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Species Homo sapiens Tissue uterus;;Endometrium;;Proliferative (Follicular) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
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Up-regulated Genes Score GO annotation TEK 2 BP    MF    CC biological_process angiogenesis blood coagulation cell-cell signaling leukocyte migration more... positive regulation of ERK1 and ERK2 cascade positive regulation of protein kinase B signaling cascade protein oligomerization protein phosphorylation signal transduction transmembrane receptor protein tyrosine kinase signaling pathway less... cellular_component apical plasma membrane basolateral plasma membrane cell surface integral to membrane more... integral to plasma membrane membrane membrane raft microvillus plasma membrane less... molecular_function ATP binding nucleotide binding protein binding protein kinase activity more... protein tyrosine kinase activity receptor activity transmembrane receptor protein tyrosine kinase activity less... CTSF 2 BP    MF    CC biological_process proteolysis cellular_component lysosome molecular_function cysteine-type endopeptidase activity cysteine-type peptidase activity peptidase activity EPB41L2 2 BP    MF    CC biological_process cortical actin cytoskeleton organization cellular_component cytoplasm cytoskeleton extrinsic to membrane plasma membrane more... signalosome spectrin less... molecular_function PH domain binding actin binding binding cytoskeletal protein binding more... spectrin binding structural molecule activity less... CCNB1 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell cycle checkpoint more... cell division cellular response to fatty acid cellular response to hypoxia cellular response to iron(III) ion cellular response to organic cyclic compound digestive tract development in utero embryonic development mitotic cell cycle mitotic cell cycle spindle checkpoint mitotic metaphase plate congression mitotic prometaphase mitotic spindle stabilization negative regulation of gene expression negative regulation of protein phosphorylation oocyte maturation positive regulation of attachment of spindle microtubules to kinetochore positive regulation of cardiac muscle cell proliferation positive regulation of histone phosphorylation positive regulation of mRNA 3'-end processing positive regulation of mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle protein complex assembly regulation of chromosome condensation regulation of cyclin-dependent protein kinase activity regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle response to DDT response to drug response to mechanical stimulus response to toxin spermatogenesis tissue regeneration ventricular cardiac muscle cell development less... cellular_component condensed nuclear chromosome outer kinetochore cytoplasm cytoskeleton cytosol more... membrane fraction microtubule organizing center nucleoplasm nucleus soluble fraction spindle pole less... molecular_function histone kinase activity kinase activity protein binding protein kinase binding more... CETN2 2 BP    MF    CC biological_process G2/M transition of mitotic cell cycle cell division centriole replication mitosis more... mitotic cell cycle nucleotide-excision repair regulation of cytokinesis spermatogenesis less... cellular_component XPC complex centriole centrosome cytoplasm more... cytoskeleton cytosol intracellular microtubule basal body nucleus photoreceptor connecting cilium less... molecular_function ATP binding ATP-dependent helicase activity G-protein beta/gamma-subunit complex binding calcium ion binding more... nucleic acid binding protein binding less... CTGF 2 BP    MF    CC biological_process DNA replication cell adhesion cellular lipid metabolic process cytosolic calcium ion transport more... epidermis development extracellular matrix constituent secretion intracellular signal transduction lung development organ senescence positive regulation of G0 to G1 transition positive regulation of cardiac muscle contraction positive regulation of caspase activity positive regulation of cell activation positive regulation of cell death positive regulation of cell proliferation positive regulation of collagen biosynthetic process positive regulation of gene expression positive regulation of protein phosphorylation regulation of cell growth response to amino acid stimulus response to anoxia response to estradiol stimulus response to fatty acid response to glucose stimulus response to mineralocorticoid stimulus response to organic cyclic compound response to peptide hormone stimulus response to wounding less... cellular_component cell cortex cis-Golgi network cytosol extracellular region more... extracellular space perinuclear region of cytoplasm plasma membrane proteinaceous extracellular matrix less... molecular_function fibronectin binding growth factor activity heparin binding insulin-like growth factor binding more... MRE11A 2 BP    MF    CC biological_process DNA duplex unwinding DNA metabolic process DNA recombination DNA repair more... cell cycle checkpoint cell proliferation chromosome organization double-strand break repair double-strand break repair via homologous recombination double-strand break repair via nonhomologous end joining heart development meiosis negative regulation of DNA endoreduplication positive regulation of kinase activity positive regulation of protein autophosphorylation reciprocal meiotic recombination regulation of mitotic recombination response to DNA damage stimulus sister chromatid cohesion synapsis telomere maintenance via telomerase less... cellular_component Mre11 complex chromosome, telomeric region condensed nuclear chromosome nuclear chromatin more... nucleolus nucleoplasm nucleus perinuclear region of cytoplasm less... molecular_function 3'-5' exonuclease activity ATP-dependent DNA helicase activity DNA binding double-stranded DNA binding more... endodeoxyribonuclease activity endonuclease activity exonuclease activity hydrolase activity manganese ion binding nuclease activity protein C-terminus binding protein binding single-stranded DNA specific endodeoxyribonuclease activity less... ZNF238 2 BP    MF    CC biological_process multicellular organismal development negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent skeletal muscle tissue development more... transcription, DNA-dependent less... cellular_component intracellular nuclear chromosome nucleus molecular_function DNA binding metal ion binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity more... zinc ion binding less... CPE 2 BP    MF    CC biological_process cardiac left ventricle morphogenesis insulin processing metabolic process neuropeptide signaling pathway more... protein localization in membrane protein modification process proteolysis less... cellular_component Golgi apparatus extracellular region nucleus plasma membrane more... stored secretory granule less... molecular_function carboxypeptidase activity cell adhesion molecule binding metal ion binding metallocarboxypeptidase activity more... metallopeptidase activity neurexin family protein binding peptidase activity zinc ion binding less... LAMP2 2 BP    MF    CC biological_process blood coagulation platelet activation platelet degranulation cellular_component endosome endosome membrane integral to membrane late endosome more... lysosomal membrane lysosome membrane membrane fraction plasma membrane platelet dense granule membrane less... molecular_function	Down-regulated Genes Score GO annotation IL15 14 BP    MF    CC biological_process NK T cell proliferation aging cell-cell signaling cellular response to vitamin D more... extrathymic T cell selection hyaluronan metabolic process immune response lymph node development negative regulation of smooth muscle cell proliferation positive regulation of T cell proliferation positive regulation of cell proliferation positive regulation of immune response positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of natural killer cell proliferation positive regulation of tissue remodeling positive regulation of tyrosine phosphorylation of Stat3 protein regulation of T cell differentiation regulation of defense response to virus by host response to nutrient levels signal transduction skeletal muscle atrophy less... cellular_component Golgi apparatus cytoplasm endosome extracellular region more... extracellular space integral to plasma membrane membrane fraction nucleus less... molecular_function cytokine activity cytokine receptor binding protein binding signal transducer activity more... CD55 12 BP    MF    CC biological_process complement activation, classical pathway elevation of cytosolic calcium ion concentration innate immune response respiratory burst more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane raft more... plasma membrane soluble fraction less... molecular_function receptor activity SPP1 10 BP    MF    CC biological_process biomineral tissue development cell adhesion decidualization embryo implantation more... inflammatory response negative regulation of collateral sprouting of intact axon in response to injury ossification osteoblast differentiation positive regulation of bone resorption positive regulation of cell-substrate adhesion response to organic substance response to steroid hormone stimulus response to vitamin D less... cellular_component apical part of cell cell projection cytoplasm extracellular region more... extracellular space membrane-bounded vesicle perinuclear region of cytoplasm less... molecular_function cytokine activity extracellular matrix binding IDO1 6 BP    MF    CC biological_process behavior cellular nitrogen compound metabolic process cytokine production involved in inflammatory response female pregnancy more... inflammatory response kynurenic acid biosynthetic process multicellular organismal response to stress negative regulation of T cell apoptosis negative regulation of activated T cell proliferation negative regulation of interleukin-10 production positive regulation of T cell tolerance induction positive regulation of apoptosis positive regulation of chronic inflammatory response positive regulation of interleukin-12 production positive regulation of type 2 immune response response to lipopolysaccharide tryptophan catabolic process tryptophan catabolic process to kynurenine less... cellular_component cytoplasm cytosol smooth muscle contractile fiber soluble fraction more... stereocilium bundle less... molecular_function amino acid binding electron carrier activity heme binding indoleamine 2,3-dioxygenase activity more... metal ion binding oxidoreductase activity oxygen binding tryptophan 2,3-dioxygenase activity less... KIR2DL3 4 BP    MF    CC biological_process immune response regulation of immune response cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function antigen binding protein binding receptor activity PAEP 4 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity IRF1 4 BP    MF    CC biological_process CD8-positive, alpha-beta T cell differentiation I-kappaB kinase/NF-kappaB cascade blood coagulation cellular response to dsRNA more... cellular response to interleukin-1 cellular response to mechanical stimulus cellular response to peptide hormone stimulus cellular response to retinoic acid cellular response to tumor necrosis factor cytokine-mediated signaling pathway female pregnancy interferon-gamma-mediated signaling pathway negative regulation of tyrosine phosphorylation of Stat1 protein positive regulation of cell death positive regulation of interleukin-12 biosynthetic process positive regulation of transcription from RNA polymerase II promoter response to growth hormone stimulus response to heat transcription from RNA polymerase II promoter type I interferon-mediated signaling pathway less... cellular_component cytosol nucleoplasm nucleus molecular_function regulatory region DNA binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity GNLY 4 BP    MF    CC biological_process cellular defense response defense response to bacterium defense response to fungus killing of cells of other organism more... cellular_component extracellular region extracellular space molecular_function DKK1 4 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... ID4 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cellular protein localization central nervous system myelination more... cerebral cortex neuron differentiation hippocampus development negative regulation of astrocyte differentiation negative regulation of fat cell differentiation negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent neuroblast proliferation positive regulation of cell proliferation positive regulation of osteoblast differentiation regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm nucleus molecular_function RNA polymerase II transcription factor binding protein binding transcription corepressor activity
Up-regulated Genes Score GO annotation TEK 2 BP    MF    CC biological_process angiogenesis blood coagulation cell-cell signaling leukocyte migration more... positive regulation of ERK1 and ERK2 cascade positive regulation of protein kinase B signaling cascade protein oligomerization protein phosphorylation signal transduction transmembrane receptor protein tyrosine kinase signaling pathway less... cellular_component apical plasma membrane basolateral plasma membrane cell surface integral to membrane more... integral to plasma membrane membrane membrane raft microvillus plasma membrane less... molecular_function ATP binding nucleotide binding protein binding protein kinase activity more... protein tyrosine kinase activity receptor activity transmembrane receptor protein tyrosine kinase activity less... CTSF 2 BP    MF    CC biological_process proteolysis cellular_component lysosome molecular_function cysteine-type endopeptidase activity cysteine-type peptidase activity peptidase activity EPB41L2 2 BP    MF    CC biological_process cortical actin cytoskeleton organization cellular_component cytoplasm cytoskeleton extrinsic to membrane plasma membrane more... signalosome spectrin less... molecular_function PH domain binding actin binding binding cytoskeletal protein binding more... spectrin binding structural molecule activity less... CCNB1 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell cycle checkpoint more... cell division cellular response to fatty acid cellular response to hypoxia cellular response to iron(III) ion cellular response to organic cyclic compound digestive tract development in utero embryonic development mitotic cell cycle mitotic cell cycle spindle checkpoint mitotic metaphase plate congression mitotic prometaphase mitotic spindle stabilization negative regulation of gene expression negative regulation of protein phosphorylation oocyte maturation positive regulation of attachment of spindle microtubules to kinetochore positive regulation of cardiac muscle cell proliferation positive regulation of histone phosphorylation positive regulation of mRNA 3'-end processing positive regulation of mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle protein complex assembly regulation of chromosome condensation regulation of cyclin-dependent protein kinase activity regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle response to DDT response to drug response to mechanical