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Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Normal
VS
Species Homo sapiens Tissue uterus;;Endometrium;;Secretory (Luteal);;Mid (Receptive) Condition Chemical treatment;;GnRH agonist
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Up-regulated Genes Score GO annotation CD36 6 BP    MF    CC biological_process apoptotic cell clearance blood coagulation cGMP-mediated signaling cell adhesion more... cell surface receptor linked signaling pathway cellular response to bacterial lipopeptide cellular response to hydroperoxide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cholesterol transport defense response to Gram-positive bacterium lipid metabolic process lipid storage lipoprotein transport low-density lipoprotein particle clearance low-density lipoprotein particle mediated signaling negative regulation of gene expression negative regulation of growth of symbiont in host negative regulation of transcription factor import into nucleus negative regulation of transcription from RNA polymerase II promoter nitric oxide mediated signal transduction phagocytosis, recognition plasma lipoprotein particle clearance plasma membrane long-chain fatty acid transport platelet activation platelet degranulation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAPKKK cascade positive regulation of blood coagulation positive regulation of blood microparticle formation positive regulation of cell-matrix adhesion positive regulation of cholesterol storage positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of macrophage derived foam cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species metabolic process positive regulation of tumor necrosis factor production regulation of removal of superoxide radicals response to stilbenoid transport less... cellular_component Golgi apparatus cell surface external side of plasma membrane integral to plasma membrane more... membrane membrane fraction membrane raft plasma membrane platelet alpha granule membrane less... molecular_function Gram-negative bacterial cell surface binding Gram-positive bacterial cell surface binding high-density lipoprotein particle binding lipid binding more... lipoprotein particle binding lipoteichoic acid receptor activity low-density lipoprotein particle binding low-density lipoprotein receptor activity receptor activity thrombospondin receptor activity transforming growth factor beta binding less... SFRP4 6 BP    MF    CC biological_process Wnt receptor signaling pathway axonogenesis brain development cell differentiation more... decidualization embryo development epithelium development gonad development mammary gland involution menstrual cycle phase multicellular organismal development negative regulation of JNK cascade negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of sodium-dependent phosphate transport phosphate ion homeostasis positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of epidermal cell differentiation positive regulation of gene expression positive regulation of receptor internalization response to estradiol stimulus response to glucocorticoid stimulus response to hormone stimulus response to peptide hormone stimulus vasculature development less... cellular_component cell surface cytoplasm extracellular region extracellular space more... neuron projection membrane nucleus less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding KCNG1 6 BP    MF    CC biological_process ion transport potassium ion transmembrane transport potassium ion transport synaptic transmission more... transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated potassium channel complex more... molecular_function potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity SLC7A4 6 BP    MF    CC biological_process basic amino acid transport cellular amino acid metabolic process transport cellular_component integral to membrane membrane molecular_function amino acid transmembrane transporter activity basic amino acid transmembrane transporter activity RABGAP1L 4 BP    MF    CC biological_process positive regulation of Rab GTPase activity regulation of protein localization cellular_component Golgi apparatus early endosome intracellular nucleus more... molecular_function GTPase activator activity Rab GTPase activator activity Rab GTPase binding EDN3 4 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding CACNA1D 4 BP    MF    CC biological_process axon guidance calcium ion transport energy reserve metabolic process ion transport more... regulation of calcium ion transport via voltage-gated calcium channel activity regulation of insulin secretion transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated calcium channel complex more... molecular_function voltage-gated calcium channel activity voltage-gated ion channel activity MOXD1 4 BP    MF    CC biological_process catecholamine metabolic process cellular process oxidation-reduction process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function copper ion binding dopamine beta-monooxygenase activity metal ion binding monooxygenase activity more... DKK2 4 BP    MF    CC biological_process multicellular organismal development negative regulation of Wnt receptor signaling pathway negative regulation of canonical Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway more... cellular_component extracellular region extracellular space molecular_function MATN2 4 BP    MF    CC biological_process biological_process cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function calcium ion binding molecular_function	Down-regulated Genes Score GO annotation CXCL13 6 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... KRT23 6 BP    MF    CC biological_process cellular_component intermediate filament molecular_function structural molecule activity AHNAK2 6 BP    MF    CC biological_process cellular_component nucleus molecular_function DKK1 6 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... CCL2 4 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging more... angiogenesis anti-apoptosis apoptotic cell clearance astrocyte cell migration cell adhesion cell surface receptor linked signaling pathway cellular calcium ion homeostasis cellular homeostasis cellular response to interferon-gamma cellular response to interleukin-1 cellular response to lipopolysaccharide cellular response to tumor necrosis factor chemokine-mediated signaling pathway chemotaxis cytokine-mediated signaling pathway helper T cell extravasation humoral immune response inflammatory response lymphocyte chemotaxis macrophage chemotaxis maternal process involved in parturition monocyte chemotaxis negative regulation of angiogenesis neutrophil chemotaxis organ morphogenesis organ regeneration positive regulation of T cell activation positive regulation of endothelial cell proliferation positive regulation of immune complex clearance by monocytes and macrophages positive regulation of macrophage chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of synaptic transmission protein phosphorylation regulation of vascular endothelial growth factor production response to activity response to amino acid stimulus response to antibiotic response to bacterium response to drug response to ethanol response to gamma radiation response to glucocorticoid stimulus response to heat response to hypoxia response to mechanical stimulus response to progesterone stimulus response to vitamin B3 signal transduction transforming growth factor beta receptor signaling pathway vascular endothelial growth factor receptor signaling pathway viral genome replication less... cellular_component cytoplasm extracellular region extracellular space neuronal cell body more... molecular_function CCR2 chemokine receptor binding G-protein-coupled receptor binding chemokine activity heparin binding more... protein kinase activity receptor binding signal transducer activity less... S100A8 4 BP    MF    CC biological_process acute inflammatory response chemotaxis chronic inflammatory response inflammatory response more... response to ethanol response to lipopolysaccharide response to zinc ion wound healing less... cellular_component cytoplasm cytoskeleton extracellular region extracellular space more... plasma membrane less... molecular_function calcium ion binding protein binding ID4 4 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cellular protein localization central nervous system myelination more... cerebral cortex neuron differentiation hippocampus development negative regulation of astrocyte differentiation negative regulation of fat cell differentiation negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent neuroblast proliferation positive regulation of cell proliferation positive regulation of osteoblast differentiation regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm nucleus molecular_function RNA polymerase II transcription factor binding protein binding transcription corepressor activity CHST2 4 BP    MF    CC biological_process N-acetylglucosamine metabolic process carbohydrate metabolic process inflammatory response multicellular organismal development more... sulfur compound metabolic process less... cellular_component Golgi apparatus integral to membrane intrinsic to Golgi membrane membrane more... trans-Golgi network less... molecular_function N-acetylglucosamine 6-O-sulfotransferase activity sulfotransferase activity transferase activity AOX1 4 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less... STC1 4 BP    MF    CC biological_process cell surface receptor linked signaling pathway cell-cell signaling cellular calcium ion homeostasis cellular response to cAMP more... cellular response to glucocorticoid stimulus cellular response to hypoxia decidualization embryo implantation ossification response to nutrient response to organic cyclic compound response to vitamin D less... cellular_component apical plasma membrane cytoplasm extracellular region extracellular space more... molecular_function hormone activity
Up-regulated Genes Score GO annotation CD36 6 BP    MF    CC biological_process apoptotic cell clearance blood coagulation cGMP-mediated signaling cell adhesion more... cell surface receptor linked signaling pathway cellular response to bacterial lipopeptide cellular response to hydroperoxide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cholesterol transport defense response to Gram-positive bacterium lipid metabolic process lipid storage lipoprotein transport low-density lipoprotein particle clearance low-density lipoprotein particle mediated signaling negative regulation of gene expression negative regulation of growth of symbiont in host negative regulation of transcription factor import into nucleus negative regulation of transcription from RNA polymerase II promoter nitric oxide mediated signal transduction phagocytosis, recognition plasma lipoprotein particle clearance plasma membrane long-chain fatty acid transport platelet activation platelet degranulation positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of MAPKKK cascade positive regulation of blood coagulation positive regulation of blood microparticle formation positive regulation of cell-matrix adhesion positive regulation of cholesterol storage positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of macrophage derived foam cell differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species metabolic process positive regulation of tumor necrosis factor production regulation of removal of superoxide radicals response to stilbenoid transport less... cellular_component Golgi apparatus cell surface external side of plasma membrane integral to plasma membrane more... membrane membrane fraction membrane raft plasma membrane platelet alpha granule membrane less... molecular_function Gram-negative bacterial cell surface binding Gram-positive bacterial cell surface binding high-density lipoprotein particle binding lipid binding more... lipoprotein particle binding lipoteichoic acid receptor activity low-density lipoprotein particle binding low-density lipoprotein receptor activity receptor activity thrombospondin receptor activity transforming growth factor beta binding less... SFRP4 6 BP    MF    CC biological_process Wnt receptor signaling pathway axonogenesis brain development cell differentiation more... decidualization embryo development epithelium development gonad development mammary gland involution menstrual cycle phase multicellular organismal development negative regulation of JNK cascade negative regulation of canonical Wnt receptor signaling pathway negative regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of sodium-dependent phosphate transport phosphate ion homeostasis positive regulation of apoptosis positive regulation of canonical Wnt receptor signaling pathway positive regulation of epidermal cell differentiation positive regulation of gene expression positive regulation of receptor internalization response to estradiol stimulus response to glucocorticoid stimulus response to hormone stimulus response to peptide hormone stimulus vasculature development less... cellular_component cell surface cytoplasm extracellular region extracellular space more... neuron projection membrane nucleus less... molecular_function PDZ domain binding Wnt-activated receptor activity Wnt-protein binding KCNG1 6 BP    MF    CC biological_process ion transport potassium ion transmembrane transport potassium ion transport synaptic transmission more... transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated potassium channel complex more... molecular_function potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity SLC7A4 6 BP    MF    CC biological_process basic amino acid transport cellular amino acid metabolic process transport cellular_component integral to membrane membrane molecular_function amino acid transmembrane transporter activity basic amino acid transmembrane transporter activity RABGAP1L 4 BP    MF    CC biological_process positive regulation of Rab GTPase activity regulation of protein localization cellular_component Golgi apparatus early endosome intracellular nucleus more... molecular_function GTPase activator activity Rab GTPase activator activity Rab GTPase binding EDN3 4 BP    MF    CC biological_process artery smooth muscle contraction blood circulation cell surface receptor linked signaling pathway cell-cell signaling more... inositol phosphate-mediated signaling melanocyte differentiation multicellular organismal development negative regulation of hormone secretion neural crest cell migration neuron differentiation neutrophil chemotaxis peptide hormone secretion positive regulation of MAP kinase activity positive regulation of cell proliferation positive regulation of heart rate positive regulation of hormone secretion positive regulation of leukocyte chemotaxis positive regulation of mitosis regulation of cell migration regulation of developmental pigmentation regulation of neurotransmitter secretion regulation of systemic arterial blood pressure by endothelin regulation of vasoconstriction signal transduction vasoconstriction vein smooth muscle contraction less... cellular_component extracellular region extracellular space soluble fraction molecular_function endothelin B receptor binding hormone activity receptor binding CACNA1D 4 BP    MF    CC biological_process axon guidance calcium ion transport energy reserve metabolic process ion transport more... regulation of calcium ion transport via voltage-gated calcium channel activity