 2 CTSW 2 CREG1 2 ANXA4 2 ANGPTL1 2 ISG15 2 VCAN 2 IGFBP5 2 CEBPG 2 IFITM2 2 PAPSS2 2 IL15 2 ANK3 2 PKP2 2 IER3 2 BCL3 2 S100A4 2 PART1 2 CD14 2 CADM1 2 SERPINA3 2 IGFBP6 2 IFI35 2 CYP4B1 2 GREB1 2 FIG4 2 S100A6 2 PDE4DIP 2 IFITM3 2 THY1 2 PTGDS 2 IGF2 2
Identifiers Repository Data-sets 19955106 PubMed 1 18497344 PubMed 3 18191855 PubMed 1 18697870 PubMed 2
Up-regulated(114) Down-regulated(54)