stimulus response to toxin spermatogenesis tissue regeneration ventricular cardiac muscle cell development less... cellular_component condensed nuclear chromosome outer kinetochore cytoplasm cytoskeleton cytosol more... membrane fraction microtubule organizing center nucleoplasm nucleus soluble fraction spindle pole less... molecular_function histone kinase activity kinase activity protein binding protein kinase binding more... CETN2 2 BP    MF    CC biological_process G2/M transition of mitotic cell cycle cell division centriole replication mitosis more... mitotic cell cycle nucleotide-excision repair regulation of cytokinesis spermatogenesis less... cellular_component XPC complex centriole centrosome cytoplasm more... cytoskeleton cytosol intracellular microtubule basal body nucleus photoreceptor connecting cilium less... molecular_function ATP binding ATP-dependent helicase activity G-protein beta/gamma-subunit complex binding calcium ion binding more... nucleic acid binding protein binding less... CTGF 2 BP    MF    CC biological_process DNA replication cell adhesion cellular lipid metabolic process cytosolic calcium ion transport more... epidermis development extracellular matrix constituent secretion intracellular signal transduction lung development organ senescence positive regulation of G0 to G1 transition positive regulation of cardiac muscle contraction positive regulation of caspase activity positive regulation of cell activation positive regulation of cell death positive regulation of cell proliferation positive regulation of collagen biosynthetic process positive regulation of gene expression positive regulation of protein phosphorylation regulation of cell growth response to amino acid stimulus response to anoxia response to estradiol stimulus response to fatty acid response to glucose stimulus response to mineralocorticoid stimulus response to organic cyclic compound response to peptide hormone stimulus response to wounding less... cellular_component cell cortex cis-Golgi network cytosol extracellular region more... extracellular space perinuclear region of cytoplasm plasma membrane proteinaceous extracellular matrix less... molecular_function fibronectin binding growth factor activity heparin binding insulin-like growth factor binding more... MRE11A 2 BP    MF    CC biological_process DNA duplex unwinding DNA metabolic process DNA recombination DNA repair more... cell cycle checkpoint cell proliferation chromosome organization double-strand break repair double-strand break repair via homologous recombination double-strand break repair via nonhomologous end joining heart development meiosis negative regulation of DNA endoreduplication positive regulation of kinase activity positive regulation of protein autophosphorylation reciprocal meiotic recombination regulation of mitotic recombination response to DNA damage stimulus sister chromatid cohesion synapsis telomere maintenance via telomerase less... cellular_component Mre11 complex chromosome, telomeric region condensed nuclear chromosome nuclear chromatin more... nucleolus nucleoplasm nucleus perinuclear region of cytoplasm less... molecular_function 3'-5' exonuclease activity ATP-dependent DNA helicase activity DNA binding double-stranded DNA binding more... endodeoxyribonuclease activity endonuclease activity exonuclease activity hydrolase activity manganese ion binding nuclease activity protein C-terminus binding protein binding single-stranded DNA specific endodeoxyribonuclease activity less... ZNF238 2 BP    MF    CC biological_process multicellular organismal development negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent skeletal muscle tissue development more... transcription, DNA-dependent less... cellular_component intracellular nuclear chromosome nucleus molecular_function DNA binding metal ion binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity more... zinc ion binding less... CPE 2 BP    MF    CC biological_process cardiac left ventricle morphogenesis insulin processing metabolic process neuropeptide signaling pathway more... protein localization in membrane protein modification process proteolysis less... cellular_component Golgi apparatus extracellular region nucleus plasma membrane more... stored secretory granule less... molecular_function carboxypeptidase activity cell adhesion molecule binding metal ion binding metallocarboxypeptidase activity more... metallopeptidase activity neurexin family protein binding peptidase activity zinc ion binding less... LAMP2 2 BP    MF    CC biological_process blood coagulation platelet activation platelet degranulation cellular_component endosome endosome membrane integral to membrane late endosome more... lysosomal membrane lysosome membrane membrane fraction plasma membrane platelet dense granule membrane less... molecular_function SMARCA2 2 BP    MF    CC biological_process chromatin remodeling negative regulation of cell growth negative regulation of cell proliferation negative regulation of transcription from RNA polymerase II promoter more... negative regulation of transcription, DNA-dependent nervous system development positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-dependent less... cellular_component SWI/SNF complex WINAC complex intermediate filament cytoskeleton intracellular membrane-bounded organelle more... nBAF complex npBAF complex nuclear chromatin nucleolus nucleoplasm nucleus less... molecular_function ATP binding DNA binding DNA-dependent ATPase activity RNA polymerase II transcription coactivator activity more... helicase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides nucleotide binding protein binding transcription coactivator activity transcription regulatory region DNA binding less... MLLT11 2 BP    MF    CC biological_process positive regulation of apoptosis positive regulation of mitochondrial depolarization positive regulation of release of cytochrome c from mitochondria positive regulation of transcription, DNA-dependent more... cellular_component cellular_component molecular_function molecular_function SH3BGRL 2 BP    MF    CC biological_process cellular_component cytoplasm nucleus molecular_function SH3 domain binding SH3/SH2 adaptor activity CSNK1E 2 BP    MF    CC biological_process DNA repair G2/M transition of mitotic cell cycle cellular protein localization mitotic cell cycle more... negative regulation of Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein phosphorylation signal transduction less... cellular_component cytoplasm cytosol nucleus molecular_function ATP binding nucleotide binding protein binding protein kinase activity more... protein serine/threonine kinase activity less... CAP2 2 BP    MF    CC biological_process activation of adenylate cyclase activity axon guidance cell morphogenesis cytoskeleton organization more... establishment or maintenance of cell polarity signal transduction less... cellular_component plasma membrane molecular_function actin binding binding SEMA3F 2 BP    MF    CC biological_process axon guidance multicellular organismal development negative chemotaxis negative regulation of axon extension involved in axon guidance more... neural crest cell migration less... cellular_component extracellular region extracellular space membrane molecular_function chemorepellent activity receptor activity AURKB 2 BP    MF    CC biological_process M phase of mitotic cell cycle aging anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process attachment of spindle microtubules to kinetochore more... cell cycle cell proliferation cytokinesis histone modification mitotic cell cycle mitotic prometaphase positive regulation of cell cycle cytokinesis protein autophosphorylation protein localization to kinetochore regulation of chromosome segregation spindle midzone assembly involved in mitosis less... cellular_component chromosome chromosome passenger complex condensed chromosome, centromeric region condensed nuclear chromosome, centromeric region more... cytoplasm cytoskeleton cytosol midbody nucleus spindle less... molecular_function ATP binding metal ion binding nucleotide binding protein binding more... protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity less... SLC25A5 2 BP    MF    CC biological_process adenine transport chromosome segregation energy reserve metabolic process interspecies interaction between organisms more... regulation of insulin secretion transmembrane transport transport viral reproduction less... cellular_component MMXD complex integral to plasma membrane membrane mitochondrial inner membrane more... mitochondrial nucleoid mitochondrion less... molecular_function adenine transmembrane transporter activity protein binding transporter activity KRIT1 2 BP    MF    CC biological_process cell redox homeostasis negative regulation of angiogenesis negative regulation of endothelial cell apoptosis negative regulation of endothelial cell migration more... negative regulation of endothelial cell proliferation positive regulation of protein binding regulation of establishment of cell polarity small GTPase mediated signal transduction less... cellular_component cell-cell junction cytoskeleton membrane protein complex more... molecular_function binding protein binding small GTPase regulator activity SPOP 2 BP    MF    CC biological_process mRNA processing cellular_component nucleus molecular_function BRCA2 2 BP    MF    CC biological_process DNA recombination DNA repair cell cycle cell cycle cytokinesis more... centrosome duplication double-strand break repair double-strand break repair via homologous recombination histone H3 acetylation histone H4 acetylation homologous chromosome orientation involved in meiotic metaphase I plate congression mammary gland development multicellular organism growth negative regulation of mammary gland epithelial cell proliferation nucleotide-excision repair positive regulation of transcription, DNA-dependent regulation of S phase of mitotic cell cycle response to estradiol stimulus response to nutrient spermatogenesis less... cellular_component BRCA2-MAGE-D1 complex centrosome cytoplasm nucleolus more... nucleoplasm nucleus protein complex stored secretory granule less... molecular_function DNA binding H3 histone acetyltransferase activity H4 histone acetyltransferase activity gamma-tubulin binding more... histone acetyltransferase activity protease binding protein binding single-stranded DNA binding less... PLK2 2 BP    MF    CC biological_process mitotic cell cycle positive regulation of I-kappaB kinase/NF-kappaB cascade signal transduction cellular_component molecular_function ATP binding nucleotide binding protein serine/threonine kinase activity signal transducer activity more... transferase activity, transferring phosphorus-containing groups less... SEMA3C 2 BP    MF    CC biological_process blood vessel remodeling cardiac right ventricle morphogenesis dichotomous subdivision of terminal units involved in salivary gland branching heart development more... immune response limb bud formation multicellular organismal development neural crest cell migration neural tube development outflow tract morphogenesis post-embryonic development pulmonary myocardium development response to drug somitogenesis less... cellular_component extracellular region extracellular space membrane molecular_function receptor activity semaphorin receptor binding ERCC5 2 BP    MF    CC biological_process DNA repair UV protection determination of adult lifespan multicellular organism growth more... negative regulation of apoptosis nucleotide-excision repair nucleotide-excision repair, DNA damage removal nucleotide-excision repair, DNA incision, 3'-to lesion response to UV response to UV-C transcription-coupled nucleotide-excision repair less... cellular_component DNA-directed RNA polymerase II, holoenzyme holo TFIIH complex nucleoplasm nucleus more... molecular_function DNA binding bubble DNA binding catalytic activity double-stranded DNA binding more... endodeoxyribonuclease activity endonuclease activity metal ion binding protein N-terminus binding protein binding protein homodimerization activity single-stranded DNA binding less... SMAD1 2 BP    MF    CC biological_process BMP signaling pathway MAPKKK cascade SMAD protein complex assembly cellular response to organic cyclic compound more... embryonic pattern specification gamete generation hindbrain development homeostatic process inflammatory response kidney development mesodermal cell fate commitment midbrain development negative regulation of cell proliferation osteoblast fate commitment positive regulation of anti-apoptosis positive regulation of cartilage development positive regulation of dendrite morphogenesis positive regulation of gene expression positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter primary miRNA processing protein phosphorylation regulation of transcription, DNA-dependent response to drug response to organic nitrogen signal transduction transcription, DNA-dependent transforming growth factor beta receptor signaling pathway ureteric bud development wound healing less... cellular_component cytoplasm cytosol integral to membrane intracellular more... nuclear inner membrane nucleoplasm nucleus transcription factor complex less... molecular_function I-SMAD binding co-SMAD binding identical protein binding protein binding more... protein kinase binding receptor signaling protein activity sequence-specific DNA binding transcription factor activity transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity less... BMI1 2 BP    MF    CC biological_process brain development chromatin modification embryonic skeletal system morphogenesis hemopoiesis more... histone acetylation histone ubiquitination humoral immune response in utero embryonic development negative regulation of apoptosis negative regulation of transcription from RNA polymerase II promoter positive regulation of B cell proliferation positive regulation of fibroblast proliferation positive regulation of immature T cell proliferation in thymus positive regulation of ubiquitin-protein ligase activity regulation of gene expression regulation of transcription, DNA-dependent rostrocaudal neural tube patterning segment specification somatic stem cell division less... cellular_component PRC1 complex PcG protein complex cytoplasm nuclear body more... nucleolus nucleus ubiquitin ligase complex less... molecular_function RING-like zinc finger domain binding chromatin binding metal ion binding protein binding more... ubiquitin-protein ligase activity zinc ion binding less... HDAC2 2 BP    MF    CC biological_process blood coagulation chromatin modification chromatin remodeling dendrite development more... embryonic digit morphogenesis epidermal cell differentiation eyelid development in camera-type eye fungiform papilla formation hair follicle placode formation hippocampus development histone deacetylation maintenance of chromatin silencing negative regulation of MHC class II biosynthetic process negative regulation of apoptosis negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell cycle negative regulation of neuron projection development negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent nerve growth factor receptor signaling pathway neuron differentiation odontogenesis of dentine-containing tooth positive regulation of cell proliferation