regulation of insulin secretion transmembrane transport less... cellular_component integral to membrane membrane plasma membrane voltage-gated calcium channel complex more... molecular_function voltage-gated calcium channel activity voltage-gated ion channel activity MOXD1 4 BP    MF    CC biological_process catecholamine metabolic process cellular process oxidation-reduction process cellular_component endoplasmic reticulum endoplasmic reticulum membrane integral to membrane membrane more... molecular_function copper ion binding dopamine beta-monooxygenase activity metal ion binding monooxygenase activity more... DKK2 4 BP    MF    CC biological_process multicellular organismal development negative regulation of Wnt receptor signaling pathway negative regulation of canonical Wnt receptor signaling pathway positive regulation of canonical Wnt receptor signaling pathway more... cellular_component extracellular region extracellular space molecular_function MATN2 4 BP    MF    CC biological_process biological_process cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function calcium ion binding molecular_function ACSM3 4 BP    MF    CC biological_process fatty acid biosynthetic process lipid metabolic process regulation of blood pressure cellular_component cellular_component mitochondrial matrix mitochondrion molecular_function ATP binding butyrate-CoA ligase activity catalytic activity fatty acid ligase activity more... ligase activity metal ion binding molecular_function nucleotide binding less... KMO 4 BP    MF    CC biological_process NAD metabolic process cellular nitrogen compound metabolic process kynurenine metabolic process pyridine nucleotide biosynthetic process more... response to salt stress tryptophan catabolic process tryptophan catabolic process to kynurenine less... cellular_component cytosol integral to membrane membrane mitochondrial inner membrane more... mitochondrial outer membrane mitochondrion less... molecular_function NAD(P)H oxidase activity electron carrier activity flavin adenine dinucleotide binding kynurenine 3-monooxygenase activity more... monooxygenase activity less... TCN1 4 BP    MF    CC biological_process cobalamin metabolic process cobalamin transport cobalt ion transport ion transport more... cellular_component extracellular region molecular_function cobalamin binding LRRC17 4 BP    MF    CC biological_process bone marrow development negative regulation of osteoclast differentiation osteoblast differentiation osteoblast proliferation more... cellular_component extracellular region extracellular space molecular_function DAAM2 4 BP    MF    CC biological_process actin cytoskeleton organization cellular component organization cellular_component molecular_function Rho GTPase binding actin binding binding PTGS1 4 BP    MF    CC biological_process aging cyclooxygenase pathway fatty acid biosynthetic process lipid metabolic process more... negative regulation of epinephrine secretion negative regulation of norepinephrine secretion oxidation-reduction process positive regulation of smooth muscle contraction positive regulation of vasoconstriction prostaglandin biosynthetic process prostanoid metabolic process regulation of blood pressure regulation of cell proliferation response to corticosterone stimulus response to organic nitrogen response to oxidative stress xenobiotic metabolic process less... cellular_component Golgi apparatus cytoplasm cytoplasmic part endoplasmic reticulum more... endoplasmic reticulum membrane intracellular membrane-bounded organelle microsome nuclear envelope nucleus photoreceptor outer segment plasma membrane less... molecular_function heme binding lipid binding metal ion binding oxidoreductase activity more... oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen peroxidase activity prostaglandin-endoperoxide synthase activity less... RASSF2 4 BP    MF    CC biological_process cell cycle signal transduction cellular_component nucleus molecular_function protein binding FZD5 4 BP    MF    CC biological_process Spemann organizer formation T cell differentiation in thymus Wnt receptor signaling pathway involved in dorsal/ventral axis specification angiogenesis more... anterior/posterior axis specification, embryo apoptosis axonogenesis brain development canonical Wnt receptor signaling pathway cellular response to molecule of bacterial origin embryonic axis specification embryonic camera-type eye development gonad development labyrinthine layer blood vessel development multicellular organismal development neuron differentiation positive regulation of interferon-gamma production positive regulation of transcription from RNA polymerase II promoter post-embryonic camera-type eye development less... cellular_component Golgi apparatus Golgi membrane cell projection cell surface more... cytoplasm integral to membrane plasma membrane less... molecular_function G-protein coupled receptor activity PDZ domain binding Wnt-activated receptor activity Wnt-protein binding more... protein binding protein kinase binding receptor activity signal transducer activity less... C5orf13 4 BP    MF    CC biological_process axon regeneration regulation of neuron differentiation regulation of transforming growth factor beta receptor signaling pathway cellular_component cytoplasm nucleus molecular_function ECM1 4 BP    MF    CC biological_process biomineral tissue development negative regulation of bone mineralization negative regulation of peptidase activity ossification more... positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of angiogenesis positive regulation of endothelial cell proliferation signal transduction less... cellular_component extracellular matrix extracellular region proteinaceous extracellular matrix molecular_function enzyme binding laminin binding protease binding protein C-terminus binding more... protein binding signal transducer activity less... DPP4 4 BP    MF    CC biological_process T cell activation T cell costimulation cell adhesion endothelial cell migration more... establishment of localization negative regulation of extracellular matrix disassembly positive regulation of cell proliferation proteolysis regulation of T cell mediated immunity regulation of cell-cell adhesion mediated by integrin response to hypoxia less... cellular_component Golgi apparatus apical plasma membrane cell junction cell surface more... endocytic vesicle endoplasmic reticulum extracellular region integral to membrane intercellular canaliculus invadopodium membrane lamellipodium lamellipodium membrane membrane membrane fraction membrane raft plasma membrane soluble fraction less... molecular_function aminopeptidase activity collagen binding dipeptidyl-peptidase activity peptidase activity more... peptide binding protease binding protein binding protein homodimerization activity receptor activity receptor binding serine-type endopeptidase activity serine-type peptidase activity less... ANO1 4 BP    MF    CC biological_process chloride transport ion transport multicellular organismal development trachea development more... cellular_component chloride channel complex cytoplasm integral to membrane plasma membrane more... molecular_function intracellular calcium activated chloride channel activity ion channel activity PAGE4 4 BP    MF    CC biological_process biological_process cellular_component cellular_component molecular_function molecular_function OPRK1 4 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway behavior immune response inhibition of adenylate cyclase activity by G-protein signaling pathway more... sensory perception synaptic transmission viral genome replication less... cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function G-protein coupled receptor activity kappa-opioid receptor activity protein binding receptor activity more... signal transducer activity less... ESR1 4 BP    MF    CC biological_process Sertoli cell proliferation androgen metabolic process antral ovarian follicle growth cellular response to estrogen stimulus more... epithelial cell development epithelial cell proliferation involved in mammary gland duct elongation estrogen receptor signaling pathway gene expression mammary gland alveolus development mammary gland branching involved in pregnancy neuroprotection osteoblast development positive regulation of ERK1 and ERK2 cascade positive regulation of epidermal growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of retinoic acid receptor signaling pathway positive regulation of survival gene product expression positive regulation of transcription from RNA polymerase II promoter prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate epithelial cord elongation regulation of apoptosis regulation of branching involved in prostate gland morphogenesis regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor regulation of transcription, DNA-dependent response to estradiol stimulus response to estrogen stimulus signal transduction steroid hormone mediated signaling pathway transcription, DNA-dependent uterus development vagina development less... cellular_component T-tubule chromatin remodeling complex cytoplasm membrane more... mitochondrial part neuron projection nucleoplasm nucleus perikaryon perinuclear region of cytoplasm plasma membrane protein complex terminal button less... molecular_function DNA binding beta-catenin binding chromatin binding enzyme binding more... estrogen receptor activity estrogen response element binding hormone binding metal ion binding nitric-oxide synthase regulator activity protein binding protein complex binding receptor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity steroid binding steroid hormone receptor activity transcription factor binding type 1 metabotropic glutamate receptor binding zinc ion binding less... RGS4 4 BP    MF    CC biological_process inactivation of MAPK activity negative regulation of signal transduction positive regulation of GTPase activity regulation of G-protein coupled receptor protein signaling pathway more... cellular_component cytoplasm cytosol membrane fraction plasma membrane more... molecular_function GTPase activator activity calmodulin binding signal transducer activity ATAD4 4 BP    MF    CC biological_process cellular_component molecular_function GPM6B 4 BP    MF    CC biological_process cell differentiation multicellular organismal development nervous system development cellular_component integral to membrane membrane molecular_function molecular_function PTGS2 4 BP    MF    CC biological_process anagen bone mineralization cellular component movement cyclooxygenase pathway more... decidualization embryo implantation fatty acid biosynthetic process memory negative regulation of calcium ion transport negative regulation of cell proliferation negative regulation of synaptic transmission, dopaminergic ovulation positive regulation of apoptosis positive regulation of brown fat cell differentiation positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fever generation positive regulation of fibroblast growth factor production positive regulation of nitric oxide biosynthetic process positive regulation of platelet-derived growth factor production positive regulation of prostaglandin biosynthetic process positive regulation of smooth muscle cell proliferation positive regulation of smooth muscle contraction positive regulation of synaptic plasticity positive regulation of synaptic transmission, glutamatergic positive regulation of transforming growth factor beta production positive regulation of vasoconstriction positive regulation vascular endothelial growth factor production prostaglandin biosynthetic process prostaglandin metabolic process prostanoid metabolic process regulation of blood pressure regulation of cell cycle regulation of inflammatory response response to cytokine stimulus response to drug response to estradiol stimulus response to fructose stimulus response to glucocorticoid stimulus response to lipopolysaccharide response to manganese ion response to organic cyclic compound response to organic nitrogen response to oxidative stress response to vitamin D xenobiotic metabolic process less... cellular_component caveola cytoplasm endoplasmic reticulum endoplasmic reticulum lumen more... endoplasmic reticulum membrane membrane microsome neuron projection nucleus protein complex less... molecular_function enzyme binding heme binding lipid binding metal ion binding more... oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen peroxidase activity prostaglandin-endoperoxide synthase activity less... OLFM1 4 BP    MF    CC biological_process multicellular organismal development nervous system development protein oligomerization cellular_component endoplasmic reticulum endoplasmic reticulum lumen extracellular space molecular_function protein binding SULT1E1 4 BP    MF    CC biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid metabolic process sulfation xenobiotic metabolic process more... cellular_component cytoplasm cytosol nuclear membrane nucleus more... molecular_function estrone sulfotransferase activity flavonol 3-sulfotransferase activity steroid binding steroid sulfotransferase activity more... transferase activity less... LRP4 4 BP    MF    CC biological_process anatomical structure development dorsal/ventral pattern formation embryonic digit morphogenesis endocytosis more... hair follicle development kidney development negative regulation of canonical Wnt receptor signaling pathway odontogenesis of dentine-containing tooth protein localization proximal/distal pattern formation receptor clustering synaptic growth at neuromuscular junction less... cellular_component cellular_component integral to membrane membrane plasma membrane more... molecular_function calcium ion binding receptor activity GREM2 4 BP    MF    CC biological_process BMP signaling pathway cellular_component extracellular region extracellular space molecular_function cytokine activity PCSK6 4 BP    MF    CC biological_process determination of left/right symmetry glycoprotein metabolic process nerve growth factor processing nerve growth factor production more... nerve growth factor receptor signaling pathway peptide hormone processing protein processing proteolysis regulation of BMP signaling pathway secretion by cell zygotic determination of anterior/posterior axis, embryo less... cellular_component Golgi lumen cell surface endomembrane system endoplasmic reticulum more... extracellular matrix extracellular region extracellular space membrane soluble fraction less... molecular_function endopeptidase activity eukaryotic cell surface binding heparin binding nerve growth factor binding more... peptidase activity serine-type endopeptidase activity less... AKR1C3 4 BP    MF    CC biological_process oxidation-reduction process prostaglandin metabolic process cellular_component cytoplasm intracellular molecular_function aldo-keto reductase (NADP) activity androsterone dehydrogenase (A-specific) activity indanol dehydrogenase activity oxidoreductase activity more... prostaglandin-F synthase activity testosterone 17-beta-dehydrogenase (NAD+) activity testosterone 17-beta-dehydrogenase (NADP+) activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity less... TSC22D3 2 BP    MF    CC biological_process anti-apoptosis body fluid secretion negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter more... regulation of transcription, DNA-dependent response to osmotic stress transcription, DNA-dependent less... cellular_component cytoplasm nucleus molecular_function MyoD binding