positive regulation of collagen biosynthetic process positive regulation of oligodendrocyte differentiation positive regulation of proteolysis positive regulation of receptor biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent less... cellular_component ESC/E(Z) complex NuRD complex Sin3 complex cytoplasm more... heterochromatin nuclear chromatin nucleoplasm nucleus replication fork transcription factor complex transcriptional repressor complex less... molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) chromatin binding more... enzyme binding histone deacetylase activity histone deacetylase activity (H3-K16 specific) hydrolase activity protein binding protein deacetylase activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding less... RECQL 2 BP    MF    CC biological_process DNA recombination DNA repair DNA replication DNA strand renaturation more... cellular_component nucleus molecular_function ATP binding ATP-dependent 3'-5' DNA helicase activity ATP-dependent DNA helicase activity ATP-dependent helicase activity more... DNA binding DNA helicase activity DNA strand annealing activity hydrolase activity nucleic acid binding nucleotide binding protein binding less... GRK5 2 BP    MF    CC biological_process G-protein signaling, coupled to cAMP nucleotide second messenger negative regulation of apoptosis protein autophosphorylation regulation of G-protein coupled receptor protein signaling pathway more... response to drug tachykinin receptor signaling pathway less... cellular_component cytoplasm plasma membrane soluble fraction molecular_function ATP binding G-protein coupled receptor kinase activity kinase activity nucleotide binding more... phospholipid binding protein binding protein kinase C binding protein serine/threonine kinase activity receptor activity signal transducer activity less... EDN3 2 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding PRAF2 2 BP    MF    CC biological_process L-glutamate transport protein transport cellular_component endosome endosome membrane integral to membrane membrane more... molecular_function RRM1 2 BP    MF    CC biological_process DNA replication deoxyribonucleotide biosynthetic process nucleobase-containing small molecule interconversion nucleobase-containing small molecule metabolic process more... oxidation-reduction process protein heterotetramerization protein oligomerization less... cellular_component cytoplasm cytosol nucleoplasm ribonucleoside-diphosphate reductase complex more... molecular_function ATP binding oxidoreductase activity purine nucleotide binding ribonucleoside-diphosphate reductase activity more... CFLAR 2 BP    MF    CC biological_process anti-apoptosis induction of apoptosis by extracellular signals interspecies interaction between organisms negative regulation of apoptosis more... negative regulation of caspase activity positive regulation of I-kappaB kinase/NF-kappaB cascade proteolysis regulation of apoptosis less... cellular_component cytoplasm molecular_function cysteine-type endopeptidase activity protein binding SELENBP1 2 BP    MF    CC biological_process protein transport cellular_component cytoplasm cytosol membrane nucleolus more... nucleus less... molecular_function protein binding selenium binding EIF2S2 2 BP    MF    CC biological_process cellular protein metabolic process gene expression in utero embryonic development male germ cell proliferation more... male gonad development translation translational initiation less... cellular_component cytosol eukaryotic translation initiation factor 2 complex molecular_function RNA binding metal ion binding protein binding translation factor activity, nucleic acid binding more... translation initiation factor activity less... EIF3I 2 BP    MF    CC biological_process cellular protein metabolic process gene expression translation translational initiation more... cellular_component cytoplasm cytosol eukaryotic translation initiation factor 3 complex molecular_function protein binding translation initiation factor activity PPIC 2 BP    MF    CC biological_process protein folding signal transduction cellular_component cytoplasm molecular_function cyclosporin A binding isomerase activity peptidyl-prolyl cis-trans isomerase activity unfolded protein binding more... RANBP1 2 BP    MF    CC biological_process intracellular transport positive regulation of mitotic centrosome separation signal transduction spindle organization more... viral reproduction less... cellular_component centrosome cytoplasm nuclear envelope nucleus more... molecular_function GDP-dissociation inhibitor activity GTPase activator activity Ran GTPase binding MSH2 2 BP    MF    CC biological_process ATP catabolic process B cell differentiation B cell mediated immunity DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis more... DNA repair cell cycle arrest determination of adult lifespan double-strand break repair germ cell development in utero embryonic development intra-S DNA damage checkpoint isotype switching maintenance of DNA repeat elements male gonad development meiotic gene conversion meiotic mismatch repair mismatch repair negative regulation of DNA recombination negative regulation of neuron apoptosis negative regulation of reciprocal meiotic recombination oxidative phosphorylation positive regulation of helicase activity postreplication repair response to UV-B response to X-ray response to amino acid stimulus response to drug response to organic cyclic compound somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments spermatogenesis less... cellular_component MutSalpha complex MutSbeta complex nuclear chromosome nucleus more... molecular_function ADP binding ATP binding ATPase activity DNA binding more... DNA-dependent ATPase activity MutLalpha complex binding Y-form DNA binding centromeric DNA binding damaged DNA binding dinucleotide insertion or deletion binding dinucleotide repeat insertion binding double-strand/single-strand DNA junction binding double-stranded DNA binding enzyme binding four-way junction DNA binding guanine/thymine mispair binding loop DNA binding magnesium ion binding mismatched DNA binding nucleotide binding oxidized purine DNA binding protein C-terminus binding protein binding protein homodimerization activity protein kinase binding single guanine insertion binding single thymine insertion binding single-stranded DNA binding less... MED12 2 BP    MF    CC biological_process androgen receptor signaling pathway gene expression negative regulation of Wnt receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter more... positive regulation of transcription, DNA-dependent regulation of transcription from RNA polymerase II promoter steroid hormone receptor signaling pathway transcription initiation from RNA polymerase II promoter less... cellular_component mediator complex nucleoplasm nucleus molecular_function RNA polymerase II transcription cofactor activity beta-catenin binding ligand-dependent nuclear receptor transcription coactivator activity protein C-terminus binding more... protein domain specific binding receptor activity thyroid hormone receptor binding transcription coactivator activity transcription cofactor activity vitamin D receptor binding less... MFAP2 2 BP    MF    CC biological_process platelet formation cellular_component extracellular region microfibril proteinaceous extracellular matrix molecular_function fibrinogen binding fibronectin binding AGL 2 BP    MF    CC biological_process carbohydrate metabolic process glucose metabolic process glycogen biosynthetic process glycogen catabolic process more... response to glucocorticoid stimulus response to hormone stimulus response to nutrient less... cellular_component cytoplasm cytosol inclusion body isoamylase complex more... nucleolus nucleus sarcoplasmic reticulum soluble fraction less... molecular_function 4-alpha-glucanotransferase activity amylo-alpha-1,6-glucosidase activity cation binding glycogen debranching enzyme activity more... hydrolase activity, acting on glycosyl bonds polysaccharide binding polyubiquitin binding protein binding sugar binding transferase activity, transferring glycosyl groups less... AKAP1 2 BP    MF    CC biological_process blood coagulation cellular response to chemical stimulus cellular response to insulin stimulus negative regulation of NFAT protein import into nucleus more... negative regulation of cardiac muscle hypertrophy negative regulation of protein dephosphorylation less... cellular_component cytosol integral to membrane lipid particle membrane more... mitochondrial crista mitochondrial matrix mitochondrial outer membrane mitochondrion neuromuscular junction postsynaptic membrane less... molecular_function RNA binding beta-tubulin binding microtubule binding protein binding more... protein complex scaffold protein domain specific binding protein kinase A regulatory subunit binding protein kinase binding protein phosphatase 2B binding less... XRCC5 2 BP    MF    CC biological_process DNA recombination DNA repair cell proliferation double-strand break repair more... double-strand break repair via nonhomologous end joining hemopoietic stem cell differentiation initiation of viral infection negative regulation of apoptosis negative regulation of transcription, DNA-dependent positive regulation of neurogenesis provirus integration telomere maintenance viral reproduction less... cellular_component DNA-dependent protein kinase-DNA ligase 4 complex Ku70:Ku80 complex chromosome cytoplasm more... nonhomologous end joining complex nuclear chromosome, telomeric region nuclear telomere cap complex nucleolus nucleoplasm nucleus less... molecular_function 5'-deoxyribose-5-phosphate lyase activity ATP binding ATP-dependent DNA helicase activity DNA binding more... double-stranded DNA binding double-stranded telomeric DNA binding helicase activity hydrolase activity, acting on acid anhydrides nucleotide binding protein C-terminus binding protein binding telomeric DNA binding transcription regulatory region DNA binding less... IRS1 2 BP    MF    CC biological_process cellular response to insulin stimulus fibroblast growth factor receptor signaling pathway glucose homeostasis insulin receptor signaling pathway more... insulin-like growth factor receptor signaling pathway lipid catabolic process mammary gland development negative regulation of insulin receptor signaling pathway negative regulation of insulin secretion negative regulation of somatostatin secretion nerve growth factor receptor signaling pathway phosphatidylinositol 3-kinase cascade phosphatidylinositol-mediated signaling positive regulation of cell migration positive regulation of cell proliferation positive regulation of fatty acid beta-oxidation positive regulation of glucagon secretion positive regulation of glucose import positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process positive regulation of insulin receptor signaling pathway positive regulation of mesenchymal cell proliferation positive regulation of phosphatidylinositol 3-kinase activity positive regulation of phosphorylation protein heterooligomerization protein localization to nucleus regulation of gene expression response to insulin stimulus response to peptide hormone stimulus signal transduction transmembrane receptor protein tyrosine kinase signaling pathway less... cellular_component caveola cytoplasm cytosol insulin receptor complex more... microsome nucleus plasma membrane less... molecular_function SH2 domain binding insulin receptor binding insulin-like growth factor receptor binding insulin-like growth factor-activated receptor activity more... phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein binding protein kinase C binding signal transducer activity transmembrane receptor protein tyrosine kinase adaptor activity less... TUSC3 2 BP    MF    CC biological_process cell redox homeostasis cellular protein metabolic process post-translational protein modification protein N-linked glycosylation via asparagine more... cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... oligosaccharyltransferase complex less... molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity NT5C2 2 BP    MF    CC biological_process nucleobase-containing small molecule metabolic process nucleotide metabolic process purine base metabolic process purine nucleotide catabolic process more... cellular_component cytoplasm cytosol molecular_function 5'-nucleotidase activity hydrolase activity metal ion binding nucleotide binding more... protein binding less... EHMT2 2 BP    MF    CC biological_process DNA methylation chromatin modification fertilization histone H3-K27 methylation more... histone H3-K9 methylation negative regulation of transcription from RNA polymerase II promoter organ growth pachytene peptidyl-lysine dimethylation spermatid development synaptonemal complex assembly less... cellular_component chromosome nucleus molecular_function histone methyltransferase activity (H3-K27 specific) histone methyltransferase activity (H3-K9 specific) histone-lysine N-methyltransferase activity metal ion binding more... methyltransferase activity p53 binding protein binding protein-lysine N-methyltransferase activity transferase activity zinc ion binding less... MDH1 2 BP    MF    CC biological_process NADH metabolic process carbohydrate metabolic process cellular carbohydrate metabolic process gluconeogenesis more... glucose metabolic process malate metabolic process oxaloacetate metabolic process oxidation-reduction process tricarboxylic acid cycle less... cellular_component centrosome cytoplasm cytosol mitochondrion more... soluble fraction less... molecular_function L-malate dehydrogenase activity NAD binding binding catalytic activity more... malate dehydrogenase activity malic enzyme activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor less... SMARCA5 2 BP    MF    CC biological_process ATP catabolic process ATP-dependent chromatin remodeling CenH3-containing nucleosome assembly at centromere chromatin assembly or disassembly more... chromatin remodeling chromatin silencing at rDNA double-strand break repair embryo development nucleosome assembly nucleosome positioning regulation of transcription from RNA polymerase II promoter transcription initiation, DNA-dependent less... cellular_component NURF complex RSF complex chromatin silencing complex condensed chromosome more... nuclear replication fork nucleolus nucleoplasm nucleus less... molecular_function ATP binding ATPase activity DNA binding helicase activity more... histone binding hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides nucleosome binding nucleotide binding protein binding less... CDK2 2 BP    MF    CC biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA replication G1/S transition of mitotic cell cycle G2 phase of mitotic cell cycle more... G2/M transition of mitotic cell cycle M/G1 transition of mitotic cell cycle Ras protein signal transduction S phase of mitotic cell cycle anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process blood coagulation cell cycle cell cycle checkpoint cell division cellular response to nitric oxide centrosome duplication histone phosphorylation meiosis mitosis mitotic cell cycle mitotic cell cycle G1/S transition DNA damage checkpoint phosphorylation positive regulation of cell proliferation positive regulation of transcription, DNA-dependent potassium ion transport protein phosphorylation regulation of DNA replication regulation of gene silencing regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle traversing start control point of mitotic cell cycle less... cellular_component Cajal body X chromosome Y chromosome centrosome more... chromosome, telomeric region condensed chromosome cyclin-dependent protein kinase holoenzyme complex cytoplasm cytosol endosome nucleoplasm nucleus transcription factor complex less... molecular_function ATP binding cyclin binding cyclin-dependent protein kinase activity histone kinase activity more... kinase activity nucleotide binding protein binding protein kinase activity protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups less... CDH2 2 BP    MF    CC biological_process adherens junction organization blood vessel morphogenesis calcium-dependent cell-cell adhesion cell adhesion more... cell junction assembly cell migration cell-cell junction organization heterophilic cell-cell adhesion homophilic cell adhesion muscle cell differentiation positive regulation of muscle cell differentiation regulation of Rho protein signal transduction regulation of axonogenesis regulation of myelination regulation of protein localization synapse assembly less... cellular_component catenin complex cell-cell adherens junction cell-cell junction fascia adherens more... integral to membrane lamellipodium membrane membrane fraction plasma membrane protein complex synapse part less... molecular_function RPTP-like protein binding alpha-catenin binding beta-catenin binding calcium ion binding more... gamma-catenin binding protein kinase binding protein phosphatase binding less... MAP2K4 2 BP    MF    CC biological_process JNK cascade MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway more... cellular response to mechanical stimulus innate immune response protein phosphorylation signal transduction stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytosol molecular_function ATP binding nucleotide binding protein binding protein kinase activity more... protein serine/threonine kinase activity protein tyrosine kinase activity less... CSRP2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development myoblast differentiation cellular_component nucleus molecular_function metal ion binding molecular_function zinc ion binding GNG11 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway GTP catabolic process cellular response to glucagon stimulus energy reserve metabolic process more... signal transduction less... cellular_component heterotrimeric G-protein complex plasma membrane molecular_function GTPase activity signal transducer activity MYO1B 2 BP    MF    CC biological_process cellular_component brush border myosin complex molecular_function ATP binding actin binding calmodulin binding motor activity more... nucleotide binding less... TMEM5 2 BP    MF    CC biological_process cellular_component integral to plasma membrane membrane molecular_function NAB1 2 BP    MF    CC biological_process Schwann cell differentiation endochondral ossification myelination negative regulation of transcription, DNA-dependent more... regulation of epidermis development regulation of transcription, DNA-dependent less... cellular_component nucleus molecular_function transcription factor binding APP 2 BP    MF    CC biological_process G2 phase of mitotic cell cycle Notch signaling pathway activation of innate immune response adult locomotory behavior more... axon cargo transport axon midline choice point recognition axonogenesis blood coagulation cell adhesion cell death cellular copper ion homeostasis collateral sprouting in absence of injury dendrite development endocytosis extracellular matrix organization forebrain development induction of apoptosis innate immune response ionotropic glutamate receptor signaling pathway locomotory behavior mRNA polyadenylation mating behavior negative regulation of neuron differentiation neuromuscular process controlling balance neuron apoptosis neuron projection development neuron remodeling platelet activation platelet degranulation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter protein phosphorylation regulation of epidermal growth factor-activated receptor activity regulation of gene expression regulation of multicellular organism growth regulation of synapse structure and activity regulation of translation smooth endoplasmic reticulum calcium ion homeostasis suckling behavior synaptic growth at neuromuscular junction visual learning less... cellular_component Golgi apparatus apical part of cell axon cell surface more... ciliary rootlet coated pit cytoplasm cytoplasmic vesicle cytosol dendritic shaft dendritic spine extracellular region integral to membrane integral to plasma membrane intracellular membrane-bounded organelle neuromuscular junction perinuclear region of cytoplasm plasma membrane platelet alpha granule lumen spindle midzone synapse synaptosome less... molecular_function DNA binding PTB domain binding acetylcholine receptor binding binding more... heparin binding identical protein binding metal ion binding peptidase activator activity peptidase inhibitor activity protein binding receptor binding serine-type endopeptidase inhibitor activity less... CCND1 2 BP    MF    CC biological_process G1 phase of mitotic cell cycle G1/S transition of mitotic cell cycle Leydig cell differentiation S phase of mitotic cell cycle more... canonical Wnt receptor signaling pathway cell division cellular response to organic substance endoplasmic reticulum unfolded protein response fat cell differentiation lactation liver development mammary gland alveolus development mitotic cell cycle mitotic cell cycle G1/S transition DNA damage checkpoint negative regulation of Wnt receptor signaling pathway negative regulation of epithelial cell differentiation organ regeneration positive regulation of cell proliferation positive regulation of cyclin-dependent protein kinase activity positive regulation of mammary gland epithelial cell proliferation positive regulation of protein phosphorylation re-entry into mitotic cell cycle regulation of cyclin-dependent protein kinase activity response to DNA damage stimulus response to UV-A response to X-ray response to calcium ion response to corticosterone stimulus response to drug response to estrogen stimulus response to ethanol response to iron ion response to magnesium ion response to organic cyclic compound response to organic nitrogen response to vitamin E less... cellular_component cyclin-dependent protein kinase holoenzyme complex cytoplasm cytosol intracellular more... membrane nucleoplasm nucleus less... molecular_function cyclin-dependent protein kinase regulator activity enzyme binding protein binding protein kinase activity more... protein kinase binding less... HPCAL1 2 BP    MF    CC biological_process cellular_component molecular_function calcium ion binding ZKSCAN1 2 BP    MF    CC biological_process regulation of transcription, DNA-dependent transcription, DNA-dependent viral reproduction cellular_component intracellular mitochondrion nucleus molecular_function DNA binding metal ion binding nucleic acid binding sequence-specific DNA binding transcription factor activity more... zinc ion binding less... DUT 2 BP    MF    CC biological_process DNA replication dUTP metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process more... nucleotide metabolic process pyrimidine base metabolic process pyrimidine nucleoside biosynthetic process less... cellular_component mitochondrion nucleoplasm nucleus molecular_function dUTP diphosphatase activity hydrolase activity protein binding MARCKS 2 BP    MF    CC biological_process energy reserve metabolic process regulation of insulin secretion cellular_component actin cytoskeleton cell cortex centrosome cytoplasm more... germinal vesicle plasma membrane less... molecular_function actin filament binding calmodulin binding protein kinase C binding FAP 2 BP    MF    CC biological_process endothelial cell migration negative regulation of extracellular matrix disassembly proteolysis cellular_component cell junction integral to membrane invadopodium membrane lamellipodium more... lamellipodium membrane membrane plasma membrane less... molecular_function dipeptidyl-peptidase activity metalloendopeptidase activity peptidase activity protein binding more... protein dimerization activity protein homodimerization activity serine-type endopeptidase activity serine-type peptidase activity less... MAPRE2 2 BP    MF    CC biological_process cell cycle cell division cell proliferation mitosis more... signal transduction less... cellular_component cytoplasm microtubule microtubule cytoskeleton molecular_function microtubule binding C1D 2 BP    MF    CC biological_process apoptosis maturation of 5.8S rRNA negative regulation of transcription, DNA-dependent cellular_component cytoplasm nuclear exosome (RNase complex) nucleolus nucleus more... transcriptional repressor complex less... molecular_function DNA binding RNA binding ligand-dependent nuclear receptor binding protein binding more... transcription corepressor activity less... LGALS8 2 BP    MF    CC biological_process cellular_component cytoplasm extracellular space molecular_function sugar binding FGFR1 2 BP    MF    CC biological_process MAPKKK cascade angiogenesis auditory receptor cell development axon guidance more... branching involved in salivary gland morphogenesis cell maturation cell migration central nervous system neuron development chondrocyte differentiation chordate embryonic development embryonic limb morphogenesis fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development generation of neurons in utero embryonic development inner ear morphogenesis insulin receptor signaling pathway lung-associated mesenchyme development mesenchymal cell differentiation midbrain development middle ear morphogenesis motogenic signaling involved in postnatal olfactory bulb interneuron migration negative regulation of apoptosis negative regulation of gene expression negative regulation of osteoblast differentiation negative regulation of transcription from RNA polymerase II promoter neuron migration organ induction outer ear morphogenesis paraxial mesoderm development peptidyl-tyrosine phosphorylation phosphatidylinositol-mediated signaling positive regulation of MAP kinase activity positive regulation of MAPKKK cascade positive regulation of cardiac muscle cell proliferation positive regulation of cell cycle positive regulation of cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of neuron differentiation positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase cascade positive regulation of phospholipase C activity positive regulation of phospholipase activity protein autophosphorylation protein phosphorylation regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling regulation of cell differentiation regulation of lateral mesodermal cell fate specification regulation of sensory perception of pain regulation of stem cell proliferation sensory perception of sound skeletal system development skeletal system morphogenesis stem cell maintenance ureteric bud development ventricular zone neuroblast division less... cellular_component extracellular region integral to membrane integral to plasma membrane membrane more... plasma membrane less... molecular_function ATP binding cell adhesion molecule binding fibroblast growth factor 1 binding fibroblast growth factor binding more... fibroblast growth factor-activated receptor activity glycoprotein binding heparin binding nucleotide binding protein binding protein homodimerization activity protein tyrosine kinase activity receptor activity transferase activity, transferring phosphorus-containing groups less... MSX2 2 BP    MF    CC biological_process BMP signaling pathway involved in heart development anagen anterior/posterior pattern specification bone morphogenesis more... bone trabecula formation branching involved in mammary gland duct morphogenesis cartilage development cellular response to estradiol stimulus cellular response to growth factor stimulus chondrocyte development cranial suture morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis enamel mineralization endochondral bone growth epithelial to mesenchymal transition involved in endocardial cushion formation frontal suture morphogenesis heart morphogenesis mammary gland epithelium development multicellular organismal development negative regulation of CREB transcription factor activity negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent odontogenesis osteoblast development osteoblast differentiation positive regulation of BMP signaling pathway positive regulation of apoptosis positive regulation of catagen positive regulation of osteoblast differentiation signal transduction involved in regulation of gene expression stem cell differentiation wound healing wound healing, spreading of epidermal cells less... cellular_component cytoplasm nucleus transcription factor complex molecular_function protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding more... transcription regulatory region DNA binding less... VEZF1 2 BP    MF    CC biological_process angiogenesis cellular defense response endothelial cell development regulation of transcription from RNA polymerase II promoter more... transcription from RNA polymerase II promoter less... cellular_component intracellular nucleolus nucleus molecular_function DNA binding metal ion binding zinc ion binding WFS1 2 BP    MF    CC biological_process ER overload response ER-associated protein catabolic process calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis more... endoplasmic reticulum unfolded protein response glucose homeostasis kidney development negative regulation of apoptosis negative regulation of neuron apoptosis negative regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity neurological system process polyubiquitinated misfolded protein transport positive regulation of calcium ion transport positive regulation of growth positive regulation of protein metabolic process positive regulation of protein ubiquitination positive regulation of proteolysis protein maturation by protein folding protein stabilization regulation of apoptosis renal water homeostasis response to endoplasmic reticulum stress sensory perception of sound visual perception less... cellular_component dendrite endoplasmic reticulum endoplasmic reticulum membrane integral to endoplasmic reticulum membrane more... integral to membrane membrane less... molecular_function ATPase binding activating transcription factor binding transporter activity ubiquitin protein ligase binding more... RBMS1 2 BP    MF    CC biological_process DNA replication RNA processing cellular_component nucleus molecular_function DNA binding RNA binding double-stranded DNA binding nucleic acid binding more... nucleotide binding protein binding single-stranded DNA binding less... MID1 2 BP    MF    CC biological_process microtubule cytoskeleton organization negative regulation of microtubule depolymerization pattern specification process positive regulation of stress-activated MAPK cascade more... cellular_component cytoplasm cytoplasmic microtubule intracellular microtubule associated complex more... microtubule cytoskeleton spindle