sequence-specific DNA binding transcription factor activity ENAH 2 BP    MF    CC biological_process T cell receptor signaling pathway actin cytoskeleton organization actin polymerization or depolymerization axon guidance more... intracellular transport neural tube closure less... cellular_component cell junction cytoplasm cytoskeleton cytosol more... filopodium focal adhesion lamellipodium stress fiber synapse less... molecular_function SH3 domain binding WW domain binding actin binding EPB41L2 2 BP    MF    CC biological_process cortical actin cytoskeleton organization cellular_component cytoplasm cytoskeleton extrinsic to membrane plasma membrane more... signalosome spectrin less... molecular_function PH domain binding actin binding binding cytoskeletal protein binding more... spectrin binding structural molecule activity less... ACPP 2 BP    MF    CC biological_process cellular_component extracellular region intracellular lysosomal membrane plasma membrane more... molecular_function 5'-nucleotidase activity acid phosphatase activity hydrolase activity PCDH7 2 BP    MF    CC biological_process cell adhesion homophilic cell adhesion cellular_component integral to membrane integral to plasma membrane plasma membrane molecular_function calcium ion binding HEY2 2 BP    MF    CC biological_process Notch signaling pathway cardiac ventricle morphogenesis cochlea development negative regulation of Notch signaling pathway more... negative regulation of gene expression negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent pattern specification process positive regulation of cardiac muscle cell proliferation regulation of transcription, DNA-dependent smooth muscle cell differentiation transcription, DNA-dependent vascular smooth muscle cell development vasculogenesis ventricular cardiac muscle cell development less... cellular_component Sin3 complex cytoplasm nucleus transcriptional repressor complex more... molecular_function DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity histone deacetylase binding more... microsatellite binding protein binding protein binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding less... MMP7 2 BP    MF    CC biological_process antibacterial peptide secretion collagen catabolic process defense response to Gram-negative bacterium defense response to Gram-positive bacterium more... metabolic process proteolysis regulation of cell proliferation response to drug less... cellular_component extracellular region extracellular space proteinaceous extracellular matrix molecular_function metal ion binding metalloendopeptidase activity peptidase activity zinc ion binding more... RAB4A 2 BP    MF    CC biological_process GTP catabolic process protein transport small GTPase mediated signal transduction cellular_component cytoplasm cytosol insoluble fraction insulin-responsive compartment more... microsome plasma membrane recycling endosome soluble fraction less... molecular_function ATPase activator activity ATPase binding GDP binding GTP binding more... GTPase activity ionotropic glutamate receptor binding nucleotide binding protein binding syntaxin binding less... IGF1 2 BP    MF    CC biological_process DNA replication Ras protein signal transduction Type I pneumocyte differentiation Type II pneumocyte differentiation more... anti-apoptosis blood coagulation blood vessel remodeling bone mineralization involved in bone maturation branching morphogenesis of a tube cellular component movement chondroitin sulfate proteoglycan biosynthetic process exocrine pancreas development glial cell differentiation glycolate metabolic process lung alveolus development lung lobe morphogenesis lung vasculature development mammary gland development muscle hypertrophy muscle organ development myoblast differentiation myoblast proliferation myotube cell development negative regulation of ERK1 and ERK2 cascade negative regulation of androgen receptor signaling pathway negative regulation of cell proliferation negative regulation of release of cytochrome c from mitochondria negative regulation of smooth muscle cell apoptosis nervous system development phosphatidylinositol-mediated signaling platelet activation platelet degranulation positive regulation of DNA binding positive regulation of DNA replication positive regulation of MAPKKK cascade positive regulation of Ras protein signal transduction positive regulation of activated T cell proliferation positive regulation of calcineurin-NFAT signaling pathway positive regulation of cardiac muscle hypertrophy positive regulation of cell proliferation positive regulation of cerebellar granule cell precursor proliferation positive regulation of epithelial cell proliferation positive regulation of fibroblast proliferation positive regulation of glucose import positive regulation of glycogen biosynthetic process positive regulation of glycolysis positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of mitosis positive regulation of osteoblast differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase cascade positive regulation of protein import into nucleus, translocation positive regulation of protein kinase B signaling cascade positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription, DNA-dependent positive regulation of tyrosine phosphorylation of Stat5 protein prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate gland epithelium morphogenesis prostate gland growth prostate gland stromal morphogenesis proteoglycan biosynthetic process regulation of establishment or maintenance of cell polarity regulation of multicellular organism growth regulation of protein metabolic process regulation of protein phosphorylation satellite cell maintenance involved in skeletal muscle regeneration signal transduction skeletal system development water homeostasis less... cellular_component extracellular region extracellular space insulin-like growth factor binding protein complex platelet alpha granule lumen more... molecular_function growth factor activity hormone activity insulin receptor binding insulin-like growth factor receptor binding more... integrin binding protein binding less... GSTM3 2 BP    MF    CC biological_process establishment of blood-nerve barrier glutathione metabolic process metabolic process response to estrogen stimulus more... cellular_component cytoplasm molecular_function glutathione transferase activity identical protein binding transferase activity NUP153 2 BP    MF    CC biological_process carbohydrate metabolic process glucose transport hexose transport interspecies interaction between organisms more... mRNA transport protein transport regulation of glucose transport transmembrane transport viral reproduction less... cellular_component cytoplasm intracellular nuclear membrane nuclear pore more... nucleolus nucleoplasm nucleus protein complex less... molecular_function DNA binding Ran GTPase binding metal ion binding protein binding more... transporter activity zinc ion binding less... PSD 2 BP    MF    CC biological_process neuron differentiation regulation of ARF protein signal transduction signal transduction cellular_component cytoplasm integral to membrane intracellular plasma membrane more... ruffle less... molecular_function ARF guanyl-nucleotide exchange factor activity signal transducer activity LIF 2 BP    MF    CC biological_process blood vessel remodeling decidualization embryo implantation immune response more... leukemia inhibitory factor signaling pathway lung alveolus development lung lobe morphogenesis lung vasculature development maternal process involved in female pregnancy multicellular organismal development muscle organ morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis negative regulation of cell proliferation negative regulation of hormone secretion negative regulation of meiosis neuron development organ regeneration positive regulation of MAPKKK cascade positive regulation of astrocyte differentiation positive regulation of cell proliferation positive regulation of corticotropin secretion positive regulation of macrophage differentiation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of neuron projection development positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation retina development in camera-type eye spongiotrophoblast differentiation stem cell maintenance transdifferentiation trophoblast giant cell differentiation less... cellular_component extracellular region extracellular space molecular_function cytokine activity growth factor activity leukemia inhibitory factor receptor binding receptor binding more... IGFBP1 2 BP    MF    CC biological_process insulin receptor signaling pathway positive regulation of cell growth regulation of cell growth signal transduction more... tissue regeneration less... cellular_component extracellular region extracellular space molecular_function insulin-like growth factor binding DNAJC6 2 BP    MF    CC biological_process cellular membrane organization post-Golgi vesicle-mediated transport cellular_component cytosol molecular_function SH3 domain binding heat shock protein binding hydrolase activity protein tyrosine phosphatase activity more... ST7 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function binding MYH11 2 BP    MF    CC biological_process axon guidance cardiac muscle fiber development elastic fiber assembly muscle contraction more... skeletal muscle myosin thick filament assembly smooth muscle contraction less... cellular_component cytosol melanosome muscle myosin complex myosin complex more... myosin filament less... molecular_function ATP binding actin binding calmodulin binding motor activity more... nucleotide binding structural constituent of muscle less... CYP3A5 2 BP    MF    CC biological_process alkaloid catabolic process drug catabolic process oxidation-reduction process oxidative demethylation more... steroid metabolic process xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function aromatase activity electron carrier activity heme binding metal ion binding more... monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding less... VPS13D 2 BP    MF    CC biological_process protein localization cellular_component molecular_function SEMA3C 2 BP    MF    CC biological_process blood vessel remodeling cardiac right ventricle morphogenesis dichotomous subdivision of terminal units involved in salivary gland branching heart development more... immune response limb bud formation multicellular organismal development neural crest cell migration neural tube development outflow tract morphogenesis post-embryonic development pulmonary myocardium development response to drug somitogenesis less... cellular_component extracellular region extracellular space membrane molecular_function receptor activity semaphorin receptor binding ANKRD55 2 BP    MF    CC biological_process cellular_component molecular_function SLC15A1 2 BP    MF    CC biological_process digestion ion transport oligopeptide transport protein transport more... transmembrane transport transport less... cellular_component integral to membrane integral to plasma membrane membrane membrane fraction more... plasma membrane less... molecular_function oligopeptide transporter activity peptide:hydrogen symporter activity symporter activity transporter activity more... ST6GAL1 2 BP    MF    CC biological_process cellular protein metabolic process humoral immune response post-translational protein modification protein N-linked glycosylation via asparagine more... protein glycosylation protein modification process less... cellular_component Golgi apparatus Golgi cisterna membrane Golgi membrane extracellular region more... integral to Golgi membrane integral to membrane membrane less... molecular_function beta-galactoside alpha-2,6-sialyltransferase activity sialyltransferase activity THBS1 2 BP    MF    CC biological_process activation of MAPK activity anti-apoptosis blood coagulation cell adhesion more... cell cycle arrest cell migration cellular response to heat chronic inflammatory response engulfment of apoptotic cell immune response induction of apoptosis negative regulation of angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of apoptosis negative regulation of blood vessel endothelial cell migration negative regulation of cGMP-mediated signaling negative regulation of caspase activity negative regulation of cell-matrix adhesion negative regulation of dendritic cell antigen processing and presentation negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of fibrinolysis negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of focal adhesion assembly negative regulation of interleukin-12 production negative regulation of nitric oxide mediated signal transduction negative regulation of plasma membrane long-chain fatty acid transport negative regulation of plasminogen activation peptide cross-linking platelet activation platelet degranulation positive regulation of angiogenesis positive regulation of blood coagulation positive regulation of blood vessel endothelial cell migration positive regulation of cell migration positive regulation of chemotaxis positive regulation of endothelial cell migration positive regulation of fibroblast migration positive regulation of macrophage activation positive regulation of macrophage chemotaxis positive regulation of phosphorylation positive regulation of protein kinase B signaling cascade positive regulation of reactive oxygen species metabolic process positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta1 production positive regulation of translation positive regulation of tumor necrosis factor biosynthetic process response to calcium ion response to drug response to glucose stimulus response to hypoxia response to magnesium ion response to progesterone stimulus sprouting angiogenesis less... cellular_component external side of plasma membrane extracellular matrix extracellular region extracellular space more... fibrinogen complex platelet alpha granule platelet alpha granule lumen stored secretory granule less... molecular_function calcium ion binding collagen V binding eukaryotic cell surface binding fibrinogen binding more... fibroblast growth factor 2 binding fibronectin binding glycoprotein binding heparin binding identical protein binding integrin binding laminin binding low-density lipoprotein particle binding phosphatidylserine binding protein binding proteoglycan binding structural molecule activity transforming growth factor beta binding less... SLC16A6 2 BP    MF    CC biological_process monocarboxylic acid transport transmembrane transport cellular_component integral to membrane integral to plasma membrane membrane fraction plasma membrane more... molecular_function monocarboxylic acid transmembrane transporter activity symporter activity CKB 2 BP    MF    CC biological_process brain development cellular chloride ion homeostasis cellular nitrogen compound metabolic process creatine metabolic process more... cellular_component cytoplasm cytosol mitochondrion molecular_function ATP binding creatine kinase activity kinase activity nucleotide binding more... PIKFYVE 2 BP    MF    CC biological_process cellular protein metabolic process intracellular signal transduction protein localization to nucleus receptor-mediated endocytosis more... retrograde transport, endosome to Golgi less... cellular_component cytoplasmic vesicle cytosol early endosome membrane endosome more... endosome membrane membrane membrane raft perinuclear region of cytoplasm vesicle membrane less... molecular_function 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity ATP binding kinase activity more... metal ion binding nucleotide binding protein binding transferase activity zinc ion binding less... EPHB3 2 BP    MF    CC biological_process angiogenesis axon guidance axonal fasciculation cell migration more... central nervous system projection neuron axonogenesis corpus callosum development dendritic spine development dendritic spine morphogenesis digestive tract morphogenesis ephrin receptor signaling pathway palate development positive regulation of synapse assembly protein autophosphorylation regulation of Cdc42 GTPase activity regulation of Rac GTPase activity regulation of axonogenesis regulation of cell-cell adhesion retinal ganglion cell axon guidance substrate adhesion-dependent cell spreading thymus development urogenital system development less... cellular_component integral to plasma membrane membrane molecular_function ATP binding axon guidance receptor activity ephrin receptor activity nucleotide binding more... receptor activity less... DHRS7 2 BP    MF    CC biological_process cellular_component molecular_function binding oxidoreductase activity CDC25A 2 BP    MF    CC biological_process DNA replication G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle M phase of mitotic cell cycle more... S phase of mitotic cell cycle cell cycle checkpoint cell division cell proliferation cellular response to UV mitosis mitotic cell cycle regulation of cyclin-dependent protein kinase activity less... cellular_component cytoplasm cytosol intracellular nucleoplasm more... nucleus less... molecular_function hydrolase activity protein binding protein tyrosine phosphatase activity VLDLR 2 BP    MF    CC biological_process cellular response to glucose starvation cellular response to hypoxia cellular response to insulin stimulus cellular response to interleukin-1 more... cellular response to lipopolysaccharide cerebral cortex development cholesterol metabolic process endocytosis heart development lipid transport memory nervous system development response to drug response to hormone stimulus response to nutrient signal transduction steroid metabolic process transport ventral spinal cord development very-low-density lipoprotein particle clearance less... cellular_component apical part of cell cell surface coated pit extracellular space more... integral to membrane membrane membrane fraction nucleus perinuclear region of cytoplasm plasma membrane very-low-density lipoprotein particle less... molecular_function apolipoprotein binding calcium ion binding low-density lipoprotein receptor activity protein binding more... receptor activity very-low-density lipoprotein particle receptor activity less... PLS1 2 BP    MF    CC biological_process cellular_component cytoplasm molecular_function actin binding actin filament binding calcium ion binding structural constituent of cytoskeleton more... HABP2 2 BP    MF    CC biological_process cell adhesion proteolysis cellular_component extracellular region extracellular space molecular_function glycosaminoglycan binding peptidase activity serine-type endopeptidase activity PLCB1 2 BP    MF    CC biological_process CD24 biosynthetic process G1 phase G2/M transition of mitotic cell cycle activation of meiosis involved in egg activation more... cerebral cortex development fat cell differentiation glutamate signaling pathway insulin-like growth factor receptor signaling pathway interleukin-1-mediated signaling pathway interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway intracellular signal transduction learning lipid catabolic process memory muscarinic acetylcholine receptor signaling pathway negative regulation of monocyte extravasation negative regulation of transcription, DNA-dependent phosphatidylinositol metabolic process positive regulation of GTPase activity positive regulation of JNK cascade positive regulation of acrosome reaction positive regulation of developmental growth positive regulation of embryonic development positive regulation of interleukin-12 production positive regulation of myoblast differentiation positive regulation of transcription, DNA-dependent regulation of G-protein coupled receptor protein signaling pathway regulation of fertilization response to monosaccharide stimulus response to organic nitrogen response to peptide hormone stimulus signal transduction synaptic transmission less... cellular_component cytoplasm cytosol membrane fraction nuclear chromatin more... nuclear speck nucleus less... molecular_function GTPase activator activity calcium ion binding calmodulin binding enzyme binding more... hydrolase activity lamin binding phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phospholipase C activity protein homodimerization activity signal transducer activity less... PCTP 2 BP    MF    CC biological_process cholesterol metabolic process lipid transport phospholipid transport transport more... cellular_component cytoplasm cytosol molecular_function lipid binding phosphatidylcholine binding phosphatidylcholine transmembrane transporter activity CNN1 2 BP    MF    CC biological_process actomyosin structure organization regulation of smooth muscle contraction cellular_component cytoskeleton molecular_function actin binding calmodulin binding CYB5A 2 BP    MF    CC biological_process electron transport chain transport vitamin metabolic process water-soluble vitamin metabolic process more... cellular_component cytoplasm endoplasmic reticulum endoplasmic reticulum membrane integral to membrane more... membrane microsome mitochondrial outer membrane mitochondrion less... molecular_function aldo-keto reductase (NADP) activity cytochrome-c oxidase activity enzyme binding heme binding more... metal ion binding less... BEX4 2 BP    MF    CC biological_process cellular_component cytoplasm nucleus molecular_function FXYD2 2 BP    MF    CC biological_process ion transmembrane transport ion transport potassium ion transport sodium ion transport more... transmembrane transport transport less... cellular_component integral to membrane membrane plasma membrane sodium:potassium-exchanging ATPase complex more... molecular_function ion channel activity sodium:potassium-exchanging ATPase activity transporter activity CBARA1 2 BP    MF    CC biological_process cellular_component molecular_function OFD1 2 BP    MF    CC biological_process G2/M transition of mitotic cell cycle cell projection organization centriole replication cilium axoneme assembly more... cilium morphogenesis epithelial cilium movement involved in determination of left/right asymmetry mitosis mitotic cell cycle spindle assembly involved in mitosis less... cellular_component centriole centrosome cilium cytoplasm more... cytoskeleton cytosol intracellular membrane-bounded organelle microtubule basal body nuclear membrane nucleus less... molecular_function alpha-tubulin binding gamma-tubulin binding protein binding KRT18 2 BP    MF    CC biological_process Golgi to plasma membrane CFTR protein transport anatomical structure morphogenesis cell cycle interspecies interaction between organisms more... negative regulation of apoptosis tumor necrosis factor-mediated signaling pathway less... cellular_component centriolar satellite cytoplasm intermediate filament keratin filament more... microtubule organizing center perinuclear region of cytoplasm less... molecular_function protein binding structural molecule activity CSRP2 2 BP    MF    CC biological_process cell differentiation multicellular organismal development myoblast differentiation cellular_component nucleus molecular_function metal ion binding molecular_function zinc ion binding DUSP6 2 BP    MF    CC biological_process MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway Toll signaling pathway cell differentiation more... dorsal/ventral pattern formation inactivation of MAPK activity innate immune response negative regulation of ERK1 and ERK2 cascade negative regulation of protein phosphorylation nerve growth factor receptor signaling pathway peptidyl-tyrosine dephosphorylation positive regulation of apoptosis protein dephosphorylation regulation of endodermal cell fate specification regulation of fibroblast growth factor receptor signaling pathway regulation of heart growth response to drug response to growth factor stimulus response to nitrosative stress response to organic cyclic compound stress-activated MAPK cascade toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor signaling pathway less... cellular_component cytoplasm cytosol nucleoplasm molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity phosphatase activity protein tyrosine phosphatase activity more... ATP2C2 2 BP    MF    CC biological_process ATP biosynthetic process calcium ion transport cation transport ion transmembrane transport more... transmembrane transport less... cellular_component Golgi membrane integral to membrane membrane molecular_function ATP binding calcium-transporting ATPase activity catalytic activity hydrolase activity more... hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding nucleotide binding protein binding less... MAGED1 2 BP    MF    CC biological_process apoptosis induction of apoptosis by extracellular signals negative regulation of epithelial cell proliferation nerve growth factor receptor signaling pathway more... regulation of apoptosis regulation of transcription, DNA-dependent less... cellular_component cytoplasm plasma membrane protein complex molecular_function protein binding ST3GAL6 2 BP    MF    CC biological_process amino sugar metabolic process glycolipid metabolic process protein glycosylation protein lipoylation more... cellular_component Golgi apparatus Golgi membrane integral to Golgi membrane integral to membrane more... membrane less... molecular_function sialyltransferase activity TMEFF1 2 BP    MF    CC biological_process multicellular organismal development cellular_component integral to membrane plasma membrane molecular_function CDH13 2 BP    MF    CC biological_process Rac protein signal transduction Rho protein signal transduction adherens junction organization calcium-dependent cell-cell adhesion more... cell adhesion cell junction assembly cell-cell junction organization endothelial cell migration homophilic cell adhesion keratinocyte proliferation lamellipodium assembly localization within membrane low-density lipoprotein particle mediated signaling mitotic cell cycle negative regulation of cell adhesion negative regulation of cell proliferation positive regulation of calcium-mediated signaling positive regulation of cell migration positive regulation of cell-matrix adhesion positive regulation of endothelial cell proliferation positive regulation of positive chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of survival gene product expression regulation of cell growth regulation of endocytosis regulation of epidermal growth factor receptor signaling pathway response to organic substance sprouting angiogenesis less... cellular_component anchored to membrane caveola cytoplasm external side of plasma membrane more... extracellular space integral to membrane membrane neuron projection perinuclear region of cytoplasm plasma membrane less... molecular_function adiponectin binding cadherin binding calcium ion binding lipoprotein particle binding more... low-density lipoprotein particle binding protein homodimerization activity less... CATSPERB 2 BP    MF    CC biological_process cell differentiation multicellular organismal development spermatogenesis cellular_component flagellum integral to membrane membrane molecular_function TSPAN1 2 BP    MF    CC biological_process cellular_component integral to membrane lysosomal membrane membrane molecular_function COMP 2 BP    MF    CC biological_process anti-apoptosis apoptosis cell adhesion limb development more... organ morphogenesis skeletal system development less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function calcium ion binding collagen binding extracellular matrix structural constituent heparan sulfate proteoglycan binding more... heparin binding protein binding less... ATP6V0E2 2 BP    MF    CC biological_process ATP hydrolysis coupled proton transport cell growth cellular iron ion homeostasis insulin receptor signaling pathway more... ion transport transferrin transport transmembrane transport vacuolar acidification less... cellular_component endosome membrane integral to membrane membrane proton-transporting V-type ATPase, V0 domain more... vacuole less... molecular_function ATPase activity, coupled to transmembrane movement of ions hydrogen ion transmembrane transporter activity hydrolase activity SLC22A5 2 BP    MF    CC biological_process carnitine transport drug transmembrane transport drug transport positive regulation of intestinal epithelial structure maintenance more... quaternary ammonium group transport quorum sensing involved in interaction with host sodium ion transport sodium-dependent organic cation transport transmembrane transport less... cellular_component apical plasma membrane basolateral plasma membrane brush border membrane integral to membrane more... plasma membrane less... molecular_function ATP binding PDZ domain binding antibiotic transporter activity carnitine transporter activity more... drug transmembrane transporter activity ion transmembrane transporter activity nucleotide binding protein binding quaternary ammonium group transmembrane transporter activity symporter activity less... TM4SF1 2 BP    MF    CC biological_process biological_process cellular_component integral to membrane integral to plasma membrane membrane molecular_function molecular_function FAP 2 BP    MF    CC biological_process endothelial cell migration negative regulation of extracellular matrix disassembly proteolysis cellular_component cell junction integral to membrane invadopodium membrane lamellipodium more... lamellipodium membrane membrane plasma membrane less... molecular_function dipeptidyl-peptidase activity metalloendopeptidase activity peptidase activity protein binding more... protein dimerization activity protein homodimerization activity serine-type endopeptidase activity serine-type peptidase activity less... MALL 2 BP    MF    CC biological_process cholesterol homeostasis cellular_component Golgi membrane clathrin-coated vesicle cytoplasmic membrane-bounded vesicle integral to membrane more... membrane raft plasma membrane less... molecular_function protein binding TMEM144 2 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function CEL 2 BP    MF    CC biological_process ceramide catabolic process cholesterol catabolic process fatty acid catabolic process intestinal cholesterol absorption more... intestinal lipid catabolic process lipid catabolic process lipid digestion lipid metabolic process pancreatic juice secretion protein esterification triglyceride metabolic process less... cellular_component cytoplasm cytosol extracellular region extracellular space more... molecular_function acylglycerol lipase activity carboxylesterase activity catalytic activity heparin binding more... hydrolase activity sterol esterase activity triglyceride lipase activity less... ATP1B1 2 BP    MF    CC biological_process ATP biosynthetic process blood coagulation ion transmembrane transport leukocyte migration more... potassium ion transport response to hypoxia sodium ion transport transmembrane transport transport less... cellular_component apical plasma membrane basolateral plasma membrane caveola integral to membrane more... membrane plasma membrane