less... molecular_function ligase activity metal ion binding ubiquitin protein ligase binding zinc ion binding more... TFF3 2 BP    MF    CC biological_process defense response digestion response to peptide hormone stimulus cellular_component apical lamina of hyaline layer extracellular region proteinaceous extracellular matrix stored secretory granule more... molecular_function molecular_function MECP2 2 BP    MF    CC biological_process negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent cellular_component heterochromatin nucleus molecular_function DNA binding double-stranded methylated DNA binding protein N-terminus binding protein binding more... protein domain specific binding transcription corepressor activity less... TCF3 2 BP    MF    CC biological_process B cell differentiation B cell lineage commitment G1 phase of mitotic cell cycle Peyer's patch development more... T cell differentiation in thymus cell development histone H3 acetylation histone H4 acetylation immunoglobulin V(D)J recombination muscle cell differentiation natural killer cell differentiation nervous system development positive regulation of B cell proliferation positive regulation of cell cycle positive regulation of muscle cell differentiation positive regulation of neuron differentiation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent protein stabilization regulation of transcription, DNA-dependent response to drug response to lipopolysaccharide transcription, DNA-dependent less... cellular_component cytoplasm nuclear nucleosome nucleoplasm nucleus more... protein complex transcription factor complex less... molecular_function DNA binding E-box binding bHLH transcription factor binding mitogen-activated protein kinase kinase kinase binding more... protein binding protein heterodimerization activity protein homodimerization activity repressing transcription factor binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription coactivator activity transcription factor binding transcription regulatory region DNA binding vitamin D response element binding less... DIO2 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process hormone biosynthetic process selenocysteine incorporation thyroid hormone generation more... thyroid hormone metabolic process less... cellular_component integral to membrane membrane plasma membrane molecular_function selenium binding thyroxine 5'-deiodinase activity ubiquitin protein ligase binding NPTX2 2 BP    MF    CC biological_process synaptic transmission cellular_component cellular_component extracellular region molecular_function metal ion binding molecular_function sugar binding PHLDA2 2 BP    MF    CC biological_process apoptosis organ morphogenesis cellular_component cytoplasm membrane molecular_function CFDP1 2 BP    MF    CC biological_process anti-apoptosis biological_process cell adhesion multicellular organismal development more... regulation of cell proliferation regulation of cell shape less... cellular_component cellular_component molecular_function molecular_function ARHGAP1 2 BP    MF    CC biological_process Rho protein signal transduction positive regulation of Rho GTPase activity regulation of GTPase activity regulation of small GTPase mediated signal transduction more... signal transduction small GTPase mediated signal transduction less... cellular_component cytoplasm cytosol intracellular intracellular membrane-bounded organelle more... plasma membrane ruffle less... molecular_function GTPase activator activity Rac GTPase activator activity Rho GTPase activator activity SH3 domain binding more... SH3/SH2 adaptor activity protein binding less... SFRP1 2 BP    MF    CC biological_process DNA fragmentation involved in apoptotic nuclear change Wnt receptor signaling pathway, planar cell polarity pathway bone trabecula formation brain development more... canonical Wnt receptor signaling pathway cellular response to BMP stimulus cellular response to X-ray cellular response to estradiol stimulus cellular response to estrogen stimulus cellular response to fibroblast growth factor stimulus cellular response to growth factor stimulus cellular response to heparin cellular response to hypoxia cellular response to interleukin-1 cellular response to prostaglandin E stimulus cellular response to starvation cellular response to transforming growth factor beta stimulus cellular response to tumor necrosis factor cellular response to vitamin D dorsal/ventral axis specification embryo development female gonad development gonad development hemopoietic progenitor cell differentiation hemopoietic stem cell differentiation male gonad development menstrual cycle phase negative regulation of B cell differentiation negative regulation of BMP signaling pathway negative regulation of Wnt receptor signaling pathway negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification negative regulation of androgen receptor signaling pathway negative regulation of apoptosis negative regulation of bone remodeling negative regulation of canonical Wnt receptor signaling pathway negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of cell growth negative regulation of cell migration negative regulation of cell proliferation negative regulation of cysteine-type endopeptidase activity negative regulation of epithelial cell proliferation negative regulation of epithelial to mesenchymal transition negative regulation of fibroblast apoptosis negative regulation of fibroblast proliferation negative regulation of gene expression negative regulation of insulin secretion negative regulation of ossification negative regulation of osteoblast differentiation negative regulation of osteoblast proliferation negative regulation of osteoclast differentiation negative regulation of peptidyl-tyrosine phosphorylation negative regulation of transcription, DNA-dependent neural crest cell fate commitment neural tube closure neural tube development osteoblast differentiation positive regulation of Rac GTPase activity positive regulation of Wnt receptor signaling pathway positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of cell growth positive regulation of cell proliferation positive regulation of cell-matrix adhesion positive regulation of epithelial cell proliferation positive regulation of fat cell differentiation positive regulation of fibroblast apoptosis positive regulation of focal adhesion assembly positive regulation of non-canonical Wnt receptor signaling pathway positive regulation of smoothened signaling pathway positive regulation of stress fiber assembly positive regulation of transcription, DNA-dependent prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of angiogenesis regulation of branching involved in prostate gland morphogenesis regulation of cell cycle process response to drug response to organic cyclic compound somatic stem cell maintenance somitogenesis stromal-epithelial cell signaling involved in prostate gland development ureteric bud development vasculature development less... cellular_component cell projection cell surface cytosol extracellular matrix more... extracellular region extracellular space intracellular plasma membrane proteinaceous extracellular matrix less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding cysteine-type endopeptidase activity more... drug binding frizzled binding heparin binding identical protein binding less... CREB1 2 BP    MF    CC biological_process MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway activation of phospholipase C activity more... axon guidance axonogenesis fibroblast growth factor receptor signaling pathway innate immune response interspecies interaction between organisms lactation nerve growth factor receptor signaling pathway phosphatidylinositol-mediated signaling pituitary gland development positive regulation of hormone secretion positive regulation of multicellular organism growth positive regulation of transcription from RNA polymerase II promoter positive regulation of transforming growth factor beta3 production protein phosphorylation regulation of apoptosis regulation of cell size regulation of circadian rhythm regulation of transcription, DNA-dependent response to drug response to organic substance signal transduction stress-activated MAPK cascade synaptic transmission toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway transcription, DNA-dependent transforming growth factor beta receptor signaling pathway less... cellular_component mitochondrion nuclear chromatin nucleolus nucleoplasm more... nucleus transcription factor complex less... molecular_function DNA binding double-stranded DNA binding protein binding protein dimerization activity more... sequence-specific DNA binding sequence-specific DNA binding transcription factor activity sequence-specific distal enhancer binding RNA polymerase II transcription factor activity transcription cofactor activity transcription factor binding less... ENPP2 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway cellular component movement chemotaxis immune response more... lipid catabolic process phosphate-containing compound metabolic process phosphatidylcholine catabolic process regulation of cell migration less... cellular_component extracellular region extracellular space integral to plasma membrane plasma membrane more... molecular_function alkylglycerophosphoethanolamine phosphodiesterase activity calcium ion binding catalytic activity hydrolase activity more... lysophospholipase activity metal ion binding nucleic acid binding nucleotide diphosphatase activity phosphodiesterase I activity polysaccharide binding scavenger receptor activity transcription factor binding zinc ion binding less... ERG 2 BP    MF    CC biological_process cell proliferation multicellular organismal development protein phosphorylation signal transduction more... cellular_component cytoplasm nucleus ribonucleoprotein complex molecular_function DNA binding protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity more... signal transducer activity less... RABIF 2 BP    MF    CC biological_process cellular membrane fusion protein transport small GTPase mediated signal transduction cellular_component molecular_function guanyl-nucleotide exchange factor activity metal ion binding zinc ion binding HADH 2 BP    MF    CC biological_process cellular lipid metabolic process fatty acid beta-oxidation fatty acid metabolic process negative regulation of insulin secretion more... response to activity response to drug response to hormone stimulus response to insulin stimulus less... cellular_component cytoplasm mitochondrial inner membrane mitochondrial matrix mitochondrion more... molecular_function 3-hydroxyacyl-CoA dehydrogenase activity NAD+ binding binding coenzyme binding more... oxidoreductase activity less... FGFR2 2 BP    MF    CC biological_process angiogenesis axonogenesis bone development bone mineralization more... bone morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in embryonic placenta morphogenesis branching involved in prostate gland morphogenesis branching involved in salivary gland morphogenesis branching morphogenesis of a nerve bud elongation involved in lung branching cell fate commitment cell-cell signaling digestive tract development embryonic digestive tract morphogenesis embryonic organ development embryonic organ morphogenesis embryonic pattern specification epidermis morphogenesis epithelial cell differentiation epithelial cell proliferation involved in salivary gland morphogenesis fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in mammary gland specification fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow gland morphogenesis hair follicle morphogenesis in utero embryonic development inner ear morphogenesis insulin receptor signaling pathway lacrimal gland development lateral sprouting from an epithelium limb bud formation lung alveolus development lung development lung lobe morphogenesis lung-associated mesenchyme development mammary gland bud formation membranous septum morphogenesis mesenchymal cell differentiation mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development midbrain development morphogenesis of embryonic epithelium multicellular organism growth negative regulation of transcription from RNA polymerase II promoter odontogenesis orbitofrontal cortex development organ growth organ morphogenesis otic vesicle formation outflow tract septum morphogenesis peptidyl-tyrosine phosphorylation positive regulation of ERK1 and ERK2 cascade positive regulation of MAPKKK cascade positive regulation of Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway positive regulation of cardiac muscle cell proliferation positive regulation of cell cycle positive regulation of cell division positive regulation of cell proliferation positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in lung morphogenesis positive regulation of mesenchymal cell proliferation positive regulation of phospholipase activity positive regulation of transcription from RNA polymerase II promoter post-embryonic development prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate epithelial cord elongation prostate gland morphogenesis protein autophosphorylation pyramidal neuron development regulation of ERK1 and ERK2 cascade regulation of branching involved in prostate gland morphogenesis regulation of cell fate commitment regulation of fibroblast growth factor receptor signaling pathway regulation of morphogenesis of a branching structure regulation of multicellular organism growth regulation of osteoblast differentiation regulation of osteoblast proliferation regulation of smooth muscle cell differentiation regulation of smoothened signaling pathway reproductive structure development skeletal system morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ureteric bud development ventricular cardiac muscle tissue morphogenesis ventricular zone neuroblast division less... cellular_component cell cortex cell surface cytoplasm excitatory synapse more... extracellular matrix extracellular region integral to membrane integral to plasma membrane membrane nucleus plasma membrane less... molecular_function ATP binding fibroblast growth factor binding fibroblast growth factor-activated receptor activity heparin binding more... nucleotide binding protein binding protein homodimerization activity protein tyrosine kinase activity receptor activity less... ACVRL1 2 BP    MF    CC biological_process angiogenesis blood circulation blood vessel endothelial cell proliferation involved in sprouting angiogenesis blood vessel maturation more... in utero embryonic development negative regulation of cell adhesion negative regulation of cell growth negative regulation of cell migration negative regulation of cell proliferation negative regulation of endothelial cell differentiation negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of focal adhesion assembly positive regulation of BMP signaling pathway positive regulation of endothelial cell differentiation positive regulation of endothelial cell proliferation positive regulation of transcription, DNA-dependent protein heterooligomerization protein phosphorylation regulation of DNA replication regulation of blood pressure regulation of blood vessel endothelial cell migration regulation of endothelial cell proliferation regulation of transcription, DNA-dependent