sodium:potassium-exchanging ATPase complex less... molecular_function protein binding sodium:potassium-exchanging ATPase activity MSX2 2 BP    MF    CC biological_process BMP signaling pathway involved in heart development anagen anterior/posterior pattern specification bone morphogenesis more... bone trabecula formation branching involved in mammary gland duct morphogenesis cartilage development cellular response to estradiol stimulus cellular response to growth factor stimulus chondrocyte development cranial suture morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis enamel mineralization endochondral bone growth epithelial to mesenchymal transition involved in endocardial cushion formation frontal suture morphogenesis heart morphogenesis mammary gland epithelium development multicellular organismal development negative regulation of CREB transcription factor activity negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription regulatory region DNA binding negative regulation of transcription, DNA-dependent odontogenesis osteoblast development osteoblast differentiation positive regulation of BMP signaling pathway positive regulation of apoptosis positive regulation of catagen positive regulation of osteoblast differentiation signal transduction involved in regulation of gene expression stem cell differentiation wound healing wound healing, spreading of epidermal cells less... cellular_component cytoplasm nucleus transcription factor complex molecular_function protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity transcription factor binding more... transcription regulatory region DNA binding less... G0S2 2 BP    MF    CC biological_process cell cycle cellular_component cellular_component molecular_function molecular_function TRPC6 2 BP    MF    CC biological_process axon guidance blood coagulation cation transport elevation of cytosolic calcium ion concentration more... ion transport platelet activation positive regulation of calcium ion transport via store-operated calcium channel activity positive regulation of ion transmembrane transporter activity transmembrane transport less... cellular_component integral to membrane membrane plasma membrane molecular_function calcium channel activity cation channel activity ion channel activity protein binding more... SLC44A4 2 BP    MF    CC biological_process transmembrane transport cellular_component integral to membrane membrane plasma membrane molecular_function DIO2 2 BP    MF    CC biological_process cellular nitrogen compound metabolic process hormone biosynthetic process selenocysteine incorporation thyroid hormone generation more... thyroid hormone metabolic process less... cellular_component integral to membrane membrane plasma membrane molecular_function selenium binding thyroxine 5'-deiodinase activity ubiquitin protein ligase binding	Down-regulated Genes Score GO annotation CXCL13 6 BP    MF    CC biological_process B cell chemotaxis activation of Rap GTPase activity cell-cell signaling chemotaxis more... chronic inflammatory response defense response to bacterium elevation of cytosolic calcium ion concentration endothelial cell chemotaxis to fibroblast growth factor germinal center formation immune response lymph node development lymphocyte chemotaxis across high endothelial venule negative regulation of apoptosis positive regulation of T cell chemotaxis positive regulation of cell-cell adhesion mediated by integrin positive regulation of integrin activation regulation of angiogenesis regulation of humoral immune response signal transduction less... cellular_component extracellular region extracellular space soluble fraction molecular_function CCR10 chemokine receptor binding CXCR3 chemokine receptor binding CXCR5 chemokine receptor binding chemokine activity more... fibroblast growth factor 2 binding heparin binding protein heterodimerization activity receptor agonist activity less... KRT23 6 BP    MF    CC biological_process cellular_component intermediate filament molecular_function structural molecule activity AHNAK2 6 BP    MF    CC biological_process cellular_component nucleus molecular_function DKK1 6 BP    MF    CC biological_process cell morphogenesis involved in differentiation endoderm formation face morphogenesis forebrain development more... hair follicle development mesoderm formation multicellular organismal development negative regulation of BMP signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of peptidyl-serine phosphorylation negative regulation of protein complex assembly negative regulation of skeletal muscle tissue development negative regulation of transcription from RNA polymerase II promoter positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway regulation of receptor internalization response to retinoic acid signal transduction less... cellular_component extracellular region extracellular space plasma membrane molecular_function growth factor activity low-density lipoprotein particle receptor binding protein binding receptor antagonist activity more... signal transducer activity less... CCL2 4 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging more... angiogenesis anti-apoptosis apoptotic cell clearance astrocyte cell migration cell adhesion cell surface receptor linked signaling pathway cellular calcium ion homeostasis cellular homeostasis cellular response to interferon-gamma cellular response to interleukin-1 cellular response to lipopolysaccharide cellular response to tumor necrosis factor chemokine-mediated signaling pathway chemotaxis cytokine-mediated signaling pathway helper T cell extravasation humoral immune response inflammatory response lymphocyte chemotaxis macrophage chemotaxis maternal process involved in parturition monocyte chemotaxis negative regulation of angiogenesis neutrophil chemotaxis organ morphogenesis organ regeneration positive regulation of T cell activation positive regulation of endothelial cell proliferation positive regulation of immune complex clearance by monocytes and macrophages positive regulation of macrophage chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of synaptic transmission protein phosphorylation regulation of vascular endothelial growth factor production response to activity response to amino acid stimulus response to antibiotic response to bacterium response to drug response to ethanol response to gamma radiation response to glucocorticoid stimulus response to heat response to hypoxia response to mechanical stimulus response to progesterone stimulus response to vitamin B3 signal transduction transforming growth factor beta receptor signaling pathway vascular endothelial growth factor receptor signaling pathway viral genome replication less... cellular_component cytoplasm extracellular region extracellular space neuronal cell body more... molecular_function CCR2 chemokine receptor binding G-protein-coupled receptor binding chemokine activity heparin binding more... protein kinase activity receptor binding signal transducer activity less... S100A8 4 BP    MF    CC biological_process acute inflammatory response chemotaxis chronic inflammatory response inflammatory response more... response to ethanol response to lipopolysaccharide response to zinc ion wound healing less... cellular_component cytoplasm cytoskeleton extracellular region extracellular space more... plasma membrane less... molecular_function calcium ion binding protein binding ID4 4 BP    MF    CC biological_process G1/S transition of mitotic cell cycle brain development cellular protein localization central nervous system myelination more... cerebral cortex neuron differentiation hippocampus development negative regulation of astrocyte differentiation negative regulation of fat cell differentiation negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent neuroblast proliferation positive regulation of cell proliferation positive regulation of osteoblast differentiation regulation of transcription from RNA polymerase II promoter less... cellular_component cytoplasm nucleus molecular_function RNA polymerase II transcription factor binding protein binding transcription corepressor activity CHST2 4 BP    MF    CC biological_process N-acetylglucosamine metabolic process carbohydrate metabolic process inflammatory response multicellular organismal development more... sulfur compound metabolic process less... cellular_component Golgi apparatus integral to membrane intrinsic to Golgi membrane membrane more... trans-Golgi network less... molecular_function N-acetylglucosamine 6-O-sulfotransferase activity sulfotransferase activity transferase activity AOX1 4 BP    MF    CC biological_process inflammatory response reactive oxygen species metabolic process cellular_component cytoplasm molecular_function 2 iron, 2 sulfur cluster binding NAD binding UDP-N-acetylmuramate dehydrogenase activity aldehyde oxidase activity more... binding electron carrier activity flavin adenine dinucleotide binding iron ion binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors xanthine dehydrogenase activity less... STC1 4 BP    MF    CC biological_process cell surface receptor linked signaling pathway cell-cell signaling cellular calcium ion homeostasis cellular response to cAMP more... cellular response to glucocorticoid stimulus cellular response to hypoxia decidualization embryo implantation ossification response to nutrient response to organic cyclic compound response to vitamin D less... cellular_component apical plasma membrane cytoplasm extracellular region extracellular space more... molecular_function hormone activity APOD 4 BP    MF    CC biological_process lipid metabolic process lipid transport cellular_component extracellular region extracellular space intracellular molecular_function lipid binding lipid transporter activity protein binding transporter activity more... KCND3 4 BP    MF    CC biological_process ion transport potassium ion transport synaptic transmission transmembrane transport more... cellular_component neuron projection neuronal cell body plasma membrane sarcolemma more... voltage-gated potassium channel complex less... molecular_function A-type (transient outward) potassium channel activity metal ion binding voltage-gated ion channel activity voltage-gated potassium channel activity more... RBP4 4 BP    MF    CC biological_process cardiac muscle tissue development detection of light stimulus involved in visual perception embryo development embryonic organ morphogenesis more... embryonic retina morphogenesis in camera-type eye embryonic skeletal system development eye development female genitalia morphogenesis gluconeogenesis glucose homeostasis heart development heart trabecula formation lung development maintenance of gastrointestinal epithelium male gonad development negative regulation of cardiac muscle cell proliferation positive regulation of immunoglobulin secretion positive regulation of insulin secretion response to ethanol response to insulin stimulus response to retinoic acid response to stimulus retina development in camera-type eye retinal metabolic process retinol metabolic process retinol transport spermatogenesis urinary bladder development uterus development vagina development less... cellular_component extracellular region extracellular space molecular_function binding protein binding retinal binding retinoid binding more... retinol binding retinol transporter activity transporter activity less... NUPR1 4 BP    MF    CC biological_process cell growth induction of apoptosis cellular_component nucleus molecular_function molecular_function COL15A1 4 BP    MF    CC biological_process angiogenesis cell adhesion cell differentiation multicellular organismal development more... signal transduction less... cellular_component basement membrane collagen type XV extracellular matrix extracellular region more... extracellular space integral to membrane less... molecular_function binding extracellular matrix structural constituent structural molecule activity CFD 4 BP    MF    CC biological_process Notch signaling pathway blood coagulation complement activation complement activation, alternative pathway more... innate immune response platelet activation platelet degranulation proteolysis less... cellular_component extracellular region extracellular space platelet alpha granule lumen molecular_function peptidase activity serine-type endopeptidase activity serine-type peptidase activity SERPINE1 4 BP    MF    CC biological_process angiogenesis blood coagulation cellular response to chemical stimulus cellular response to gravity more... cellular response to lipopolysaccharide chronological cell aging defense response to Gram-negative bacterium fibrinolysis glucose homeostasis negative regulation of apoptosis negative regulation of blood coagulation negative regulation of cell adhesion mediated by integrin negative regulation of cell migration negative regulation of endopeptidase activity negative regulation of fibrinolysis negative regulation of plasminogen activation negative regulation of smooth muscle cell migration negative regulation of smooth muscle cell-matrix adhesion negative regulation of vascular wound healing negative regulation of wound healing platelet activation platelet degranulation positive regulation of angiogenesis positive regulation of blood coagulation positive regulation of coagulation positive regulation of inflammatory response positive regulation of interleukin-8 production positive regulation of leukotriene production involved in inflammatory response positive regulation of monocyte chemotaxis positive regulation of receptor-mediated endocytosis regulation of receptor activity response to cytokine stimulus response to estrogen stimulus response to glucocorticoid stimulus response to hyperoxia response to reactive oxygen species tissue regeneration less... cellular_component extracellular matrix extracellular region extracellular space plasma membrane more... platelet alpha granule lumen soluble fraction less... molecular_function peptidase inhibitor activity protease binding protein binding receptor binding more... serine-type endopeptidase inhibitor activity less... GAS1 4 BP    MF    CC biological_process axon guidance camera-type eye development cell cycle cell cycle arrest more... cell fate commitment cerebellum morphogenesis developmental growth dorsal/ventral neural tube patterning embryonic cranial skeleton morphogenesis embryonic digit morphogenesis embryonic skeletal system development eye morphogenesis middle ear morphogenesis negative regulation of S phase of mitotic cell cycle negative regulation of cell proliferation negative regulation of epithelial cell proliferation negative regulation of mitotic cell cycle negative regulation of smoothened signaling pathway outer ear morphogenesis palate development positive regulation of epithelial cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of smoothened signaling pathway programmed cell death regulation of apoptosis less... cellular_component anchored to plasma membrane plasma membrane molecular_function molecular_function GLIPR1 4 BP    MF    CC biological_process cellular lipid metabolic process cellular_component extracellular region integral to membrane plasma membrane molecular_function MYC 4 BP    MF    CC biological_process branching involved in ureteric bud morphogenesis cell cycle arrest cell proliferation cellular iron ion homeostasis more... positive regulation of cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of metanephric cap mesenchymal cell proliferation positive regulation of transcription, DNA-dependent regulation of telomere maintenance regulation of transcription from RNA polymerase II promoter response to drug transcription, DNA-dependent less... cellular_component nucleolus nucleoplasm nucleus spindle more... molecular_function DNA binding E-box binding protein binding sequence-specific DNA binding transcription factor activity more... TMEM45A 4 BP    MF    CC biological_process cellular_component integral to membrane membrane molecular_function C1R 4 BP    MF    CC biological_process complement activation complement activation, classical pathway immune response innate immune response more... proteolysis less... cellular_component extracellular region molecular_function calcium ion binding peptidase activity serine-type endopeptidase activity serine-type peptidase activity more... PLA2G2A 4 BP    MF    CC biological_process defense response to Gram-positive bacterium lipid catabolic process low-density lipoprotein particle remodeling phosphatidic acid metabolic process more... phospholipid metabolic process positive regulation of inflammatory response positive regulation of macrophage derived foam cell differentiation less... cellular_component endoplasmic reticulum extracellular region extracellular space membrane more... stored secretory granule less... molecular_function calcium ion binding calcium-dependent phospholipase A2 activity hydrolase activity phospholipase A2 activity more... phospholipid binding less... SLCO4A1 4 BP    MF    CC biological_process ion transport sodium-independent organic anion transport thyroid hormone metabolic process transmembrane transport more... cellular_component integral to membrane membrane plasma membrane molecular_function thyroid hormone transmembrane transporter activity transporter activity VCAN 4 BP    MF    CC biological_process axon regeneration cell adhesion cell recognition glial cell migration more... heart development multicellular organismal development response to wounding less... cellular_component extracellular matrix extracellular region extracellular space proteinaceous extracellular matrix more... molecular_function binding calcium ion binding glycosaminoglycan binding hyaluronic acid binding more... sugar binding less... IGFBP5 4 BP    MF    CC biological_process cellular response to cAMP cellular response to organic cyclic compound glucose homeostasis glucose metabolic process more... hair follicle morphogenesis intracellular signal transduction mammary gland involution negative regulation of cell migration negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of smooth muscle cell migration negative regulation of smooth muscle cell proliferation negative regulation of translation osteoblast differentiation positive regulation of protein kinase B signaling cascade regulation of cell growth signal transduction skeletal muscle tissue growth striated muscle cell differentiation less... cellular_component extracellular region insulin-like growth factor binding protein complex molecular_function fibronectin binding insulin-like growth factor I binding insulin-like growth factor binding protein binding more... OSMR 4 BP    MF    CC biological_process cell proliferation cell surface receptor linked signaling pathway positive regulation of acute inflammatory response positive regulation of cell proliferation more... response to cytokine stimulus less... cellular_component integral to membrane membrane oncostatin-M receptor complex molecular_function growth factor binding oncostatin-M receptor activity receptor activity C10orf10 4 BP    MF    CC biological_process cellular_component molecular_function TUBB6 4 BP    MF    CC biological_process 'de novo' posttranslational protein folding cellular protein metabolic process microtubule-based movement protein folding more... protein polymerization less... cellular_component cytoplasm cytoskeleton microtubule molecular_function GTP binding GTPase activity nucleotide binding structural molecule activity more... S100P 4 BP    MF    CC biological_process endothelial cell migration cellular_component cytoplasm nucleus molecular_function calcium ion binding calcium-dependent protein binding magnesium ion binding protein binding more... CP 4 BP    MF    CC biological_process cellular iron ion homeostasis copper ion transport ion transport transmembrane transport more... cellular_component extracellular region extracellular space molecular_function chaperone binding copper ion binding ferroxidase activity metal ion binding more... oxidoreductase activity less... NNMT 4 BP    MF    CC biological_process methylation organ regeneration response to drug response to organic nitrogen more... xenobiotic metabolic process less... cellular_component cytoplasm cytosol soluble fraction molecular_function methyltransferase activity nicotinamide N-methyltransferase activity transferase activity DEFB1 4 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway acute inflammatory response chemotaxis defense response to bacterium more... immune response innate immune response response to bacterium response to testosterone stimulus less... cellular_component extracellular region soluble fraction molecular_function TIMP3 4 BP    MF    CC biological_process aging central nervous system development negative regulation of membrane protein ectodomain proteolysis negative regulation of proteolysis more... response to amino acid stimulus response to estrogen stimulus response to folic acid response to hormone stimulus response to mechanical stimulus response to organic cyclic compound response to stimulus tissue regeneration visual perception less... cellular_component basement membrane cytoplasm extracellular matrix extracellular region more... molecular_function enzyme inhibitor activity metal ion binding metalloendopeptidase inhibitor activity protein binding more... ST7OT1 4 BP    MF    CC biological_process cellular_component molecular_function LMCD1 4 BP    MF    CC biological_process negative regulation of transcription from RNA polymerase II promoter positive regulation of calcineurin-NFAT signaling pathway regulation of cardiac muscle hypertrophy regulation of transcription, DNA-dependent more... cellular_component cytoplasm extracellular matrix extracellular space nucleus more... molecular_function metal ion binding transcription corepressor activity zinc ion binding ASS1 4 BP    MF    CC biological_process acute-phase response aging arginine biosynthetic process argininosuccinate metabolic process more... cellular amino acid biosynthetic process cellular nitrogen compound metabolic process cellular response to amino acid stimulus cellular response to ammonium ion cellular response to cAMP cellular response to dexamethasone stimulus cellular response to glucagon stimulus cellular response to interferon-gamma cellular response to lipopolysaccharide cellular response to oleic acid cellular response to tumor necrosis factor diaphragm development kidney development liver development midgut development response to biotic stimulus response to drug response to estradiol stimulus response to fatty acid response to glucocorticoid stimulus response to growth hormone stimulus response to mycotoxin response to nutrient response to steroid hormone stimulus response to zinc ion urea cycle less... cellular_component cell body fiber cytoplasm cytosol endoplasmic reticulum more... lysosome mitochondrial outer membrane mitochondrion nucleus perikaryon less... molecular_function ATP binding argininosuccinate synthase activity ligase activity nucleotide binding more... protein binding toxin binding less... GLUL 4 BP    MF    CC biological_process cell proliferation cellular amino acid biosynthetic process cellular nitrogen compound metabolic process glutamine biosynthetic process more... neurotransmitter uptake nitrogen compound metabolic process response to glucose stimulus synaptic transmission less... cellular_component Golgi apparatus cytoplasm cytosol intracellular more... mitochondrion less... molecular_function ATP binding glutamate decarboxylase activity glutamate-ammonia ligase activity ligase activity more... lyase activity nucleotide binding less... TGM2 4 BP    MF    CC biological_process apoptotic cell clearance blood vessel remodeling branching involved in salivary gland morphogenesis elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger more... induction of apoptosis isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine peptide cross-linking positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of cell adhesion positive regulation of inflammatory response positive regulation of smooth muscle cell proliferation protein homooligomerization salivary gland cavitation less... cellular_component cytoplasm mitochondrion plasma membrane molecular_function GTP binding metal ion binding protein binding protein domain specific binding more... protein-glutamine gamma-glutamyltransferase activity transferase activity transferase activity, transferring acyl groups less... C3 4 BP    MF    CC biological_process G-protein coupled receptor protein signaling pathway complement activation complement activation, alternative pathway complement activation, classical pathway more... immune response inflammatory response innate immune response positive regulation of activation of membrane attack complex positive regulation of angiogenesis positive regulation of phagocytosis positive regulation of type IIa hypersensitivity positive regulation vascular endothelial growth factor production regulation of immune response signal transduction less... cellular_component extracellular region extracellular space molecular_function endopeptidase inhibitor activity protein binding receptor binding CD55 4 BP    MF    CC biological_process complement activation, classical pathway elevation of cytosolic calcium ion concentration innate immune response respiratory burst more... cellular_component anchored to membrane extracellular region integral to plasma membrane membrane raft more... plasma membrane soluble fraction less... molecular_function receptor activity HPSE 4 BP    MF    CC biological_process carbohydrate metabolic process cell adhesion cell-matrix adhesion positive regulation of blood coagulation more... positive regulation of osteoblast proliferation positive regulation of protein kinase B signaling cascade positive regulation vascular endothelial growth factor production proteoglycan metabolic process regulation of hair follicle development less... cellular_component extracellular region lysosomal membrane lysosome membrane more... nucleus less... molecular_function beta-glucuronidase activity catalytic activity cation binding hydrolase activity, acting on glycosyl bonds more... protein binding protein dimerization activity syndecan binding less... PTPRR 4 BP    MF    CC biological_process in utero embryonic development nervous system development neuron differentiation peptidyl-tyrosine dephosphorylation more... protein dephosphorylation less... cellular_component Golgi apparatus cell surface cytoplasm integral to membrane more... nucleus perinuclear region of cytoplasm plasma membrane less... molecular_function hydrolase activity protein kinase binding protein tyrosine phosphatase activity receptor activity more... transmembrane receptor protein tyrosine phosphatase activity less... MAFF 4 BP    MF    CC biological_process blood coagulation parturition response to stress transcription from RNA polymerase II promoter more... cellular_component nucleoplasm nucleus molecular_function sequence-specific DNA binding sequence-specific DNA binding transcription factor activity SERPING1 4 BP    MF    CC biological_process blood circulation blood coagulation blood coagulation, intrinsic pathway complement activation, classical pathway more... innate immune response negative regulation of complement activation, lectin pathway negative regulation of endopeptidase activity platelet activation platelet degranulation less... cellular_component extracellular region extracellular space platelet alpha granule lumen molecular_function peptidase activity peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity more... CEBPD 4 BP    MF    CC biological_process transcription from RNA polymerase II promoter cellular_component nucleus molecular_function protein dimerization activity sequence-specific DNA binding sequence-specific DNA binding transcription factor activity AMIGO2 4 BP    MF    CC biological_process anti-apoptosis cell adhesion heterophilic cell-cell adhesion homophilic cell adhesion more... negative regulation of programmed cell death less... cellular_component integral to membrane nucleus plasma membrane molecular_function SCGB2A2 4 BP    MF    CC biological_process biological_process cellular_component cellular_component extracellular region molecular_function binding molecular_function steroid binding CD52 4 BP    MF    CC biological_process elevation of cytosolic calcium ion concentration respiratory burst cellular_component anchored to membrane integral to plasma membrane membrane fraction plasma membrane more... molecular_function IL15 4 BP    MF    CC biological_process NK T cell proliferation aging cell-cell signaling cellular response to vitamin D more... extrathymic T cell selection hyaluronan metabolic process immune response lymph node development negative regulation of smooth muscle cell proliferation positive regulation of T cell proliferation positive regulation of cell proliferation positive regulation of immune response positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of natural killer cell differentiation positive regulation of natural killer cell proliferation positive regulation of tissue remodeling positive regulation of tyrosine phosphorylation of Stat3 protein regulation of T cell differentiation regulation of defense response to virus by host response to nutrient levels signal transduction skeletal muscle atrophy less... cellular_component Golgi apparatus cytoplasm endosome extracellular region more... extracellular space integral to plasma membrane membrane fraction nucleus less... molecular_function cytokine activity cytokine receptor binding protein binding signal transducer activity more... SOD2 4 BP    MF    CC biological_process age-dependent response to oxidative stress age-dependent response to reactive oxygen species aging anti-apoptosis more... cellular response to ethanol detection of oxygen erythrophore differentiation glutathione metabolic process heart development hemopoiesis hydrogen peroxide biosynthetic process iron ion homeostasis liver development locomotory behavior mitochondrion organization negative regulation of apoptosis negative regulation of cell proliferation negative regulation of fat cell differentiation negative regulation of fibroblast proliferation negative regulation of neuron apoptosis neuron development oxidation-reduction process oxygen homeostasis positive regulation of nitric oxide biosynthetic process post-embryonic development protein homooligomerization protein homotetramerization regulation of blood pressure regulation of catalytic activity regulation of mitochondrial membrane potential regulation of transcription from RNA polymerase II promoter release of cytochrome c from mitochondria removal of superoxide radicals respiratory electron transport chain response to L-ascorbic acid response to activity response to axon injury response to cadmium ion response to drug response to electrical stimulus response to hydrogen peroxide response to hyperoxia response