signal transduction transforming growth factor beta receptor signaling pathway wound healing, spreading of epidermal cells less... cellular_component cell surface dendrite integral to plasma membrane membrane more... neuronal cell body less... molecular_function ATP binding SMAD binding activin binding activin receptor activity, type I more... metal ion binding nucleotide binding protein binding protein kinase activity protein serine/threonine kinase activity receptor activity receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups transforming growth factor beta binding transforming growth factor beta receptor activity, type I transforming growth factor beta-activated receptor activity transmembrane receptor protein serine/threonine kinase activity less... RCBTB2 2 BP    MF    CC biological_process cellular_component molecular_function Ran guanyl-nucleotide exchange factor activity SFRP4 2 BP    MF    CC biological_process Wnt receptor signaling pathway axonogenesis brain development cell differentiation more... decidualization embryo development epithelium development gonad development mammary gland involution menstrual cycle phase multicellular organismal development negative regulation of JNK cascade negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of sodium-dependent phosphate transport phosphate ion homeostasis positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of epidermal cell differentiation positive regulation of gene expression positive regulation of receptor internalization response to estradiol stimulus response to glucocorticoid stimulus response to hormone stimulus response to peptide hormone stimulus vasculature development less... cellular_component cell surface cytoplasm extracellular region extracellular space more... neuron projection membrane nucleus less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding PARG 2 BP    MF    CC biological_process carbohydrate metabolic process detection of bacterium positive regulation of DNA repair response to DNA damage stimulus more... cellular_component chromatin cytoplasm cytosol intracellular membrane-bounded organelle more... microsome nucleolus nucleus soluble fraction less... molecular_function chromatin binding hydrolase activity poly(ADP-ribose) glycohydrolase activity RYK 2 BP    MF    CC biological_process Wnt receptor signaling pathway axon guidance commissural neuron axon guidance corpus callosum development more... negative chemotaxis negative regulation of axon extension involved in axon guidance neuron differentiation neuron projection development positive regulation of MAPKKK cascade protein phosphorylation signal transduction skeletal system morphogenesis less... cellular_component cytoplasm integral to membrane integral to plasma membrane membrane more... membrane fraction nucleus plasma membrane less... molecular_function ATP binding Wnt-protein binding frizzled binding nucleotide binding more... protein binding protein tyrosine kinase activity receptor activity transferase activity, transferring phosphorus-containing groups transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity less... PCGF2 2 BP    MF    CC biological_process anterior/posterior pattern specification embryonic skeletal system morphogenesis histone acetylation in utero embryonic development more... negative regulation of apoptosis negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-dependent transcription, DNA-dependent less... cellular_component PRC1 complex PcG protein complex nuclear body nuclear chromatin more... nucleus sex chromatin less... molecular_function DNA binding chromatin binding metal ion binding protein binding more... sequence-specific DNA binding transcription factor activity ubiquitin-protein ligase activity zinc ion binding less... HMGB2 2 BP    MF    CC biological_process DNA fragmentation involved in apoptotic nuclear change DNA ligation involved in DNA repair DNA topological change V(D)J recombination more... apoptosis base-excision repair, DNA ligation cell chemotaxis cellular component disassembly involved in apoptosis cellular response to lipopolysaccharide chromatin organization male gonad development negative regulation of transcription, DNA-dependent nucleosome assembly phosphatidylinositol-mediated signaling positive chemotaxis positive regulation of DNA binding positive regulation of endothelial cell proliferation positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation positive regulation of nuclease activity positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent regulation of transcription from RNA polymerase II promoter response to steroid hormone stimulus spermatid nucleus differentiation spermatogenesis transcription, DNA-dependent less... cellular_component condensed chromosome cytoplasm extracellular space nucleolus more... nucleoplasm nucleus perinuclear region of cytoplasm protein complex less... molecular_function DNA bending activity DNA binding RAGE receptor binding chemoattractant activity more... damaged DNA binding double-stranded DNA binding protein binding protein domain specific binding sequence-specific DNA binding transcription factor activity single-stranded DNA binding transcription regulatory region DNA binding less... IER2 2 BP    MF    CC biological_process cellular_component cytoplasm molecular_function BCAM 2 BP    MF    CC biological_process cell adhesion cell-matrix adhesion signal transduction cellular_component cell surface external side of plasma membrane integral to plasma membrane plasma membrane more... molecular_function laminin binding laminin receptor activity transmembrane signaling receptor activity HDGF 2 BP    MF    CC biological_process cell proliferation regulation of transcription, DNA-dependent signal transduction cellular_component cytoplasm extracellular space nucleoplasm nucleus more... molecular_function DNA binding growth factor activity heparin binding nucleotide binding more... KDM6A 2 BP    MF    CC biological_process chromatin modification histone H3-K4 methylation cellular_component histone methyltransferase complex nucleus molecular_function binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen more...	Down-regulated Genes Score GO annotation IL15 14 BP    MF    CC biological_process NK T cell proliferation aging cell-cell signaling cellular response to vitamin D more... extrathymic T cell selection hyaluronan metabolic process immune response lymph node development negative regulation of smooth muscle cell proliferation positive regulation of T cell proliferation positive regulation of cell proliferation positive regulation of immune response positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of natural killer cell proliferation positive regulation of tissue remodeling positive regulation of tyrosine phosphorylation of Stat3 protein regulation of T cell differentiation regulation of defense response to virus by host response to nutrient levels signal transduction skeletal muscle atrophy less... cellular_component Golgi apparatus cytoplasm endosome extracellular region more... extracellular space integral to plasma membrane membrane fraction nucleus less... molecular_function cytokine activity cytokine receptor binding protein binding signal transducer activity more... CD55 12 BP    MF    CC biological_process complement activation, classical pathway elevation of cytosolic calcium ion concentration innate immune response respiratory burst more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane raft more... plasma membrane soluble fraction less... molecular_function receptor activity SPP1 10 BP    MF    CC biological_process biomineral tissue development cell adhesion decidualization embryo implantation more... inflammatory response negative regulation of collateral sprouting of intact axon in response to injury ossification osteoblast differentiation positive regulation of bone resorption positive regulation of cell-substrate adhesion response to organic substance response to steroid hormone stimulus response to vitamin D less... cellular_component apical part of cell cell projection cytoplasm extracellular region more... extracellular space membrane-bounded vesicle perinuclear region of cytoplasm less... molecular_function cytokine activity extracellular matrix binding IDO1 6 BP    MF    CC biological_process behavior cellular nitrogen compound metabolic process cytokine production involved in inflammatory response female pregnancy more... inflammatory response kynurenic acid biosynthetic process multicellular organismal response to stress negative regulation of T cell apoptosis negative regulation of activated T cell proliferation negative regulation of interleukin-10 production positive regulation of T cell tolerance induction positive regulation of apoptosis positive regulation of chronic inflammatory response positive regulation of interleukin-12 production positive regulation of type 2 immune response response to lipopolysaccharide tryptophan catabolic process tryptophan catabolic process to kynurenine less... cellular_component cytoplasm cytosol smooth muscle contractile fiber soluble fraction more... stereocilium bundle less... molecular_function amino acid binding electron carrier activity heme binding indoleamine 2,3-dioxygenase activity more... metal ion binding oxidoreductase activity oxygen binding tryptophan 2,3-dioxygenase activity less... KIR2DL3 4 BP    MF    CC biological_process immune response regulation of immune response cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function antigen binding protein binding receptor activity PAEP 4 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity IRF1 4 BP    MF    CC biological_process CD8-positive, alpha-beta T cell differentiation I-kappaB kinase/NF-kappaB cascade blood coagulation cellular response to dsRNA more... cellular response to interleukin-1 cellular response to mechanical stimulus cellular response to peptide hormone stimulus cellular response to retinoic acid cellular response to tumor necrosis factor cytokine-mediated signaling pathway female pregnancy interferon-gamma-mediated signaling pathway negative regulation of tyrosine phosphorylation of Stat1 protein positive regulation of cell death positive regulation of interleukin-12 biosynthetic process positive regulation of transcription from RNA polymerase II promoter response to growth hormone stimulus response to heat transcription from RNA polymerase II promoter type I interferon-mediated signaling pathway less... cellular_component cytosol nucleoplasm nucleus molecular_function regulatory region DNA binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity GNLY 4 BP    MF    CC biological_process cellular defense response defense response to bacterium defense response to fungus killing of cells of other organism more... cellular_component extracellular region extracellular space molecular_function DKK1 4 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... ID4 2 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cellular protein localization central nervous system myelination more... cerebral cortex neuron differentiation hippocampus development negative regulation of astrocyte differentiation negative regulation of fat cell differentiation negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent neuroblast proliferation positive regulation of cell proliferation positive regulation of osteoblast differentiation regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm nucleus molecular_function RNA polymerase II transcription factor binding protein binding transcription corepressor activity PLA2G16 2 BP    MF    CC biological_process biological_process lipid catabolic process negative regulation of cell cycle cellular_component cellular_component cytoplasm integral to membrane membrane more... membrane fraction perinuclear region of cytoplasm less... molecular_function hydrolase activity molecular_function protein binding MMP7 2 BP    MF    CC biological_process antibacterial peptide secretion collagen catabolic process defense response to Gram-negative bacterium defense response to Gram-positive bacterium more... metabolic process proteolysis regulation of cell proliferation response to drug less... cellular_component extracellular region extracellular space proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... AOX1 2 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less... GBP2 2 BP    MF    CC biological_process cytokine-mediated signaling pathway immune response interferon-gamma-mediated signaling pathway type I interferon-mediated signaling pathway more... cellular_component cytosol plasma membrane molecular_function GTP binding GTPase activity nucleotide binding CLDN4 2 BP    MF    CC biological_process calcium-independent cell-cell adhesion female pregnancy response to progesterone stimulus cellular_component apical plasma membrane apicolateral plasma membrane basal plasma membrane cell junction more... integral to membrane integral to plasma membrane lateral plasma membrane membrane plasma membrane tight junction less... molecular_function identical protein binding structural molecule activity transmembrane signaling receptor activity C4BPA 2 BP    MF    CC biological_process binding of sperm to zona pellucida complement activation, classical pathway innate immune response cellular_component acrosomal matrix extracellular region molecular_function protein binding IGFBP1 2 BP    MF    CC biological_process insulin receptor signaling pathway positive regulation of cell growth regulation of cell growth signal transduction more... tissue regeneration less... cellular_component extracellular region extracellular space molecular_function insulin-like growth factor binding CDA 2 BP    MF    CC biological_process cell surface receptor linked signaling pathway cellular response to external biotic stimulus cytidine deamination cytosine metabolic process more... negative regulation of cell growth negative regulation of nucleotide metabolic process nucleobase-containing small molecule metabolic process protein homotetramerization pyrimidine base metabolic process pyrimidine nucleoside salvage pyrimidine-containing compound salvage response to cycloheximide less... cellular_component cytosol extracellular region molecular_function cytidine deaminase activity hydrolase activity metal ion binding nucleoside binding more... protein homodimerization activity zinc ion binding less... DEPDC6 2 BP    MF    CC biological_process cellular_component molecular_function CFD 2 BP    MF    CC biological_process Notch signaling pathway blood coagulation complement activation complement activation, alternative pathway more... innate immune response platelet activation platelet degranulation proteolysis less... cellular_component extracellular region extracellular space platelet alpha granule lumen molecular_function peptidase activity serine-type endopeptidase activity serine-type peptidase activity RARRES3 2 BP    MF    CC biological_process lipid catabolic process negative regulation of cell proliferation cellular_component molecular_function hydrolase activity RNASE4 2 BP    MF    CC biological_process mRNA cleavage cellular_component cellular_component extracellular region molecular_function endonuclease activity hydrolase activity nucleic acid binding pancreatic ribonuclease activity