to hypoxia response to lipopolysaccharide response to manganese ion response to nutrient levels response to selenium ion response to silicon dioxide response to superoxide response to zinc ion superoxide anion generation superoxide metabolic process vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure less... cellular_component cytoplasm mitochondrial inner membrane mitochondrial matrix mitochondrial nucleoid more... mitochondrion soluble fraction less... molecular_function DNA binding identical protein binding manganese ion binding metal ion binding more... oxidoreductase activity oxygen binding superoxide dismutase activity less... BCL6 4 BP    MF    CC biological_process B cell differentiation actin cytoskeleton organization cell morphogenesis erythrocyte development more... germinal center formation negative regulation of B cell apoptosis negative regulation of Rho protein signal transduction negative regulation of S phase of mitotic cell cycle negative regulation of T-helper 2 cell differentiation negative regulation of apoptosis negative regulation of cell differentiation negative regulation of cell growth negative regulation of cell proliferation negative regulation of cell-matrix adhesion negative regulation of isotype switching to IgE isotypes negative regulation of mast cell cytokine production negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-dependent negative regulation of type 2 immune response positive regulation of B cell proliferation positive regulation of apoptosis positive regulation of cellular component movement protein import into nucleus, translocation protein localization regulation of Rho GTPase activity regulation of germinal center formation regulation of immune response regulation of inflammatory response regulation of memory T cell differentiation response to DNA damage stimulus spermatogenesis transcription, DNA-dependent less... cellular_component intracellular nucleolus nucleus replication fork more... molecular_function chromatin DNA binding chromatin binding metal ion binding nucleic acid binding more... protein binding sequence-specific DNA binding sequence-specific DNA binding transcription factor activity zinc ion binding less... PROS1 4 BP    MF    CC biological_process blood coagulation cellular protein metabolic process leukocyte migration negative regulation of endopeptidase activity more... peptidyl-glutamic acid carboxylation platelet activation platelet degranulation post-translational protein modification proteolysis less... cellular_component Golgi lumen Golgi membrane endoplasmic reticulum membrane extracellular region more... platelet alpha granule lumen less... molecular_function calcium ion binding endopeptidase inhibitor activity MET 4 BP    MF    CC biological_process activation of MAPK activity adult behavior axon guidance brain development more... cell aging cell proliferation cell surface receptor linked signaling pathway cellular response to arsenic-containing substance cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to interleukin-6 cellular response to peptide hormone stimulus central nervous system neuron differentiation glucose homeostasis hepatocyte growth factor receptor signaling pathway lactation liver development male gonad development multicellular organismal development muscle cell migration muscle organ development myoblast proliferation myotube differentiation negative regulation of peptidyl-threonine phosphorylation neuron migration oligodendrocyte development pancreas development placenta development positive regulation of DNA replication positive regulation of dendrite morphogenesis positive regulation of gene expression positive regulation of glucose transport positive regulation of mitosis positive regulation of neuron projection development positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein autophosphorylation regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling response to acid response to drug response to organic cyclic compound response to wounding signal transduction skeletal muscle tissue development sperm motility less... cellular_component basal plasma membrane cytoplasm dendrite excitatory synapse more... extracellular space flagellum integral to membrane integral to plasma membrane membrane membrane fraction neuronal cell body plasma membrane postsynaptic density postsynaptic membrane less... molecular_function ATP binding beta-catenin binding hepatocyte growth factor-activated receptor activity nucleotide binding more... phosphatidylinositol 3-kinase binding phospholipase binding protein binding protein complex binding protein heterodimerization activity protein tyrosine kinase activity receptor activity transferase activity, transferring phosphorus-containing groups less... KIAA0146 4 BP    MF    CC biological_process cellular_component molecular_function S100A4 4 BP    MF    CC biological_process epithelial to mesenchymal transition positive regulation of I-kappaB kinase/NF-kappaB cascade cellular_component neuron projection nucleus perinuclear region of cytoplasm molecular_function RAGE receptor binding calcium ion binding calcium-dependent protein binding identical protein binding more... protein binding less... SOCS3 4 BP    MF    CC biological_process JAK-STAT cascade aging anti-apoptosis branching involved in embryonic placenta morphogenesis more... cytokine-mediated signaling pathway interferon-gamma-mediated signaling pathway negative regulation of insulin receptor signaling pathway organ regeneration placenta blood vessel development positive regulation of cell differentiation regulation of growth regulation of interferon-gamma-mediated signaling pathway regulation of protein phosphorylation regulation of type I interferon-mediated signaling pathway response to bacterium response to cytokine stimulus response to drug response to estradiol stimulus response to food response to gamma radiation response to glucocorticoid stimulus response to heat response to hypoxia response to insulin stimulus response to lipopolysaccharide response to organic cyclic compound response to progesterone stimulus spongiotrophoblast differentiation trophoblast giant cell differentiation type I interferon-mediated signaling pathway less... cellular_component cytoplasm cytosol molecular_function protein kinase inhibitor activity GADD45B 4 BP    MF    CC biological_process activation of MAPKK activity activation of MAPKKK activity apoptosis cell differentiation more... multicellular organismal development negative regulation of protein kinase activity regulation of cell cycle response to stress less... cellular_component molecular_function FAM134B 4 BP    MF    CC biological_process sensory perception of pain cellular_component Golgi apparatus cis-Golgi network endoplasmic reticulum integral to membrane more... membrane less... molecular_function DUSP1 4 BP    MF    CC biological_process cell cycle cellular response to hormone stimulus endoderm formation inactivation of MAPK activity more... intracellular signal transduction positive regulation of anti-apoptosis positive regulation of apoptosis protein dephosphorylation regulation of apoptosis response to cAMP response to calcium ion response to estradiol stimulus response to glucocorticoid stimulus response to hydrogen peroxide response to light stimulus response to oxidative stress response to retinoic acid response to testosterone stimulus less... cellular_component nucleoplasm nucleus soluble fraction molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity non-membrane spanning protein tyrosine phosphatase activity phosphatase activity more... protein binding protein tyrosine phosphatase activity protein tyrosine/threonine phosphatase activity less... FBLN5 4 BP    MF    CC biological_process cell adhesion cell-matrix adhesion elastic fiber assembly extracellular matrix organization more... protein localization at cell surface regulation of removal of superoxide radicals less... cellular_component elastic fiber extracellular matrix extracellular region extracellular space more... proteinaceous extracellular matrix soluble fraction less... molecular_function calcium ion binding integrin binding protein C-terminus binding SCGB1D2 4 BP    MF    CC biological_process cellular_component extracellular region extracellular space molecular_function binding SLC18A2 4 BP    MF    CC biological_process aging cellular response to ammonium ion cellular response to drug death more... endocytic recycling glucose homeostasis insulin secretion locomotory behavior monoamine transport negative regulation of neurotransmitter transport neurotransmitter secretion post-embryonic development response to amphetamine response to cocaine response to corticosterone stimulus response to herbicide response to starvation response to zinc ion synaptic transmission synaptic vesicle amine transport transmembrane transport less... cellular_component clathrin sculpted monoamine transport vesicle membrane cytoplasm cytoplasmic vesicle cytoplasmic vesicle membrane more... dense core granule integral to plasma membrane membrane fraction neuron projection neuronal cell body plasma membrane synaptic vesicle membrane terminal button less... molecular_function drug binding enzyme binding heat shock protein binding monoamine transmembrane transporter activity more... serotonin transmembrane transporter activity less... PILRA 4 BP    MF    CC biological_process interspecies interaction between organisms signal transduction cellular_component extracellular region integral to membrane plasma membrane molecular_function protein binding receptor activity ODAM 2 BP    MF    CC biological_process biomineral tissue development odontogenesis of dentine-containing tooth cellular_component extracellular region fibril molecular_function SLPI 2 BP    MF    CC biological_process negative regulation of endopeptidase activity negative regulation of protein binding negative regulation of viral genome replication cellular_component extracellular matrix extracellular region molecular_function endopeptidase inhibitor activity enzyme binding protein binding serine-type endopeptidase inhibitor activity more... SEPT4 2 BP    MF    CC biological_process GTP catabolic process apoptosis brain development cell cycle more... cytokinesis positive regulation of apoptosis positive regulation of protein ubiquitination regulation of apoptosis sperm capacitation sperm mitochondrion organization less... cellular_component cell projection cytoplasm cytoskeleton microtubule-based flagellum more... mitochondrion nucleus less... molecular_function GTP binding GTPase activity nucleotide binding protein binding more... structural molecule activity less... PLAT 2 BP    MF    CC biological_process blood coagulation blood vessel morphogenesis fibrinolysis negative regulation of proteolysis more... platelet-derived growth factor receptor signaling pathway protein modification process proteolysis regulation of synaptic plasticity response to cAMP response to glucocorticoid stimulus response to hypoxia response to peptide hormone stimulus smooth muscle cell migration synaptic transmission, glutamatergic less... cellular_component apical part of cell cell surface cytoplasm extracellular matrix more... extracellular region extracellular space stored secretory granule synapse less... molecular_function peptidase activity protein binding serine-type endopeptidase activity SERHL2 2 BP    MF    CC biological_process cellular_component cytoplasm cytoplasmic membrane-bounded vesicle mitochondrion perinuclear region of cytoplasm more... peroxisome less... molecular_function hydrolase activity CLDN4 2 BP    MF    CC biological_process calcium-independent cell-cell adhesion female pregnancy response to progesterone stimulus cellular_component apical plasma membrane apicolateral plasma membrane basal plasma membrane cell junction more... integral to membrane integral to plasma membrane lateral plasma membrane membrane plasma membrane tight junction less... molecular_function identical protein binding structural molecule activity transmembrane signaling receptor activity HLA-DMB 2 BP    MF    CC biological_process T cell costimulation T cell receptor signaling pathway antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II more... cytokine-mediated signaling pathway immune response interferon-gamma-mediated signaling pathway less... cellular_component MHC class II protein complex endosome integral to membrane late endosome membrane more... lysosomal membrane membrane plasma membrane less... molecular_function DEPDC6 2 BP    MF    CC biological_process cellular_component molecular_function CDA 2 BP    MF    CC biological_process cell surface receptor linked signaling pathway cellular response to external biotic stimulus cytidine deamination cytosine metabolic process more... negative regulation of cell growth negative regulation of nucleotide metabolic process nucleobase-containing small molecule metabolic process protein homotetramerization pyrimidine base metabolic process pyrimidine nucleoside salvage pyrimidine-containing compound salvage response to cycloheximide less... cellular_component cytosol extracellular region molecular_function cytidine deaminase activity hydrolase activity metal ion binding nucleoside binding more... protein homodimerization activity zinc ion binding less... TNFSF10 2 BP    MF    CC biological_process activation of caspase activity activation of pro-apoptotic gene products apoptosis cell-cell signaling more... immune response induction of apoptosis induction of apoptosis by extracellular signals positive regulation of I-kappaB kinase/NF-kappaB cascade signal transduction less... cellular_component extracellular region extracellular space integral to plasma membrane membrane more... soluble fraction less... molecular_function cytokine activity metal ion binding protein binding receptor binding more... tumor necrosis factor receptor binding less... TNS1 2 BP    MF    CC biological_process cell-substrate junction assembly fibroblast migration intracellular signal transduction cellular_component cell-substrate junction cytoplasm cytoskeleton focal adhesion more... molecular_function actin binding metal ion binding protein binding CRLF1 2 BP    MF    CC biological_process negative regulation of neuron apoptosis positive regulation of cell proliferation positive regulation of tyrosine phosphorylation of Stat3 protein ureteric bud development more... cellular_component extracellular region extracellular space molecular_function ciliary neurotrophic factor receptor binding cytokine activity cytokine binding protein binding more... protein heterodimerization activity receptor activity less... COLEC11 2 BP    MF    CC biological_process developmental process cellular_component collagen extracellular region molecular_function binding mannose binding sugar binding SERPINA5 2 BP    MF    CC biological_process fusion of sperm to egg plasma membrane negative regulation of endopeptidase activity negative regulation of proteolysis regulation of proteolysis more... spermatogenesis less... cellular_component extracellular region membrane protein complex molecular_function acrosin binding glycosaminoglycan binding heparin binding peptidase inhibitor activity more... protease binding serine-type endopeptidase inhibitor activity less... IGFBP4 2 BP    MF    CC biological_process DNA metabolic process cell proliferation inflammatory response regulation of cell growth more... signal transduction skeletal system development less... cellular_component