more... SLC1A1 2 BP    MF    CC biological_process D-aspartate import L-glutamate import L-glutamate transport dicarboxylic acid transport more... ion transport protein homooligomerization synaptic transmission transmembrane transport less... cellular_component integral to plasma membrane membrane membrane fraction plasma membrane more... molecular_function L-glutamate transmembrane transporter activity glutamate binding glutamate:sodium symporter activity sodium:dicarboxylate symporter activity more... symporter activity less... LYPD3 2 BP    MF    CC biological_process cellular_component anchored to plasma membrane integral to membrane plasma membrane molecular_function CKB 2 BP    MF    CC biological_process brain development cellular chloride ion homeostasis cellular nitrogen compound metabolic process creatine metabolic process more... cellular_component cytoplasm cytosol mitochondrion molecular_function ATP binding creatine kinase activity kinase activity nucleotide binding more... POLD4 2 BP    MF    CC biological_process DNA repair DNA replication DNA strand elongation involved in DNA replication S phase of mitotic cell cycle more... base-excision repair mitotic cell cycle nucleotide-excision repair nucleotide-excision repair, DNA gap filling positive regulation of endothelial cell proliferation telomere maintenance telomere maintenance via recombination telomere maintenance via semi-conservative replication transcription-coupled nucleotide-excision repair less... cellular_component nucleoplasm nucleus molecular_function DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding transferase activity more... MT1H 2 BP    MF    CC biological_process cellular_component molecular_function metal ion binding protein binding CXCL13 2 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... ANXA4 2 BP    MF    CC biological_process anti-apoptosis negative regulation of coagulation signal transduction cellular_component cytoplasm molecular_function calcium ion binding calcium-dependent phospholipid binding phospholipase inhibitor activity ARID5B 2 BP    MF    CC biological_process adipose tissue development adrenal gland development cell development face morphogenesis more... fat cell differentiation fat pad development female gonad development fibroblast migration kidney development liver development male gonad development multicellular organism growth muscle organ morphogenesis negative regulation of transcription, DNA-dependent nitrogen compound metabolic process palate development platelet-derived growth factor receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity post-embryonic development skeletal system morphogenesis less... cellular_component intracellular nucleus molecular_function DNA binding protein binding transcription coactivator activity transcription regulatory region DNA binding more... HABP2 2 BP    MF    CC biological_process cell adhesion proteolysis cellular_component extracellular region extracellular space molecular_function glycosaminoglycan binding peptidase activity serine-type endopeptidase activity FXYD2 2 BP    MF    CC biological_process ion transmembrane transport ion transport potassium ion transport sodium ion transport more... transmembrane transport transport less... cellular_component integral to membrane membrane plasma membrane sodium:potassium-exchanging ATPase complex more... molecular_function ion channel activity sodium:potassium-exchanging ATPase activity transporter activity EFNA1 2 BP    MF    CC biological_process activation of MAPK activity aortic valve morphogenesis cell migration cell-cell signaling more... endocardial cushion to mesenchymal transition involved in heart valve formation ephrin receptor signaling pathway mitral valve morphogenesis negative regulation of dendritic spine morphogenesis negative regulation of epithelial to mesenchymal transition negative regulation of transcription from RNA polymerase II promoter neuron differentiation notochord formation positive regulation of peptidyl-tyrosine phosphorylation regulation of angiogenesis regulation of axonogenesis regulation of blood vessel endothelial cell migration regulation of cell adhesion mediated by integrin regulation of peptidyl-tyrosine phosphorylation substrate adhesion-dependent cell spreading less... cellular_component anchored to plasma membrane extracellular region integral to plasma membrane plasma membrane more... molecular_function ephrin receptor binding protein binding receptor binding DCN 2 BP    MF    CC biological_process aging kidney development organ morphogenesis peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan more... placenta development response to lipopolysaccharide response to mechanical stimulus skeletal muscle tissue development wound healing less... cellular_component collagen type VI extracellular matrix extracellular region extracellular space more... proteinaceous extracellular matrix less... molecular_function collagen binding extracellular matrix binding glycosaminoglycan binding protein N-terminus binding more... C10orf10 2 BP    MF    CC biological_process cellular_component molecular_function ATP6V1A 2 BP    MF    CC biological_process ATP hydrolysis coupled proton transport ATP metabolic process cellular iron ion homeostasis insulin receptor signaling pathway more... ion transport proton transport transferrin transport transmembrane transport transport less... cellular_component apical plasma membrane cytosol integral to plasma membrane microvillus more... mitochondrion plasma membrane proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain less... molecular_function ATP binding hydrogen ion transporting ATP synthase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances more... nucleotide binding proton-transporting ATPase activity, rotational mechanism less... MFAP5 2 BP    MF    CC biological_process cellular_component extracellular region microfibril proteinaceous extracellular matrix molecular_function extracellular matrix structural constituent FOSL2 2 BP    MF    CC biological_process cell death positive regulation of fibroblast proliferation regulation of transcription from RNA polymerase II promoter transcription, DNA-dependent more... cellular_component nucleolus nucleus molecular_function protein dimerization activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity S100P 2 BP    MF    CC biological_process endothelial cell migration cellular_component cytoplasm nucleus molecular_function calcium ion binding calcium-dependent protein binding magnesium ion binding protein binding more... CATSPERB 2 BP    MF    CC biological_process cell differentiation multicellular organismal development spermatogenesis cellular_component flagellum integral to membrane membrane molecular_function SNX10 2 BP    MF    CC biological_process cell communication endosome organization protein transport cellular_component cytoplasm endosome extrinsic to endosome membrane membrane more... molecular_function 1-phosphatidylinositol binding lipid binding phosphatidylinositol binding COMP 2 BP    MF    CC biological_process anti-apoptosis apoptosis cell adhesion limb development more... organ morphogenesis skeletal system development less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding collagen binding extracellular matrix structural constituent heparan sulfate proteoglycan binding more... heparin binding protein binding less... PRD 2 BP    MF    CC biological_process cellular_component molecular_function KRT7 2 BP    MF    CC biological_process DNA replication cytoskeleton organization interphase interspecies interaction between organisms more... regulation of translation less... cellular_component Golgi apparatus cytoplasm intermediate filament keratin filament more... nucleolus nucleus less... molecular_function protein binding structural molecule activity CP 2 BP    MF    CC biological_process cellular iron ion homeostasis copper ion transport ion transport transmembrane transport more... cellular_component extracellular region extracellular space molecular_function chaperone binding copper ion binding ferroxidase activity metal ion binding more... oxidoreductase activity less... SYNE2 2 BP    MF    CC biological_process centrosome localization cytoskeletal anchoring at nuclear membrane nuclear migration nuclear migration along microfilament more... positive regulation of cell migration less... cellular_component SUN-KASH complex Z disc cytoplasm cytoskeleton more... filopodium membrane focal adhesion integral to membrane lamellipodium membrane mitochondrial part nuclear envelope nuclear lumen nuclear membrane nuclear outer membrane nucleoplasm nucleus plasma membrane sarcoplasmic reticulum sarcoplasmic reticulum membrane less... molecular_function actin binding protein binding GABARAPL1 2 BP    MF    CC biological_process cellular_component Golgi apparatus autophagic vacuole cytoplasm cytoskeleton more... endoplasmic reticulum intracellular membrane microtubule less... molecular_function GABA receptor binding beta-tubulin binding protein binding receptor activity more... TCN1 2 BP    MF    CC biological_process cobalamin metabolic process cobalamin transport cobalt ion transport ion transport more... cellular_component extracellular region molecular_function cobalamin binding THBD 2 BP    MF    CC biological_process blood coagulation embryo development female pregnancy leukocyte migration more... negative regulation of blood coagulation negative regulation of fibrinolysis negative regulation of platelet activation response to X-ray response to cAMP response to lipopolysaccharide less... cellular_component cell surface extracellular space integral to membrane integral to plasma membrane more... membrane plasma membrane less... molecular_function binding calcium ion binding protein binding receptor activity more... transmembrane signaling receptor activity less... NNMT 2 BP    MF    CC biological_process methylation organ regeneration response to drug response to organic nitrogen more... xenobiotic metabolic process less... cellular_component cytoplasm cytosol soluble fraction molecular_function methyltransferase activity nicotinamide N-methyltransferase activity transferase activity TSPAN8 2 BP    MF    CC biological_process negative regulation of blood coagulation protein glycosylation signal transduction cellular_component integral to membrane lysosome membrane molecular_function signal transducer activity GABRP 2 BP    MF    CC biological_process ion transport cellular_component cell junction chloride channel complex integral to membrane membrane more... plasma membrane postsynaptic membrane synapse less... molecular_function GABA-A receptor activity chloride channel activity extracellular ligand-gated ion channel activity ion channel activity more... receptor activity less... ANXA5 2 BP    MF    CC biological_process anti-apoptosis blood coagulation negative regulation of coagulation positive regulation of apoptosis more... protein homooligomerization response to organic substance signal transduction less... cellular_component cell projection cytoplasm endothelial microparticle intercalated disc more... intracellular sarcolemma less... molecular_function calcium ion binding calcium-dependent phospholipid binding eukaryotic cell surface binding phospholipase inhibitor activity more... phospholipid binding receptor tyrosine kinase binding less... MT2A 2 BP    MF    CC biological_process cellular copper ion homeostasis cytokine-mediated signaling pathway interferon-gamma-mediated signaling pathway cellular_component cytosol molecular_function metal ion binding protein binding DEFB1 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway acute inflammatory response chemotaxis defense response to bacterium more... immune response innate immune response response to bacterium response to testosterone stimulus less... cellular_component extracellular region soluble fraction molecular_function ACADSB 2 BP    MF    CC biological_process acyl-CoA metabolic process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process fatty acid metabolic process more... lipid metabolic process less... cellular_component mitochondrial matrix mitochondrion molecular_function acyl-CoA dehydrogenase activity electron carrier activity flavin adenine dinucleotide binding short-branched-chain-acyl-CoA dehydrogenase activity more... DDX52 2 BP    MF    CC biological_process cellular_component nucleolus nucleus molecular_function ATP binding ATP-dependent helicase activity RNA binding helicase activity more... hydrolase activity nucleic acid binding nucleotide binding less... ARG2 2 BP    MF    CC biological_process apoptosis arginine metabolic process cellular nitrogen compound metabolic process cellular response to dexamethasone stimulus more... cellular response to interferon-gamma cellular response to lipopolysaccharide lung development maternal process involved in female pregnancy midgut development negative regulation of nitric-oxide synthase activity negative regulation of striated muscle contraction nitric oxide biosynthetic process regulation of L-arginine import regulation of nitric oxide biosynthetic process response to amino acid stimulus response to axon injury response to cadmium ion response to drug response to glucose stimulus response to herbicide response to hormone stimulus response to hypoxia response to mercury ion response to nutrient response to selenium ion response to vitamin E urea cycle ureteric bud development less... cellular_component mitochondrial matrix mitochondrion molecular_function arginase activity hydrolase activity metal ion binding nitric-oxide synthase binding more... GPX3 2 BP    MF    CC biological_process female pregnancy glutathione metabolic process hydrogen peroxide catabolic process oxidation-reduction process more... protein homotetramerization response to corticosterone stimulus response to drug response to lipid hydroperoxide response to molecule of fungal origin response to organic cyclic compound response to oxidative stress response to selenium ion less... cellular_component extracellular region extracellular space soluble fraction molecular_function glutathione binding glutathione peroxidase activity oxidoreductase activity selenium binding more... transcription factor binding less... LMCD1 2 BP    MF    CC biological_process negative regulation of transcription from RNA polymerase II promoter positive regulation of calcineurin-NFAT signaling pathway regulation of cardiac muscle hypertrophy regulation of transcription, DNA-dependent more... cellular_component cytoplasm extracellular matrix extracellular space nucleus more... molecular_function metal ion binding transcription corepressor activity zinc ion binding ADAMTS1 2 BP    MF    CC biological_process heart trabecula formation integrin-mediated signaling pathway kidney development negative regulation of cell proliferation more... ovulation from ovarian follicle proteolysis less... cellular_component basement membrane cytoplasmic vesicle extracellular matrix extracellular region more... molecular_function heparin binding metal ion binding metalloendopeptidase activity metallopeptidase activity more... peptidase activity zinc ion binding less... HPSE 2 BP    MF    CC biological_process carbohydrate metabolic process cell adhesion cell-matrix adhesion positive regulation of blood