extracellular region extracellular space molecular_function insulin-like growth factor binding TNNC1 2 BP    MF    CC biological_process cardiac muscle contraction muscle filament sliding regulation of ATPase activity regulation of muscle contraction more... regulation of muscle filament sliding speed ventricular cardiac muscle tissue morphogenesis less... cellular_component cytosol troponin complex molecular_function actin filament binding calcium ion binding calcium-dependent protein binding protein binding more... protein homodimerization activity troponin I binding troponin T binding less... CWH43 2 BP    MF    CC biological_process GPI anchor biosynthetic process cellular_component integral to membrane membrane molecular_function PAEP 2 BP    MF    CC biological_process multicellular organismal development transport cellular_component extracellular region molecular_function binding transporter activity CYP2J2 2 BP    MF    CC biological_process epoxygenase P450 pathway icosanoid metabolic process linoleic acid metabolic process regulation of heart contraction more... xenobiotic metabolic process less... cellular_component endoplasmic reticulum endoplasmic reticulum membrane membrane microsome more... molecular_function arachidonic acid 11,12-epoxygenase activity arachidonic acid 14,15-epoxygenase activity arachidonic acid epoxygenase activity aromatase activity more... electron carrier activity heme binding linoleic acid epoxygenase activity metal ion binding less... MTL5 2 BP    MF    CC biological_process cell differentiation cellular metal ion homeostasis multicellular organismal development response to metal ion more... spermatogenesis less... cellular_component cytoplasm nucleus soluble fraction molecular_function metal ion binding DYNC1I1 2 BP    MF    CC biological_process transport vesicle transport along microtubule cellular_component chromosome condensed chromosome kinetochore cytoplasm cytoplasmic dynein complex more... cytoskeleton kinetochore microtubule perinuclear region of cytoplasm spindle pole vesicle less... molecular_function microtubule binding microtubule motor activity motor activity protein binding more... SLC1A1 2 BP    MF    CC biological_process D-aspartate import L-glutamate import L-glutamate transport dicarboxylic acid transport more... ion transport protein homooligomerization synaptic transmission transmembrane transport less... cellular_component integral to plasma membrane membrane membrane fraction plasma membrane more... molecular_function L-glutamate transmembrane transporter activity glutamate binding glutamate:sodium symporter activity sodium:dicarboxylate symporter activity more... symporter activity less... CD59 2 BP    MF    CC biological_process blood coagulation cell surface receptor linked signaling pathway cellular_component anchored to external side of plasma membrane anchored to membrane extracellular region membrane fraction more... plasma membrane less... molecular_function CYR61 2 BP    MF    CC biological_process anatomical structure morphogenesis apoptosis involved in heart morphogenesis atrial septum morphogenesis atrioventricular valve morphogenesis more... cell proliferation chemotaxis chondroblast differentiation chorio-allantoic fusion extracellular matrix organization intussusceptive angiogenesis labyrinthine layer blood vessel development negative regulation of apoptosis positive regulation of BMP signaling pathway positive regulation of cartilage development positive regulation of caspase activity positive regulation of cell migration positive regulation of cell-substrate adhesion positive regulation of ceramide biosynthetic process positive regulation of osteoblast differentiation positive regulation of osteoblast proliferation positive regulation of phospholipase activity positive regulation of protein kinase activity positive regulation of protein phosphorylation positive regulation of transcription from RNA polymerase II promoter reactive oxygen species metabolic process regulation of ERK1 and ERK2 cascade regulation of cell growth ventricular septum development wound healing, spreading of cells less... cellular_component extracellular region molecular_function extracellular matrix binding heparin binding insulin-like growth factor binding integrin binding more... TNFAIP2 2 BP    MF    CC biological_process angiogenesis cell differentiation multicellular organismal development cellular_component extracellular space molecular_function RARRES1 2 BP    MF    CC biological_process negative regulation of cell proliferation cellular_component integral to membrane membrane molecular_function APOL1 2 BP    MF    CC biological_process chloride transport cholesterol metabolic process cytolysis innate immune response more... killing of cells of other organism lipid transport lipoprotein metabolic process steroid metabolic process transport less... cellular_component extracellular region extracellular space high-density lipoprotein particle intrinsic to membrane more... very-low-density lipoprotein particle less... molecular_function chloride channel activity lipid binding protein binding TLE2 2 BP    MF    CC biological_process Wnt receptor signaling pathway negative regulation of canonical Wnt receptor signaling pathway negative regulation of transcription, DNA-dependent organ morphogenesis more... regulation of transcription, DNA-dependent signal transduction less... cellular_component nucleus molecular_function protein binding transcription corepressor activity BCKDHB 2 BP    MF    CC biological_process branched chain family amino acid catabolic process cellular nitrogen compound metabolic process response to cAMP response to glucocorticoid stimulus more... response to nutrient less... cellular_component mitochondrial alpha-ketoglutarate dehydrogenase complex mitochondrial matrix mitochondrion molecular_function 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity alpha-ketoacid dehydrogenase activity carboxy-lyase activity catalytic activity more... protein binding protein complex binding less... ANXA4 2 BP    MF    CC biological_process anti-apoptosis negative regulation of coagulation signal transduction cellular_component cytoplasm molecular_function calcium ion binding calcium-dependent phospholipid binding phospholipase inhibitor activity ARID5B 2 BP    MF    CC biological_process adipose tissue development adrenal gland development cell development face morphogenesis more... fat cell differentiation fat pad development female gonad development fibroblast migration kidney development liver development male gonad development multicellular organism growth muscle organ morphogenesis negative regulation of transcription, DNA-dependent nitrogen compound metabolic process palate development platelet-derived growth factor receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity post-embryonic development skeletal system morphogenesis less... cellular_component intracellular nucleus molecular_function DNA binding protein binding transcription coactivator activity transcription regulatory region DNA binding more... NPR1 2 BP    MF    CC biological_process body fluid secretion cGMP biosynthetic process cell surface receptor linked signaling pathway cyclic nucleotide biosynthetic process more... dopamine metabolic process intracellular signal transduction negative regulation of angiogenesis negative regulation of cell growth negative regulation of smooth muscle cell proliferation positive regulation of cGMP biosynthetic process positive regulation of renal sodium excretion positive regulation of urine volume receptor guanylyl cyclase signaling pathway regulation of blood pressure regulation of blood vessel size regulation of vascular permeability regulation of vasodilation less... cellular_component integral to plasma membrane plasma membrane molecular_function ATP binding GTP binding guanylate cyclase activity hormone binding more... natriuretic peptide receptor activity nucleotide binding peptide hormone binding peptide receptor activity, G-protein coupled phosphorus-oxygen lyase activity protein kinase activity protein kinase binding receptor activity transferase activity, transferring phosphorus-containing groups less... NFIB 2 BP    MF    CC biological_process Clara cell differentiation DNA replication Type I pneumocyte differentiation Type II pneumocyte differentiation more... anterior commissure morphogenesis chondrocyte differentiation commissural neuron axon guidance epithelial cell proliferation involved in lung morphogenesis forebrain development glial cell differentiation hindbrain development lung ciliated cell differentiation mesenchymal cell proliferation involved in lung development negative regulation of DNA binding negative regulation of cell proliferation negative regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter principal sensory nucleus of trigeminal nerve development transcription from RNA polymerase II promoter less... cellular_component cerebellar mossy fiber intracellular nucleolus nucleus more... molecular_function DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription RNA polymerase II transcription corepressor activity double-stranded DNA binding more... sequence-specific DNA binding RNA polymerase II transcription factor activity sequence-specific DNA binding transcription factor activity less... PRKAG2 2 BP    MF    CC biological_process ATP biosynthetic process carnitine shuttle cell cycle arrest cellular lipid metabolic process more... energy reserve metabolic process glycogen metabolic process insulin receptor signaling pathway intracellular protein kinase cascade negative regulation of protein kinase activity positive regulation of peptidyl-threonine phosphorylation positive regulation of protein kinase activity regulation of catalytic activity regulation of fatty acid biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid oxidation regulation of glucose import regulation of glycolysis sterol biosynthetic process less... cellular_component AMP-activated protein kinase complex cytosol nucleoplasm molecular_function ADP binding AMP binding AMP-activated protein kinase activity ATP binding more... cAMP-dependent protein kinase activity cAMP-dependent protein kinase inhibitor activity cAMP-dependent protein kinase regulator activity catalytic activity phosphorylase kinase regulator activity protein kinase activator activity protein kinase binding less... ADAMTS8 2 BP    MF    CC biological_process negative regulation of cell proliferation proteolysis cellular_component extracellular region proteinaceous extracellular matrix molecular_function heparin binding integrin binding low affinity phosphate transmembrane transporter activity metal ion binding more... metalloendopeptidase activity metallopeptidase activity peptidase activity zinc ion binding less... GCH1 2 BP    MF    CC biological_process GTP catabolic process dihydrobiopterin metabolic process dopamine biosynthetic process induction of apoptosis more... negative regulation of blood pressure neuromuscular process controlling posture nitric oxide biosynthetic process positive regulation of nitric-oxide synthase activity protein complex assembly protein heterooligomerization protein homooligomerization pteridine-containing compound biosynthetic process regulation of blood pressure regulation of lung blood pressure response to interferon-gamma response to lipopolysaccharide response to pain response to tumor necrosis factor tetrahydrobiopterin biosynthetic process tetrahydrofolate biosynthetic process vasodilation less... cellular_component cytoplasm cytoplasmic vesicle cytosol nuclear membrane more... nucleolus nucleus protein complex soluble fraction less... molecular_function GTP binding GTP cyclohydrolase I activity GTP-dependent protein binding calcium ion binding more... coenzyme binding hydrolase activity nucleotide binding protein binding protein homodimerization activity zinc ion binding less...
Up-regulated Genes Score CD36 6 SFRP4 6 KCNG1 6 SLC7A4 6 RABGAP1L 4 EDN3 4 CACNA1D 4 MOXD1 4 DKK2 4 MATN2 4 ACSM3 4 KMO 4 TCN1 4 LRRC17 4 DAAM2 4 PTGS1 4 RASSF2 4 FZD5 4 C5orf13 4 ECM1 4 DPP4 4 ANO1 4 PAGE4 4 OPRK1 4 ESR1 4 RGS4 4 ATAD4 4 GPM6B 4 PTGS2 4 OLFM1 4 SULT1E1 4 LRP4 4 GREM2 4 PCSK6 4 AKR1C3 4 TSC22D3 2 ENAH 2 EPB41L2 2 ACPP 2 PCDH7 2 HEY2 2 MMP7 2 RAB4A 2 IGF1 2 GSTM3 2 NUP153 2 PSD 2 LIF 2 IGFBP1 2 DNAJC6 2 ST7 2 MYH11 2 CYP3A5 2 VPS13D 2 SEMA3C 2 ANKRD55 2 SLC15A1 2 ST6GAL1 2 THBS1 2 SLC16A6 2 CKB 2 PIKFYVE 2 EPHB3 2 DHRS7 2 CDC25A 2 VLDLR 2 PLS1 2 HABP2 2 PLCB1 2 PCTP 2 CNN1 2 CYB5A 2 BEX4 2 FXYD2 2 CBARA1 2 OFD1 2 KRT18 2 CSRP2 2 DUSP6 2 ATP2C2 2 MAGED1 2 ST3GAL6 2 TMEFF1 2 CDH13 2 CATSPERB 2 TSPAN1 2 COMP 2 ATP6V0E2 2 SLC22A5 2 TM4SF1 2 FAP 2 MALL 2 TMEM144 2 CEL 2 ATP1B1 2 MSX2 2 G0S2 2 TRPC6 2 SLC44A4 2 DIO2 2 TRAK1 2 SLMO2 2 PION 2 NEBL 2 PECI 2 IMPA2 2 SPAG4 2 PDGFC 2 THBS2 2 FBXO21 2 PROM1 2 ACADSB 2 STX18 2 PIP5K1B 2 LCN2 2 PLOD1 2 QPRT 2 PAPOLA 2 F3 2 BTG3 2 CST1 2 IL6ST 2 MPPED2 2 CTTN 2 STEAP4 2 TAGLN 2 PELI1 2 KYNU 2 GALNT10 2 PPARGC1A 2 PYY 2 SCD 2 DDIT4 2 C1orf106 2 ABLIM3 2 PPPDE1 2 NUDT4 2 VNN1 2 ACSL3 2 HK2 2 PDZK1IP1 2 ZNF652 2 AIMP1 2 SFN 2 CYP2C9 2 ABP1 2 KIAA1199 2 MORC4 2 CKMT2 2 PTGER2 2 HIBCH 2 LOXL1 2 BAG5 2 IGFBP3 2 PRAME 2 KIAA0040 2 WDR77 2 TPD52 2 AQP3 2 DUSP4 2 KCNK13 2 TTC39A 2 ENDOG 2 AGR2 2 FAM174B 2 RMI1 2 TPPP3 2 ANG 2 ACP6 2 SOX17 2 SLC25A1 2 ADRA2A 2 MSX1 2 MMP11 2 HMGN5 2 KCNJ2 2 TMOD1 2 CXCR4 2 BCL2A1 2 PAX8 2 PGRMC1 2 DHFR 2 OTUB2 2	Down-regulated Genes Score CXCL13 6 KRT23 6 AHNAK2 6 DKK1 6 CCL2 4 S100A8 4 ID4 4 CHST2 4 AOX1 4 STC1 4 APOD 4 KCND3 4 RBP4 4 NUPR1 4 COL15A1 4 CFD 4 SERPINE1 4 GAS1 4 GLIPR1 4 MYC 4 TMEM45A 4 C1R 4 PLA2G2A 4 SLCO4A1 4 VCAN 4 IGFBP5 4 OSMR 4 C10orf10 4 TUBB6 4 S100P 4 CP 4 NNMT 4 DEFB1 4 TIMP3 4 ST7OT1 4 LMCD1 4 ASS1 4 GLUL 4 TGM2 4 C3 4 CD55 4 HPSE 4 PTPRR 4 MAFF 4 SERPING1 4 CEBPD 4 AMIGO2 4 SCGB2A2 4 CD52 4 IL15 4 SOD2 4 BCL6 4 PROS1 4 MET 4 KIAA0146 4 S100A4 4 SOCS3 4 GADD45B 4 FAM134B 4 DUSP1 4 FBLN5 4 SCGB1D2 4 SLC18A2 4 PILRA 4 ODAM 2 SLPI 2 SEPT4 2 PLAT 2 SERHL2 2 CLDN4 2 HLA-DMB 2 DEPDC6 2 CDA 2 TNFSF10 2 TNS1 2 CRLF1 2 COLEC11 2 SERPINA5 2 IGFBP4 2 TNNC1 2 CWH43 2 PAEP 2 CYP2J2 2 MTL5 2 DYNC1I1 2 SLC1A1 2 CD59 2 CYR61 2 TNFAIP2 2 RARRES1 2 APOL1 2 TLE2 2 BCKDHB 2 ANXA4 2 ARID5B 2 NPR1 2 NFIB 2 PRKAG2 2 ADAMTS8 2 GCH1 2 EFNA1 2 MAP3K5 2 CRIP1 2 GAL 2 PLA2G4A 2 TFCP2L1 2 NQO1 2 KLRC3 2 C4A 2 XCL1 2 ANK3 2 PDK4 2 FOSL2 2 ABCB9 2 BCL3 2 FAM155B 2 MAF 2 LOX 2 CAPN6 2 PART1 2 SYNE2 2 RAB40B 2 RAMP2 2 ISG20 2 GABARAPL1 2 NID2 2 SLC39A14 2 DCXR 2 GUCY1B3 2 SERPINA3 2 COBL 2 DUSP2 2 HSPB6 2 IGFBP6 2 PSD3 2 NPTX2 2 TPD52L1 2 SLC5A1 2 PIGF 2 ALDH3B2 2 TSPAN8 2 CTSC 2 CSDA 2 CITED2 2 GABRE 2 LRRC1 2 DFNB31 2 KLF6 2 PPM1H 2 CBR3 2 SLC43A1 2 ARG2 2 MYL9 2 GPX3 2 EPAS1 2 FBLN2 2 TRPM6 2 NDRG2 2 HSD11B2 2 IFNGR1 2 CYP1B1 2 LAMA4 2 TFPI2 2 CBLB 2 SLC16A7 2 EZR 2 GSN 2 KHDRBS3 2 VCAM1 2 BDKRB2 2 AOC3 2 MOCOS 2 FXYD3 2 RPL5 2 XCL2 2 PROL1 2 PIM1 2 RHOQ 2 LAMC1 2 HOMER2 2 ELP3 2 SORBS2 2 WNT4 2 SCGB1D1 2 HGD 2 RAB31 2 GABRA2 2 PDE9A 2 CHST6 2 TRPC4 2 LEPREL1 2 UCK2 2 SLC16A3 2 GMPR 2 LYN 2 CTNNA2 2 CYP26A1 2 IER3 2 WFDC2 2 TNFAIP8 2 SRPX 2 RP1-21O18.1 2 CORO1A 2 BIRC3 2 GJA1 2 MPZL2 2 CREB3L1 2 FOLR1 2 DUOX1 2 OLFM4 2 GBP1 2 MAOA 2 CXCL14 2 FKBP5 2 HEY1 2 LPAR2 2 SULT1C2 2 SORD 2 SERPINB9 2 SPOCK1 2 LAMB3 2 INHBB 2 CDC7 2 PNMA2 2 TPM2 2 GOLSYN 2 FERMT2 2 GP2 2 SLC15A2 2 BANK1 2 MOSC1 2 SERPINA1 2 RND3 2 MAP2K6 2 CTSL2 2 TMC5 2 PROCR 2 IGF2 2 ABCG1 2 STOM 2
Identifiers Repository Data-sets 19955106 PubMed 5 18191855 PubMed 8 15695772 PubMed 4
Up-regulated(183) Down-regulated(240)