coagulation more... positive regulation of osteoblast proliferation positive regulation of protein kinase B signaling cascade positive regulation vascular endothelial growth factor production proteoglycan metabolic process regulation of hair follicle development less... cellular_component extracellular region lysosomal membrane lysosome membrane more... nucleus less... molecular_function beta-glucuronidase activity catalytic activity cation binding hydrolase activity, acting on glycosyl bonds more... protein binding protein dimerization activity syndecan binding less... PTPRR 2 BP    MF    CC biological_process in utero embryonic development nervous system development neuron differentiation peptidyl-tyrosine dephosphorylation more... protein dephosphorylation less... cellular_component Golgi apparatus cell surface cytoplasm integral to membrane more... nucleus perinuclear region of cytoplasm plasma membrane less... molecular_function hydrolase activity protein kinase binding protein tyrosine phosphatase activity receptor activity more... transmembrane receptor protein tyrosine phosphatase activity less... DPP4 2 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... ABCC3 2 BP    MF    CC biological_process bile acid and bile salt transport bile acid metabolic process organic anion transport transmembrane transport more... transport less... cellular_component integral to plasma membrane membrane fraction plasma membrane molecular_function ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding more... organic anion transmembrane transporter activity transporter activity less... SERPING1 2 BP    MF    CC biological_process blood circulation blood coagulation blood coagulation, intrinsic pathway complement activation, classical pathway more... innate immune response negative regulation of complement activation, lectin pathway negative regulation of endopeptidase activity platelet activation platelet degranulation less... cellular_component extracellular region extracellular space platelet alpha granule lumen molecular_function peptidase activity peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity more... TIMP1 2 BP    MF    CC biological_process aging blood coagulation cell activation erythrocyte maturation more... negative regulation of apoptosis negative regulation of membrane protein ectodomain proteolysis platelet activation platelet degranulation positive regulation of cell proliferation response to cytokine stimulus response to peptide hormone stimulus wound healing less... cellular_component basement membrane extracellular region platelet alpha granule lumen molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... EDNRB 2 BP    MF    CC biological_process activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger cell surface receptor linked signaling pathway developmental pigmentation enteric nervous system development more... enteric smooth muscle cell differentiation macrophage chemotaxis melanocyte differentiation negative regulation of adenylate cyclase activity negative regulation of cellular protein metabolic process negative regulation of neuron maturation negative regulation of transcription from RNA polymerase II promoter nervous system development neural crest cell migration peripheral nervous system development posterior midgut development regulation of blood pressure regulation of pH vasoconstriction vein smooth muscle contraction less... cellular_component integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity endothelin-B receptor activity peptide hormone binding receptor activity more... signal transducer activity less... AMIGO2 2 BP    MF    CC biological_process anti-apoptosis cell adhesion heterophilic cell-cell adhesion homophilic cell adhesion more... negative regulation of programmed cell death less... cellular_component integral to membrane nucleus plasma membrane molecular_function SCGB2A2 2 BP    MF    CC biological_process biological_process cellular_component cellular_component extracellular region molecular_function binding molecular_function steroid binding TBC1D2 2 BP    MF    CC biological_process positive regulation of Rab GTPase activity cellular_component cell junction cytoplasm cytoplasmic membrane-bounded vesicle cytoplasmic vesicle more... intracellular nucleus less... molecular_function GTPase activator activity Rab GTPase activator activity cadherin binding S100A1 2 BP    MF    CC biological_process intracellular signal transduction negative regulation of transcription from RNA polymerase II promoter regulation of heart contraction cellular_component cytoplasm intracellular nucleus protein complex more... sarcoplasmic reticulum less... molecular_function ATPase binding S100 alpha binding S100 beta binding calcium ion binding more... identical protein binding protein binding protein homodimerization activity less... ENPEP 2 BP    MF    CC biological_process angiogenesis cell migration cell proliferation cell-cell signaling more... proteolysis less... cellular_component apical plasma membrane brush border cytoplasmic vesicle external side of plasma membrane more... integral to plasma membrane plasma membrane less... molecular_function aminopeptidase activity metal ion binding metalloexopeptidase activity peptidase activity more... zinc ion binding less... SOD2 2 BP    MF    CC biological_process age-dependent response to oxidative stress age-dependent response to reactive oxygen species aging anti-apoptosis more... cellular response to ethanol detection of oxygen erythrophore differentiation glutathione metabolic process heart development hemopoiesis hydrogen peroxide biosynthetic process iron ion homeostasis liver development locomotory behavior mitochondrion organization negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of fibroblast proliferation negative regulation of neuron apoptosis neuron development oxidation-reduction process oxygen homeostasis positive regulation of nitric oxide biosynthetic process post-embryonic development protein homooligomerization protein homotetramerization regulation of blood pressure regulation of catalytic activity regulation of mitochondrial membrane potential regulation of transcription from RNA polymerase II promoter release of cytochrome c from mitochondria removal of superoxide radicals respiratory electron transport chain response to L-ascorbic acid response to activity response to axon injury response to cadmium ion response to drug response to electrical stimulus response to hydrogen peroxide response to hyperoxia response to hypoxia response to lipopolysaccharide response to manganese ion response to nutrient levels response to selenium ion response to silicon dioxide response to superoxide response to zinc ion superoxide anion generation superoxide metabolic process vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure less... cellular_component cytoplasm mitochondrial inner membrane mitochondrial matrix mitochondrial nucleoid more... mitochondrion soluble fraction less... molecular_function DNA binding identical protein binding manganese ion binding metal ion binding more... oxidoreductase activity oxygen binding superoxide dismutase activity less... WFDC2 2 BP    MF    CC biological_process negative regulation of endopeptidase activity proteolysis spermatogenesis cellular_component extracellular region extracellular space molecular_function endopeptidase inhibitor activity peptidase inhibitor activity serine-type endopeptidase inhibitor activity BCL6 2 BP    MF    CC biological_process B cell differentiation actin cytoskeleton organization cell morphogenesis erythrocyte development more... germinal center formation negative regulation of B cell apoptosis negative regulation of Rho protein signal transduction negative regulation of S phase of mitotic cell cycle negative regulation of T-helper 2 cell differentiation negative regulation of apoptosis negative regulation of cell differentiation negative regulation of cell growth negative regulation of cell proliferation negative regulation of cell-matrix adhesion negative regulation of isotype switching to IgE isotypes negative regulation of mast cell cytokine production negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent negative regulation of type 2 immune response positive regulation of B cell proliferation positive regulation of apoptosis positive regulation of cellular component movement protein import into nucleus, translocation protein localization regulation of Rho GTPase activity regulation of germinal center formation regulation of immune response regulation of inflammatory response regulation of memory T cell differentiation response to DNA damage stimulus spermatogenesis transcription, DNA-dependent less... cellular_component intracellular nucleolus nucleus replication fork more... molecular_function chromatin DNA binding chromatin binding metal ion binding nucleic acid binding more... protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity zinc ion binding less... S100A4 2 BP    MF    CC biological_process epithelial to mesenchymal transition positive regulation of I-kappaB kinase/NF-kappaB cascade cellular_component neuron projection nucleus perinuclear region of cytoplasm molecular_function RAGE receptor binding calcium ion binding calcium-dependent protein binding identical protein binding more... protein binding less... RPRM 2 BP    MF    CC biological_process cell cycle arrest regulation of mitotic cell cycle cellular_component cytoplasm integral to membrane membrane molecular_function CXCL14 2 BP    MF    CC biological_process cell-cell signaling chemotaxis immune response signal transduction more... cellular_component Golgi apparatus extracellular region extracellular space molecular_function chemokine activity MAOA 2 BP    MF    CC biological_process behavior catecholamine metabolic process cellular biogenic amine metabolic process dopamine catabolic process more... neurotransmitter biosynthetic process neurotransmitter catabolic process neurotransmitter secretion phenylethylamine metabolic process serotonin metabolic process synaptic transmission xenobiotic metabolic process less... cellular_component integral to membrane membrane mitochondrial outer membrane mitochondrion more... soluble fraction less... molecular_function flavin adenine dinucleotide binding oxidoreductase activity primary amine oxidase activity serotonin binding more... FAM134B 2 BP    MF    CC biological_process sensory perception of pain cellular_component Golgi apparatus cis-Golgi network endoplasmic reticulum integral to membrane more... membrane less... molecular_function GAST 2 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway signal transduction cellular_component extracellular region molecular_function hormone activity GDF15 2 BP    MF    CC biological_process cell-cell signaling signal transduction transforming growth factor beta receptor signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity LAMB3 2 BP    MF    CC biological_process cell adhesion cell junction assembly epidermis development hemidesmosome assembly more... cellular_component basement membrane extracellular region molecular_function protein binding protein complex binding structural molecule activity ANG 2 BP    MF    CC biological_process actin filament polymerization activation of phospholipase A2 activity activation of phospholipase C activity activation of protein kinase B activity more... angiogenesis cell communication cell death cell differentiation cell migration diacylglycerol biosynthetic process homeostatic process multicellular organismal development negative regulation of smooth muscle cell proliferation negative regulation of translation oocyte maturation ovarian follicle development placenta development positive regulation of endothelial cell proliferation positive regulation of phosphorylation positive regulation of protein secretion rRNA transcription response to hormone stimulus response to hypoxia less... cellular_component angiogenin-PRI complex basal lamina extracellular region extracellular space more... growth cone neuronal cell body nucleolus nucleus less... molecular_function DNA binding actin binding copper ion binding endonuclease activity more... heparin binding hydrolase activity pancreatic ribonuclease activity peptide binding protein binding rRNA binding receptor binding ribonuclease activity less... MT1G 2 BP    MF    CC biological_process cellular_component molecular_function metal ion binding protein binding GADD45A 2 BP    MF    CC biological_process DNA repair G2/M transition of mitotic cell cycle apoptosis cell cycle arrest more... cellular response to ionizing radiation cellular response to mechanical stimulus centrosome cycle negative regulation of protein kinase activity positive regulation of reactive oxygen species metabolic process regulation of cyclin-dependent protein kinase activity signal transduction in response to DNA damage less... cellular_component nucleus molecular_function protein binding
Up-regulated Genes Score TEK 2 CTSF 2 EPB41L2 2 CCNB1 2 CETN2 2 CTGF 2 MRE11A 2 ZNF238 2 CPE 2 LAMP2 2 SMARCA2 2 MLLT11 2 SH3BGRL 2 CSNK1E 2 CAP2 2 SEMA3F 2 AURKB 2 SLC25A5 2 KRIT1 2 SPOP 2 BRCA2 2 PLK2 2 SEMA3C 2 ERCC5 2 SMAD1 2 BMI1 2 HDAC2 2 RECQL 2 GRK5 2 EDN3 2 PRAF2 2 RRM1 2 CFLAR 2 SELENBP1 2 EIF2S2 2 EIF3I 2 PPIC 2 RANBP1 2 MSH2 2 MED12 2 MFAP2 2 AGL 2 AKAP1 2 XRCC5 2 IRS1 2 TUSC3 2 NT5C2 2 EHMT2 2 MDH1 2 SMARCA5 2 CDK2 2 CDH2 2 MAP2K4 2 CSRP2 2 GNG11 2 MYO1B 2 TMEM5 2 NAB1 2 APP 2 CCND1 2 HPCAL1 2 ZKSCAN1 2 DUT 2 MARCKS 2 FAP 2 MAPRE2 2 C1D 2 LGALS8 2 FGFR1 2 MSX2 2 VEZF1 2 WFS1 2 RBMS1 2 MID1 2 TFF3 2 MECP2 2 TCF3 2 DIO2 2 NPTX2 2 PHLDA2 2 CFDP1 2 ARHGAP1 2 SFRP1 2 CREB1 2 ENPP2 2 ERG 2 RABIF 2 HADH 2 FGFR2 2 ACVRL1 2 RCBTB2 2 SFRP4 2 PARG 2 RYK 2 PCGF2 2 HMGB2 2 IER2 2 BCAM 2 HDGF 2 KDM6A 2 NDC80 2 EXT1 2 NOVA1 2 FOP 2 MAP2K3 2 HLA-DQB1 2 BGN 2 CENPA 2 ZNF195 2 BRCA1 2 VEGFA 2 PRPSAP1 2 ZNF91 2 EIF4G1 2 KHDRBS3 2 VRK1 2 TIA1 2 HSBP1 2 PPP3CB 2 PFN2 2 SATB1 2 GATA2 2 PRKCI 2 MED7 2 NRIP1 2 ALDH3A2 2 NIPSNAP1 2 MTHFD1 2 BCR 2 AK5 2 TESK1 2 ACSL3 2 TCF7 2 NMT2 2 BICD1 2 CBX1 2 POSTN 2 FSCN1 2 SCG5 2 PPP1R12B 2 SEC22B 2 ALDH1A1 2 MBD1 2 IMMT 2 HOXB7 2 HMGB1L5 2 ITSN2 2 TNC 2 GLI1 2 SEC24A 2 GCA 2 TAF5 2 DPP6 2 PARP2 2 F13A1 2 YWHAQ 2 DKC1 2 INA 2 TIAL1 2 ALDH5A1 2 SLC20A2 2 OLFM1 2 NCOA1 2 SAP18 2 CUGBP2 2 DGKZ 2 RAE1 2 SRGN 2 MXRA5 2 CTAG1B 2 CCR1 2 TANK 2 TSC22D1 2 P2RX4 2 HES1 2 CLEC11A 2 MSX1 2 PATZ1 2 TNFRSF10B 2 PPARA 2 PGRMC1 2 MEGF9 2 EXTL2 2	Down-regulated Genes Score IL15 14 CD55 12 SPP1 10 IDO1 6 KIR2DL3 4 PAEP 4 IRF1 4 GNLY 4 DKK1 4 ID4 2 PLA2G16 2 MMP7 2 AOX1 2 GBP2 2 CLDN4 2 C4BPA 2 IGFBP1 2 CDA 2 DEPDC6 2 CFD 2 RARRES3 2 RNASE4 2 SLC1A1 2 LYPD3 2 CKB 2 POLD4 2 MT1H 2 CXCL13 2 ANXA4 2 ARID5B 2 HABP2 2 FXYD2 2 EFNA1 2 DCN 2 C10orf10 2 ATP6V1A 2 MFAP5 2 FOSL2 2 S100P 2 CATSPERB 2 SNX10 2 COMP 2 PRD 2 KRT7 2 CP 2 SYNE2 2 GABARAPL1 2 TCN1 2 THBD 2 NNMT 2 TSPAN8 2 GABRP 2 ANXA5 2 MT2A 2 DEFB1 2 ACADSB 2 DDX52 2 ARG2 2 GPX3 2 LMCD1 2 ADAMTS1 2 HPSE 2 PTPRR 2 DPP4 2 ABCC3 2 SERPING1 2 TIMP1 2 EDNRB 2 AMIGO2 2 SCGB2A2 2 TBC1D2 2 S100A1 2 ENPEP 2 SOD2 2 WFDC2 2 BCL6 2 S100A4 2 RPRM 2 CXCL14 2 MAOA 2 FAM134B 2 GAST 2 GDF15 2 LAMB3 2 ANG 2 MT1G 2 GADD45A 2
Identifiers Repository Data-sets 15373944 PubMed 2 20619403 PubMed 2 12021176 PubMed 6 15494045 PubMed 2 18524812 PubMed 4 18793766 PubMed 4
Up-regulated(183) Down-regulated(87)